JP2008543758A5 - - Google Patents
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- Publication number
- JP2008543758A5 JP2008543758A5 JP2008515878A JP2008515878A JP2008543758A5 JP 2008543758 A5 JP2008543758 A5 JP 2008543758A5 JP 2008515878 A JP2008515878 A JP 2008515878A JP 2008515878 A JP2008515878 A JP 2008515878A JP 2008543758 A5 JP2008543758 A5 JP 2008543758A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tanaproget
- ethinyl estradiol
- pharmaceutically acceptable
- daily dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 48
- PYVFWTPEBMRKSR-UHFFFAOYSA-N tanaproget Chemical compound CN1C(C#N)=CC=C1C1=CC=C(NC(=S)OC2(C)C)C2=C1 PYVFWTPEBMRKSR-UHFFFAOYSA-N 0.000 claims 17
- 229950001471 tanaproget Drugs 0.000 claims 17
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 14
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 14
- 229960002568 ethinylestradiol Drugs 0.000 claims 14
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 14
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 9
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 7
- 229960004977 anhydrous lactose Drugs 0.000 claims 7
- 229960001681 croscarmellose sodium Drugs 0.000 claims 7
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 7
- 235000019359 magnesium stearate Nutrition 0.000 claims 7
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 7
- 239000008108 microcrystalline cellulose Substances 0.000 claims 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 3
- 238000002657 hormone replacement therapy Methods 0.000 claims 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 229960001375 lactose Drugs 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 229940057948 magnesium stearate Drugs 0.000 claims 2
- 230000000708 anti-progestin effect Effects 0.000 claims 1
- 239000003418 antiprogestin Substances 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 230000002254 contraceptive effect Effects 0.000 claims 1
- 238000007908 dry granulation Methods 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940068196 placebo Drugs 0.000 claims 1
- 239000000902 placebo Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68880605P | 2005-06-09 | 2005-06-09 | |
| US60/688,806 | 2005-06-09 | ||
| PCT/US2006/022150 WO2006135638A2 (en) | 2005-06-09 | 2006-06-07 | Tanaproget compositions containing ethinyl estradiol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008543758A JP2008543758A (ja) | 2008-12-04 |
| JP2008543758A5 true JP2008543758A5 (https=) | 2009-07-23 |
| JP5339903B2 JP5339903B2 (ja) | 2013-11-13 |
Family
ID=37432377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008515878A Expired - Fee Related JP5339903B2 (ja) | 2005-06-09 | 2006-06-07 | エチニルエストラジオールを含むタナプロゲット組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20060280800A1 (https=) |
| EP (1) | EP1893217A2 (https=) |
| JP (1) | JP5339903B2 (https=) |
| CN (2) | CN103989687A (https=) |
| AR (1) | AR057060A1 (https=) |
| AU (1) | AU2006258048A1 (https=) |
| BR (1) | BRPI0611250A2 (https=) |
| CA (1) | CA2610767C (https=) |
| HN (1) | HN2006020928A (https=) |
| MX (1) | MX2007015571A (https=) |
| PE (1) | PE20070001A1 (https=) |
| TW (1) | TW200716137A (https=) |
| WO (1) | WO2006135638A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG120970A1 (en) * | 1999-05-04 | 2006-04-26 | Ligand Pharm Inc | Cyclothiocarbamate derivatives as progesterone receptor modulators |
| MX2007013467A (es) * | 2005-04-28 | 2008-01-21 | Wyeth Corp | Tanaproget micronizado y composiciones que contienen el mismo. |
| CN101166521A (zh) | 2005-04-28 | 2008-04-23 | 惠氏公司 | 通过湿制粒法制备包含微粒化他那普戈特的组合物 |
| CN101166736B (zh) * | 2005-04-28 | 2013-02-06 | 惠氏公司 | 他那普戈特的多晶型ⅱ |
| CN101166532B (zh) * | 2005-04-28 | 2011-06-22 | 惠氏公司 | 微粒化的他那普戈特、组合物及其制备方法 |
| CA2610767C (en) | 2005-06-09 | 2014-09-23 | Wyeth | Tanaproget compositions containing ethinyl estradiol |
| BRPI0819571A2 (pt) | 2007-12-20 | 2019-09-24 | Teva Womenss Health Inc | "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica" |
| SG11201401583YA (en) * | 2011-10-17 | 2014-09-26 | Lexicon Pharmaceuticals Inc | Solid dosage forms of (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20140006315A1 (en) * | 2012-07-02 | 2014-01-02 | Stèphane Etheve | Method of marketing oregano capsules containing thymoquinone |
| US9326997B2 (en) | 2012-09-24 | 2016-05-03 | Ahlam E. Elakkad | Composition and method for treation Oligoovulation, Oligomenorrhea and Amenorrhea |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2014159377A1 (en) * | 2013-03-14 | 2014-10-02 | Teva Women's Health, Inc. | Compositions containing tanaproget and natural estrogens |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG120970A1 (en) * | 1999-05-04 | 2006-04-26 | Ligand Pharm Inc | Cyclothiocarbamate derivatives as progesterone receptor modulators |
| US6423699B1 (en) * | 1999-05-04 | 2002-07-23 | American Home Products Corporation | Combination therapies using benzimidazolones |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| JP2005535628A (ja) | 2002-06-25 | 2005-11-24 | ワイス | Ｐｒモジュレーターとしてのシクロチオカルバメート誘導体 |
| CN1662241A (zh) * | 2002-06-25 | 2005-08-31 | 惠氏公司 | 环硫代氨基甲酸酯衍生物在治疗与激素有关的病症中的用途 |
| US20060009428A1 (en) | 2004-07-07 | 2006-01-12 | Wyeth | Cyclic progestin regimens and kits |
| MX2007001812A (es) * | 2004-08-13 | 2007-03-26 | Wyeth Corp | Derivados de tanaproget, metabolitos, y usos de los mismos. |
| CN101166532B (zh) | 2005-04-28 | 2011-06-22 | 惠氏公司 | 微粒化的他那普戈特、组合物及其制备方法 |
| CN101166736B (zh) | 2005-04-28 | 2013-02-06 | 惠氏公司 | 他那普戈特的多晶型ⅱ |
| AU2006241189B2 (en) | 2005-04-28 | 2012-01-19 | Wyeth Llc | Purified form of tanaproget |
| CN101166521A (zh) | 2005-04-28 | 2008-04-23 | 惠氏公司 | 通过湿制粒法制备包含微粒化他那普戈特的组合物 |
| MX2007013467A (es) | 2005-04-28 | 2008-01-21 | Wyeth Corp | Tanaproget micronizado y composiciones que contienen el mismo. |
| CA2610767C (en) | 2005-06-09 | 2014-09-23 | Wyeth | Tanaproget compositions containing ethinyl estradiol |
-
2006
- 2006-06-07 CA CA2610767A patent/CA2610767C/en not_active Expired - Fee Related
- 2006-06-07 CN CN201410160290.6A patent/CN103989687A/zh active Pending
- 2006-06-07 CN CNA200680020195XA patent/CN101193639A/zh active Pending
- 2006-06-07 WO PCT/US2006/022150 patent/WO2006135638A2/en not_active Ceased
- 2006-06-07 BR BRPI0611250-1A patent/BRPI0611250A2/pt not_active IP Right Cessation
- 2006-06-07 TW TW095120116A patent/TW200716137A/zh unknown
- 2006-06-07 PE PE2006000630A patent/PE20070001A1/es not_active Application Discontinuation
- 2006-06-07 HN HN2006020928A patent/HN2006020928A/es unknown
- 2006-06-07 JP JP2008515878A patent/JP5339903B2/ja not_active Expired - Fee Related
- 2006-06-07 EP EP06772444A patent/EP1893217A2/en not_active Ceased
- 2006-06-07 US US11/448,965 patent/US20060280800A1/en not_active Abandoned
- 2006-06-07 AU AU2006258048A patent/AU2006258048A1/en not_active Abandoned
- 2006-06-07 MX MX2007015571A patent/MX2007015571A/es unknown
- 2006-06-08 AR ARP060102394A patent/AR057060A1/es not_active Application Discontinuation
-
2011
- 2011-11-09 US US13/292,405 patent/US8664208B2/en not_active Expired - Fee Related
-
2014
- 2014-01-16 US US14/156,863 patent/US20140194398A1/en not_active Abandoned
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