JP2008543278A5 - - Google Patents
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- JP2008543278A5 JP2008543278A5 JP2008510449A JP2008510449A JP2008543278A5 JP 2008543278 A5 JP2008543278 A5 JP 2008543278A5 JP 2008510449 A JP2008510449 A JP 2008510449A JP 2008510449 A JP2008510449 A JP 2008510449A JP 2008543278 A5 JP2008543278 A5 JP 2008543278A5
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- JP
- Japan
- Prior art keywords
- conjugate
- antibody molecule
- conjugate according
- seq
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 102000013462 Interleukin-12 Human genes 0.000 claims description 10
- 108010065805 Interleukin-12 Proteins 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 230000033115 angiogenesis Effects 0.000 claims description 4
- 108010029485 Protein Isoforms Proteins 0.000 claims description 2
- 102000001708 Protein Isoforms Human genes 0.000 claims description 2
- 102000007000 Tenascin Human genes 0.000 claims description 2
- 108010008125 Tenascin Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims 11
- 108020001507 fusion proteins Proteins 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 239000000833 heterodimer Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 description 5
- 230000008685 targeting Effects 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 206010012689 Diabetic retinopathy Diseases 0.000 description 4
- 206010064930 age-related macular degeneration Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 201000011066 hemangioma Diseases 0.000 description 4
- 208000002780 macular degeneration Diseases 0.000 description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 description 4
- 230000009870 specific binding Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 208000034038 Pathologic Neovascularization Diseases 0.000 description 2
- 239000000032 diagnostic agent Substances 0.000 description 2
- 229940039227 diagnostic agent Drugs 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 229940088623 biologically active substance Drugs 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68010505P | 2005-05-11 | 2005-05-11 | |
| PCT/EP2006/004114 WO2006119897A2 (en) | 2005-05-11 | 2006-05-03 | Fusion protein of antibody l19 against fibronectin ed-b and interleukin 12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008543278A JP2008543278A (ja) | 2008-12-04 |
| JP2008543278A5 true JP2008543278A5 (https=) | 2009-05-07 |
Family
ID=37027526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510449A Pending JP2008543278A (ja) | 2005-05-11 | 2006-05-03 | フィブロネクチンed−bに対する抗体l19とインターロイキン12との融合タンパク質 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8455625B2 (https=) |
| EP (1) | EP1891102B1 (https=) |
| JP (1) | JP2008543278A (https=) |
| KR (1) | KR101281208B1 (https=) |
| CN (1) | CN101258162A (https=) |
| AT (1) | ATE459648T1 (https=) |
| AU (1) | AU2006246061A1 (https=) |
| BR (1) | BRPI0609100A2 (https=) |
| CA (1) | CA2607954A1 (https=) |
| DE (1) | DE602006012667D1 (https=) |
| EA (1) | EA011992B1 (https=) |
| ES (1) | ES2341126T3 (https=) |
| MX (1) | MX2007013875A (https=) |
| WO (1) | WO2006119897A2 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| CA2648484A1 (en) * | 2006-05-08 | 2007-11-15 | Philogen Spa | Antibody-targeted cytokines for therapy |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| WO2008120101A2 (en) | 2007-04-02 | 2008-10-09 | Philogen S.P.A. | The ed-a antigen of fibrinogen is associated with the neovasculature of tumour metastases |
| US10202442B2 (en) | 2007-07-25 | 2019-02-12 | Philogen S.P.A. | Antigen associated with lung cancers and lymphomas |
| DK3281952T3 (da) | 2007-10-30 | 2020-08-03 | Philogen Spa | Antigen, der er forbundet med reumatoid artritis |
| WO2009126725A1 (en) * | 2008-04-09 | 2009-10-15 | The Regents Of The University Of Michigan | Method of modulating neovascularization |
| CA2747154C (en) | 2008-12-19 | 2015-11-10 | Philogen S.P.A. | Immunocytokines for tumour therapy with chemotherapeutic agents |
| EP2461832B1 (en) | 2009-08-05 | 2017-06-28 | Philogen S.p.A. | Targeting of bone marrow neovasculature |
| JP5764127B2 (ja) | 2009-08-17 | 2015-08-12 | ロシュ グリクアート アーゲー | 標的化イムノコンジュゲート |
| RU2553333C2 (ru) | 2009-12-14 | 2015-06-10 | Сцил Протеинс Гмбх | Способ идентификации гетеромультимерных модифицированных убиквитиновых белков со способностью связываться с лигандами |
| WO2012001196A2 (es) | 2010-06-28 | 2012-01-05 | Proyecto De Biomedicina Cima, S.L. | Vectores alfavirales y usos de los mismos para la expresión de genes heterólogos |
| RU2429005C1 (ru) * | 2010-10-07 | 2011-09-20 | Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН | Способ стимуляции противоопухолевой активности цитотоксических эффекторов иммунной системы |
| SG192673A1 (en) | 2011-02-10 | 2013-09-30 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
| KR20130118941A (ko) | 2011-02-10 | 2013-10-30 | 로슈 글리카트 아게 | 면역치료법 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| CA2837804C (en) | 2011-06-15 | 2018-03-20 | Scil Proteins Gmbh | Dimeric binding proteins based on modified ubiquitins |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| ES2872964T3 (es) | 2011-07-27 | 2021-11-03 | Philogen Spa | Inmunoconjugado de IL-12 |
| CA2849033C (en) * | 2011-09-26 | 2020-05-05 | Philogen S.P.A. | Immunocytokine combination therapy |
| EP2861616A1 (en) | 2012-06-13 | 2015-04-22 | Scil Proteins GmbH | Human fusion proteins comprising single chain tnfalpha and targeting domains |
| ES2743423T3 (es) | 2012-10-03 | 2020-02-19 | Philogen Spa | Conjugado de anticuerpos para su uso en el tratamiento de una enfermedad inflamatoria intestinal |
| WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
| WO2014182532A1 (en) * | 2013-05-07 | 2014-11-13 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Mesothelin-specific immunocytokine and use thereof |
| JP2017501712A (ja) * | 2013-12-18 | 2017-01-19 | イントレキソン コーポレーション | 単鎖il−12核酸、ポリペプチド、およびそれらの使用 |
| GB201409558D0 (en) | 2014-05-29 | 2014-07-16 | Ucb Biopharma Sprl | Method |
| GB201412659D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH | 新規なegfr結合タンパク質 |
| GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| JP6856938B2 (ja) | 2015-07-16 | 2021-04-14 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH | 新規な免疫グロブリン結合タンパク質およびアフィニティ精製におけるそれらの使用 |
| GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
| CR20180087A (es) | 2015-07-16 | 2018-05-14 | Philogen Spa | Inmunoconjugados de il22 |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| GB201521382D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521383D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl And Ucb Celltech | Method |
| GB201521389D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Method |
| GB201521393D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521391D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| US12304935B2 (en) | 2016-07-29 | 2025-05-20 | Juno Therapeutics, Inc. | Immunomodulatory polypeptides and related compositions and methods |
| CN109963864B (zh) | 2016-08-11 | 2024-01-02 | 瑞普利金公司 | 用于亲和色谱的碱性稳定性fc结合蛋白 |
| ES3007557T3 (en) * | 2016-10-17 | 2025-03-20 | Pfizer | Anti-edb antibodies and antibody-drug conjugates |
| GB201621806D0 (en) | 2016-12-21 | 2017-02-01 | Philogen Spa | Immunocytokines with progressive activation mechanism |
| CN108250302A (zh) * | 2016-12-29 | 2018-07-06 | 天津天锐生物科技有限公司 | 一种多功能蛋白质 |
| JP2020530280A (ja) | 2017-07-03 | 2020-10-22 | トルク セラピューティクス, インコーポレイテッド | 免疫刺激性融合分子およびその使用 |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| TWI844524B (zh) * | 2018-02-09 | 2024-06-11 | 義大利商費洛根公司 | 靶向edb之il-12組合物 |
| KR102140557B1 (ko) * | 2018-03-30 | 2020-08-03 | 한국과학기술원 | 단백질-단백질 결합체를 형성 매개 펩타이드 및 이를 이용한 단백질-단백질 결합체 형성 방법 |
| CN120365435A (zh) * | 2018-08-30 | 2025-07-25 | 免疫生物公司 | 单链嵌合多肽和多链嵌合多肽以及其用途 |
| EP3843788A1 (en) | 2018-08-30 | 2021-07-07 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| CN112996805A (zh) | 2018-08-30 | 2021-06-18 | Hcw生物科技公司 | 多链嵌合多肽和其用途 |
| EP3660039A1 (en) | 2018-11-30 | 2020-06-03 | Philogen S.p.A. | Il2 immunoconjugates |
| WO2020070150A1 (en) | 2018-10-02 | 2020-04-09 | Philogen S.P.A | Il2 immunoconjugates |
| MX2021007283A (es) | 2018-12-18 | 2021-07-15 | Navigo Proteins Gmbh | Proteinas de union especificas del folr1 novedosas para diagnostico y tratamiento del cancer. |
| CN113557242A (zh) * | 2019-02-01 | 2021-10-26 | 得克萨斯大学体系董事会 | 用于治疗癌症的修饰的il-12 t细胞疗法 |
| US12583888B2 (en) | 2019-02-04 | 2026-03-24 | University Of Tartu | Bi-specific extracellular matrix binding peptides and methods of use thereof |
| CN111848811B (zh) * | 2019-04-27 | 2024-10-01 | 张晋宇 | 一种蛋白质异二聚体及其用途 |
| WO2020249757A1 (en) | 2019-06-14 | 2020-12-17 | Philogen S.P.A | Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha |
| JP7713393B2 (ja) | 2019-06-21 | 2025-07-25 | イミュニティーバイオ インコーポレイテッド | 多鎖キメラポリペプチドおよびその使用 |
| EP4103599A1 (en) | 2020-02-11 | 2022-12-21 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| US12115191B2 (en) | 2020-02-11 | 2024-10-15 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| KR20220140535A (ko) | 2020-02-11 | 2022-10-18 | 에이치씨더블유 바이올로직스, 인크. | 크로마토그래피 수지 및 이의 용도 |
| AU2021257594B2 (en) * | 2020-04-14 | 2024-02-15 | Philogen S.P.A. | Dosage units and regimen, uses, methods or formulations of compositions comprising a recombinant protein comprising interleukin-12 and an antibody binding the extra-domain B of fibronectin |
| EP4143231A1 (en) | 2020-04-29 | 2023-03-08 | HCW Biologics, Inc. | Anti-cd26 proteins and uses thereof |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| US20230399371A1 (en) * | 2020-10-29 | 2023-12-14 | Proviva Therapeutics (Hong Kong) Limited | Il-12 compositions and methods of use thereof |
| JP7690131B2 (ja) | 2022-01-04 | 2025-06-09 | フィロジェン ソチエタ ペル アツィオーニ | Il-12を含むイムノサイトカインとキナーゼ阻害剤の組合せ |
| EP4507711A1 (en) | 2022-04-13 | 2025-02-19 | ImmunityBio, Inc. | Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder |
| CA3266566A1 (en) | 2022-09-06 | 2024-03-14 | Philochem Ag | MULTIVALENT FIBROBLAST ACTIVATING PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS |
| WO2026003203A1 (en) | 2024-06-27 | 2026-01-02 | Philogen S.P.A. | Combination of an immunocytokine comprising targeted il2 and a jak inhibitor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2590912T3 (es) * | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
-
2006
- 2006-05-03 CA CA002607954A patent/CA2607954A1/en not_active Abandoned
- 2006-05-03 ES ES06742774T patent/ES2341126T3/es not_active Expired - Lifetime
- 2006-05-03 DE DE602006012667T patent/DE602006012667D1/de not_active Expired - Lifetime
- 2006-05-03 MX MX2007013875A patent/MX2007013875A/es active IP Right Grant
- 2006-05-03 WO PCT/EP2006/004114 patent/WO2006119897A2/en not_active Ceased
- 2006-05-03 KR KR1020077028774A patent/KR101281208B1/ko not_active Expired - Fee Related
- 2006-05-03 US US11/913,483 patent/US8455625B2/en not_active Expired - Fee Related
- 2006-05-03 JP JP2008510449A patent/JP2008543278A/ja active Pending
- 2006-05-03 EA EA200702460A patent/EA011992B1/ru not_active IP Right Cessation
- 2006-05-03 AT AT06742774T patent/ATE459648T1/de active
- 2006-05-03 CN CNA2006800158042A patent/CN101258162A/zh active Pending
- 2006-05-03 BR BRPI0609100-8A patent/BRPI0609100A2/pt not_active IP Right Cessation
- 2006-05-03 EP EP06742774A patent/EP1891102B1/en not_active Expired - Lifetime
- 2006-05-03 AU AU2006246061A patent/AU2006246061A1/en not_active Abandoned
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