JP2008546706A5 - - Google Patents

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Publication number
JP2008546706A5
JP2008546706A5 JP2008517095A JP2008517095A JP2008546706A5 JP 2008546706 A5 JP2008546706 A5 JP 2008546706A5 JP 2008517095 A JP2008517095 A JP 2008517095A JP 2008517095 A JP2008517095 A JP 2008517095A JP 2008546706 A5 JP2008546706 A5 JP 2008546706A5
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JP
Japan
Prior art keywords
trimethoxy
methoxy
group
composition
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008517095A
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English (en)
Japanese (ja)
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JP2008546706A (ja
JP5354775B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/023251 external-priority patent/WO2006138427A2/en
Publication of JP2008546706A publication Critical patent/JP2008546706A/ja
Publication of JP2008546706A5 publication Critical patent/JP2008546706A5/ja
Application granted granted Critical
Publication of JP5354775B2 publication Critical patent/JP5354775B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2008517095A 2005-06-14 2006-06-14 チューブリン結合活性を有するコンブレタスタチンアナログ Expired - Fee Related JP5354775B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69068905P 2005-06-14 2005-06-14
US60/690,689 2005-06-14
PCT/US2006/023251 WO2006138427A2 (en) 2005-06-14 2006-06-14 Combretastatin analogs with tubulin binding activity

Publications (3)

Publication Number Publication Date
JP2008546706A JP2008546706A (ja) 2008-12-25
JP2008546706A5 true JP2008546706A5 (https=) 2009-11-26
JP5354775B2 JP5354775B2 (ja) 2013-11-27

Family

ID=37076178

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008517095A Expired - Fee Related JP5354775B2 (ja) 2005-06-14 2006-06-14 チューブリン結合活性を有するコンブレタスタチンアナログ

Country Status (6)

Country Link
US (2) US7429681B2 (https=)
EP (1) EP1896391B1 (https=)
JP (1) JP5354775B2 (https=)
CA (1) CA2611712C (https=)
ES (1) ES2551086T3 (https=)
WO (1) WO2006138427A2 (https=)

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EP2048126A1 (de) * 2007-10-11 2009-04-15 Bayer Schering Pharma AG Benzocycloheptanderivate als selektiv wirksame Estrogene
WO2009067706A1 (en) 2007-11-21 2009-05-28 Oxigene, Inc. Method for treating hematopoietic neoplasms
WO2010132498A1 (en) * 2009-05-11 2010-11-18 Oxigene, Inc. Vascular disrupting agents for treatment of polypoidal choroidal vasculopathy
WO2011022772A1 (en) 2009-08-27 2011-03-03 Bionomics Limited Combination therapy for treating proliferative diseases
US20150018566A1 (en) 2011-08-25 2015-01-15 The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy Tubulin binding agents
AU2013204313C1 (en) 2012-06-01 2016-04-07 Bionomics Limited Combination Therapy
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US11419934B2 (en) 2015-08-18 2022-08-23 Oncotelic Therapeutics, Inc. Use of VDAS to enhance immunomodulating therapies against tumors
WO2017066668A1 (en) * 2015-10-15 2017-04-20 Baylor University Drug-linker conjugate pharmaceutical compositions
EA034994B1 (ru) * 2016-02-15 2020-04-15 Санофи 6,7-дигидро-5h-бензо[7]аннуленовые производные в качестве модуляторов эстрогеновых рецепторов
US20180002355A1 (en) * 2016-07-01 2018-01-04 Baylor University Benzocyclooctene-based and indene-based anticancer agents
ES3039455T3 (en) 2016-11-17 2025-10-21 Sanofi Sa Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
EP3434272A1 (en) 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
US10807932B2 (en) * 2018-08-17 2020-10-20 Baylor University Benzosuberene analogues and related compounds with activity as anticancer agents
BR112021003440A2 (pt) 2018-09-07 2021-05-18 Sanofi sais de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil) pirrolidin-3-il]oxifenil]-8,9-di-hidro-7h-benzo[7]anuleno-2-carboxilato de metila e seu processo de preparação
EP4037768B1 (en) 2019-10-01 2023-10-11 Sanofi Novel substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof
AU2020399168A1 (en) 2019-12-09 2022-07-28 Sanofi Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative
TW202146007A (zh) 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合
TW202233572A (zh) 2020-10-19 2022-09-01 法商賽諾菲公司 新穎之經取代的6,7-二氫-5h-苯並[7]輪烯衍生物，其製備方法及其治療用途
WO2022084280A1 (en) 2020-10-19 2022-04-28 Sanofi Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof

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