JP2008544246A - 正確な磁気バイオセンサー - Google Patents

正確な磁気バイオセンサー Download PDF

Info

Publication number
JP2008544246A
JP2008544246A JP2008516478A JP2008516478A JP2008544246A JP 2008544246 A JP2008544246 A JP 2008544246A JP 2008516478 A JP2008516478 A JP 2008516478A JP 2008516478 A JP2008516478 A JP 2008516478A JP 2008544246 A JP2008544246 A JP 2008544246A
Authority
JP
Japan
Prior art keywords
label
concentration
magnetic
target
binding site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008516478A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008544246A5 (https=
Inventor
メンノ ダブリュ ジェイ プリンス
アルベルト エイチ ジェイ イミンク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV, Koninklijke Philips Electronics NV filed Critical Koninklijke Philips NV
Publication of JP2008544246A publication Critical patent/JP2008544246A/ja
Publication of JP2008544246A5 publication Critical patent/JP2008544246A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2008516478A 2005-06-17 2006-06-12 正確な磁気バイオセンサー Pending JP2008544246A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05105361 2005-06-17
PCT/IB2006/051866 WO2006134546A2 (en) 2005-06-17 2006-06-12 Accurate magnetic biosensor

Publications (2)

Publication Number Publication Date
JP2008544246A true JP2008544246A (ja) 2008-12-04
JP2008544246A5 JP2008544246A5 (https=) 2009-07-30

Family

ID=37309075

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008516478A Pending JP2008544246A (ja) 2005-06-17 2006-06-12 正確な磁気バイオセンサー

Country Status (7)

Country Link
US (1) US20080206104A1 (https=)
EP (1) EP1894009A2 (https=)
JP (1) JP2008544246A (https=)
CN (1) CN101198870A (https=)
BR (1) BRPI0612623A2 (https=)
RU (1) RU2415432C2 (https=)
WO (1) WO2006134546A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505572A (ja) * 2007-12-04 2011-02-24 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 標識粒子を用いた流体内分子測定方法
JP2015528571A (ja) * 2012-09-04 2015-09-28 コーニンクレッカ フィリップス エヌ ヴェ センサデバイス及びサンプリングする方法
JP2020534507A (ja) * 2018-07-27 2020-11-26 ゼプト ライフ テクノロジー， エルエルシーＺｅｐｔｏ Ｌｉｆｅ Ｔｅｃｈｎｏｌｏｇｙ， Ｌｌｃ Ｇｍｒによるバイオマーカの検出における被検物質の検知のためのシステムおよび方法
US12600825B2 (en) 2020-01-08 2026-04-14 Zepto Life Technology, Inc. Polymer compositions and biosurfaces comprising them on sensors

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2076785A2 (en) * 2006-02-03 2009-07-08 Koninklijke Philips Electronics N.V. Magnetic sensor device with reference unit
DE102006016334B4 (de) * 2006-04-06 2018-11-15 Boehringer Ingelheim Vetmedica Gmbh Verfahren und Vorrichtung zur Detektion magnetisierbarer Partikel
EP2027468B1 (en) * 2006-05-09 2011-06-22 Koninklijke Philips Electronics N.V. Detection of target molecules in a sample by using a magnetic field
CN101438142B (zh) 2006-05-10 2013-10-30 皇家飞利浦电子股份有限公司 快速磁生物传感器
EP2038635A2 (en) * 2006-06-28 2009-03-25 Koninklijke Philips Electronics N.V. A magnetic sensor device for and a method of sensing magnetic particles
CN101490528A (zh) * 2006-07-17 2009-07-22 皇家飞利浦电子股份有限公司 将可磁化对象磁吸引到传感器表面和磁排斥离开传感器表面
BRPI0719892B8 (pt) 2006-10-12 2021-07-27 Koninklijke Philips Electronics Nv sistema de detecção preparado para detectar pelo menos uma molécula alvo, método para detectar pelo menos uma molécula alvo, e, componente de sensor preparado para uso com um sistema de detecção para detectar pelo menos uma molécula alvo
WO2008102218A1 (en) * 2007-02-23 2008-08-28 Koninklijke Philips Electronics N.V. A sensor device for and a method of sensing magnetic particles
WO2008102299A1 (en) * 2007-02-23 2008-08-28 Koninklijke Philips Electronics N.V. Magnetic sensor device with field generator and sensor element
DE102007015543A1 (de) * 2007-03-30 2008-10-09 Siemens Ag Verfahren und Anordnung zur Detektion biologischer Reaktionsprodukte
EP2017619A1 (en) * 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Magnetic sensor device
EP2017618A1 (en) * 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Methods and systems for detecting
JP2009042104A (ja) * 2007-08-09 2009-02-26 Canon Inc 物質固定装置、物質検出装置および物質固定方法
EP2028491A1 (en) * 2007-08-22 2009-02-25 Koninklijke Philips Electronics N.V. Method of directing magnetic or magnetisable objects to prepare bio-sensor device
GB0716968D0 (en) * 2007-08-31 2007-10-10 Vivacta Ltd Sensor
EP2073016A1 (en) * 2007-12-20 2009-06-24 Koninklijke Philips Electronics N.V. Magnetic label based detection
CA2711956A1 (en) 2008-01-17 2009-07-23 The Regents Of The University Of California Integrated magnetic field generation and detection platform
JP5628784B2 (ja) * 2008-03-17 2014-11-19 コーニンクレッカ フィリップス エヌ ヴェ 磁性粒子によるアッセイ用カートリッジ
US8053250B2 (en) * 2008-06-27 2011-11-08 Rex Chin-Yih Hong Method and system for suppressing bindings on magnetic particles
EP2340434B1 (en) 2008-10-17 2014-03-19 Koninklijke Philips N.V. Pulsed magnetic actuation for sensitive assays
EP2208531A1 (en) 2008-12-30 2010-07-21 Atonomics A/S Distribution of particles in capillary channel by application of magnetic field
US8993236B2 (en) * 2009-04-17 2015-03-31 California Institute Of Technology Electromagnetic molecular sensors and methods of using same
US9599591B2 (en) 2009-03-06 2017-03-21 California Institute Of Technology Low cost, portable sensor for molecular assays
US20120208296A1 (en) 2009-08-19 2012-08-16 Koninklijke Philips Electronics N.V. Detection of different target components by cluster formation
US9772272B2 (en) 2009-09-28 2017-09-26 Koninklijke Philips N.V. Substance determining apparatus
RU2595843C2 (ru) 2009-10-16 2016-08-27 Омик Аб Способ анализа и устройства с применением магнитных частиц
JPWO2011049044A1 (ja) * 2009-10-19 2013-03-14 国立大学法人東京工業大学 磁性微粒子を用いるバイオセンサ
CN102656443B (zh) 2009-12-18 2016-01-20 皇家飞利浦电子股份有限公司 物质确定设备
EP2362219A1 (en) * 2010-02-19 2011-08-31 Nxp B.V. Sensor measuring method and sensing apparatus
US9778225B2 (en) 2010-11-15 2017-10-03 Regents Of The University Of Minnesota Magnetic search coil for measuring real-time brownian relaxation of magnetic nanoparticles
US9304130B2 (en) * 2010-12-16 2016-04-05 International Business Machines Corporation Trenched sample assembly for detection of analytes with electromagnetic read-write heads
US9040311B2 (en) 2011-05-03 2015-05-26 International Business Machines Corporation Calibration assembly for aide in detection of analytes with electromagnetic read-write heads
US8855957B2 (en) 2011-05-03 2014-10-07 International Business Machines Corporation Method for calibrating read sensors of electromagnetic read-write heads
US9958416B2 (en) 2011-11-23 2018-05-01 The General Hospital Corporation Analyte detection using magnetic hall effect
US9977015B2 (en) * 2012-05-15 2018-05-22 Massachusetts Institute Of Technology Systems and methods for detecting molecular interactions using magnetic beads
US9435800B2 (en) 2012-09-14 2016-09-06 International Business Machines Corporation Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles
KR101517594B1 (ko) 2013-10-16 2015-05-04 (주)타스컴 바이오 센서
WO2015173729A1 (en) * 2014-05-12 2015-11-19 Qi, Huan Method and system for analyte sensing
JP6594995B2 (ja) * 2015-03-26 2019-10-23 コーニンクレッカ フィリップス エヌ ヴェ バイオセンサカートリッジの製造
EP3290938A1 (en) 2016-09-05 2018-03-07 Industrial Technology Research Institute Biomolecule magnetic sensor
US20180266991A1 (en) * 2017-03-15 2018-09-20 Qualcomm Incorporated Magneto-impedance (mi) sensors employing current confinement and exchange bias layer(s) for increased sensitivity
GB201720162D0 (en) * 2017-12-04 2018-01-17 Univ Oxford Innovation Ltd Method
EP4592678A1 (en) 2024-01-26 2025-07-30 Technische Universität München Method and device for detecting a concentration of at least one analyte in a sample

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040241758A1 (en) * 1992-05-26 2004-12-02 Immunex Corporation CD 30 ligand
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
JP2005513485A (ja) * 2001-12-21 2005-05-12 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 流体中の磁性粒子密度を測定する磁気抵抗検出装置、システム、及び方法
WO2005111596A1 (en) * 2004-05-18 2005-11-24 Koninklijke Philips Electronics N.V. Magnetic rotation to improve signal-over-background in biosensing

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8701980A (nl) * 1987-08-24 1989-03-16 Catena Product Dev Bv Inductieve naderingssensor.
US5981297A (en) * 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
WO2000068675A1 (en) * 1999-05-10 2000-11-16 California Institute Of Technology Use of spatiotemporal response behavior in sensor arrays to detect analytes in fluids
US6875621B2 (en) * 1999-10-13 2005-04-05 Nve Corporation Magnetizable bead detector
RU2198919C1 (ru) * 2001-11-21 2003-02-20 Московский городской научно-практический центр борьбы с туберкулезом Комитета здравоохранения Москвы Устройство для сбора иммуномагнитных частиц, связанных при помощи специфических антител с бактериальными или вирусными инфекционными агентами, из инфицированной биологической жидкости
WO2003054523A2 (en) * 2001-12-21 2003-07-03 Koninklijke Philips Electronics N.V. Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array
US7419821B2 (en) * 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
AU2003239963A1 (en) * 2002-05-31 2003-12-19 The Regents Of The University Of California Method and apparatus for detecting substances of interest
EP1376111A1 (en) * 2002-06-24 2004-01-02 Universite Catholique De Louvain Method and device for high sensitivity detection of the presence of DNA and other probes
US20050118603A1 (en) * 2002-10-11 2005-06-02 Ahram Biosystems Inc. Target detection system having a conformationally sensitive probe comprising a nucleic acid based signal transducer
EP1697755A1 (en) * 2003-07-30 2006-09-06 Koninklijke Philips Electronics N.V. On-chip magnetic sensor device with suppressed cross-talk

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040241758A1 (en) * 1992-05-26 2004-12-02 Immunex Corporation CD 30 ligand
JP2005513485A (ja) * 2001-12-21 2005-05-12 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 流体中の磁性粒子密度を測定する磁気抵抗検出装置、システム、及び方法
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
WO2005111596A1 (en) * 2004-05-18 2005-11-24 Koninklijke Philips Electronics N.V. Magnetic rotation to improve signal-over-background in biosensing

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505572A (ja) * 2007-12-04 2011-02-24 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 標識粒子を用いた流体内分子測定方法
JP2015528571A (ja) * 2012-09-04 2015-09-28 コーニンクレッカ フィリップス エヌ ヴェ センサデバイス及びサンプリングする方法
JP2020534507A (ja) * 2018-07-27 2020-11-26 ゼプト ライフ テクノロジー， エルエルシーＺｅｐｔｏ Ｌｉｆｅ Ｔｅｃｈｎｏｌｏｇｙ， Ｌｌｃ Ｇｍｒによるバイオマーカの検出における被検物質の検知のためのシステムおよび方法
US12174135B2 (en) 2018-07-27 2024-12-24 Zepto Life Technology, Inc. System and method for GMR-based detection of biomarkers
US12241851B2 (en) 2018-07-27 2025-03-04 Zepto Life Technology, Inc. System and method for processing analyte signals in GMR-based detection of biomarkers
US12600825B2 (en) 2020-01-08 2026-04-14 Zepto Life Technology, Inc. Polymer compositions and biosurfaces comprising them on sensors

Also Published As

Publication number Publication date
RU2008101786A (ru) 2009-07-27
US20080206104A1 (en) 2008-08-28
WO2006134546A3 (en) 2007-03-08
RU2415432C2 (ru) 2011-03-27
EP1894009A2 (en) 2008-03-05
CN101198870A (zh) 2008-06-11
BRPI0612623A2 (pt) 2016-11-29
WO2006134546A2 (en) 2006-12-21

Similar Documents

Publication Publication Date Title
JP2008544246A (ja) 正確な磁気バイオセンサー
JP2008544246A5 (https=)
JP5628784B2 (ja) 磁性粒子によるアッセイ用カートリッジ
JP5970153B2 (ja) 凝集パラメータの測定
US20100289483A1 (en) Sensor cartridge
EP2078199B1 (en) Magnetic and/or electric label assisted detection system and method
EP2558204B1 (en) Assay apparatus incorporating a microfluidic channel and assay method
JP2010534320A (ja) 磁気センサ装置
CN102047117A (zh) 用于检测唾液中分析物的设备和方法
CN101111769A (zh) 快速而灵敏的生物感测
JP2010500594A (ja) 磁気センサ装置
US20070224604A1 (en) Method of Determining the Presence and/or Concentration of Substances of Interest in Fluids
US20090105087A1 (en) Microelectronic device with controllable reference substance supply
US20080206892A1 (en) Rapid Magnetic Biosensor With Integrated Arrival Time Measuremnt
EP3295163B1 (en) Devices and methods for increasing magnetic sensor sensitivity
CN101438162A (zh) 精准的磁性生物传感器
WO2010086772A1 (en) System and method for assay

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20090611

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090611

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20111027

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120306

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120918