JP2013505947A5 - - Google Patents
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- JP2013505947A5 JP2013505947A5 JP2012531044A JP2012531044A JP2013505947A5 JP 2013505947 A5 JP2013505947 A5 JP 2013505947A5 JP 2012531044 A JP2012531044 A JP 2012531044A JP 2012531044 A JP2012531044 A JP 2012531044A JP 2013505947 A5 JP2013505947 A5 JP 2013505947A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- moiety
- propylene
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 98
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 98
- 125000003545 alkoxy group Chemical group 0.000 claims description 70
- 125000000217 alkyl group Chemical group 0.000 claims description 66
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 60
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 58
- 239000005977 Ethylene Substances 0.000 claims description 58
- -1 perhaloalkyl Chemical group 0.000 claims description 56
- 125000001475 halogen functional group Chemical group 0.000 claims description 54
- 125000001072 heteroaryl group Chemical group 0.000 claims description 54
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 50
- 125000003118 aryl group Chemical group 0.000 claims description 48
- 125000000623 heterocyclic group Chemical group 0.000 claims description 46
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 44
- 229910052799 carbon Inorganic materials 0.000 claims description 43
- 125000005102 carbonylalkoxy group Chemical group 0.000 claims description 40
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 40
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 36
- 125000004442 acylamino group Chemical group 0.000 claims description 36
- 150000001875 compounds Chemical class 0.000 claims description 36
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 34
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 34
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 32
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 30
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 25
- 125000004423 acyloxy group Chemical group 0.000 claims description 22
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 22
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 22
- 125000000304 alkynyl group Chemical group 0.000 claims description 18
- 125000002252 acyl group Chemical group 0.000 claims description 16
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 16
- 125000004104 aryloxy group Chemical group 0.000 claims description 16
- 125000005589 carbonylalkylenealkoxy group Chemical group 0.000 claims description 16
- 125000004001 thioalkyl group Chemical group 0.000 claims description 16
- 125000005121 aminocarbonylalkoxy group Chemical group 0.000 claims description 12
- 150000003573 thiols Chemical class 0.000 claims description 10
- 208000028017 Psychotic disease Diseases 0.000 claims description 8
- 208000010877 cognitive disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 8
- 230000001404 mediated effect Effects 0.000 claims description 8
- 239000002858 neurotransmitter agent Substances 0.000 claims description 8
- 150000001721 carbon Chemical group 0.000 claims description 7
- 208000012902 Nervous system disease Diseases 0.000 claims description 6
- 208000025966 Neurological disease Diseases 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- 208000028698 Cognitive impairment Diseases 0.000 claims description 2
- 125000002393 azetidinyl group Chemical group 0.000 claims description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 2
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 16
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 15
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 description 15
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 description 5
- 201000001119 neuropathy Diseases 0.000 description 2
- 230000007823 neuropathy Effects 0.000 description 2
- 208000033808 peripheral neuropathy Diseases 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 1
- 125000006312 cyclopentyl amino group Chemical group [H]N(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24514709P | 2009-09-23 | 2009-09-23 | |
| US24526009P | 2009-09-23 | 2009-09-23 | |
| US61/245,147 | 2009-09-23 | ||
| US61/245,260 | 2009-09-23 | ||
| PCT/US2010/050080 WO2011038163A1 (en) | 2009-09-23 | 2010-09-23 | Pyrido[3,4-b]indoles and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505947A JP2013505947A (ja) | 2013-02-21 |
| JP2013505947A5 true JP2013505947A5 (https=) | 2013-11-07 |
| JP5791612B2 JP5791612B2 (ja) | 2015-10-07 |
Family
ID=43796211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012531044A Expired - Fee Related JP5791612B2 (ja) | 2009-09-23 | 2010-09-23 | ピリド［３，４−ｂ］インドールおよび使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9079904B2 (https=) |
| EP (1) | EP2480080A4 (https=) |
| JP (1) | JP5791612B2 (https=) |
| CN (1) | CN102724875B (https=) |
| AU (1) | AU2010298168B2 (https=) |
| BR (1) | BR112012006646A2 (https=) |
| CA (1) | CA2775133A1 (https=) |
| WO (1) | WO2011038163A1 (https=) |
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| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| RU2544856C2 (ru) * | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| WO2009120717A2 (en) | 2008-03-24 | 2009-10-01 | Medivation Technologies, Inc. | Pyrido [3, 4-b] indoles and methods of use |
| CL2009000725A1 (es) | 2008-03-24 | 2009-05-29 | Medivation Technologies Inc | Compuestos derivados de heterociclos con uniones puente sustituidos, moduladores de receptores adrenergicos, de serotonina, de dopamina y de histaminas; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento del trastorno cognitivo y trastorno psicotico. |
| AU2009308708B2 (en) | 2008-10-31 | 2015-11-19 | Medivation Technologies, Inc. | Azepino [4, 5-b] indoles and methods of use |
| TWI477503B (zh) | 2008-10-31 | 2015-03-21 | Medivation Technologies Inc | 含有剛性部分之吡啶并〔４，３－ｂ〕吲哚 |
| EP2424366B1 (en) | 2009-04-29 | 2016-02-17 | Medivation Technologies, Inc. | Pyrido [4, 3-b]indoles and methods of use |
| CA2760541A1 (en) | 2009-04-29 | 2010-11-04 | Medivation Technologies, Inc. | Pyrido[4,3-b] indoles and methods of use |
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| US9434747B2 (en) | 2011-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Methods of treating diabetes |
| US8791132B2 (en) | 2011-02-18 | 2014-07-29 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
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| MX2017011951A (es) | 2015-03-17 | 2018-06-15 | Pfizer | Derivados sustituidos de indol 3 novedosos, composiciones farmaceuticas y metodos para uso. |
| TW201710258A (zh) | 2015-06-23 | 2017-03-16 | 碩騰服務公司 | 咔啉抗寄生蟲藥 |
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| WO2017048702A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN110372631B (zh) * | 2019-07-24 | 2021-03-02 | 东南大学成贤学院 | 一种氨噻肟酰胺乙醛的制备方法 |
| US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
| KR20230066311A (ko) * | 2020-06-10 | 2023-05-15 | 델릭스 테라퓨틱스, 인크. | 삼환형 사이코플라스토겐 및 이의 용도 |
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-
2010
- 2010-09-23 US US12/889,323 patent/US9079904B2/en not_active Expired - Fee Related
- 2010-09-23 CN CN201080047262.3A patent/CN102724875B/zh not_active Expired - Fee Related
- 2010-09-23 JP JP2012531044A patent/JP5791612B2/ja not_active Expired - Fee Related
- 2010-09-23 EP EP10819492.9A patent/EP2480080A4/en not_active Withdrawn
- 2010-09-23 WO PCT/US2010/050080 patent/WO2011038163A1/en not_active Ceased
- 2010-09-23 AU AU2010298168A patent/AU2010298168B2/en not_active Ceased
- 2010-09-23 BR BR112012006646A patent/BR112012006646A2/pt not_active IP Right Cessation
- 2010-09-23 CA CA2775133A patent/CA2775133A1/en not_active Abandoned
-
2013
- 2013-03-08 US US13/791,559 patent/US9085580B2/en not_active Expired - Fee Related
-
2015
- 2015-06-12 US US14/738,465 patent/US9271971B2/en not_active Expired - Fee Related
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