JP2008543278A5 - - Google Patents

Download PDF

Info

Publication number
JP2008543278A5
JP2008543278A5 JP2008510449A JP2008510449A JP2008543278A5 JP 2008543278 A5 JP2008543278 A5 JP 2008543278A5 JP 2008510449 A JP2008510449 A JP 2008510449A JP 2008510449 A JP2008510449 A JP 2008510449A JP 2008543278 A5 JP2008543278 A5 JP 2008543278A5
Authority
JP
Japan
Prior art keywords
conjugate
antibody molecule
conjugate according
seq
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008510449A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008543278A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2006/004114 external-priority patent/WO2006119897A2/en
Publication of JP2008543278A publication Critical patent/JP2008543278A/ja
Publication of JP2008543278A5 publication Critical patent/JP2008543278A5/ja
Pending legal-status Critical Current

Links

JP2008510449A 2005-05-11 2006-05-03 フィブロネクチンed−bに対する抗体l19とインターロイキン12との融合タンパク質 Pending JP2008543278A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68010505P 2005-05-11 2005-05-11
PCT/EP2006/004114 WO2006119897A2 (en) 2005-05-11 2006-05-03 Fusion protein of antibody l19 against fibronectin ed-b and interleukin 12

Publications (2)

Publication Number Publication Date
JP2008543278A JP2008543278A (ja) 2008-12-04
JP2008543278A5 true JP2008543278A5 (https=) 2009-05-07

Family

ID=37027526

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008510449A Pending JP2008543278A (ja) 2005-05-11 2006-05-03 フィブロネクチンed−bに対する抗体l19とインターロイキン12との融合タンパク質

Country Status (14)

Country Link
US (1) US8455625B2 (https=)
EP (1) EP1891102B1 (https=)
JP (1) JP2008543278A (https=)
KR (1) KR101281208B1 (https=)
CN (1) CN101258162A (https=)
AT (1) ATE459648T1 (https=)
AU (1) AU2006246061A1 (https=)
BR (1) BRPI0609100A2 (https=)
CA (1) CA2607954A1 (https=)
DE (1) DE602006012667D1 (https=)
EA (1) EA011992B1 (https=)
ES (1) ES2341126T3 (https=)
MX (1) MX2007013875A (https=)
WO (1) WO2006119897A2 (https=)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
CA2648484A1 (en) * 2006-05-08 2007-11-15 Philogen Spa Antibody-targeted cytokines for therapy
EP1925664A1 (en) 2006-11-15 2008-05-28 Scil proteins GmbH Artificial binding proteins based on a modified alpha helical region of ubiquitin
WO2008120101A2 (en) 2007-04-02 2008-10-09 Philogen S.P.A. The ed-a antigen of fibrinogen is associated with the neovasculature of tumour metastases
US10202442B2 (en) 2007-07-25 2019-02-12 Philogen S.P.A. Antigen associated with lung cancers and lymphomas
DK3281952T3 (da) 2007-10-30 2020-08-03 Philogen Spa Antigen, der er forbundet med reumatoid artritis
WO2009126725A1 (en) * 2008-04-09 2009-10-15 The Regents Of The University Of Michigan Method of modulating neovascularization
CA2747154C (en) 2008-12-19 2015-11-10 Philogen S.P.A. Immunocytokines for tumour therapy with chemotherapeutic agents
EP2461832B1 (en) 2009-08-05 2017-06-28 Philogen S.p.A. Targeting of bone marrow neovasculature
JP5764127B2 (ja) 2009-08-17 2015-08-12 ロシュ グリクアート アーゲー 標的化イムノコンジュゲート
RU2553333C2 (ru) 2009-12-14 2015-06-10 Сцил Протеинс Гмбх Способ идентификации гетеромультимерных модифицированных убиквитиновых белков со способностью связываться с лигандами
WO2012001196A2 (es) 2010-06-28 2012-01-05 Proyecto De Biomedicina Cima, S.L. Vectores alfavirales y usos de los mismos para la expresión de genes heterólogos
RU2429005C1 (ru) * 2010-10-07 2011-09-20 Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН Способ стимуляции противоопухолевой активности цитотоксических эффекторов иммунной системы
SG192673A1 (en) 2011-02-10 2013-09-30 Roche Glycart Ag Mutant interleukin-2 polypeptides
KR20130118941A (ko) 2011-02-10 2013-10-30 로슈 글리카트 아게 면역치료법
EA201892619A1 (ru) 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
CA2837804C (en) 2011-06-15 2018-03-20 Scil Proteins Gmbh Dimeric binding proteins based on modified ubiquitins
WO2012171541A1 (en) 2011-06-15 2012-12-20 Scil Proteins Gmbh Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins
ES2872964T3 (es) 2011-07-27 2021-11-03 Philogen Spa Inmunoconjugado de IL-12
CA2849033C (en) * 2011-09-26 2020-05-05 Philogen S.P.A. Immunocytokine combination therapy
EP2861616A1 (en) 2012-06-13 2015-04-22 Scil Proteins GmbH Human fusion proteins comprising single chain tnfalpha and targeting domains
ES2743423T3 (es) 2012-10-03 2020-02-19 Philogen Spa Conjugado de anticuerpos para su uso en el tratamiento de una enfermedad inflamatoria intestinal
WO2014094799A1 (en) 2012-12-19 2014-06-26 Scil-Proteins-Gmbh Ubiquitin moieties as a means for prolonging serum half-life
WO2014182532A1 (en) * 2013-05-07 2014-11-13 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Mesothelin-specific immunocytokine and use thereof
JP2017501712A (ja) * 2013-12-18 2017-01-19 イントレキソン コーポレーション 単鎖il−12核酸、ポリペプチド、およびそれらの使用
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
JP6738340B2 (ja) 2015-02-06 2020-08-12 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH 新規なegfr結合タンパク質
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
JP6856938B2 (ja) 2015-07-16 2021-04-14 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH 新規な免疫グロブリン結合タンパク質およびアフィニティ精製におけるそれらの使用
GB201601075D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
CR20180087A (es) 2015-07-16 2018-05-14 Philogen Spa Inmunoconjugados de il22
WO2017013136A1 (en) 2015-07-20 2017-01-26 Scil Proteins Gmbh Novel binding proteins based on di-ubiquitin muteins and methods for generation
GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521383D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl And Ucb Celltech Method
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521393D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521391D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
US11813336B2 (en) 2016-05-04 2023-11-14 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
US12304935B2 (en) 2016-07-29 2025-05-20 Juno Therapeutics, Inc. Immunomodulatory polypeptides and related compositions and methods
CN109963864B (zh) 2016-08-11 2024-01-02 瑞普利金公司 用于亲和色谱的碱性稳定性fc结合蛋白
ES3007557T3 (en) * 2016-10-17 2025-03-20 Pfizer Anti-edb antibodies and antibody-drug conjugates
GB201621806D0 (en) 2016-12-21 2017-02-01 Philogen Spa Immunocytokines with progressive activation mechanism
CN108250302A (zh) * 2016-12-29 2018-07-06 天津天锐生物科技有限公司 一种多功能蛋白质
JP2020530280A (ja) 2017-07-03 2020-10-22 トルク セラピューティクス, インコーポレイテッド 免疫刺激性融合分子およびその使用
US11414466B2 (en) 2017-11-07 2022-08-16 Navigo Proteins Gmbh Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer
TWI844524B (zh) * 2018-02-09 2024-06-11 義大利商費洛根公司 靶向edb之il-12組合物
KR102140557B1 (ko) * 2018-03-30 2020-08-03 한국과학기술원 단백질-단백질 결합체를 형성 매개 펩타이드 및 이를 이용한 단백질-단백질 결합체 형성 방법
CN120365435A (zh) * 2018-08-30 2025-07-25 免疫生物公司 单链嵌合多肽和多链嵌合多肽以及其用途
EP3843788A1 (en) 2018-08-30 2021-07-07 HCW Biologics, Inc. Single-chain chimeric polypeptides and uses thereof
CN112996805A (zh) 2018-08-30 2021-06-18 Hcw生物科技公司 多链嵌合多肽和其用途
EP3660039A1 (en) 2018-11-30 2020-06-03 Philogen S.p.A. Il2 immunoconjugates
WO2020070150A1 (en) 2018-10-02 2020-04-09 Philogen S.P.A Il2 immunoconjugates
MX2021007283A (es) 2018-12-18 2021-07-15 Navigo Proteins Gmbh Proteinas de union especificas del folr1 novedosas para diagnostico y tratamiento del cancer.
CN113557242A (zh) * 2019-02-01 2021-10-26 得克萨斯大学体系董事会 用于治疗癌症的修饰的il-12 t细胞疗法
US12583888B2 (en) 2019-02-04 2026-03-24 University Of Tartu Bi-specific extracellular matrix binding peptides and methods of use thereof
CN111848811B (zh) * 2019-04-27 2024-10-01 张晋宇 一种蛋白质异二聚体及其用途
WO2020249757A1 (en) 2019-06-14 2020-12-17 Philogen S.P.A Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha
JP7713393B2 (ja) 2019-06-21 2025-07-25 イミュニティーバイオ インコーポレイテッド 多鎖キメラポリペプチドおよびその使用
EP4103599A1 (en) 2020-02-11 2022-12-21 HCW Biologics, Inc. Methods of activating regulatory t cells
US12115191B2 (en) 2020-02-11 2024-10-15 Immunitybio, Inc. Methods of treating age-related and inflammatory diseases
KR20220140535A (ko) 2020-02-11 2022-10-18 에이치씨더블유 바이올로직스, 인크. 크로마토그래피 수지 및 이의 용도
AU2021257594B2 (en) * 2020-04-14 2024-02-15 Philogen S.P.A. Dosage units and regimen, uses, methods or formulations of compositions comprising a recombinant protein comprising interleukin-12 and an antibody binding the extra-domain B of fibronectin
EP4143231A1 (en) 2020-04-29 2023-03-08 HCW Biologics, Inc. Anti-cd26 proteins and uses thereof
US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
US20230399371A1 (en) * 2020-10-29 2023-12-14 Proviva Therapeutics (Hong Kong) Limited Il-12 compositions and methods of use thereof
JP7690131B2 (ja) 2022-01-04 2025-06-09 フィロジェン ソチエタ ペル アツィオーニ Il-12を含むイムノサイトカインとキナーゼ阻害剤の組合せ
EP4507711A1 (en) 2022-04-13 2025-02-19 ImmunityBio, Inc. Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder
CA3266566A1 (en) 2022-09-06 2024-03-14 Philochem Ag MULTIVALENT FIBROBLAST ACTIVATING PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS
WO2026003203A1 (en) 2024-06-27 2026-01-02 Philogen S.P.A. Combination of an immunocytokine comprising targeted il2 and a jak inhibitor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2590912T3 (es) * 1997-12-08 2016-11-24 Merck Patent Gmbh Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario

Similar Documents

Publication Publication Date Title
JP2008543278A5 (https=)
KR101281208B1 (ko) 피브로넥틴 ed-b에 대한 항체 l19 및 인터루킨12의 융합 단백질
Holz et al. A review of protein-and peptide-based chemical conjugates: past, present, and future
Shipunova et al. Versatile platform for nanoparticle surface bioengineering based on SiO2-binding peptide and proteinaceous Barnase* Barstar interface
CN101616691B (zh) 多聚体缀合物
US20240277863A1 (en) Antibody-urease conjugates for therapeutic purposes
WO2000056774A1 (en) Methods of using bioelastomers
AU2018266091B2 (en) Multispecific protein drug and library thereof, preparing method therefor and application thereof
Zhang et al. Enhancing antitumor efficacy of nucleoside analog 5-fluorodeoxyuridine on HER2-overexpressing breast cancer by affibody-engineered DNA nanoparticle
Grigoletto et al. The evolution of polymer conjugation and drug targeting for the delivery of proteins and bioactive molecules
AU2020366846A1 (en) Humanized antibody and method for using the same
Nanaware-Kharade et al. Therapeutic anti-methamphetamine antibody fragment-nanoparticle conjugates: synthesis and in vitro characterization
CN101249262A (zh) 人源化单克隆抗体Trastuzumab修饰的包裹毒素蛋白的靶向纳米粒及其制备与应用
CN113039194A (zh) 具有免疫调节特性的肽
Anand et al. Polypeptides: PASylation and XTEN
CN101475643A (zh) 一种双单链抗体强化融合蛋白dFv-LDP-AE及其制备方法和应用
KR102019407B1 (ko) 타겟분자를 선택적으로 포획하는 덱스트란 고분자 기반의 증폭된 핵산 압타머 나노구조체의 제조방법
CN105247047A (zh) 抗体-尿素酶偶联物在诊断和治疗中的应用
HK1238557A1 (en) Antibody-urease conjugates for therapeutic purposes
HK1113579B (en) Fusion protein of antibody l19 against fibronectin ed-b and interleukin 12