EA200702604A1 - Производные бензофуранона как нестероидные модуляторы рецептора прогестерона - Google Patents

Производные бензофуранона как нестероидные модуляторы рецептора прогестерона

Info

Publication number
EA200702604A1
EA200702604A1 EA200702604A EA200702604A EA200702604A1 EA 200702604 A1 EA200702604 A1 EA 200702604A1 EA 200702604 A EA200702604 A EA 200702604A EA 200702604 A EA200702604 A EA 200702604A EA 200702604 A1 EA200702604 A1 EA 200702604A1
Authority
EA
Eurasian Patent Office
Prior art keywords
progesterone receptor
steroidal
benzofuranone
modulator
derivatives
Prior art date
Application number
EA200702604A
Other languages
English (en)
Russian (ru)
Inventor
Вольфганг Шведе
Карстен Мёллер
Аня Шмидт
Ульрике Фурманн
Норберт Шмеес
Ульрих Боте
Original Assignee
Байер Шеринг Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Шеринг Фарма Акциенгезельшафт filed Critical Байер Шеринг Фарма Акциенгезельшафт
Publication of EA200702604A1 publication Critical patent/EA200702604A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
EA200702604A 2005-06-24 2006-06-22 Производные бензофуранона как нестероидные модуляторы рецептора прогестерона EA200702604A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030294A DE102005030294A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren
PCT/EP2006/006532 WO2006136462A1 (de) 2005-06-24 2006-06-22 Nonsteroidal progesterone receptor modulators

Publications (1)

Publication Number Publication Date
EA200702604A1 true EA200702604A1 (ru) 2008-06-30

Family

ID=36716643

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702604A EA200702604A1 (ru) 2005-06-24 2006-06-22 Производные бензофуранона как нестероидные модуляторы рецептора прогестерона

Country Status (22)

Country Link
EP (1) EP1899315A1 (de)
JP (1) JP2008543911A (de)
KR (1) KR20080018275A (de)
CN (1) CN101248056A (de)
AR (1) AR057409A1 (de)
AU (1) AU2006261049A1 (de)
BR (1) BRPI0612305A2 (de)
CA (1) CA2611900A1 (de)
CR (1) CR9595A (de)
DE (1) DE102005030294A1 (de)
DO (1) DOP2006000150A (de)
EA (1) EA200702604A1 (de)
EC (1) ECSP078043A (de)
GT (1) GT200600272A (de)
IL (1) IL188022A0 (de)
MX (1) MX2008000070A (de)
NO (1) NO20080441L (de)
PE (1) PE20070170A1 (de)
TW (1) TW200738665A (de)
UY (1) UY29626A1 (de)
WO (1) WO2006136462A1 (de)
ZA (1) ZA200800689B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (es) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag Moduladores no esteroides de receptores de progesterona
DE102007032800A1 (de) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102007058747A1 (de) * 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
TWI477276B (zh) * 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
US10328022B2 (en) 2012-05-31 2019-06-25 Repros Therapeutics Inc. Formulations and methods for vaginal delivery of antiprogestins
WO2014070517A1 (en) 2012-11-02 2014-05-08 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19723722A1 (de) * 1997-05-30 1998-12-10 Schering Ag Nichtsteroidale Gestagene
CN1353717A (zh) * 1999-05-04 2002-06-12 莱加制药公司 四环黄体酮受体调节剂化合物及其方法
US6358948B1 (en) * 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
AU2003202216A1 (en) * 2002-01-14 2003-07-30 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof
EP1482925B1 (de) * 2002-03-11 2007-01-17 Schering AG 5-(2-hydroxy-3-'1-(3-trifluormethylphenyl)-cyclopropl]-propionylamino)-phtalid und verwandte verbindungen mit progesteron-rezeptor-modulierender wirkung zur verwendung bei der fertilitätskontrolle und hormonersatztherapie
DE10346939A1 (de) * 2003-10-06 2005-05-19 Schering Ag Heterocyclisch substituierte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Also Published As

Publication number Publication date
AU2006261049A1 (en) 2006-12-28
EP1899315A1 (de) 2008-03-19
GT200600272A (es) 2007-08-20
DE102005030294A1 (de) 2007-01-04
BRPI0612305A2 (pt) 2010-11-03
PE20070170A1 (es) 2007-03-02
DOP2006000150A (es) 2006-12-31
ECSP078043A (es) 2008-01-23
NO20080441L (no) 2008-03-07
AR057409A1 (es) 2007-12-05
UY29626A1 (es) 2007-01-31
JP2008543911A (ja) 2008-12-04
MX2008000070A (es) 2008-03-19
KR20080018275A (ko) 2008-02-27
TW200738665A (en) 2007-10-16
ZA200800689B (en) 2009-07-29
IL188022A0 (en) 2008-03-20
CN101248056A (zh) 2008-08-20
WO2006136462A1 (de) 2006-12-28
CA2611900A1 (en) 2006-12-28
CR9595A (es) 2008-05-05

Similar Documents

Publication Publication Date Title
EA200702604A1 (ru) Производные бензофуранона как нестероидные модуляторы рецептора прогестерона
NO20063760L (no) Selektive ostrogenreseptormodulatorer for behandling av vasomotoriske symptomer
DK1768625T3 (da) Sammensætninger med vedvarende frigørelse indeholdende progesteron-receptormodulatorer
WO2007016385A3 (en) Use of substituted 5-amino-1h-pyrrole-2-carbonitrile derivatives as progesterone receptor modulators
EA201190138A1 (ru) Производные фуропиримидиндиона в качестве модуляторов trpa1
EA200970065A1 (ru) Производные пиперазинила, предназначенные для лечения заболеваний, опосредованных рецептором gpr38
ECSP12012355A (es) Derivados de 6,7-dihidro-5h-benzo[7]anulenos, métodos para su preparación, preparaciones farmacéuticas que los contienen y su uso para la preparación de medicamentos
EA200800421A1 (ru) Соединения
EA200702524A1 (ru) Нестероидные модуляторы рецептора прогестерона
DE602005019905D1 (de) -modulatoren
UY29625A1 (es) Uso de moduladores no esteroides de receptores de progesterona
MA32477B1 (fr) Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique
WO2008113851A3 (en) Novel c11 modified retrosteroids as progesterone receptor modulator compounds
EA201000097A1 (ru) 8-бета-замещенные эстратриены в качестве селективно активных эстрогенов
DK1809602T3 (da) Indolderivater, der kan anvendes som progesteronreceptormodulatorer
UY30815A1 (es) Moduladores no esteroidales del receptor de progesterona
UY30805A1 (es) Moduladores no esteroides de receptores de progesterona
TH85615B (th) สารปรับโพรเจสเตอโรนรีเซปเตอร์ชนิดนอนสเตียรอยด์
TH85615A (th) สารปรับโพรเจสเตอโรนรีเซปเตอร์ชนิดนอนสเตียรอยด์