JP2008542237A - トピラメートの小児科用製剤 - Google Patents
トピラメートの小児科用製剤 Download PDFInfo
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- JP2008542237A JP2008542237A JP2008512825A JP2008512825A JP2008542237A JP 2008542237 A JP2008542237 A JP 2008542237A JP 2008512825 A JP2008512825 A JP 2008512825A JP 2008512825 A JP2008512825 A JP 2008512825A JP 2008542237 A JP2008542237 A JP 2008542237A
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- topiramate
- composition according
- peg
- pharmaceutically acceptable
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- HEKURBKACCBNEJ-UHFFFAOYSA-M potassium;1,1-dioxo-1,2-benzothiazol-2-id-3-one Chemical compound [K+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 HEKURBKACCBNEJ-UHFFFAOYSA-M 0.000 description 1
- 238000004094 preconcentration Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229940095574 propionic acid Drugs 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 229930188195 rebaudioside Natural products 0.000 description 1
- 210000001116 retinal neuron Anatomy 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229940001607 sodium bisulfite Drugs 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- 229940001482 sodium sulfite Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 229940001474 sodium thiosulfate Drugs 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05104491 | 2005-05-25 | ||
| US69039105P | 2005-06-14 | 2005-06-14 | |
| PCT/EP2006/062518 WO2006125774A1 (en) | 2005-05-25 | 2006-05-23 | Pediatric formulation of topiramate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008542237A true JP2008542237A (ja) | 2008-11-27 |
| JP2008542237A5 JP2008542237A5 (enExample) | 2009-07-09 |
Family
ID=35045349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512825A Withdrawn JP2008542237A (ja) | 2005-05-25 | 2006-05-23 | トピラメートの小児科用製剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060270611A1 (enExample) |
| EP (1) | EP1888030A1 (enExample) |
| JP (1) | JP2008542237A (enExample) |
| CN (1) | CN101257889A (enExample) |
| AR (1) | AR053737A1 (enExample) |
| AU (1) | AU2006251213A1 (enExample) |
| BR (1) | BRPI0610210A2 (enExample) |
| CA (1) | CA2609719A1 (enExample) |
| MX (1) | MX2007014713A (enExample) |
| RU (1) | RU2007148444A (enExample) |
| TW (1) | TW200716202A (enExample) |
| WO (1) | WO2006125774A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015536956A (ja) * | 2012-11-09 | 2015-12-24 | パーデュー ファーマ | ヒドロモルホンおよびナロキソンを含む医薬組成物 |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2246044A1 (en) * | 2009-04-21 | 2010-11-03 | Pierre Fabre Dermo-Cosmétique | Paediatric solutions comprising a beta-blocker |
| WO2011141490A1 (en) | 2010-05-10 | 2011-11-17 | Euro-Celtique S.A. | Combination of active loaded granules with additional actives |
| MX340188B (es) | 2010-05-10 | 2016-06-30 | Euro-Celtique S A * | Elaboracion de granulos sin activos y tabletas que comprenden los mismos. |
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| JP6232135B2 (ja) | 2013-11-13 | 2017-11-15 | ユーロ−セルティーク エス．エイ． | 疼痛およびオピオイドによる腸機能障害症候群の治療のためのヒドロモルホンおよびナロキソン |
| CN104188920A (zh) * | 2014-07-28 | 2014-12-10 | 安徽省逸欣铭医药科技有限公司 | 托吡酯颗粒剂及其制备方法 |
| KR102615486B1 (ko) * | 2015-08-24 | 2023-12-19 | 조게닉스 인터내셔널 리미티드 | 펜플루라민을 사용하여 레녹스-가스토 증후군을 치료하는 방법 |
| WO2017085687A1 (en) | 2015-11-20 | 2017-05-26 | West-Ward Pharmaceuticals International Limited | Stable formulation of phenobarbital sodium injection |
| DK3800177T3 (da) | 2015-12-22 | 2025-03-31 | Zogenix International Ltd | Fenfluramin-sammensætninger og fremgangsmåder til fremstilling af samme |
| US10689324B2 (en) | 2015-12-22 | 2020-06-23 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| RU2021106383A (ru) | 2016-08-24 | 2021-04-05 | Зодженикс Интернэшнл Лимитед | Состав для ингибирования образования агонистов 5-ht2b и способы его применения |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| WO2019186515A1 (en) * | 2018-03-30 | 2019-10-03 | Ftf Pharma Private Limited | Liquid pharmaceutical compositions of antiepileptic drugs |
| CA3097335A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| US10517841B1 (en) | 2018-06-14 | 2019-12-31 | Zogenix International Limited | Compositions and methods for treating respiratory depression with fenfluramine |
| WO2020053662A2 (en) * | 2018-09-13 | 2020-03-19 | Ftf Pharma Private Limited | Non-aqueous solutions for oral dosage |
| WO2020105005A1 (en) | 2018-11-19 | 2020-05-28 | Zogenix International Limited | Methods of treating rett syndrome using fenfluramine |
| WO2020104837A1 (en) | 2018-11-21 | 2020-05-28 | Rosemont Pharmaceuticals Limited | Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability |
| US20210169844A1 (en) | 2019-12-10 | 2021-06-10 | Tulex Pharmaceuticals Inc. | Compositions and methods for treating epilepsy, seizures and other conditions |
| GB2594242A (en) * | 2020-04-14 | 2021-10-27 | Syri Ltd | A stable and ready to administer liquid pharmaceutical composition of topiramate |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| US20250120951A1 (en) * | 2021-07-30 | 2025-04-17 | Epygenix Therapeutics, Inc. | Clemizole formulation |
| CN117159458A (zh) * | 2022-05-27 | 2023-12-05 | 北京万全德众医药生物技术有限公司 | 托吡酯口服溶液及其制备方法 |
| US12109188B1 (en) | 2023-03-24 | 2024-10-08 | Tap Pharmaceuticals Ag | Liquid pharmaceutical formulations of topiramate |
| US12290504B2 (en) * | 2023-04-11 | 2025-05-06 | Tap Pharmaceuticals Ag | Aqueous formulations of topiramate |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| AU651244B2 (en) * | 1991-09-19 | 1994-07-14 | Mcneilab, Inc. | Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-0-(1-methylethylidene)-beta-D- fructopyranose and (1-methylcyclohexyl)methanol |
| US20030077227A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
| JP2004331502A (ja) * | 2001-06-18 | 2004-11-25 | Ortho Mcneil Pharmaceut Inc | 視神経細胞保護剤 |
| US6559293B1 (en) * | 2002-02-15 | 2003-05-06 | Transform Pharmaceuticals, Inc. | Topiramate sodium trihydrate |
| EP1684713A1 (en) * | 2003-11-14 | 2006-08-02 | ALZA Corporation | Controlled release of topirimate in liquid dosage forms |
-
2006
- 2006-05-23 MX MX2007014713A patent/MX2007014713A/es not_active Application Discontinuation
- 2006-05-23 CA CA002609719A patent/CA2609719A1/en not_active Abandoned
- 2006-05-23 WO PCT/EP2006/062518 patent/WO2006125774A1/en not_active Ceased
- 2006-05-23 CN CNA2006800178845A patent/CN101257889A/zh active Pending
- 2006-05-23 BR BRPI0610210-7A patent/BRPI0610210A2/pt not_active IP Right Cessation
- 2006-05-23 JP JP2008512825A patent/JP2008542237A/ja not_active Withdrawn
- 2006-05-23 EP EP06755288A patent/EP1888030A1/en not_active Withdrawn
- 2006-05-23 AU AU2006251213A patent/AU2006251213A1/en not_active Abandoned
- 2006-05-23 US US11/419,834 patent/US20060270611A1/en not_active Abandoned
- 2006-05-23 RU RU2007148444/15A patent/RU2007148444A/ru not_active Application Discontinuation
- 2006-05-24 AR ARP060102160A patent/AR053737A1/es not_active Application Discontinuation
- 2006-05-24 TW TW095118344A patent/TW200716202A/zh unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015536956A (ja) * | 2012-11-09 | 2015-12-24 | パーデュー ファーマ | ヒドロモルホンおよびナロキソンを含む医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101257889A (zh) | 2008-09-03 |
| US20060270611A1 (en) | 2006-11-30 |
| CA2609719A1 (en) | 2006-11-30 |
| EP1888030A1 (en) | 2008-02-20 |
| RU2007148444A (ru) | 2009-06-27 |
| MX2007014713A (es) | 2008-02-14 |
| AU2006251213A1 (en) | 2006-11-30 |
| WO2006125774A1 (en) | 2006-11-30 |
| BRPI0610210A2 (pt) | 2010-06-01 |
| AR053737A1 (es) | 2007-05-16 |
| TW200716202A (en) | 2007-05-01 |
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