JP2009196986A - 歯磨き組成物 - Google Patents
歯磨き組成物 Download PDFInfo
- Publication number
- JP2009196986A JP2009196986A JP2009013186A JP2009013186A JP2009196986A JP 2009196986 A JP2009196986 A JP 2009196986A JP 2009013186 A JP2009013186 A JP 2009013186A JP 2009013186 A JP2009013186 A JP 2009013186A JP 2009196986 A JP2009196986 A JP 2009196986A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- water
- catechins
- polymer
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 83
- 239000000551 dentifrice Substances 0.000 title claims abstract description 20
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims abstract description 49
- 235000005487 catechin Nutrition 0.000 claims abstract description 49
- 150000003839 salts Chemical class 0.000 claims abstract description 45
- 150000001765 catechin Chemical class 0.000 claims abstract description 40
- 229920000642 polymer Polymers 0.000 claims abstract description 34
- 239000002253 acid Substances 0.000 claims abstract description 27
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims abstract description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 10
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims abstract description 9
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000002949 phytic acid Nutrition 0.000 claims abstract description 9
- 239000000467 phytic acid Substances 0.000 claims abstract description 9
- 229940068041 phytic acid Drugs 0.000 claims abstract description 9
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 8
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000001630 malic acid Substances 0.000 claims abstract description 8
- 235000011090 malic acid Nutrition 0.000 claims abstract description 8
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims abstract description 5
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000015165 citric acid Nutrition 0.000 claims abstract description 5
- 235000011087 fumaric acid Nutrition 0.000 claims abstract description 5
- 239000001530 fumaric acid Substances 0.000 claims abstract description 5
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 5
- 239000004310 lactic acid Substances 0.000 claims abstract description 5
- 235000002906 tartaric acid Nutrition 0.000 claims abstract description 5
- 239000011975 tartaric acid Substances 0.000 claims abstract description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 4
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims abstract description 4
- 235000002639 sodium chloride Nutrition 0.000 claims description 49
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- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 9
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- 238000002845 discoloration Methods 0.000 abstract description 23
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- 230000002349 favourable effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229940034610 toothpaste Drugs 0.000 description 48
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- -1 polyphenol compound Chemical class 0.000 description 29
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 21
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 19
- 239000004386 Erythritol Substances 0.000 description 18
- 235000019414 erythritol Nutrition 0.000 description 18
- 229940009714 erythritol Drugs 0.000 description 18
- 235000014113 dietary fatty acids Nutrition 0.000 description 12
- 239000000194 fatty acid Substances 0.000 description 12
- 229930195729 fatty acid Natural products 0.000 description 12
- 239000002245 particle Substances 0.000 description 12
- 235000019640 taste Nutrition 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 244000269722 Thea sinensis Species 0.000 description 7
- 235000013616 tea Nutrition 0.000 description 7
- 238000003860 storage Methods 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000003945 anionic surfactant Substances 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229940094952 green tea extract Drugs 0.000 description 4
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- 210000000214 mouth Anatomy 0.000 description 4
- 208000028169 periodontal disease Diseases 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- LVJJFMLUMNSUFN-UHFFFAOYSA-N gallocatechin gallate Natural products C1=C(O)C=C2OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C1OC(=O)C1=CC(O)=C(O)C(O)=C1 LVJJFMLUMNSUFN-UHFFFAOYSA-N 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229920000591 gum Polymers 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 235000013824 polyphenols Nutrition 0.000 description 3
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 3
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 3
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- 239000011734 sodium Substances 0.000 description 3
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- 239000000126 substance Substances 0.000 description 3
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- LSHVYAFMTMFKBA-PZJWPPBQSA-N (+)-catechin-3-O-gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-PZJWPPBQSA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-araboascorbic acid Natural products OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 description 2
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Landscapes
- Cosmetics (AREA)
Abstract
【解決手段】次の成分(A)、(B)、(C)及び(D):
(A)カテキン類
(B)カテキン類と水不溶性の複合体を形成する水溶性ポリマー(以下ポリマーAという)
(C)リンゴ酸、クエン酸、フィチン酸、乳酸、コハク酸、酒石酸、フマル酸及びこれらの塩から選ばれる酸又はその塩
(D)水
を含有する歯磨き組成物。
【選択図】なし
Description
しかしながら、ポリフェノール化合物(カテキン類等)は酸素に触れることにより酸化、重合がおこり、顕著に変色するため、それを配合した口腔用組成物自体の経時変色は避けられない。
一方、各種の薬剤、変性しやすい有効成分等を口腔用組成物に配合する方法として、当該成分をカプセル化することやシェル等に内包して安定化するという方法も提案されている(特許文献5、6等)。
(A)カテキン類
(B)カテキン類と水不溶性の複合体を形成するポリマー(以下ポリマーAという)
(C)リンゴ酸、クエン酸、フィチン酸、乳酸、コハク酸、酒石酸、フマル酸及びこれらの塩から選ばれる酸又はその塩
(D)水
を含有する歯磨き組成物を提供するものである。
なお、水不溶性の複合体とは、カテキン類の水溶液とポリマーAの水溶液を混合した際に不溶物として水中から析出する物質のことである。水不溶性の複合体の析出は、混合液の濁り、あるいは、混合液をレーザー回折/散乱式粒度分布測定装置で測定した際に水不溶性複合体由来のピークが存在することによって確認することができる。なお、水不溶性の複合体には、例えば口腔内に適用した場合に、徐々に溶解するものも含まれる。
本発明において、ポリマーAの重量平均分子量は、一般的な重量平均分子量測定法である粘度法によって測定された値である。尚、ポリマーAの重量平均分子量は、光散乱法等の他の測定方法によっても測定することができる。そして、ポリマーAがポリビニルピロリドンである場合は、粘度の測定値からFikentscherの公式に基づいて計算されたK−値によって重量平均分子量を決定する。
成分(C)の酸の塩としては、ナトリウム塩、カリウム塩等のアルカリ金属の塩;マグネシウム塩、カルシウム塩等のアルカリ土類金属の塩などが挙げられる。
本発明においては、カテキン類の変色をより効果的に抑制する観点から、成分(C)の酸又はその塩に加えて、さらに縮合ポリリン酸又はその塩を含有することが好ましく、特に歯磨き組成物の味の観点(カテキン類の変色の抑制と味とのバランス)から縮合ポリリン酸又はその塩とリンゴ酸又はその塩、或いは縮合ポリリン酸又はその塩とフィチン酸又はその塩を組み合わせて用いることが好ましい。
縮合ポリリン酸又はその塩としては、ピロリン酸、トリポリリン酸、テトラポリリン酸、ペンタポリリン酸、ヘキサメタリン酸、ウルトラポリリン酸又はこれらの塩が挙げられ、特にピロリン酸、トリポリリン酸、ヘキサメタリン酸が好ましい。
本発明に用いられる粘結剤としては、例えば、アルギン酸ナトリウム、カルボキシメチルセルロースナトリウム、カラギーナン、キサンタンガム、ポリアクリル酸ナトリウム、トラガントガム、アラビアガム、グアーガム、カラヤガム、ローカストビーンガム、ジェランガム、タマリンドガム、サイリウムシードガム、コンドロイチン硫酸ナトリウム及びメトキシエチレン無水マレイン酸共重合体等が挙げられ、特にカルボキシメチルセルロースナトリウム、カラギーナン及びキサンタンガムが好ましい。これらは1種又は2種以上を組み合わせて使用してもよい。
エリスリトールの構造としては、L−エリスリトール、D−エリスリトール、meso−エリスリトールの3種の異性体が存在するが、本発明はこれらいずれの構造も使用できる。エリスリトールとしては、通常入手可能なものを使用でき、例えばブドウ糖を発酵させた後、再結晶して得られる結晶状のエリスリトール等が挙げられる。結晶状のエリスリトールは、市販品としては、日研化学(株)、三菱化学フーズ(株)、セレスター社製等のものが入手可能である。また、粒径の大きなものは、粉砕して粒子径を調整したものを使用することもできる。エリスリトールの粉砕には、ローラミル、ハンマーミル、高速度粉砕機、パルベライザーなどを使用するのが一般的であるが、粒度の調整が簡便で、かつ、生産効率にも優れる高速度粉砕機、ハンマーミルによる粉砕が好ましい。
篩:JIS標準篩 φ75mm
目開き:上段より、それぞれ500μm、355μm、250μm、180μm、125μm、90μm及び45μmの目開きを有する篩の下に受器を有する。
振盪機:ミクロ型電磁振動機M−2型(筒井理化学器機(株))
方法:試料15gを500μm篩上に載せ、電磁振動機にて5分間分級する。250μm、180μm、125μm、90μm及び45μmの目開きを有する篩上に存在するエリスリトールの合計量を粒子径45μm以上355μm未満のエリスリトールとする。
本発明の歯磨き組成物における研磨剤の含有量は、0〜15質量%が好ましく、特に0〜12質量%が好ましい。
抗酸化剤の含有量は、外観色の変化抑制効果の点から、本発明の歯磨き組成物中、0.0005〜50質量%、更に0.001〜20質量%、特に0.01〜5質量%が好ましい。
陰イオン界面活性剤は、本発明の歯磨き組成物中に0〜5質量%含有することが好ましく、より好ましくは0〜2質量%である。
非イオン界面活性剤の含有量は、本発明の歯磨き組成物中に0.1〜30質量%、より好ましくは0.2〜10質量%である。
実施例1
茶エキス(サンフェノン100S 太陽化学(株)、カテキン含有量60〜70%)を用い、表1に示す組成の歯磨き組成物A1とA2(本発明品)及び歯磨き組成物B〜D(比較品)を調製した。歯磨き組成物A1、A2、B〜DはpHが5.5〜5.7になるように調整した。歯磨き組成物A1、A2、Cは、茶エキスと、ポリビニルピロリドン又はヒドロキシエチルセルロースとによって複合体を形成してから、他の成分と混合して歯磨き組成物を調製した。得られた歯磨き組成物A1〜Dについて、下記方法で変色及び味を評価した。結果を表1に示す。
得られた歯磨き組成物を容器に充填し、50℃、1ヶ月保存し、保存後の明度差を下記方法により測定し、この明度差によって変色度合いを評価した。保存後の歯磨き組成物を透明で内容量が3cm×3cm×1cmのケース(AS ONE社、PS CASE No.1)に、いっぱいになるように詰める。そのケースと共に、色濃度標準としてKODAK GRAY SCALEのA,2,4,6,8,10,12,14,Bの9点(色濃度1〜9とする)と、CASMATCH(大日本印刷製)が同視野に入るようにし、白紙の上で撮影を行った。撮影条件はリングライト一様照明の下、一定のシャッター速度、しぼり、焦点距離で行った。撮影した画像をADOBE PHOTOSHOPにてCASMATCHを基準に用いて色補正後、WINROOF(三谷商事株式会社)にて被測定部位の明度(HSBカラーモデルのBrightness)を定量化し、50℃、1ヶ月保存品の明度と製造直後(初期)の明度の差異を下記式(I)で求め変色度とした。
変色度=[50℃、1ヶ月保存後の明度]−[初期の明度] (I)
歯磨き組成物A1〜Dの香味について、12名のパネラーにより、下記の3段階の基準で味の評価を行い、その平均値で示した。
評価基準
1:渋くない
2:あまり渋くない
3:渋い
表2に示す組成の歯磨き組成物E〜K(本発明品)及び歯磨き組成物L(比較例)を調製した。歯磨き組成物E〜KはpHが5.5〜5.7になるように調整した。歯磨き組成物E〜Kについても茶カテキンはポリマーAと複合体を形成してから、他の成分と混合して歯磨き組成物を調製した。得られた歯磨き組成物E〜Lについて、実施例1と同様の方法で変色及び味を評価した。結果を表2に示す。
*6:粒子径が45μm未満13質量%、45μm以上250μm未満82質量%、250μm以上355μm未満5質量%の粒度分布を有するエリスリトール
Claims (6)
- 次の成分(A)、(B)、(C)及び(D):
(A)カテキン類
(B)カテキン類と水不溶性の複合体を形成するポリマー(以下ポリマーAという)
(C)リンゴ酸、クエン酸、フィチン酸、乳酸、コハク酸、酒石酸、フマル酸及びこれらの塩から選ばれる酸又はその塩
(D)水
を含有する歯磨き組成物。 - カテキン類とポリマーAは、水不溶性の複合体を形成してから配合されている請求項1記載の歯磨き組成物。
- ポリマーAが水溶性のポリマーである請求項1又は2記載の歯磨き組成物。
- 水溶性のポリマーがポリビニルピロリドン系重合体及び水溶性セルロースエーテルから選択される請求項3記載の歯磨き組成物。
- さらに縮合ポリリン酸又はその塩を含有する請求項1〜4のいずれか1項に記載の歯磨き組成物。
- 成分(C)の酸又はその塩が、リンゴ酸、フィチン酸及びこれらの塩から選ばれる請求項1〜5のいずれか1項に記載の歯磨き組成物。
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