JP2008544246A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008544246A5 JP2008544246A5 JP2008516478A JP2008516478A JP2008544246A5 JP 2008544246 A5 JP2008544246 A5 JP 2008544246A5 JP 2008516478 A JP2008516478 A JP 2008516478A JP 2008516478 A JP2008516478 A JP 2008516478A JP 2008544246 A5 JP2008544246 A5 JP 2008544246A5
- Authority
- JP
- Japan
- Prior art keywords
- label
- magnetic
- concentration
- target
- binding site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000005291 magnetic effect Effects 0.000 claims description 181
- 230000027455 binding Effects 0.000 claims description 116
- 238000009739 binding Methods 0.000 claims description 116
- 238000001514 detection method Methods 0.000 claims description 94
- 238000004458 analytical method Methods 0.000 claims description 64
- 238000000034 method Methods 0.000 claims description 58
- 239000012530 fluid Substances 0.000 claims description 40
- 239000011324 bead Substances 0.000 claims description 22
- 239000000758 substrate Substances 0.000 claims description 20
- 239000003153 chemical reaction reagent Substances 0.000 claims description 16
- 230000008878 coupling Effects 0.000 claims description 14
- 238000010168 coupling process Methods 0.000 claims description 14
- 238000005859 coupling reaction Methods 0.000 claims description 14
- 230000005764 inhibitory process Effects 0.000 claims description 12
- 230000009870 specific binding Effects 0.000 claims description 12
- 230000000903 blocking effect Effects 0.000 claims description 11
- 230000002860 competitive effect Effects 0.000 claims description 8
- 230000007704 transition Effects 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 description 21
- 238000012360 testing method Methods 0.000 description 14
- 230000008569 process Effects 0.000 description 10
- 239000000463 material Substances 0.000 description 8
- 230000008901 benefit Effects 0.000 description 7
- 230000001419 dependent effect Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- 239000006249 magnetic particle Substances 0.000 description 6
- 238000000018 DNA microarray Methods 0.000 description 5
- 239000003990 capacitor Substances 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000009871 nonspecific binding Effects 0.000 description 5
- 239000012620 biological material Substances 0.000 description 4
- 238000010494 dissociation reaction Methods 0.000 description 4
- 230000005593 dissociations Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 150000003384 small molecules Chemical class 0.000 description 4
- 102000053602 DNA Human genes 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 239000000696 magnetic material Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920002477 rna polymer Polymers 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 241000238366 Cephalopoda Species 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000003255 drug test Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000009149 molecular binding Effects 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 210000003103 bodily secretion Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 230000005292 diamagnetic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000005294 ferromagnetic effect Effects 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000001459 lithography Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002052 molecular layer Substances 0.000 description 1
- 239000002773 nucleotide Chemical class 0.000 description 1
- 125000003729 nucleotide group Chemical class 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105361 | 2005-06-17 | ||
| PCT/IB2006/051866 WO2006134546A2 (en) | 2005-06-17 | 2006-06-12 | Accurate magnetic biosensor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008544246A JP2008544246A (ja) | 2008-12-04 |
| JP2008544246A5 true JP2008544246A5 (enExample) | 2009-07-30 |
Family
ID=37309075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008516478A Pending JP2008544246A (ja) | 2005-06-17 | 2006-06-12 | 正確な磁気バイオセンサー |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080206104A1 (enExample) |
| EP (1) | EP1894009A2 (enExample) |
| JP (1) | JP2008544246A (enExample) |
| CN (1) | CN101198870A (enExample) |
| BR (1) | BRPI0612623A2 (enExample) |
| RU (1) | RU2415432C2 (enExample) |
| WO (1) | WO2006134546A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090009156A1 (en) * | 2006-02-03 | 2009-01-08 | Konninklijke Philips Electronics N.V. | Magnetic Sensor Device With Reference Unit |
| DE102006016334B4 (de) * | 2006-04-06 | 2018-11-15 | Boehringer Ingelheim Vetmedica Gmbh | Verfahren und Vorrichtung zur Detektion magnetisierbarer Partikel |
| BRPI0711346A8 (pt) * | 2006-05-09 | 2015-10-06 | Koninklije Philips Electronics N V | Método para detectar um alvo em uma amostra suspeita de conter o alvo, e, uso de um magneto |
| WO2007129275A2 (en) * | 2006-05-10 | 2007-11-15 | Koninklijke Philips Electronics N.V. | Rapid magnetic biosensor |
| US20090278534A1 (en) * | 2006-06-28 | 2009-11-12 | Koninklijke Philips Electronics N.V. | Magnetic sensor device for and a method of sensing magnetic particles |
| WO2008010110A1 (en) * | 2006-07-17 | 2008-01-24 | Koninklijke Philips Electronics N. V. | Attraction and repulsion of magnetic of magnetizable objects to and from a sensor surface |
| RU2456618C2 (ru) | 2006-10-12 | 2012-07-20 | Конинклейке Филипс Электроникс Н.В. | Система и способ обнаружения с помощью магнитной и/или электрической метки |
| EP2115467A1 (en) * | 2007-02-23 | 2009-11-11 | Koninklijke Philips Electronics N.V. | Magnetic sensor device with field generator and sensor element |
| US8190372B2 (en) * | 2007-02-23 | 2012-05-29 | Koninklijke Philips Electronics N.V. | Sensor device for and a method of sensing magnetic particles |
| DE102007015543A1 (de) * | 2007-03-30 | 2008-10-09 | Siemens Ag | Verfahren und Anordnung zur Detektion biologischer Reaktionsprodukte |
| EP2017619A1 (en) * | 2007-07-20 | 2009-01-21 | Koninklijke Philips Electronics N.V. | Magnetic sensor device |
| EP2017618A1 (en) * | 2007-07-20 | 2009-01-21 | Koninklijke Philips Electronics N.V. | Methods and systems for detecting |
| JP2009042104A (ja) * | 2007-08-09 | 2009-02-26 | Canon Inc | 物質固定装置、物質検出装置および物質固定方法 |
| EP2028491A1 (en) * | 2007-08-22 | 2009-02-25 | Koninklijke Philips Electronics N.V. | Method of directing magnetic or magnetisable objects to prepare bio-sensor device |
| GB0716968D0 (en) * | 2007-08-31 | 2007-10-10 | Vivacta Ltd | Sensor |
| US20100273269A1 (en) * | 2007-12-04 | 2010-10-28 | Koninklijke Philips Electronics N.V. | Method of measuring molecules in a fluid using label particles |
| EP2073016A1 (en) * | 2007-12-20 | 2009-06-24 | Koninklijke Philips Electronics N.V. | Magnetic label based detection |
| EP2235516B1 (en) | 2008-01-17 | 2017-10-11 | The Regents of The University of California | Integrated magnetic field generation and detection platform |
| US20110014719A1 (en) * | 2008-03-17 | 2011-01-20 | Koninklijke Philips Electronics N.V. | Cartridge for assays with magnetic particles |
| US8053250B2 (en) * | 2008-06-27 | 2011-11-08 | Rex Chin-Yih Hong | Method and system for suppressing bindings on magnetic particles |
| JP5996868B2 (ja) | 2008-10-17 | 2016-09-21 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 高感度アッセイのためのパルス磁気作動 |
| EP2208531A1 (en) | 2008-12-30 | 2010-07-21 | Atonomics A/S | Distribution of particles in capillary channel by application of magnetic field |
| US9599591B2 (en) | 2009-03-06 | 2017-03-21 | California Institute Of Technology | Low cost, portable sensor for molecular assays |
| WO2010121223A2 (en) * | 2009-04-17 | 2010-10-21 | California Institute Of Technology | Electromagnetic molecular sensors and methods of using same |
| WO2011021142A1 (en) | 2009-08-19 | 2011-02-24 | Koninklijke Philips Electronics N.V. | Detection of different target components by cluster formation |
| CN102575976B (zh) * | 2009-09-28 | 2016-03-30 | 皇家飞利浦电子股份有限公司 | 物质确定设备 |
| CA2777807A1 (en) | 2009-10-16 | 2011-04-21 | Amic Ab | An assay method and devices involving the use of magnetic particles |
| WO2011049044A1 (ja) * | 2009-10-19 | 2011-04-28 | 国立大学法人東京工業大学 | 磁性微粒子を用いるバイオセンサ |
| WO2011073866A1 (en) | 2009-12-18 | 2011-06-23 | Koninklijke Philips Electronics N.V. | Substance determining apparatus |
| EP2362219A1 (en) | 2010-02-19 | 2011-08-31 | Nxp B.V. | Sensor measuring method and sensing apparatus |
| WO2012068146A1 (en) * | 2010-11-15 | 2012-05-24 | Regents Of The University Of Minnesota | Search coil |
| US9304130B2 (en) | 2010-12-16 | 2016-04-05 | International Business Machines Corporation | Trenched sample assembly for detection of analytes with electromagnetic read-write heads |
| US9040311B2 (en) | 2011-05-03 | 2015-05-26 | International Business Machines Corporation | Calibration assembly for aide in detection of analytes with electromagnetic read-write heads |
| US8855957B2 (en) | 2011-05-03 | 2014-10-07 | International Business Machines Corporation | Method for calibrating read sensors of electromagnetic read-write heads |
| WO2013078332A1 (en) * | 2011-11-23 | 2013-05-30 | The General Hospital Corporation | Analyte detection using magnetic hall effect |
| WO2013173497A1 (en) * | 2012-05-15 | 2013-11-21 | Massachusetts Institute Of Technology | Systems and methods for detecting molecular interactions using magnetic beads |
| WO2014037880A1 (en) * | 2012-09-04 | 2014-03-13 | Koninklijke Philips N.V. | A sensor device and a method of sampling |
| US9435800B2 (en) | 2012-09-14 | 2016-09-06 | International Business Machines Corporation | Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles |
| KR101517594B1 (ko) | 2013-10-16 | 2015-05-04 | (주)타스컴 | 바이오 센서 |
| EP3143386A4 (en) * | 2014-05-12 | 2017-11-29 | Qi, Huan | Method and system for analyte sensing |
| JP6594995B2 (ja) | 2015-03-26 | 2019-10-23 | コーニンクレッカ フィリップス エヌ ヴェ | バイオセンサカートリッジの製造 |
| CN107796865B (zh) | 2016-09-05 | 2021-05-25 | 财团法人工业技术研究院 | 生物分子磁传感器 |
| US20180266991A1 (en) * | 2017-03-15 | 2018-09-20 | Qualcomm Incorporated | Magneto-impedance (mi) sensors employing current confinement and exchange bias layer(s) for increased sensitivity |
| GB201720162D0 (en) * | 2017-12-04 | 2018-01-17 | Univ Oxford Innovation Ltd | Method |
| CA3106680A1 (en) * | 2018-07-27 | 2020-01-30 | Zepto Life Technology, LLC | System and method for sensing analytes in gmr-based detection of biomarkers |
| EP4592678A1 (en) | 2024-01-26 | 2025-07-30 | Technische Universität München | Method and device for detecting a concentration of at least one analyte in a sample |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8701980A (nl) * | 1987-08-24 | 1989-03-16 | Catena Product Dev Bv | Inductieve naderingssensor. |
| WO1993024135A1 (en) * | 1992-05-26 | 1993-12-09 | Immunex Corporation | Novel cytokine that binds cd30 |
| US5981297A (en) * | 1997-02-05 | 1999-11-09 | The United States Of America As Represented By The Secretary Of The Navy | Biosensor using magnetically-detected label |
| AU6046700A (en) * | 1999-05-10 | 2000-11-21 | California Institute Of Technology | Use of spatiotemporal response behavior in sensor arrays to detect analytes in fluids |
| US6875621B2 (en) * | 1999-10-13 | 2005-04-05 | Nve Corporation | Magnetizable bead detector |
| RU2198919C1 (ru) * | 2001-11-21 | 2003-02-20 | Московский городской научно-практический центр борьбы с туберкулезом Комитета здравоохранения Москвы | Устройство для сбора иммуномагнитных частиц, связанных при помощи специфических антител с бактериальными или вирусными инфекционными агентами, из инфицированной биологической жидкости |
| US7106051B2 (en) * | 2001-12-21 | 2006-09-12 | Koninklijke Philips Electronics, N.V. | Magnetoresistive sensing device, system and method for determining a density of magnetic particles in fluid |
| JP2005513475A (ja) * | 2001-12-21 | 2005-05-12 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | マイクロアレイ上の磁気ナノ粒子の領域密度を測定するセンサー及び方法 |
| US7419821B2 (en) * | 2002-03-05 | 2008-09-02 | I-Stat Corporation | Apparatus and methods for analyte measurement and immunoassay |
| EP1525447A4 (en) * | 2002-05-31 | 2006-12-06 | Univ California | METHOD AND DEVICE FOR DETECTING INTERESTING SUBSTANCES |
| EP1376111A1 (en) * | 2002-06-24 | 2004-01-02 | Universite Catholique De Louvain | Method and device for high sensitivity detection of the presence of DNA and other probes |
| US20050118603A1 (en) * | 2002-10-11 | 2005-06-02 | Ahram Biosystems Inc. | Target detection system having a conformationally sensitive probe comprising a nucleic acid based signal transducer |
| US20080309329A1 (en) * | 2003-07-30 | 2008-12-18 | Koninklike Philips Electronics N.V. | On-Chip Magnetic Sensor Device with Suppressed Cross-Talk |
| WO2005074417A2 (en) * | 2003-09-03 | 2005-08-18 | Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
| US7892817B2 (en) * | 2004-05-18 | 2011-02-22 | Koninklijke Philips Electronics, N.V. | Magnetic rotation to improve signal-over-background in biosensing |
-
2006
- 2006-06-12 WO PCT/IB2006/051866 patent/WO2006134546A2/en not_active Ceased
- 2006-06-12 RU RU2008101786/14A patent/RU2415432C2/ru not_active IP Right Cessation
- 2006-06-12 CN CNA2006800213124A patent/CN101198870A/zh active Pending
- 2006-06-12 US US11/917,211 patent/US20080206104A1/en not_active Abandoned
- 2006-06-12 EP EP06765725A patent/EP1894009A2/en not_active Withdrawn
- 2006-06-12 BR BRPI0612623A patent/BRPI0612623A2/pt not_active IP Right Cessation
- 2006-06-12 JP JP2008516478A patent/JP2008544246A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008544246A5 (enExample) | ||
| JP2008544246A (ja) | 正確な磁気バイオセンサー | |
| JP5628784B2 (ja) | 磁性粒子によるアッセイ用カートリッジ | |
| JP5970153B2 (ja) | 凝集パラメータの測定 | |
| CN103597344B (zh) | 用于样品中分析物的高通量检测的系统和方法 | |
| US20100289483A1 (en) | Sensor cartridge | |
| EP2078199B1 (en) | Magnetic and/or electric label assisted detection system and method | |
| JP2010534320A (ja) | 磁気センサ装置 | |
| JP2010500594A (ja) | 磁気センサ装置 | |
| US20070224604A1 (en) | Method of Determining the Presence and/or Concentration of Substances of Interest in Fluids | |
| WO2009083856A2 (en) | Concentrated unbound magnetic particle assay for biosensors | |
| US20090105087A1 (en) | Microelectronic device with controllable reference substance supply | |
| US20080206892A1 (en) | Rapid Magnetic Biosensor With Integrated Arrival Time Measuremnt | |
| JP2009536342A (ja) | 正確な磁気バイオセンサ | |
| EP3295163B1 (en) | Devices and methods for increasing magnetic sensor sensitivity | |
| WO2010086772A1 (en) | System and method for assay | |
| EP1936350A1 (en) | A method for quantitatively measuring agglutination parameters |