JP2009039088A5 - - Google Patents
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- Publication number
- JP2009039088A5 JP2009039088A5 JP2007214047A JP2007214047A JP2009039088A5 JP 2009039088 A5 JP2009039088 A5 JP 2009039088A5 JP 2007214047 A JP2007214047 A JP 2007214047A JP 2007214047 A JP2007214047 A JP 2007214047A JP 2009039088 A5 JP2009039088 A5 JP 2009039088A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- therapeutic
- formula
- ameliorating agent
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003795 chemical substances by application Substances 0.000 claims 12
- 201000000980 schizophrenia Diseases 0.000 claims 11
- 230000001225 therapeutic effect Effects 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000000962 organic group Chemical group 0.000 claims 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 230000009145 protein modification Effects 0.000 claims 3
- -1 quinolinylmethylene, furanylmethylene, diazolylmethylene Chemical group 0.000 claims 3
- 125000005236 alkanoylamino group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- QELUYTUMUWHWMC-UHFFFAOYSA-N edaravone Chemical compound O=C1CC(C)=NN1C1=CC=CC=C1 QELUYTUMUWHWMC-UHFFFAOYSA-N 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 2
- 239000002516 radical scavenger Substances 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 239000011726 vitamin B6 Substances 0.000 claims 2
- 235000019158 vitamin B6 Nutrition 0.000 claims 2
- 229940011671 vitamin b6 Drugs 0.000 claims 2
- GFEZPGADIMGWOH-UHFFFAOYSA-N 6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol Chemical group CC1=NC=C2COCC2=C1O GFEZPGADIMGWOH-UHFFFAOYSA-N 0.000 claims 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- NHZMQXZHNVQTQA-UHFFFAOYSA-N Pyridoxamine Natural products CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229950009041 edaravone Drugs 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 235000008151 pyridoxamine Nutrition 0.000 claims 1
- 239000011699 pyridoxamine Substances 0.000 claims 1
- 125000002486 pyridoxamine group Chemical group 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 150000003839 salts Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007214047A JP5288365B2 (ja) | 2007-07-17 | 2007-08-20 | 統合失調症の検査および治療 |
| ES08792016.1T ES2515168T3 (es) | 2007-08-20 | 2008-07-31 | Detección y tratamiento de la esquizofrenia |
| SI200831305T SI2189537T1 (sl) | 2007-08-20 | 2008-07-31 | Detekcija in zdravljenje shizofrenije |
| PT87920161T PT2189537E (pt) | 2007-08-20 | 2008-07-31 | Detecção e tratamento da esquizofrenia |
| HRP20140993AT HRP20140993T1 (hr) | 2007-08-20 | 2008-07-31 | Otkrivanje i lijeäśenje shizofrenije |
| US12/674,018 US8809329B2 (en) | 2007-08-20 | 2008-07-31 | Detection and treatment of schizophrenia |
| EP20130003496 EP2662453A3 (en) | 2007-08-20 | 2008-07-31 | Detection and treatment of schizophrenia |
| DK08792016.1T DK2189537T3 (da) | 2007-08-20 | 2008-07-31 | Detektion og behandling af skizofreni |
| EP08792016.1A EP2189537B1 (en) | 2007-08-20 | 2008-07-31 | Detection and treatment of schizophrenia |
| PCT/JP2008/063803 WO2009025159A1 (ja) | 2007-08-20 | 2008-07-31 | 統合失調症の検査および治療 |
| PL08792016T PL2189537T3 (pl) | 2007-08-20 | 2008-07-31 | Wykrywanie i leczenie schizofrenii |
| US14/325,808 US20140335517A1 (en) | 2007-08-20 | 2014-07-08 | Detection and treatment of schizophrenia |
| CY20141100824T CY1115640T1 (el) | 2007-08-20 | 2014-10-10 | Διαγνωση και αγωγη εναντι της σχιζοφρενειας |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007186371 | 2007-07-17 | ||
| JP2007186371 | 2007-07-17 | ||
| JP2007214047A JP5288365B2 (ja) | 2007-07-17 | 2007-08-20 | 統合失調症の検査および治療 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013108428A Division JP5738346B2 (ja) | 2007-07-17 | 2013-05-22 | 統合失調症の検査 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009039088A JP2009039088A (ja) | 2009-02-26 |
| JP2009039088A5 true JP2009039088A5 (https=) | 2010-09-30 |
| JP5288365B2 JP5288365B2 (ja) | 2013-09-11 |
Family
ID=40378067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007214047A Expired - Fee Related JP5288365B2 (ja) | 2007-07-17 | 2007-08-20 | 統合失調症の検査および治療 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8809329B2 (https=) |
| EP (2) | EP2662453A3 (https=) |
| JP (1) | JP5288365B2 (https=) |
| CY (1) | CY1115640T1 (https=) |
| DK (1) | DK2189537T3 (https=) |
| ES (1) | ES2515168T3 (https=) |
| HR (1) | HRP20140993T1 (https=) |
| PL (1) | PL2189537T3 (https=) |
| PT (1) | PT2189537E (https=) |
| SI (1) | SI2189537T1 (https=) |
| WO (1) | WO2009025159A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2765263C (en) * | 2009-06-12 | 2016-07-12 | Jong Hoon Kim | Compound for inhibiting activity of ribonuclease, and container for storing nucleic acid containing the same |
| WO2011142460A1 (ja) * | 2010-05-14 | 2011-11-17 | 財団法人東京都医学総合研究所 | 統合失調症の検出方法 |
| CN102993191B (zh) * | 2012-12-18 | 2015-05-27 | 苏州大学 | 一种含有吖内酯与吡唑啉酮的杂环手性化合物及其衍生物、合成方法及用途 |
| US20170258791A1 (en) | 2014-08-29 | 2017-09-14 | Project Pm Co., Ltd. | Pharmaceutical composition formed by combining pyridoxamine compound and thiamine compound |
| KR101796391B1 (ko) * | 2015-07-24 | 2017-11-09 | 동국대학교 산학협력단 | Blt 저해 활성을 갖는 신규 화합물 및 이를 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 조성물 |
| JP6105111B1 (ja) | 2016-03-02 | 2017-03-29 | 国立大学法人東北大学 | 自閉スペクトラム症改善用組成物 |
| JP6924964B2 (ja) * | 2017-07-07 | 2021-08-25 | パナソニックＩｐマネジメント株式会社 | 情報提供方法、情報処理システム、情報端末、及び情報処理方法 |
| CN110022769B (zh) * | 2017-07-07 | 2022-09-27 | 松下知识产权经营株式会社 | 信息提供方法、信息处理系统、信息终端及信息处理方法 |
| KR20200024744A (ko) * | 2017-07-07 | 2020-03-09 | 파나소닉 아이피 매니지먼트 가부시키가이샤 | 정보 제공 방법, 정보 처리 시스템, 정보 단말, 및 정보 처리 방법 |
| WO2019168062A1 (ja) | 2018-02-27 | 2019-09-06 | キッコーマン株式会社 | 新規酵素及びそれを用いたペントシジンの測定方法 |
| US20220396822A1 (en) * | 2019-08-27 | 2022-12-15 | Kikkoman Corporation | Method for Measuring Pentosidine and Measurement Kit |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52102431A (en) | 1976-02-25 | 1977-08-27 | Kyowa Hakko Kogyo Co Ltd | Remedies for mental disorder |
| JP3507884B2 (ja) | 2000-03-07 | 2004-03-15 | 新潟大学長 | 遺伝子発現を指標とする統合失調症の客観的診断法 |
| CA2436522A1 (en) | 2001-01-31 | 2002-08-08 | Katia Vancompernolle | Phosphorylated glyoxalase i and its use |
| JP2003038198A (ja) | 2001-07-27 | 2003-02-12 | Univ Niigata | 精神分裂病により発現量が変化する遺伝子を規定する核酸を解析する方法 |
| NL1019368C2 (nl) * | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparaat voor het verbeteren van receptorwerking. |
| JP2003212795A (ja) | 2002-01-15 | 2003-07-30 | Japan Science & Technology Corp | 精神分裂病の診断薬 |
| JP4299243B2 (ja) | 2002-07-04 | 2009-07-22 | 田辺三菱製薬株式会社 | 統合失調症の検査、診断方法 |
| JP2004251865A (ja) | 2003-02-19 | 2004-09-09 | Takashi Muramatsu | 統合失調症およびアルツハイマー病の検査薬 |
| JP4143498B2 (ja) | 2003-07-31 | 2008-09-03 | 独立行政法人科学技術振興機構 | 統合失調症の判定方法 |
| CA2540355A1 (en) | 2003-09-30 | 2005-04-07 | Sankyo Company, Limited | Phenylene derivative having tetrazole ring or thiazolidinedione ring |
| US20050249823A1 (en) * | 2003-11-04 | 2005-11-10 | Murphy Tanya K | Methods for the prevention or amelioration of neuropsychiatric and related diseases |
| KR101205748B1 (ko) | 2003-12-05 | 2012-11-28 | 토카이 유니버시티 에듀케이셔널시스템 | 단백질 개질물 형성 저해제 |
| JP2005278490A (ja) | 2004-03-29 | 2005-10-13 | Japan Science & Technology Agency | 統合失調症に関与する生物学的マーカーの判定方法およびその利用 |
| US20100137635A1 (en) * | 2005-06-07 | 2010-06-03 | Inbiotex Inc. | Radical scavenger and active oxygen eliminating agent |
| TW200720261A (en) | 2005-08-31 | 2007-06-01 | Sankyo Co | Phenylene derivatives |
-
2007
- 2007-08-20 JP JP2007214047A patent/JP5288365B2/ja not_active Expired - Fee Related
-
2008
- 2008-07-31 US US12/674,018 patent/US8809329B2/en active Active
- 2008-07-31 PT PT87920161T patent/PT2189537E/pt unknown
- 2008-07-31 EP EP20130003496 patent/EP2662453A3/en not_active Withdrawn
- 2008-07-31 HR HRP20140993AT patent/HRP20140993T1/hr unknown
- 2008-07-31 PL PL08792016T patent/PL2189537T3/pl unknown
- 2008-07-31 EP EP08792016.1A patent/EP2189537B1/en not_active Not-in-force
- 2008-07-31 ES ES08792016.1T patent/ES2515168T3/es active Active
- 2008-07-31 WO PCT/JP2008/063803 patent/WO2009025159A1/ja not_active Ceased
- 2008-07-31 SI SI200831305T patent/SI2189537T1/sl unknown
- 2008-07-31 DK DK08792016.1T patent/DK2189537T3/da active
-
2014
- 2014-07-08 US US14/325,808 patent/US20140335517A1/en not_active Abandoned
- 2014-10-10 CY CY20141100824T patent/CY1115640T1/el unknown
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