JP2008543911A - 非ステロイド性プロゲステロン受容体モジュレーターとしてのベンゾフラノン誘導体 - Google Patents

非ステロイド性プロゲステロン受容体モジュレーターとしてのベンゾフラノン誘導体 Download PDF

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Publication number
JP2008543911A
JP2008543911A JP2008517445A JP2008517445A JP2008543911A JP 2008543911 A JP2008543911 A JP 2008543911A JP 2008517445 A JP2008517445 A JP 2008517445A JP 2008517445 A JP2008517445 A JP 2008517445A JP 2008543911 A JP2008543911 A JP 2008543911A
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JP
Japan
Prior art keywords
group
compound according
alkyl
ethynyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008517445A
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English (en)
Japanese (ja)
Inventor
シュベデ，ボルフガンク
メラー，カルステン
シュミット，アンヤ
フールマン，ウルリケ
シュメース，ノルベルト
ボテ，ウルリヒ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of JP2008543911A publication Critical patent/JP2008543911A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
JP2008517445A 2005-06-24 2006-06-22 非ステロイド性プロゲステロン受容体モジュレーターとしてのベンゾフラノン誘導体 Pending JP2008543911A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030294A DE102005030294A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren
PCT/EP2006/006532 WO2006136462A1 (de) 2005-06-24 2006-06-22 Nonsteroidal progesterone receptor modulators

Publications (1)

Publication Number Publication Date
JP2008543911A true JP2008543911A (ja) 2008-12-04

Family

ID=36716643

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008517445A Pending JP2008543911A (ja) 2005-06-24 2006-06-22 非ステロイド性プロゲステロン受容体モジュレーターとしてのベンゾフラノン誘導体

Country Status (22)

Country Link
EP (1) EP1899315A1 (de)
JP (1) JP2008543911A (de)
KR (1) KR20080018275A (de)
CN (1) CN101248056A (de)
AR (1) AR057409A1 (de)
AU (1) AU2006261049A1 (de)
BR (1) BRPI0612305A2 (de)
CA (1) CA2611900A1 (de)
CR (1) CR9595A (de)
DE (1) DE102005030294A1 (de)
DO (1) DOP2006000150A (de)
EA (1) EA200702604A1 (de)
EC (1) ECSP078043A (de)
GT (1) GT200600272A (de)
IL (1) IL188022A0 (de)
MX (1) MX2008000070A (de)
NO (1) NO20080441L (de)
PE (1) PE20070170A1 (de)
TW (1) TW200738665A (de)
UY (1) UY29626A1 (de)
WO (1) WO2006136462A1 (de)
ZA (1) ZA200800689B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (es) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag Moduladores no esteroides de receptores de progesterona
DE102007032800A1 (de) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102007058747A1 (de) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
TWI477276B (zh) * 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
CA2872644A1 (en) 2012-05-31 2013-12-05 Repros Therapeutics Inc. Formulations and methods for vaginal delivery of antiprogestins
JP6343619B2 (ja) 2012-11-02 2018-06-13 レプロス セラピューティクス インコーポレイティド プロゲステロン依存性病態を処置する方法およびその組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19723722A1 (de) * 1997-05-30 1998-12-10 Schering Ag Nichtsteroidale Gestagene
EP1175422A2 (de) * 1999-05-04 2002-01-30 Ligand Pharmaceuticals Incorporated Tetracyclische progesteronrezeptor-modulator-verbindungen und verfahren
US6358948B1 (en) * 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6960581B2 (en) * 2002-01-14 2005-11-01 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
BR0308394A (pt) * 2002-03-11 2005-01-25 Schering Ag 5-{2-hidróxi-3-[1-(3-trifluormetilfenil)-ciclopropil]-pr oprionilamino}-ftaleto e compostos relacionados com atividade moduladora de receptores de progesterona para uso em controle da fertilidade e terapia de reposição hormonal
DE10346939A1 (de) * 2003-10-06 2005-05-19 Schering Ag Heterocyclisch substituierte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Also Published As

Publication number Publication date
EA200702604A1 (ru) 2008-06-30
KR20080018275A (ko) 2008-02-27
CN101248056A (zh) 2008-08-20
CA2611900A1 (en) 2006-12-28
GT200600272A (es) 2007-08-20
WO2006136462A1 (de) 2006-12-28
MX2008000070A (es) 2008-03-19
CR9595A (es) 2008-05-05
ECSP078043A (es) 2008-01-23
UY29626A1 (es) 2007-01-31
TW200738665A (en) 2007-10-16
EP1899315A1 (de) 2008-03-19
NO20080441L (no) 2008-03-07
DOP2006000150A (es) 2006-12-31
IL188022A0 (en) 2008-03-20
BRPI0612305A2 (pt) 2010-11-03
DE102005030294A1 (de) 2007-01-04
AU2006261049A1 (en) 2006-12-28
PE20070170A1 (es) 2007-03-02
ZA200800689B (en) 2009-07-29
AR057409A1 (es) 2007-12-05

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