JP2009102263A5 - - Google Patents
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- Publication number
- JP2009102263A5 JP2009102263A5 JP2007275858A JP2007275858A JP2009102263A5 JP 2009102263 A5 JP2009102263 A5 JP 2009102263A5 JP 2007275858 A JP2007275858 A JP 2007275858A JP 2007275858 A JP2007275858 A JP 2007275858A JP 2009102263 A5 JP2009102263 A5 JP 2009102263A5
- Authority
- JP
- Japan
- Prior art keywords
- carnitine
- solvent
- crystallizing
- mother liquor
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 16
- 238000000034 method Methods 0.000 claims 9
- 239000002904 solvent Substances 0.000 claims 8
- 239000012452 mother liquor Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 238000001953 recrystallisation Methods 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 2
- 239000012046 mixed solvent Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- GUYHPGUANSLONG-SNAWJCMRSA-N (E)-4-(trimethylammonio)but-2-enoate Chemical compound C[N+](C)(C)C\C=C\C([O-])=O GUYHPGUANSLONG-SNAWJCMRSA-N 0.000 claims 1
- PHIQHXFUZVPYII-LURJTMIESA-N (S)-carnitine Chemical compound C[N+](C)(C)C[C@@H](O)CC([O-])=O PHIQHXFUZVPYII-LURJTMIESA-N 0.000 claims 1
- 229960004203 carnitine Drugs 0.000 claims 1
- 238000004064 recycling Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007275858A JP5561506B2 (ja) | 2007-10-24 | 2007-10-24 | Ｌ−カルニチンの単離精製方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007275858A JP5561506B2 (ja) | 2007-10-24 | 2007-10-24 | Ｌ−カルニチンの単離精製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009102263A JP2009102263A (ja) | 2009-05-14 |
| JP2009102263A5 true JP2009102263A5 (https=) | 2010-09-24 |
| JP5561506B2 JP5561506B2 (ja) | 2014-07-30 |
Family
ID=40704420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007275858A Expired - Fee Related JP5561506B2 (ja) | 2007-10-24 | 2007-10-24 | Ｌ−カルニチンの単離精製方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5561506B2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI485126B (zh) * | 2009-11-18 | 2015-05-21 | Lonza Ag | 製造ｌ－肉鹼的方法 |
| EP2325164A1 (en) * | 2009-11-18 | 2011-05-25 | Lonza Ltd. | Methods for the production of l-carnitine |
| CN103910645B (zh) * | 2013-01-07 | 2015-07-22 | 长春海悦药业有限公司 | 一种左卡尼汀化合物及其制备方法 |
| CN114249665B (zh) * | 2021-12-07 | 2024-01-23 | 安徽普利药业有限公司 | 一种左卡尼汀原料药制备方法 |
| US20240425444A1 (en) * | 2023-06-23 | 2024-12-26 | Hubei Xujie Pharmaceutical Co. Ltd. | Process for producing crystalline l-carnitine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1323066A (en) * | 1969-10-13 | 1973-07-11 | Ici Ltd | Purification of 4-methyl-2,6-di-tert butyl phenol |
| JPS514974A (en) * | 1974-07-02 | 1976-01-16 | Dan Kagaku Kk | Ionbiimuno purofuairuhoho |
| CH664374A5 (de) * | 1985-02-27 | 1988-02-29 | Lonza Ag | Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg. |
| IT1190358B (it) * | 1985-05-24 | 1988-02-16 | Sclavo Spa | Procedimento per la preparazione di l-carnitina |
| DE4111913A1 (de) * | 1991-04-12 | 1992-10-15 | Degussa | Verfahren zur herstellung von l-carnitin aus d,l-carnitinnitrilsalzen |
| JP3270558B2 (ja) * | 1992-02-17 | 2002-04-02 | 三井化学株式会社 | Ｌ−フェニルアラニンの精製方法および製造方法 |
| JP3188305B2 (ja) * | 1992-05-07 | 2001-07-16 | 月島機械株式会社 | 吸収凝縮器を設けた断熱冷却式溶融晶析方法とその装置 |
| JP4967659B2 (ja) * | 2004-09-08 | 2012-07-04 | 和光純薬工業株式会社 | Ｌ−カルニチンの精製方法 |
-
2007
- 2007-10-24 JP JP2007275858A patent/JP5561506B2/ja not_active Expired - Fee Related
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