WO2019186515A1 - Liquid pharmaceutical compositions of antiepileptic drugs - Google Patents
Liquid pharmaceutical compositions of antiepileptic drugs Download PDFInfo
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- WO2019186515A1 WO2019186515A1 PCT/IB2019/052642 IB2019052642W WO2019186515A1 WO 2019186515 A1 WO2019186515 A1 WO 2019186515A1 IB 2019052642 W IB2019052642 W IB 2019052642W WO 2019186515 A1 WO2019186515 A1 WO 2019186515A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Definitions
- the present invention relates, in general to the pharmaceutical field, and more precisely it relates to the liquid pharmaceutical compositions of an active pharmaceutical ingredient
- the present invention relates to the liquid compositions comprising antiepileptic/anticonvulsant/antiseizurc drugs.
- disclosed liquid compositions may be advantageous for die patients having swallowing difficulties such as pediatric or geriatric patients or when the patients are unable to take solid oral dosage forms.
- Palatability is one of the main elements of patient acceptability of an oral pediatric medicine. Palatability is defined as the overall appreciation of an oral medicinal product in relation to its smell, taste, aftertaste and feeling in the mouth. Design of the formulation of an oral pediatric medicine should be considered together with its palatability.
- oral liquid dosage forms including solutions, syrups, suspensions, elixirs, and concentrates offer unique advantages to many patients.
- liquids may provide better patient compliance for those with swallowing difficulties and better dosage control versus a fixed tablet dose.
- liquid dosage forms are generally formulated for use in geriatric and pediatric patients.
- “challenges” surrounding the formulation and development of these forms.
- Oral liquids arc formulated as solutions, suspensions and emulsions depending on the nature of the active ingredient particularly solubility and stability. They are also designed as ready to use liquids and powders for reconstitution into liquid orals like syrups, solutions, suspensions and emulsions.
- Liquid formulation needs various excipients including vehicle, solubilizer, stabilizer, and viscosity builder, preservative and off course sweeteners, color and flavor.
- excipients including vehicle, solubilizer, stabilizer, and viscosity builder, preservative and off course sweeteners, color and flavor.
- the selection of these excipients is of major concern to design stable, effective and palatable oral liquid formulation.
- Characteristics of active drag are of major concern in developing an oral liquid dosage formulation.
- the major challenges in developing oral liquid dosage forms are (i) the stability of a drag in solution, (ii) the solubility of a drag at the required level, and (iii) an acceptable taste. It is the effective use of excipients, which allows formulators overcome these challenges. Additionally, an excipient’s compatibility with a drag in the solid state cannot inf» the same compatibility in solution.
- the decision to develop a solution, syrup or a suspension of a drug is influenced by many fectors like solubility and the desired release profile of the drug and properties of the base vehicle like surface tension, viscosity, boiling point, and specific heat of solution, all of which may be affected in various ways.
- solubility may be affected in various ways.
- lack of solubility of the drug in the base vddcle may demand the need for miscible co-solvents.
- a miscible solvent may be needed to decrease the solubility of the drug in a primary vehicle in formulating a suspension.
- Suspensions are an important class of pharmaceutical dosage forms that may be given by many routes, including oral, topical, parenteral, and also used in the eye for ophthalmic purposes.
- large proportions of new drug candidates that are emerging are predominantly water insoluble and, therefore, demonstrate poor bioavailability in the solution dosage form.
- suspensions present a viable formulation option for many drugs, particularly for water insoluble, hydrophobic drug substances, there are certain criteria that a well- formulated suspension should meet
- the suspension dosage form has long been used for poorly soluble active ingredients for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. Drugs from suspension formulations typically exhibit an improved bioavailability when compared to the same drug formulated as a tablet or capsule.
- Suspensions are an important class of pharmaceutical dosage forms.
- the advantages of suspension dosage forms include effective dispensing of hydrophobic drugs; avoidance of the use of co-solvents; masking of unpleasant taste of certain ingredients; offering resistance to degradation of drugs due to hydrolysis, oxidation or microbial activity; easy swallowing for young or elderly patients; and efficient intramuscular depot therapy.
- relatively higher concentration of drugs can be incorporated into suspension products. To date, numerous theories have been introduced and successfully used to explain the unique behavior of suspension preparations.
- Epilepsy is not just one condition, but a group of many different“epilepsies” with one ti l ing in common: a tendency to have seizures that start in the brain.
- Epilepsy is usually only diagnosed after a person has had more than one seizure.
- Epilepsy is most commonly diagnosed in children and in people over 65. There are over fifty million people with epilepsy in the world. Therefore, if finished dosage form is in liquid, it will be easier to administer dose as compared to any other type of dosage forms.
- liquid pharmaceutical compositions of antiepileptic drugs are advantageous and much more required, they are not much explored by the formulation scientists. Therefore, looking at the need existing in the art for the preparation of liquid pharmaceutical compositions of antiepileptic drugs to mask its taste and make them overall acceptable to all types of patient population, the present inventors have formulated antiepileptic drugs in liquid pharmaceutical compositions having palatability and acceptability along with prolonged stability. These properties of the liquid compositions of the present invention make them favorable for use in the pharmaceutical industry.
- liquid pharmaceutical compositions according to the present invention include liquids, liquid dispersions, suspensions, solutions, emulsions, sprays, spot-ah, syrups, elixirs, drops, gels, solution-gels, concentrates and the like.
- the present invention provides liquid pharmaceutical compositions of antiepileptic drugs having palatability.
- Liquid dosage forms are designed as ready to use liquids and as powder for reconstitution into liquid orals like syrups, solutions, suspensions and emulsions.
- Powder for reconstitution may require skills & expertise and needs to be prepared by a healthcare provider and may not be prepared by the patient or caregiver.
- the - reconstitution process may also be a time consuming process and the patient cannot be benefited by the immediate dose of an antiepileptic drug as and when required.
- ready to use, liquid compositions of an antiepileptic drug may be very useful and die patients can be given required doses immediately using ready to use, liquid compositions of an antiepileptic drug. Therefore, a yet another object of the present invention is to provide ready to use, liquid pharmaceutical compositions of an antiepileptic drug ' .
- the solution dosage form can be a viable alternative for patients who have problems in swallowing the tablet or capsule dosage form, ft provides assurance of dosage uniformity upon administration to patients and eliminates difficulty of administration.
- a solution can also provide physicians more flexibility in designing dosage regimens for patients.
- Solution dosage form of an antiepileptic drug is suitable for administration to both pediatric and geriatric patients while also compensating for a good Organoleptic properties and remaining suitably stable. Hence, the development of a liquid formulation is desirable since it offers improved patient compliance.
- a yet another object of the present invention is therefore to develop solution dosage forms of an antiepileptic drug.
- the solution dosage forms according to the present invention comprises an antiepileptic drug or pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients or additives selected from the group comprising of vehicles, solvents/co-solvents, solubilizers, surfactants, pH adjusting agents and/or pH modifying agents and/or buffering agents or any combination thereof.
- the solution dosage forms according to the present invention may further comprise one or more agents selected from the group comprising of preservatives, sweetening agents, flavoring agents and coloring agents or any combination thereof.
- Suspensions possess certain advantages over other liquid dosage forms. Some drugs are insoluble in all acceptable media and must, therefore, be administered as a tablet, capsule, or as a suspension. In addition, disagreeable tastes can be masked by a suspension of die drug or a derivative of the drug. Drugs in suspension are chemically more stable than in solution. In another object, the present invention therefore provides suspension dosage forms of an antiepileptic drug.
- the suspension dosage forms according to the present invention comprises an antiepileptic drug or pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients or additives selected from the group comprising of vehicles, solvents/co- solvents, solubilizers, suspending agents/thickening agents/viscosity modifying agents, anti-foaming agents, anti-caking agents, wetting agents, surfactants, pH adjusting agents and/or pH modifying agents and/TM- buffering agents or any combination thereof.
- the suspension dosage forms according to the present invention may further comprise one or more agents selected from the group comprising of preservatives, sweetening agents, flavoring agents and coloring agents or any combination thereof.
- a yet another object of the present invention is to provide liquid pharmaceutical compositions of antiepileptic drugs comprising one or more pharmaceutically acceptable excipients or additives selected from the group comprising of vehicles, solvents/co-solvents/ solubilizers/solubilizing agents, solubility enhancing agents, tonicity agents, penetration/penneation enhancers, mucoadhesives, preservatives, pH adjusting agents/pH modifying agents/buffering agents, surfactants, anti-foaming agents, suspending agents/thickening agents/viscosity ⁇ modifying agents, bulking agents/auxiliary suspending agents, wetting agents, anti-oxidants, chelating agents, anti-caking agents, sweetening agents, flavoring agents, coloring agents and the like or any combination thereof.
- pharmaceutically acceptable excipients or additives selected from the group comprising of vehicles, solvents/co-solvents/ solubilizers/solubilizing agents, solubility enhancing agents, tonicity agents, penetration/penneation
- a yet another object of the present invention is to provide liquid pharmaceutical compositions of antiepileptic drugs having portability, prolonged stability and improved and/or comparable pharmacokinetic profile or bioavailability when compared to the known or marketed formulations.
- the liquid pharmaceutical compositions of the present invention comprise sweeteners) and flavoring agent(s) which masks the bitter taste of antiepiJeptic drugs and provides pleasant taste.
- an antiepileptic drug for preparing liquid pharmaceutical compositions according to the present invention is selected from the group comprising of Primidone, Topiramate, Vigabatrin, Zonisamide, Clobazam, Gabapentin, Levetiracetam, Perampanel, Phenobarbital, Pregabalin, Rufinamide or pharmaceutically acceptable salts, polymorphs, solvates, hydrates, anhydrous forms, prodrags, chelates, and complexes thereof and Valproic acid or its salts such as Sodium valproate, Divalproex sodium or chemical derivatives thereof such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes.
- a yet another object of the present invention is to provide processes for the preparation of liquid pharmaceutical compositions of antiepileptic drugs prepared according to the presort invention.
- a yet another object of the present invention is to provide method for the treatment of epilepsy and/or convulsion and/or seizure and/or a disease or a condition that can be treated by antiepileptic drugs comprising administering to a patient, such as human, an effective dosage amount of a liquid pharmaceutical composition comprising an antiepileptic drag and one or more pharmaceutically acceptable excipients or additives as disclosed and described herein.
- a yet another object of the present invention is to use the liquid pharmaceutical compositions of the present invention fin the treatment of epilepsy and/or convulsion and/or seizure and/or a disease or a condition that can be treated by administration of antiepileptic drugs.
- Epilepsy is not just one condition, but a group of many different“epilepsies” with one tiling in common: a tendency to have seizures that start in the brain. Epilepsy is usually only diagnosed after a person has had more than one seizure. Not all seizures are due to epilepsy.
- An epilepsy is most commonly diagnosed in children and in people over 65. There are over half a million people with epilepsy in the world, so around 1 in 100 people.
- Tuberous sclerosis a genetic condition that causes growths m organs including the brain
- Tuberous sclerosis can cause epilepsy or neurofibromatosis, a genetic condition that causes benign tumors to grow on the covering of nerves
- Neurofibromatosis can cause epilepsy which can cause growths affecting the brain.
- seizures happen suddenly without warning, last a short time (a few seconds or minutes) and stop by themselves. Seizures can be different for each person. Just knowing that someone has epilepsy does not tell what their epilepsy is like, or what seizures they have. Calling seizures‘major’ or‘minor’ does not tell what happens to the person during the seizure. Some people have more than one type of seizure. But even if someone's seizures are unique, they usually follow the same pattern each time they happen. Not all seizures involve convulsions (jerking or shaking movements). Some people seem vacant, wander around or are confused during a seizure. Some people have seizures when they are awake, called“awake seizures”.
- Epilepsy is a neurological condition-which means it affects the brain. It is also a physical condition, because the body is affected when someone has a seizure. Epilepsy is described as the tendency to have repeated seizures that start in the brain. Epilepsy is usually only diagnosed after the person has had more than one seizure. Race can have a seizure if the circumstances are right, but most people do not have seizures under “normal conditions”. Seizures are sometimes called“fits” or“attacks”. Seizures happen when there is a sudden interruption in the way the brain normally works. Epilepsy is a variable condition that affects different people in different ways. There are over 40 different types of seizure. What seizures look like can vary.
- One in 20 people will have a one-off epileptic seizure at some point in their life (although this does not necessarily mean that they have epilepsy).
- One in 50 people will have epilepsy at some time in their lift (not everyone with epilepsy will have it for life).
- Around 87 people are diagnosed with epilepsy every day.
- the estimated proportion of the general population with active epilepsy (i.e. continuing seizures or with the need for treatment) at a given time is between 4 and 10 per 1000 people. However, some studies in low- and middle-income countries suggest that the proportion is much higher, between 7 and 14 per 1000 people. Close to 80% of people with epilepsy live in low- and middle- income countries. Up to 5% of people with epilepsy will be affected by flashing lights (called photosensitive epilepsy), so most people with epilepsy do not have seizures triggered by flashing lights.
- Epilepsy can start at any age, but is most commonly diagnosed in people under 20 and people over 65. This is because some causes are more common in young people (such as difficulties at their birth, childhood infections or accidents) and in older people (such as strokes that lead to epilepsy).
- Epilepsy For some people their epilepsy might‘go away’ and they stop having seizures. This is called spontaneous remission. Epilepsy can be difficult to diagnose and there arc a number of different tests that might be done to help with a diagnosis such as an EEG (Electroencephalogram) or an MRI (Magnetic Resonance Imaging) scan.
- EEG Electroencephalogram
- MRI Magnetic Resonance Imaging
- Epilepsy is usually treated with medication called anti-epileptic drugs (AEDs).
- AEDs aim to stop seizures from happening, but they do not cure epilepsy. With the right AEDs, up to 70% of people with epilepsy could have their seizures controlled (stopped).
- the first AED used to treat epilepsy was phenobarbitone in 1912. There arc now over 25 different AEDs available in the market For people who do not have their seizures controlled with AEDs, surgery may be an option. This can involve removing the part of their brain that causes the seizures.
- oral liquid dose forms do have the in-built flexibility that allows the dose to be tailored to the patients’ needs.
- a solution dosage form e.g. a simple mixture
- drugs are sufficiently soluble to allow suitable strength solution medicines to be developed and manufactured with an acceptable shelf-life, hi such cases, an alternative approach could be to develop a stable aqueous suspension that will allow consistent dosing of the patient.
- Pharmaceutical suspensions have several advantages and disadvantages when compared to other dosage forms. Since suspensions are liquids, dose adjustment for patients with renal or hepatic impairment, or for pediatric or geriatric patients, may be more straightforward. This is an oversimplification of the development of a dosing strategy for a drug candidate. There are many other details that must be considered for a formulation development project to be successful, but it does provide a simple overview of some of the issues.
- the suspension must be physically stable (no appreciable settling) for a sufficient time, chemically stable over the required time (shelf-life), possess a viscosity that allows it to be used for its intended purpose, be easily reconstituted by shaking, and be acceptable in use to the patient, care-giver or other user.
- Some materials may possess a combination of properties useful in the formulation and manufacture of stable, elegant pharmaceutical suspensions. Formulation scientists need to consider the totality of properties possessed by a particular excipient. Even though it is being added for one particular characteristic, the other properties will still be present, and will still influence the formulation.
- active pharmaceutical ingredients are quite hydrophobic with limited solubility. They may also be quite distasteful Other drugs may also have quite a high chemical degradation precluding them to be administered as aqueous solutions, and in this case, it may be possible to synthesize an insoluble derivative. In other cases, some drugs are required to be present in the gastrointestinal tract or in the pre-comeal pocket with long residence time. For such drugs, a suspension is an ideal delivery system as it provides better chemical stability and larger surface area and is often more bioavailable than aqueous solutions, tablets, and capsules.
- Formulation of an elegant, stable, preserved, safe, and effective suspension is a technically challenging task compared aqueous solutions, tablets, and capsules.
- Pharmaceutical suspensions are thermodynamically unstable systems. Thus, preparation of such systems is often associated with problems of physical stability, content uniformity, sedimentation, caking, rc-suspendibility, and crystal growth. Furthermore, issues related to the masking of bitter taste and undesirable odor of the pharmaceutical ingredient must be taken into consideration.
- the drug should not have a quick sedimentation rate. Furthermore, it should resuspend easily upon shaking and it must not cake.
- Re-suspension should produce a homogeneous mix of drug particles such that there is a content uniformity with each dose.
- a quick means to identify whether or not a drug may be more suitable for solution or suspension is to overlap the pH-stability profile with the pH-solubility profile. This overlap creates a window, which may suggest which dosage form might be most desirable and subsequently the type of excipients needed.
- Oral liquid formulation needs a meticulous blend of ingredients to perform various functions like wetting and solubilization, stabilization and to impart suitable color, taste and viscosity.
- the blend should be compatible, non-reactive and stable.
- the common excipients generally required for any liquid formulation are vehicles (base), viscosity builders, stabilizers, preservatives, colors and flavors.
- solubilizes are required in case of clear liquids, suspending agents are needed for suspensions and emulsifying agents for emulsions.
- Such pharmaceutically acceptable excipients include, vehicles, solvents/co-solvents, solubilizers, solubility enhancing agents, tonicity agents, penneation/penetration enhancers, mucoadhesives, suspending agents/thickening agents/viscosity modifying agents, bulking agents/auxiliary suspending agents, wetting agents, anti-foaming agents, anti-caking agents, stabilizing agents, anti-oxidants, chelating agents, buffering agents/pH modifying agents/pH adjusting agents, surfactants, preservatives, sweetening agents, flavoring agents and the like or any combination thereof.
- the present invention provides liquid pharmaceutical compositions of antiepileptic drugs in the form of suspensions comprising an antiepileptic drug, vehicle(s), solvent(s)/co-solvent(s), solubilizers), suspending agent(s)/thickcning agent(s)/viscosify modifying agent(s), preservative ⁇ ), anti-foaming ageat(s), wetting agent(s), surfactants), pH adjusting agent(sypH modifiers) or buffering agent(s) or both, sweeteners) and flavoring agent(s).
- liquid pharmaceutical compositions of the invention may be administered orally or via the oral cavity.
- the liquid pharmaceutical compositions of the present invention may also be administered transmucosally, sublingually, via the buccal cavity, via mucosal membranes and/or through the gastrointestinal tract.
- the liquid pharmaceutical compositions of the present invention may be administered via pulmonary, intravenous, rectal, opththalmic, colonic, parenteral, mtracistemal, mtravaginal, intraperitoneal, local, or topical administration.
- the liquid pharmaceutical compositions of the present invention are in the form of immediate release dosage forms or modified release dosage forms, such as extended release, controlled release, sustained release, prolonged release and delayed release.
- the liquid pharmaceutical compositions comprise an antiepileptic drug and one or more suitable excipients or additives for the preparation of modified release dosage forms such as rate controlling polymers.
- the liquid phannaceutical compositions of the present invention may also be prepared by reconstitution of dry powder in suitable diluent or media such as water.
- the dry powder for reconstitution may be in the form of immediate release forms and comprise an antiepileptic drug and one or more suitable excipients selected form the group comprising of fillers, binders, diluents, disintegrants, pore formers, lubricants, glidants, sweeteners, stabilizing agents, antioxidants, flavoring agents, suspending agents/thickening agents/viscosity modifying agents, surfactants, preservatives and plasticizers.
- the dry powder for reconstitution may also be in the form of modified release forms and comprise modified release pellets, granules or particles. Such modified release pellets, granules or particles comprise one or more suitable excipients such as rate controlling polymers.
- the pH of the liquid compositions of the present invention is between about 2.0 ami about 11.0. In some of the aspects, the pH of the compositions is between about 3.0 and about 9.0. In some of the aspects, the pH of the compositions is between about 4.0 and about 8.0. In some of the aspects, the pH of the compositions is between about 5.0 and about 7.0. In some of the aspects, the pH of the compositions is between about 5.5 and about 6.5.
- the liquid pharmaceutical compositions of the present invention are stable for prolonged time when stored under storage conditions.
- the tom “storage conditions” as used herein without limitation include typical storage conditions such as 2°C-8°C, 40°C ⁇ 2°C/75 ⁇ 5% RH, 30 o C ⁇ 2°C/65 ⁇ 5 e / ⁇ RH, 25°C ⁇ 2°C/40tfc5% RH and accelerated conditions such as 40°Ot2 o C/75 ⁇ 5% RH.
- the tom “prolonged time” as used herein indicates that the liquid pharmaceutical compositions of the present invention are stable for at least 1 month, at least 3 months, at least 6 months or at least 12 months when stored under storage conditions.
- the terms“stable” or“stability” encompass any characteristic of the liquid compositions which may be affected by storage conditions including, without limitation, potency, total impurities, degradation products, specific optical rotation, optical purity, water content, appearance, viscosity, sterility, and colour and clarity.
- the storage conditions which may affect stability include, for example, duration of storage, temperature, humidity, and/or light exposure.
- stable liquid pharmaceutical compositions or stability of the liquid pharmaceutical compositions refer to compositions which retain at least about 90%, or about least about 95%, or at least about
- stable liquid pharmaceutical compositions or stability of the liquid pharmaceutical compositions refer to less than about 15% (area percent), or less than about 10% (area percent), or less than about 7% (area percent), or less than about 5% (area percent), or less than about 2% (area percent) of an antiepileptic drug- related impurities are present after storage under typical and/or accelerated conditions.
- liquid pharmaceutical compositions of the present invention contain no more than about 15% (area percent), or no more than about 10% (area percent), or no more than about 7% (area percent), or no more than about 5% (area percent), or no more than about 2% (area percent), or no more than about 1% (area percent), or no more than about 0.5% (area percent), or no more than about 0.2% (area percent), or no more titan about 0.1% (area percent) any known or unknown single active pharmaceutical ingredient-related impurity or other impurity after storage under typical and/or accelerated conditions.
- liquid pharmaceutical compositions of the present invention contain no more than about 15% (area percent), or no more than about 10% (area percent), or no more than about 7% (area percent), or no more than about 5% (area percent), or no more than about 2% (area percent), or no more than about 1% (area percent), or no more than about 0.5% (area percent), or no more than about 0.2% (area percent), or no more than about 0.1% (area percent) total active pharmaceutical ingredient-related impurities or other impurities after storage under typical and/or accelerated conditions.
- the team“comprise/comprises/comprising” as used herein mean that other ingredients, steps, etc. are optionally present
- the steps can be carried in any order or simultaneously (except where the context excludes that possibility), and the method can include one or more steps which are carried out before any of the defined steps, between . two of the defined steps, or after all of the defined steps (except where the context excludes that possibility).
- the term“about,” as used herein, refers to any value which lies within the range defined by a variation of up to ⁇ 10% of the value.
- liquid pharmaceutical compositions of the present invention may be packaged within any type of pharmaceutically-acoeptable package, containers, pumps, bottles with spray pump, bottles with dropper assembly, bottles, collapsible tubes, glass ampoules, stoppered vials, pre-filled syringes, low- density polyethylene (LDPE), high-density polyethylene (HOPE), polyolefin, polypropylene containers/bottles depending upon the quantity of the final dosage form.
- LDPE low- density polyethylene
- HOPE high-density polyethylene
- polypropylene containers/bottles depending upon the quantity of the final dosage form.
- the bottles or containers without limitation include clear/transparent/opaque or amber colored glass bottles or containers and clear/transparent/opaque or amber colored plastic bottles or containers made from polyethylene, polyamide, polycarbonate, acrylic multipolymers, polypropylene, polyethylene terephthalate, polyvinyl chloride, polystyrene and the like.
- closures may have different shapes and sizes.
- the closure of the packaging material may be made from polyethylene, polyamide, polycarbonate, acrylic multipolymers, polypropylene, polyethylene terephthalate, polyvinyl chloride, polystyrene and the like.
- Liquid pharmaceutical compositions of the present invention may be packaged in a sterile single use bottle/container that contains a unit dose for administration to a patient
- Suitable bottles/containers may contain volumes between 1-10 ml, 10-20 ml, 20-40 ml, and 40-100 ml, and even more.
- the container may typically comprise an antiepileptic drug in an amount of between 1040 mg, between 40-80 mg, between 80- 130 mg, and even more.
- the container may be a multiuse container (i.e., retains at least one more unit dose after a first unit dose is dispensed).
- the present invention provides concentrate liquid compositions which may be diluted using suitable diluent before administering to the patient
- the liquid compositions of the invention are ready-to- use liquid compositions. Such ready-to-use compositions of the invention are administered directly to tire patients in required doses without any prior preparation e.g. reconstitution in suitable diluent such as water.
- suitable excipients which may be used to prepare liquid compositions of the present invention. It is in no way the intention of the present inventoi(s ⁇ /applicant(s) to limit the scope of the liquid compositions of the present invention by the description of following embodiments.
- Described embodiments are for illustrative purpose only and a skilled person may use other excipients fixnn the same or different classes as well which may provide liquid compositions of the present invention same or improved physico-chemical properties, palatabilrty, stability and the like and retain or increase patients’ acceptability towards he therapy.
- excipients, classes of excipients and compositions resulted therefrom are also part of the present invention and covered within the scope of the present invention. .
- Vehicles may be used in the liquid compositions of the present invention.
- Vehicles are the liquid bases that cany drugs and other excipients in dissolved or dispersed state.
- Vehicles may be aqueous or non-aqueous or mixture thereof.
- Non-aqueous solvents/co- solvents may also be added in the liquid compositions of the present invention to increase the solubility of poorly soluble substances and enhance the chemical stability of a drug.
- Suitable solvents/co-solvents, solubilizers or vehicles, that may be employed, in the liquid compositions of the invention include, but are not ' limited to, dichloromethane, acetonitrile, ethyl acetate, acetone, propylene carbonate, water, glycerine, coconut fatty acid diethanolamide, medium and/or long chain fatty acids or glycerides, monoglycerides, diglycerides, triglycerides, structured triglycerides, soyabean oil, peanut oil, com oil, com oil monoglycerides, com oil diglycerides, com oil triglycerides, polyethylene glycol, caprytocaproylmacrogiycerides, caproyl 90, propylene glycol, polyoxyethylenesorbitan fatty acid esters, polyoxyethylene castor oil derivatives, castor oil, cottonseed oil, olive oil, safflower oil, peppermint oil, coconut oil, palm seed oil,
- wetting agents as used herein are routinely used in pharmaceutical formulations, especially in liquid dosage forms to create a homogeneous dispersion of solid particles in a liquid vehicle. This process can be challenging due to a layer of adsorbed air on the particle’s surface. Hence, even particles with a high density may float on the surface of the liquid until the air phase is displaced completely.
- the use of a wetting agent allows removal of adsorbed air and easy penetration of the liquid vehicle into pores of the particle in a short period of time.
- alcohol, glycerin, and PG are frequently used to facilitate the removal of adsorbed air from the surface of particles.
- wetting agents are Benzalkonium chloride, Benzethonium chloride, Cetylpyridinium chloride, Docusate sodium, Nonoxynol 9, Octoxynol, Poloxamer, Poloxamer 124, Poloxamer 188, 237, 338, 407, Polyoxyl 35 castor oil, Polyoxyl 40 hydrogenated castor oil, Polyoxyl 10 oleyl ether, Polyoxyl 20 cetyistearyl ether, Polyoxyl 40 stearate, Polysorbalc 20, Polysorbate 40, Polysoibatc 60, Polysoibatc 80, Sodium lauryl sulfate, Sorbitan monolaurate, Sorbitan monooleate, Sorbitan monopalmitate, Sorbitan monostearate, Tyloxapol and the like or any combinations thereof.
- Solubility enhancing agents may include, but are not limited to, DL-mcthionine, caffeine, nicotinamide, vanillin, benzyl alcohol, ethanol and diethylene glycol monoethyl ether and the like or combinations thereof.
- Stabilizing agents may include, but are not limited to, sodium metabisulphite, sodium bisulphite, ethylene diamine tetraacctic acid (EDTA) or salts thereof, ascorbic acid and the like or combinations thereof.
- EDTA ethylene diamine tetraacctic acid
- Penetration/permeation enhancers may include, but are not limited to, nicotinamide, caffeine, peppermint oil, sodium glycocholate, phospholipids, alkyl saccharides, aprotinin, benzalkonium chloride, ceramides, cetylpyridinium chloride, chitosan, chitosan-4-thiobutyIamidme, cyclodextrins, dextran sulfate, dodccyl azacycloheptyI-2- ketone, ether lipids (plasmologens), glycerol, glycosylated sphingosines, lauric acid, 23 -lauryl etiicr, lysophosphatidyl choline, menthol, methoxysalicylate, phosphatidyl choline, l-palmitoyl-2-glutaroyl-sn-glycerc>-3-phosphocholme, polycar
- Mucoadhesives may also be added in the compositions of the present invention.
- suitable mucoadhesives include, but are not limited to, hydroxypropyl cellulose, gelatin, crosslmked polyacrylic acid, polymethacrylic acid, polyhydroxyethyl methacrylic acid, hydroxypropyl methyl cellulose, polyethylene glycol, sodium carboxymethyl cellulose, hyaluronic acid, chitosan, polycarbophil, pectin, xanthan gum, alginate, copolymers of dextran, polyacrylamide, acacia, copolymer of caprolactone and ethylene oxide, caibopol 934, tragacanth, eudragit and the like or combinations thereof.
- the pH of an oral liquid formulation is a key point in many regards. Control of the formulation pH, could prevent large changes during storage. Therefore, most formulations utilize a buffer to control potential changes in the solution pH.
- the amount of buffer capacity needed is generally between 0.01 and 0.1 M, and a concentration between 0.05 and 0.5 M is usually sufficient.
- the selection of a suitable buffer should be based on (i) Whether the acid-base forms are listed for use in oral liquids, (ii) The stability of the drug and excipients in the buffer, and (iii) The compatibility between the buffer and container. A combination of buffers can also be used to gain a wider range of pH compared to the individual buffer alone. However, not all buffers are suitable for use in oral liquids.
- Suspending agents impart viscosity, and thus retard particle sedimentation.
- Other factors considered in the selection of the appropriate agent include desired rheological property, suspending ability in the system, chemical compatibility whh other excipients, pH stability, length of time to hydrate, batch-to-batch reproducibility, and cost
- pH adjusting agents/modifiers and buffers arc Acetic acid, Adipic acid, Ammonium carbonate, Ammonium hydroxide, Ammonium phosphate, Boric acid, Citric acid, Diethanolamine, Fumaric acid, Hydrochloric arid, Malic arid, Nitric acid, Propionic arid, Potassium acetate, Potassium bicarbonate, Potassium chloride, Potassium citrate, Potassium metaphosphate, Potassium phosphate, Sodium acetate, Sodium bicarbonate, Sodium borate, Sodium carbonate.
- Suspending agents can be classified into cellulose derivatives, clays, natural gums, and synthetic gums. In many cases, these excipients are used in combination. There are many water soluble hydrocolloids that can act as suspending agents in the formulation of pharmaceutical suspensions. They can be of natural, semi-synthetic or synthetic origin.
- Non-limiting examples of suspending agents are Acacia, Agar, Algmic add, Carbomer, Carmellose sodium, Dextrin, Gelatin, Veegum or Gel white, Gellan gum, Sodium alginate, Methylcellulose, Hydroxyethyl cellulose, Hydroxypropyl cellulose, Hydroxypropylmcthyl cellulose, Hydroxypropyl starch, Hypromellose, Maltodextrin, Methylcellulose, Modified starch, Pectin, Poloxamer, Polycarbophil, Polyethylene glycol, Polyvinyl acetate, Poly (vinyl alcohol), Potassium alginate, Polyvinyl pyrrolidone, Pregelatinized starch, Propylene glycol alginate, Sodium alginate., Carboxymethyl cellulose or an alkali metal salt thereof Microcrystalline cellulose, gum Arabic, Karaya gum, Sterculia gum, Tragacanth, Xanthangum, Bentonite, Carageenan,
- preservatives become inevitable to prevent tire growth of microorganisms during the product’s manufacture and shelf life, although it may be most desirable to develop a“preservative-free" formulation to address the increasing concerns about the biological activity of these compounds.
- Most formulations require some kind of preservative to ensure no microbial growth.
- the majority of preservatives are bacteriostatic rather than bacteriocidal, and consists of both acid and nonacid types.
- the acidic types are phenol, chloro-cresol, 9- phenyl phenol, alkyl esters of para-hydroxybcnzoic acid, benzoic acid, boric acid, and sorbic acid, and their respective salts.
- Neutral preservatives include chlorobutanol, benzyl alcohol, and beta- phenylethyl alcohol. Under alkaline conditions, it is generally regarded that microbial growth is insignificant and at these pH values, the need for a preservative is not generally recommended.
- Non-limiting examples of preservatives are Alcohol, Ethanol, Chlorobutanol, Phenoxyethanol, Potassium benzoate, Benzyl alcohol, Benzoic acid, Potassium sorbatc, Sorbic add, Benzalkonium chloride, Benzcthonium chloride, Cetrimonium bromide, Cetylpyridinium chloride, BronopoL, Chlorbutol, Chlorocresol, Cresol, Butylparaben, Methylparabcn, Propylparaben, Ethylparaben, Phenol, Thymol, Phenylethanol, Sodium benzoate, Antimicrobial solvents like Propylene glycol, Glycerin, Chloroform and the like or any combinations thereof.
- some formulation ingredients like nonionic surfactants, quaternary ammonium compounds, gelatin, ferric salts, calcium salts and salts of heavy metals, including silver, lead, and mercury prevent microbial growth.
- Antioxidants can be compounds that can reduce a drug that has been oxidized, or compounds that are more readily oxidized than the agents they are to protect (oxygen scavengers). Many of the lipid-soluble antioxidants act as scavengers. Antioxidants can also act as chain terminators, reacting with free radicals in solution to stop the free- radical propagation cycle. Mixtures of chelating agents and antioxidants are often used because there appears to be a synergistic effect This occurs because many of the agents act at differing steps in the oxidative process.
- rancidity refers to many typical off-flavors that result flora autoxidation of un saturated fatty acids that are present in oils ami fits, and it affects many oils and fits.
- the distinct rancid odour may result from short-chain, volatile monomers resulting flora the cleavage of the longer chain, less volatile oils and fits.
- Non-limiting examples of anti-oxidants are a-Tocopherol acetate, Ascorbic add, Erythorbic acid, Butylated hydroxytoluene (BHT), d-o-Tocopherol natural, Monothioglycerol, Sodium bisulfite, Sodium sulfite, Sodium metabisulfite, Potassium metabisulfite, Acetone sodium bisulfite, Ascorbyl palmitate, Cysteine, d-a-tocophcrol synthetic, Nordihydroguaiaretic acid, Sodium formaldehyde sulfoxylate, Sodium thiosulfate, Acetylcysteine, Ascorbyl palmitate, Butylated hydroxyanisole (BHA), Cysteine hydrochloride, Dithiothrertol, Propyl gallatc, Thiourea and the like or any combinations thereof.
- BHT Butylated hydroxytoluene
- bulking agents also known as auxiliary suspending agents are used.
- Non-limiting examples of bulking agents are Calcium carbonate, Calcium hydroxide, Cellulose, Crospovidone, Dibasic calcium phosphate, Magnesium carbonate, Magnesium hydroxide, Microcrystalline cellulose, Silica (silicon dioxide), Titanium dioxide and the like or any . combinations thereof
- Surfactant is a general name for materials that possess surface activity; in solution they toid to orient at the surface of the liquid.
- Surfactants are amphiphilic molecules, i.e. part of the molecule is hydrophilic, and part is lipophilic. This combination of the two opposite affinities in the same molecule causes them to orient to the interface and thereby reduce the interfacial tension between the continuous and disperse phases, such as in emulsions and suspensions.
- Ionic surfactants work primarily through electrostatic forces
- non-ionic surfactants work primarily through static forces.
- Non-limiting examples of surfactants are Sodium lauryl sulfate, Docusate sodium, Cocamidopropyl amino betaine, Polyoxyethylene soibitan fatty acid esters (Polysoibale, Tween®), Polyoxyethylene 15 hydroxystearate (Macrogol 15 hydroxystearate, Solutol HS15®), Polyoxyethylene castor oil derivatives (Cremophor® EL, ELP, RH 40), Polyoxyethylene stearates (Myrj®), Soibitan fatty acid esters (Span®), Polyoxyethylene alkyl ethers (Brij®), Polyoxyethylene nonylphenol ether (Nonoxynol®) and the like or any combinations thereof.
- Anti-foaming agents may be used in the preparation of the liquid pharmaceutical compositions of the present invention to lower the surface tension and cohesive binding of liquid phase.
- Non-limiting examples of anti-foaming agents are simethicone, organic phosphates, alcohols, paraffin oils, stearates, glycols and the like or any combinations thereof.
- Chelating agents also known as sequestrants, are molecules that have the ability to form stable complexes with metal ions, particularly di-valent and tri-valent metal ions including trace metals and heavy metals. These metal ions are often implicated in API degradation by acting as catalysts, e.g. Mg 2 * will catalyze both ester hydrolysis and the Maillaid interaction between primary or secondary amines and reducing sugars. Oxidative degradation is also often catalyzed by heavy metals. In addition, certain trace metals arc required for microbial growth, and chelation (sequestration) to form complexes can help prevent microbial growth and spoilage, and thus allow lower levels of microbiocidal agents to be used.
- Non-limiting examples of chelating agents arc Calcium disodium edetate, Disodium edetatc, Edetic acid (also known as ethylenediaminetetraacetic acid/EDTA), Citric acid and the like or any combinations thereof Palatabilhy of oral medicines is an important factor in compliance. There are several components to palatability including flavor, mouth-feel and sweetness. Most patients prefer medicines that are not too bitter but may be slightly“tart” (acidic). Most APIs are bitter. However, for bitterness to develop, the drug must be sufficiently soluble to interact with taste receptors on the tongue. For insoluble APIs in the form of suspensions, components of the suspension are also bitter, e.g. preservatives, or very salty, e.g. buffer systems. However, a slight saltiness and a slight bitterness are desirable for palatability.
- sweetening agents are sugar alcohols (also known as polyhydric alcohols, polyols and hydrogenated sugars).
- sugar alcohols also known as polyhydric alcohols, polyols and hydrogenated sugars.
- ionic and have the potential to interact with other components of the suspension Some sweetening agents are more stable than others in aqueous solution.
- sweetening agents are Glucose, Sucralose, Trehalose, Fructose, Xylose, Dextrose, Galactose, Tagatose, Maltose, Sucrose, Glycerol, Dulcitol, Mannitol, Lactitol, Sorbitol, Xylitol, Saccharine or the corresponding sodium, potassium or calcium salt Cyclamatc or the corresponding sodium or calcium salt, Aspartame, or Acesulfeme or the potassium salt thereof, Dulcin or Ammonium glycyrrhizinate, Alitame, Inulin, Isomalt, Neohesperidin dihydrochalcone, Thaumatin and the like or any combinations thereof.
- Flavors are used to improve the palatability of oral medicines.
- One problem that can arise with oral suspensions is that the suspension may produce a“cloying” sensation in the mouth. While this is not the same as a bitter taste, it can nevertheless cause problems for the patient and affect compliance. This can be a particular problem with high levels of inorganic components. Flavors can help reduce this“cloying” taste and thereby improve palatability, and ultimately patient compliance.
- Flavors can adsorb onto finely divided solids, thus reducing their effectiveness. They can also be absorbed by packaging. Flavor preferences vary with age, but the citrus flavors appear generally acceptable to most age groups.
- Non-limiting examples of flavoring agents are synthetic flavor oils and flavoring aromatics and/or natural oils, extracts from plants leaves, flowers, fruits, and so forth and the like or any combinations thereof. These may include cinnamon oil, oil ofwintergreen, peppermint oils, clove oil, bay oil, anise oil, eucalyptus, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, oil of bitter almonds, and cassia oil and the like or any combinations thereof.
- flavors are vanilla, citrus oil, including lemon, orange, grape, lime and grapefruit, and fruit essences, including apple, banana, pear, peach, strawberry, raspberry, cherry, plum, pineapple, apricot, and so forth and the like or any combinations thereof.
- Solid forms, such as spray dried forms of flavoring agents may also be useful in the liquid compositions disclosed herein.
- Coloring agents may also be used in the preparation of the liquid compositions of the present invention.
- Pharmaceutical colors come in two types; soluble dyes and insoluble pigments. For pharmaceutical suspensions intended for oral use, soluble dyes are often used; however, pigments may also be used and would be part of the disperse phase. Soluble dyes have the potential to interact with other components of the formulation.
- the liquid pharmaceutical compositions of the present invention comprise particles of an antiepileptic drug (active pharmaceutical ingredient), wherein the dgo of the particles of an antiepileptic drug (active pharmaceutical ingredient) is less than about 1000 pm, or less than about 950 pm, or less than about 900 pm, or less than about 850 pm, or less than about 800 pm, or less than about 750 pm, or less than about 700 pm, or less than about 650 pm, or less than about 600 pm, or less than about 550 pm, or less than about 500 pm, or less than about 450 pm, or less than about 400 pm, or less than about 350 pm, or less than about 300 pm, or less than about 250 pm, or less than about 200 pm, or less than about 150 pm, or less than about 100 pm, or less than about 90 pm, or less than about 80 pm, or less than about 70 pm, or less than about 60 pm, or less than about 50 pm, or less than about 40 pm, or less than about 30 pm, or less than about 20 pm, or less than about 10 pm
- One or more preservatives are added in the sufficient quantity of the vehicle; 2.
- One or more sweetener, optionally one or more antifoaming agents, optionally one or more surfactants, one or more solvents/co-solvents or solubilizers are sequentially added;
- the present invention provides a liquid composition
- a liquid composition comprising Valproic acid or its pharmaceutically acceptable salts and chemical derivatives such as Sodium valproate or Divalproex sodium or polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, anti-foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
- Sodium valproate or Divalproex sodium or polymorphs such as Sodium valproate or Divalproex sodium or polymorphs, solvates, hydrates, anhydrous forms, prod
- the liquid pharmaceutical compositions of the present invention are suitable for administration to a subject to treat or prevent a disease or a condition.
- the subject is a mammal- More preferably, tihe mammal is a human.
- the disease or condition is a disease or condition that is treatable by the administration of an antiepileptic drug as described herein.
- the present invention is directed to the method for the treatment of epilepsy and/or convulsion and/or seizure and/or a disease or a condition that can be treated by antiepileptic drugs comprising administering to a patient, such as human, an effective dosage amount of. a liquid pharmaceutical composition comprising an antiepileptic drug and one or more pharmaceutically acceptable excipients or additives as disclosed and described herein.
- Effective dosage amount as used herein with respect to, for example liquid pharmaceutical compositions of the present invention shall mean that dosage that provides tire specific pharmacological response for which an antiepileptic drug administered in a significant number of subjects in need of such treatment It is emphasized that "effective dosage amount”, administered to a particular subject in a particular instance will not always be effective in treating the diseases described herein, even though such dosage is deemed a“effective dosage amount” by those skilled in the ait.
- the present invention is directed to use liquid pharmaceutical compositions of the present invention for the treatment of epilepsy and/or convulsion and/or seizure and/or a disease or a condition that can be treated by administration of antiepileptic drugs.
- the liquid pharmaceutical compositions of the present invention are proposed to have unexpectedly dramatic dissolution profiles. Rapid dissolution of an administered active agent is preferable, as faster dissolution generally leads to greater bioavailability and faster onset of action. To improve the dissolution profile and bioavailability of an antiepileptic drug it would be useful to increase dissolution of the antiepileptic drug used so that it could attain a level close to 100% dissolution of the drug substance.
- the liquid pharmaceutical compositions of the present invention comprising an antiepileptic drag or salt thereof or derivative thereof, exhibit improved or comparable pharmacokinetic profiles as compared to marketed or known compositions.
- the Cmax and/or AUC of the liquid pharmaceutical compositions of an antiepileptic drug of the present invention can be greater than or substantially equal to the Cmax and/or AUC for known or marketed compositions administered at the same dose
- the Tmax of the liquid compositions of the present invention can be lower than or substantially equal to that obtained for a known or marketed compositions, administered at the same dose.
- combinations of an improved or ⁇ comparable Cmax, AUC and Tmax profile can be exhibited by the liquid compositions of the invention, as compared to known or marketed compositions, hi further aspects, the liquid compositions of the present invention may result in minimal different absorption levels when administered under fed as compered to fasting conditions.
- the liquid compositions of the present invention exhibit in comparative pharmacokinetic testing with marketed or known formulation, administered at the same dose, a Tmax not greater than about 90%, not greater than about 80%, not greater than about 70%, not greater than about 60%, not greater than about 50%, not greater than about 30%, not greater than about 25%, not greater than about 20%, not great» than about 15%, not greater than about 10%, or not greater than about 5% of die Tmax exhibited by the marketed or known formulation.
- the liquid compositions of the present invention exhibit in comparative pharmacokinetic testing with marketed or known formulation, administered at the same dose, a Cmax which is at least about 50%, at least about 100%, at least about 200%, at least about 300%, at least about 400%, at least about 500%, at least about 600% ! , at least about 700%, at least about 800%, at least about 900%, at least about 1000%, at least about 1100%, at least about 1200%, at least about 1300%, at least about 1400%, at least about 1500%, at least about 1600%, at least about 1700%, at least about 1800%, or at least about 1900% greater than the Cmax exhibited by the marketed or known formulation.
- a Cmax which is at least about 50%, at least about 100%, at least about 200%, at least about 300%, at least about 400%, at least about 500%, at least about 600% ! , at least about 700%, at least about 800%, at least about 900%, at least about 1000%, at least about 1100%,
- the Tmax of an antiepileptic drug or salt thereof used for the preparation of the liquid composition according to the present invention when assayed in the plasma of the mammalian subject, is less than about 6 to about 8 hours.
- liquid compositions of the present invention exhibit improved or comparable bioavailability as compared to known or marketed compositions.
- liquid pharmaceutical compositions of the present invention are suitable for use in the industry.
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Abstract
Epilepsy is most commonly diagnosed in children and in people over 65. Most antiepileptic drugs are bitter in taste and therefore sometimes become unacceptable- to patients when administered orally because of its smell, taste, aftertaste and feeling in the mouth. Additionally, solid oral dosage forms may not be suitable option for pediatric and geriatric patients or for the patients having swallowing difficulties. The present invention therefore describes liquid pharmaceutical compositions of antiepileptic drugs which are acceptable to all types of patients' population.
Description
LIQUID PHARMACEUTICAL COMPOSITIONS OF ANTIEPILEPTIC DRUGS
FILED OF THE INVENTION
The present invention relates, in general to the pharmaceutical field, and more precisely it relates to the liquid pharmaceutical compositions of an active pharmaceutical ingredient In particular, the present invention relates to the liquid compositions comprising antiepileptic/anticonvulsant/antiseizurc drugs. In some of the aspects of the present invention, disclosed liquid compositions may be advantageous for die patients having swallowing difficulties such as pediatric or geriatric patients or when the patients are unable to take solid oral dosage forms. BACKGROUND OF THE INVENTION
Children generally rcj ect taking medicine which does not have a favorable shape, taste, flavor, etc. However, if a child who needs to take a medicine, rejects taking it, he might never recover from bis condition. When a child is unable to take medicine orally, it is intravenously administered, and he and his caregivers then may experience stress. Syrups and suspensions arc considered as favorable types of dosage forms in which to orally administer medicine to infants and children. However, they may have disadvantages such as solubility, a bad taste, portability problems or required refrigerator storage. World Health Organization (WHO) currently favors that infants and children be treated with oral solid medicines. New oral solid tablets, such as a mini- tablet, instead of liquid medicines are proposed for this group, however, there are a few reports that mini-tablets are suitable for infants and children. Palatability is one of the main elements of patient acceptability of an oral pediatric medicine. Palatability is defined as the overall appreciation of an oral medicinal product in relation to its smell, taste, aftertaste and feeling in the mouth. Design of the formulation of an oral pediatric medicine should be considered together with its palatability.
Compared to conventional tablets and capsules, oral liquid dosage forms including solutions, syrups, suspensions, elixirs, and concentrates offer unique advantages to many patients. For example, liquids may provide better patient compliance for those with swallowing difficulties and better dosage control versus a fixed tablet dose. Hence, liquid dosage forms are generally formulated for use in geriatric and pediatric patients. However, there are also a number of“challenges” surrounding the formulation and development of these forms.
Oral liquids arc formulated as solutions, suspensions and emulsions depending on the nature of the active ingredient particularly solubility and stability. They are also designed as ready to use liquids and powders for reconstitution into liquid orals like syrups, solutions, suspensions and emulsions. Liquid formulation needs various excipients including vehicle, solubilizer, stabilizer, and viscosity builder, preservative and off course sweeteners, color and flavor. The selection of these excipients is of major concern to design stable, effective and palatable oral liquid formulation.
Characteristics of active drag are of major concern in developing an oral liquid dosage formulation. The major challenges in developing oral liquid dosage forms are (i) the stability of a drag in solution, (ii) the solubility of a drag at the required level, and (iii) an acceptable taste. It is the effective use of excipients, which allows formulators overcome these challenges. Additionally, an excipient’s compatibility with a drag in the solid state cannot inf» the same compatibility in solution.
The decision to develop a solution, syrup or a suspension of a drug is influenced by many fectors like solubility and the desired release profile of the drug and properties of the base vehicle like surface tension, viscosity, boiling point, and specific heat of solution, all of which may be affected in various ways. In case of dear liquids, lack of solubility of the drug in the base vddcle may demand the need for miscible co-solvents.
Similarly, a miscible solvent may be needed to decrease the solubility of the drug in a primary vehicle in formulating a suspension.
The therapeutic utility of drags involves the application of dosage forms/delivery systems, which save as carrier systems together with several excipients to deliver the active therapeutic agent to the site of action. Suspensions are an important class of pharmaceutical dosage forms that may be given by many routes, including oral, topical, parenteral, and also used in the eye for ophthalmic purposes. Surprisingly, large proportions of new drug candidates that are emerging are predominantly water insoluble and, therefore, demonstrate poor bioavailability in the solution dosage form. While suspensions present a viable formulation option for many drugs, particularly for water insoluble, hydrophobic drug substances, there are certain criteria that a well- formulated suspension should meet
The suspension dosage form has long been used for poorly soluble active ingredients for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. Drugs from suspension formulations typically exhibit an improved bioavailability when compared to the same drug formulated as a tablet or capsule.
A good understanding of the fundamentals of disperse systems is essential in the development ofa suitable pharmaceutical suspension. The development of a suspension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important The particle size distribution in tiie finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product
Suspensions are an important class of pharmaceutical dosage forms. The advantages of suspension dosage forms include effective dispensing of hydrophobic drugs; avoidance of the use of co-solvents; masking of unpleasant taste of certain ingredients; offering resistance to degradation of drugs due to hydrolysis, oxidation or microbial activity; easy swallowing for young or elderly patients; and efficient intramuscular depot therapy. In addition, when compared to solution dosage forms, relatively higher concentration of drugs can be incorporated into suspension products. To date, numerous theories have been introduced and successfully used to explain the unique behavior of suspension preparations.
Epilepsy is not just one condition, but a group of many different“epilepsies” with one tiling in common: a tendency to have seizures that start in the brain. Epilepsy is usually only diagnosed after a person has had more than one seizure. Anyone can develop epilepsy, at any time of life. It happens in people of all ages, races and social classes. Epilepsy is most commonly diagnosed in children and in people over 65. There are over fifty million people with epilepsy in the world. Therefore, if finished dosage form is in liquid, it will be easier to administer dose as compared to any other type of dosage forms.
Though liquid pharmaceutical compositions of antiepileptic drugs are advantageous and much more required, they are not much explored by the formulation scientists.
Therefore, looking at the need existing in the art for the preparation of liquid pharmaceutical compositions of antiepileptic drugs to mask its taste and make them overall acceptable to all types of patient population, the present inventors have formulated antiepileptic drugs in liquid pharmaceutical compositions having palatability and acceptability along with prolonged stability. These properties of the liquid compositions of the present invention make them favorable for use in the pharmaceutical industry.
OBJECTS OF THE INVENTION
One in 20 people will have a one-off epileptic seizure at some point in their life (although this does not necessarily mean that they have epilepsy). One in 50 people will have epilepsy at some time in their life (not everyone with epilepsy will have it for life). Around 87 people arc diagnosed with epilepsy every day. Epilepsy is most commonly diagnosed in children and in people over 65. Because of their liquid character, liquid dosage forms represent an ideal dosage form for patients who have difficulty swallowing tablets or capsules. This factor is of particular importance in administration of drugs to children and aged patients. It is therefore principal object of 11» present invention to provide liquid pharmaceutical compositions of antiepileptic drugs. The liquid pharmaceutical compositions according to the present invention include liquids, liquid dispersions, suspensions, solutions, emulsions, sprays, spot-ah, syrups, elixirs, drops, gels, solution-gels, concentrates and the like.
Most antiepileptic drugs are bitter in taste and are therefore not acceptable to some patients’ population such as pediatric. Bitter taste of the drugs can be masked by preparing liquid dosage forms such as solutions or suspensions which comprise sweeteners as well as flavors. Acceptability of antiepileptic dosage forms can thus be increased by increasing its palatability. Therefore in another object, the present invention provides liquid pharmaceutical compositions of antiepileptic drugs having palatability.
Liquid dosage forms are designed as ready to use liquids and as powder for reconstitution into liquid orals like syrups, solutions, suspensions and emulsions. Powder for reconstitution may require skills & expertise and needs to be prepared by a healthcare provider and may not be prepared by the patient or caregiver. The -
reconstitution process may also be a time consuming process and the patient cannot be benefited by the immediate dose of an antiepileptic drug as and when required. In such a situation, ready to use, liquid compositions of an antiepileptic drug may be very useful and die patients can be given required doses immediately using ready to use, liquid compositions of an antiepileptic drug. Therefore, a yet another object of the present invention is to provide ready to use, liquid pharmaceutical compositions of an antiepileptic drug'.
The solution dosage form can be a viable alternative for patients who have problems in swallowing the tablet or capsule dosage form, ft provides assurance of dosage uniformity upon administration to patients and eliminates difficulty of administration. A solution can also provide physicians more flexibility in designing dosage regimens for patients. Solution dosage form of an antiepileptic drug is suitable for administration to both pediatric and geriatric patients while also compensating for a good Organoleptic properties and remaining suitably stable. Hence, the development of a liquid formulation is desirable since it offers improved patient compliance. A yet another object of the present invention is therefore to develop solution dosage forms of an antiepileptic drug. The solution dosage forms according to the present invention comprises an antiepileptic drug or pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients or additives selected from the group comprising of vehicles, solvents/co-solvents, solubilizers, surfactants, pH adjusting agents and/or pH modifying agents and/or buffering agents or any combination thereof. The solution dosage forms according to the present invention may further comprise one or more agents selected from the group comprising of preservatives, sweetening agents, flavoring agents and coloring agents or any combination thereof.
Suspensions possess certain advantages over other liquid dosage forms. Some drugs are insoluble in all acceptable media and must, therefore, be administered as a tablet, capsule, or as a suspension. In addition, disagreeable tastes can be masked by a suspension of die drug or a derivative of the drug. Drugs in suspension are chemically more stable than in solution. In another object, the present invention therefore provides suspension dosage forms of an antiepileptic drug. The suspension dosage forms according to the present invention comprises an antiepileptic drug or pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable
excipients or additives selected from the group comprising of vehicles, solvents/co- solvents, solubilizers, suspending agents/thickening agents/viscosity modifying agents, anti-foaming agents, anti-caking agents, wetting agents, surfactants, pH adjusting agents and/or pH modifying agents and/™- buffering agents or any combination thereof. The suspension dosage forms according to the present invention may further comprise one or more agents selected from the group comprising of preservatives, sweetening agents, flavoring agents and coloring agents or any combination thereof.
A yet another object of the present invention is to provide liquid pharmaceutical compositions of antiepileptic drugs comprising one or more pharmaceutically acceptable excipients or additives selected from the group comprising of vehicles, solvents/co-solvents/ solubilizers/solubilizing agents, solubility enhancing agents, tonicity agents, penetration/penneation enhancers, mucoadhesives, preservatives, pH adjusting agents/pH modifying agents/buffering agents, surfactants, anti-foaming agents, suspending agents/thickening agents/viscosity· modifying agents, bulking agents/auxiliary suspending agents, wetting agents, anti-oxidants, chelating agents, anti-caking agents, sweetening agents, flavoring agents, coloring agents and the like or any combination thereof. A yet another object of the present invention is to provide liquid pharmaceutical compositions of antiepileptic drugs having portability, prolonged stability and improved and/or comparable pharmacokinetic profile or bioavailability when compared to the known or marketed formulations. The liquid pharmaceutical compositions of the present invention comprise sweeteners) and flavoring agent(s) which masks the bitter taste of antiepiJeptic drugs and provides pleasant taste.
In one of the further objects, an antiepileptic drug for preparing liquid pharmaceutical compositions according to the present invention is selected from the group comprising of Primidone, Topiramate, Vigabatrin, Zonisamide, Clobazam, Gabapentin, Levetiracetam, Perampanel, Phenobarbital, Pregabalin, Rufinamide or pharmaceutically acceptable salts, polymorphs, solvates, hydrates, anhydrous forms, prodrags, chelates, and complexes thereof and Valproic acid or its salts such as Sodium valproate, Divalproex sodium or chemical derivatives thereof such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes.
A yet another object of the present invention is to provide processes for the preparation of liquid pharmaceutical compositions of antiepileptic drugs prepared according to the presort invention. A yet another object of the present invention is to provide method for the treatment of epilepsy and/or convulsion and/or seizure and/or a disease or a condition that can be treated by antiepileptic drugs comprising administering to a patient, such as human, an effective dosage amount of a liquid pharmaceutical composition comprising an antiepileptic drag and one or more pharmaceutically acceptable excipients or additives as disclosed and described herein.
A yet another object of the present invention is to use the liquid pharmaceutical compositions of the present invention fin the treatment of epilepsy and/or convulsion and/or seizure and/or a disease or a condition that can be treated by administration of antiepileptic drugs.
DESCRIPTION OF THE INVENTION
Epilepsy is not just one condition, but a group of many different“epilepsies” with one tiling in common: a tendency to have seizures that start in the brain. Epilepsy is usually only diagnosed after a person has had more than one seizure. Not all seizures are due to epilepsy. Anyone can develop epilepsy, at any time of life. It happens in people of all ages, races and social classes. Epilepsy is most commonly diagnosed in children and in people over 65. There are over half a million people with epilepsy in the world, so around 1 in 100 people.
Different epilepsies are due to many different underlying causes. The causes can be complex, and sometimes hard to identify. A person might start having seizures because they have one or more of the following.
• A genetic tendency, passed down from one or both parents (inherited).
• A genetic tendency that is not inherited, but is a new change in the person's genes.
• A structural (sometimes called“symptomatic”) change in the brain, such as the · brain not developing properly, or damage caused by a brain injury, infections like meningitis, a stroke or a tumor.
• Structural changes due to genetic conditions such as tuberous sclerosis, a genetic condition that causes growths m organs including the brain; Tuberous sclerosis can cause epilepsy or neurofibromatosis, a genetic condition that causes benign tumors to grow on the covering of nerves; Neurofibromatosis can cause epilepsy which can cause growths affecting the brain. Some researchers now believe that the chance of developing epilepsy is probably always genetic to some extent, in that any person who starts having seizures has always had some level of genetic likelihood to do so. This level can range from high to low and anywhere in between. Even if seizures start after a brain injury or other structural change, this may be due to both the structural change and the person's genetic tendency to seizures, combined. This makes sense if we consider that many people might have a similar brain injury, but not all of them develop epilepsy afterwards.
Most seizures happen suddenly without warning, last a short time (a few seconds or minutes) and stop by themselves. Seizures can be different for each person. Just knowing that someone has epilepsy does not tell what their epilepsy is like, or what seizures they have. Calling seizures‘major’ or‘minor’ does not tell what happens to the person during the seizure. Some people have more than one type of seizure. But even if someone's seizures are unique, they usually follow the same pattern each time they happen. Not all seizures involve convulsions (jerking or shaking movements). Some people seem vacant, wander around or are confused during a seizure. Some people have seizures when they are awake, called“awake seizures”. Some people have seizures while they are asleep, called“asleep seizures” (or“nocturnal seizures”). The names“awake” and“asleep” do not explain the type of seizures, only when they happen. Injuries can happen during seizures, but many people don't hurt themselves and don't need to go to hospital or see a doctor.
Epilepsy is a neurological condition-which means it affects the brain. It is also a physical condition, because the body is affected when someone has a seizure. Epilepsy
is described as the tendency to have repeated seizures that start in the brain. Epilepsy is usually only diagnosed after the person has had more than one seizure. Anyone can have a seizure if the circumstances are right, but most people do not have seizures under “normal conditions”. Seizures are sometimes called“fits” or“attacks”. Seizures happen when there is a sudden interruption in the way the brain normally works. Epilepsy is a variable condition that affects different people in different ways. There are over 40 different types of seizure. What seizures look like can vary. For example someone may go“blank” for a couple of seconds, they may wander around and be quite confused, or they may fall to the ground and shake (convulse). So not all seizures involve convulsions. Some people are unconscious during their seizures and so they do not remember what happens to them. It can be really useful to have a description of what happened from someone who saw their seizure to help with diagnosis. This is sometimes called an“eyewitness account”. There are many different causes (reasons) why someone might develop epilepsy. Sometimes a cause for epilepsy can be found (for example ahead injury) but sometimes the person’s epilepsy starts“out of the blue” and the cause cannot be found.
One in 20 people will have a one-off epileptic seizure at some point in their life (although this does not necessarily mean that they have epilepsy). One in 50 people will have epilepsy at some time in their lift (not everyone with epilepsy will have it for life). Around 87 people are diagnosed with epilepsy every day. Approximately 50 million people currently live with epilepsy worldwide. The estimated proportion of the general population with active epilepsy (i.e. continuing seizures or with the need for treatment) at a given time is between 4 and 10 per 1000 people. However, some studies in low- and middle-income countries suggest that the proportion is much higher, between 7 and 14 per 1000 people. Close to 80% of people with epilepsy live in low- and middle- income countries. Up to 5% of people with epilepsy will be affected by flashing lights (called photosensitive epilepsy), so most people with epilepsy do not have seizures triggered by flashing lights.
Globally, an estimated 2.4 million people are diagnosed with epilepsy each year. In high-income countries, annual new cases are between 30 and 50 per 100000 people in the general population. In low- and middle-income countries, this figure can be up to two times higher. The higher figure in low- and middle-income countries is likely due
to the increased risk of endemic conditions such as malaria or neurocysticercosis; the higher incidence of road traffic injuries; birth-related injuries; and variations in medical infrastructure, availability of preventive health programs and accessible care. Epilepsy can start at any age, but is most commonly diagnosed in people under 20 and people over 65. This is because some causes are more common in young people (such as difficulties at their birth, childhood infections or accidents) and in older people (such as strokes that lead to epilepsy). For some people their epilepsy might‘go away’ and they stop having seizures. This is called spontaneous remission. Epilepsy can be difficult to diagnose and there arc a number of different tests that might be done to help with a diagnosis such as an EEG (Electroencephalogram) or an MRI (Magnetic Resonance Imaging) scan.
Epilepsy is usually treated with medication called anti-epileptic drugs (AEDs). AEDs aim to stop seizures from happening, but they do not cure epilepsy. With the right AEDs, up to 70% of people with epilepsy could have their seizures controlled (stopped). The first AED used to treat epilepsy was phenobarbitone in 1912. There arc now over 25 different AEDs available in the market For people who do not have their seizures controlled with AEDs, surgery may be an option. This can involve removing the part of their brain that causes the seizures.
An important consideration in any treatment regime is to ensure that the patient receives the correct dose of medicine. For many patients and many drugs there is an acceptable dose window that allows fixed-dose medicines to be used to treat patients with a wide range of body weights without the need to precisely adjust the dose. However, there are other groups of patients where the“fixed-unit-dose” model may not be appropriate, depending on the drug’s therapeutic index and pharmacokinetics, e.g. pediatric patients, geriatric patients, patients with severe renal insufficiency and patients with severe hepatic insufficiency. Oral solid unit dose forms, e.g. tablets and capsules, are not convenient under such circumstances since they are fixed strength unit dose forms. In contrast, oral liquid dose forms do have the in-built flexibility that allows the dose to be tailored to the patients’ needs.
Where the drug is sufficiently soluble, a solution dosage form, e.g. a simple mixture, may be used. But not all drugs are sufficiently soluble to allow suitable strength solution medicines to be developed and manufactured with an acceptable shelf-life, hi such cases, an alternative approach could be to develop a stable aqueous suspension that will allow consistent dosing of the patient. Pharmaceutical suspensions have several advantages and disadvantages when compared to other dosage forms. Since suspensions are liquids, dose adjustment for patients with renal or hepatic impairment, or for pediatric or geriatric patients, may be more straightforward. This is an oversimplification of the development of a dosing strategy for a drug candidate. There are many other details that must be considered for a formulation development project to be successful, but it does provide a simple overview of some of the issues.
The suspension must be physically stable (no appreciable settling) for a sufficient time, chemically stable over the required time (shelf-life), possess a viscosity that allows it to be used for its intended purpose, be easily reconstituted by shaking, and be acceptable in use to the patient, care-giver or other user.
Some materials may possess a combination of properties useful in the formulation and manufacture of stable, elegant pharmaceutical suspensions. Formulation scientists need to consider the totality of properties possessed by a particular excipient. Even though it is being added for one particular characteristic, the other properties will still be present, and will still influence the formulation.
Many of the recently discovered active pharmaceutical ingredients are quite hydrophobic with limited solubility. They may also be quite distasteful Other drugs may also have quite a high chemical degradation precluding them to be administered as aqueous solutions, and in this case, it may be possible to synthesize an insoluble derivative. In other cases, some drugs are required to be present in the gastrointestinal tract or in the pre-comeal pocket with long residence time. For such drugs, a suspension is an ideal delivery system as it provides better chemical stability and larger surface area and is often more bioavailable than aqueous solutions, tablets, and capsules.
Formulation of an elegant, stable, preserved, safe, and effective suspension is a technically challenging task compared aqueous solutions, tablets, and capsules.
Pharmaceutical suspensions are thermodynamically unstable systems. Thus, preparation of such systems is often associated with problems of physical stability, content uniformity, sedimentation, caking, rc-suspendibility, and crystal growth. Furthermore, issues related to the masking of bitter taste and undesirable odor of the pharmaceutical ingredient must be taken into consideration.
Some desirable attributes of a suspension are described as follows,
1. It should be safe, effective, stable, and pharmaceutically elegant during the shelf life of the product.
2. The drug should not have a quick sedimentation rate. Furthermore, it should resuspend easily upon shaking and it must not cake.
3. Physical attributes such as particle size, particle size distribution, viscosity should remain fairly uniform throughout the shelf life of the product
4. to viscosity must promote free and uniform flow from the container. The product must have appropriate substantivity that it spreads freely over the affected area.
5. Re-suspension should produce a homogeneous mix of drug particles such that there is a content uniformity with each dose.
A quick means to identify whether or not a drug may be more suitable for solution or suspension is to overlap the pH-stability profile with the pH-solubility profile. This overlap creates a window, which may suggest which dosage form might be most desirable and subsequently the type of excipients needed.
Oral liquid formulation needs a meticulous blend of ingredients to perform various functions like wetting and solubilization, stabilization and to impart suitable color, taste and viscosity. The blend should be compatible, non-reactive and stable. The common excipients generally required for any liquid formulation are vehicles (base), viscosity builders, stabilizers, preservatives, colors and flavors. In addition, solubilizes are required in case of clear liquids, suspending agents are needed for suspensions and emulsifying agents for emulsions.
In one of the principal aspects, the present invention provides liquid pharmaceutical compositions comprising antiepileptic drugs and one or more pharmaceutically acceptable excipients or additives.
The liquid pharmaceutical compositions according to the present invention include, but not limited to, liquids, liquid dispersions, suspensions, solutions, emulsions, ointments, creams, sprays, spot-on, syrups, elixirs, drops, gels, solution-gels, concentrates and the like. Such liquid pharmaceutical compositions can be prepared using appropriate one or more pharmaceutically acceptable excipients or additives. Such excipients or additives may be known to those skilled in the art
The solution dosage form can be a viable alternative for patients who have problems in swallowing the tablet or capsule dosage form, ft provides assurance of dosage uniformity upon administration to patients and eliminates difficulty of administration. A solution can also provide physicians more flexibility in designing dosage regimens for patients. Solution dosage forms of antiepileptic drugs are suitable for administration to both pediatric and geriatric patients while also compensating for a good organoleptic properties and remaining suitably stable. The development of a liquid formulation is therefore desirable since it offers improved patient compliance. In me of the further aspects, the present invention therefore provides solution dosage forms of antiepileptic drugs.
Suspensions possess certain advantages oVer other liquid dosage forms. Some drugs are insoluble in all acceptable media and must, therefore, be administered as a tablet, capsule, or as a suspension. In addition, disagreeable tastes can be masked by a suspension of the drug or a derivative of the drug. Drugs in suspension are chemically more stable than in solution. Therefore, in one of the further aspects, the present invention provides suspension dosage forms of antiepileptic drugs.
Liquid dosage forms are designed as ready to use liquids and as powder for reconstitution into liquid orals like syrups, solutions, suspensions and emulsions. Powder for reconstitution may require skills & expertise and needs to be prepared by a healthcare provider and may not be prepared by the patient or caregiver. The reconstitution process may also be a time consuming process and the patient cannot be benefited by the immediate dose of an antiepileptic drug as and when required. In such a situation, ready to use, liquid compositions of an antiepileptic drug may be very useful and tile patients can be given required doses immediately using ready to use, liquid compositions of an antiepileptic drug. In one of the further aspects, the present
invention therefore provides ready to use, liquid pharmaceutical compositions of antiepileptic drugs.
Liquid pharmaceutical compositions of an active drug can be prepared using one or more pharmaceutically acceptable excipients or additives suitable for the preparation of liquid compositions. In one of the forth» aspects, the present invention provides liquid pharmaceutical compositions of an antiepileptic drug and one or more excipients or additives suitable for preparing liquid pharmaceutical compositions. The term“pharmaceutically acceptable excipients or additives” as used herein refers to such pharmaceutically acceptable excipients which are known to those skilled in the art for the purposes of preparing liquid pharmaceutical compositions of the present invention. Such pharmaceutically acceptable excipients, without limitation include, vehicles, solvents/co-solvents, solubilizers, solubility enhancing agents, tonicity agents, penneation/penetration enhancers, mucoadhesives, suspending agents/thickening agents/viscosity modifying agents, bulking agents/auxiliary suspending agents, wetting agents, anti-foaming agents, anti-caking agents, stabilizing agents, anti-oxidants, chelating agents, buffering agents/pH modifying agents/pH adjusting agents, surfactants, preservatives, sweetening agents, flavoring agents and the like or any combination thereof. Such pharmaceutically acceptable excipients can be used in an amount which provides the liquid pharmaceutical compositions of the present invention desired property for which they are intended or desired to use. hi one of the further aspects, the present invention provides liquid pharmaceutical compositions of antiepileptic drugs in the form of solution dosage forms comprising an antiepileptic drug and one or more pharmaceutically acceptable excipients or additives selected from the group comprising of vehicles, solvents/co-solvcnts and/or solubilizers, pH adjusting agents and/or pH modifying agents and/or buffering agents or any combination thereof. One or more surfactants may also be added in the solution dosage forms of the present invention.
In one of the further aspects, the presort invention provides liquid pharmaceutical compositions of antiepileptic drugs in the form of suspension dosage forms comprising an antiepileptic drug and one or more pharmaceutically acceptable excipients or
additives selected from the group comprising of vehicles, solvcnts/co-solvents and/or solubilizers, suspending agents/thickening agents/viscosity modifying agents, anti- foaming agents, surfactants, antioxidants, pH adjusting agents and/or pH modifying agents and/or buffering agents or any combination thereof. One or more anti-caking agents may also be added in the suspension dosage forms of the present invention.
Microbiological contamination presents a significant health hazard in oral liquids. Therefore, the use of preservatives become inevitable to prevent the growth of microorganisms during the product’s manufacture and shelf life. Therefore, in one of the further aspects, the liquid pharmaceutical compositions of the present invention may also comprise anti-microbial agents or preserving agents or preservatives.
Increase in the palatabilhy of the drug formulations increases the patient compliance and patient acceptability towards the drug, hi one of the further aspects,' the present invention therefore provides palatable liquid compositions comprising an antiepileptic drug and at least one or both selected from sweeteners/ sweetening agents and flavoring · agents.
The liquid compositions according to the present invention, without limitation include, aqueous dosage forms, alcoholic and/or hydro-alcoholic dosage forms and non-aqueous dosage forms. Aqueous dosage forms according to the present invention may also comprise one or more non-aqueous and/or organic solvents.
In certain aspects, the present invention provides liquid pharmaceutical compositions of antiepileptic drugs in the form of suspensions comprising an antiepileptic drug, vehicle(s), solvent(s)/co-solvent(s), solubilizers), suspending agent(s)/thickcning agent(s)/viscosify modifying agent(s), preservative^), anti-foaming ageat(s), wetting agent(s), surfactants), pH adjusting agent(sypH modifiers) or buffering agent(s) or both, sweeteners) and flavoring agent(s).
In certain aspects, the present invention provides liquid pharmaceutical compositions of antiepileptic drugs in the form of solutions comprising an antiepileptic drug, vehicle(s), solvent(s)/co-solvent(s), solubilizers), preservative^), surfactants), pH
adjusting agent(s)/pH modifiers) or buffering agent(s) or both, sweetencr(s) and flavoring agent(s).
In one of the further aspects, the liquid pharmaceutical compositions of the invention may be administered orally or via the oral cavity. The liquid pharmaceutical compositions of the present invention may also be administered transmucosally, sublingually, via the buccal cavity, via mucosal membranes and/or through the gastrointestinal tract In one of the further aspects, the liquid pharmaceutical compositions of the present invention may be administered via pulmonary, intravenous, rectal, opththalmic, colonic, parenteral, mtracistemal, mtravaginal, intraperitoneal, local, or topical administration.
Sometimes during epileptic stroke it becomes difficult to administer the patients solid and even the liquid oral dosage .forms of the drug. In some of the aspects, the present invention therefore provides the liquid pharmaceutical compositions in the form of spray which may be administered by oral route or nasal route. Sprays are known by various names such as aerosol sprays, liquid pump sprays, or activated mists etc.
In certain aspects, the present invention provides liquid pharmaceutical compositions of antiepileptic drugs m the form of spray comprising an antiepileptic drug and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents/co-solvents, sohibilizera/sohibilizing agents, solubility enhancing agents, penetration enhancers, mucoadhesives, stabilizing agents, buffering agents/pH adjusting agents/pH modifying agents, tonicity agents, preservatives, viscositymodifying agents, sweetening agents, flavoring agents and the like or combinations thereof.
In some of the aspects, the liquid pharmaceutical compositions of the present invention are in the form of immediate release dosage forms or modified release dosage forms, such as extended release, controlled release, sustained release, prolonged release and delayed release. In some of the aspects, the liquid pharmaceutical compositions comprise an antiepileptic drug and one or more suitable excipients or additives for the preparation of modified release dosage forms such as rate controlling polymers.
The liquid phannaceutical compositions of the present invention may also be prepared by reconstitution of dry powder in suitable diluent or media such as water. The dry powder for reconstitution may be in the form of immediate release forms and comprise an antiepileptic drug and one or more suitable excipients selected form the group comprising of fillers, binders, diluents, disintegrants, pore formers, lubricants, glidants, sweeteners, stabilizing agents, antioxidants, flavoring agents, suspending agents/thickening agents/viscosity modifying agents, surfactants, preservatives and plasticizers. The dry powder for reconstitution may also be in the form of modified release forms and comprise modified release pellets, granules or particles. Such modified release pellets, granules or particles comprise one or more suitable excipients such as rate controlling polymers. hi one of the further aspects, the liquid pharmaceutical compositions of the invention are suitable for administration to all types of patients’ population. In particular, liquid phannaceutical compositions of the invention are suitable for pediatric- and geriatric patients. The liquid pharmaceutical compositions of tire invention are also useful for the patients who are unable to take solid oral therapy.
In one of the further aspects, the pH of the liquid compositions of the present invention is between about 2.0 ami about 11.0. In some of the aspects, the pH of the compositions is between about 3.0 and about 9.0. In some of the aspects, the pH of the compositions is between about 4.0 and about 8.0. In some of the aspects, the pH of the compositions is between about 5.0 and about 7.0. In some of the aspects, the pH of the compositions is between about 5.5 and about 6.5.
In one of the further aspects, the liquid pharmaceutical compositions of the present invention are stable for prolonged time when stored under storage conditions. The tom “storage conditions” as used herein without limitation include typical storage conditions such as 2°C-8°C, 40°C±2°C/75±5% RH, 30oC±2°C/65±5e/· RH, 25°C±2°C/40tfc5% RH and accelerated conditions such as 40°Ot2oC/75±5% RH. The tom “prolonged time” as used herein indicates that the liquid pharmaceutical compositions of the present invention are stable for at least 1 month, at least 3 months, at least 6 months or at least 12 months when stored under storage conditions.
As used herein, the terms“stable” or“stability” encompass any characteristic of the liquid compositions which may be affected by storage conditions including, without limitation, potency, total impurities, degradation products, specific optical rotation, optical purity, water content, appearance, viscosity, sterility, and colour and clarity. The storage conditions which may affect stability include, for example, duration of storage, temperature, humidity, and/or light exposure.
In some of the aspects of the present invention, stable liquid pharmaceutical compositions or stability of the liquid pharmaceutical compositions refer to compositions which retain at least about 90%, or about least about 95%, or at least about
96%, or at least about 98%, of the labelled concentration of an antiepileptic drug contained in the said composition after storage under typical and/or accelerated conditions, hi further aspects, stable liquid pharmaceutical compositions or stability of the liquid pharmaceutical compositions refer to less than about 15% (area percent), or less than about 10% (area percent), or less than about 7% (area percent), or less than about 5% (area percent), or less than about 2% (area percent) of an antiepileptic drug- related impurities are present after storage under typical and/or accelerated conditions.
In some of the aspects, liquid pharmaceutical compositions of the present invention contain no more than about 15% (area percent), or no more than about 10% (area percent), or no more than about 7% (area percent), or no more than about 5% (area percent), or no more than about 2% (area percent), or no more than about 1% (area percent), or no more than about 0.5% (area percent), or no more than about 0.2% (area percent), or no more titan about 0.1% (area percent) any known or unknown single active pharmaceutical ingredient-related impurity or other impurity after storage under typical and/or accelerated conditions.
In some of the aspects, liquid pharmaceutical compositions of the present invention contain no more than about 15% (area percent), or no more than about 10% (area percent), or no more than about 7% (area percent), or no more than about 5% (area percent), or no more than about 2% (area percent), or no more than about 1% (area percent), or no more than about 0.5% (area percent), or no more than about 0.2% (area percent), or no more than about 0.1% (area percent) total active pharmaceutical
ingredient-related impurities or other impurities after storage under typical and/or accelerated conditions.
Methods for determining the stability of the liquid pharmaceutical compositions of the present invention with respect to a given parameter are well-known to those of skill in the art For example, individual impurities and total impurities can be assessed by high- performance liquid chromatography (HPLQ or thin layer chromatography (TLC). Unless otherwise indicated to the contrary, a percentage amount of any individual impurities (known/unknown), or total inpurities reported herein in the liquid compositions are determined by a peak area percent method using HPLC.
The team“comprise/comprises/comprising” as used herein mean that other ingredients, steps, etc. are optionally present When reference is made heron to a method comprising two or more defined steps, the steps can be carried in any order or simultaneously (except where the context excludes that possibility), and the method can include one or more steps which are carried out before any of the defined steps, between . two of the defined steps, or after all of the defined steps (except where the context excludes that possibility). The term“about," as used herein, refers to any value which lies within the range defined by a variation of up to ±10% of the value.
The use of the terms“a” and“an" and“the” and similar referents in the context of describing the invention (especially in the context of the claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context
All percentages mentioned herein, unless otherwise indicated, are on a w/v basis, i.e. percentage ingredient (actrve/inactive) present in the total volume of the liquid pharmaceutical composition.
In accordance with the methods of use and administration of medicinal products, packaging materials, closures and containers vary a great deal and have to meet a wide variety of different requirements. The liquid pharmaceutical compositions of the
present invention may be packaged within any type of pharmaceutically-acoeptable package, containers, pumps, bottles with spray pump, bottles with dropper assembly, bottles, collapsible tubes, glass ampoules, stoppered vials, pre-filled syringes, low- density polyethylene (LDPE), high-density polyethylene (HOPE), polyolefin, polypropylene containers/bottles depending upon the quantity of the final dosage form.
The bottles or containers without limitation include clear/transparent/opaque or amber colored glass bottles or containers and clear/transparent/opaque or amber colored plastic bottles or containers made from polyethylene, polyamide, polycarbonate, acrylic multipolymers, polypropylene, polyethylene terephthalate, polyvinyl chloride, polystyrene and the like. Depending upon the type of the containers or bottles, closures may have different shapes and sizes. The closure of the packaging material may be made from polyethylene, polyamide, polycarbonate, acrylic multipolymers, polypropylene, polyethylene terephthalate, polyvinyl chloride, polystyrene and the like.
Liquid pharmaceutical compositions of the present invention may be packaged in a sterile single use bottle/container that contains a unit dose for administration to a patient Suitable bottles/containers may contain volumes between 1-10 ml, 10-20 ml, 20-40 ml, and 40-100 ml, and even more. The container may typically comprise an antiepileptic drug in an amount of between 1040 mg, between 40-80 mg, between 80- 130 mg, and even more. Thus, it may also be noted that the container may be a multiuse container (i.e., retains at least one more unit dose after a first unit dose is dispensed).
In some of the further aspects, the present invention provides concentrate liquid compositions which may be diluted using suitable diluent before administering to the patient In some of the aspects, the liquid compositions of the invention are ready-to- use liquid compositions. Such ready-to-use compositions of the invention are administered directly to tire patients in required doses without any prior preparation e.g. reconstitution in suitable diluent such as water. Following embodiments of the invention describe suitable excipients which may be used to prepare liquid compositions of the present invention. It is in no way the intention of the present inventoi(s}/applicant(s) to limit the scope of the liquid compositions of the present invention by the description of following embodiments. Described embodiments are for illustrative purpose only and a skilled person may use other
excipients fixnn the same or different classes as well which may provide liquid compositions of the present invention same or improved physico-chemical properties, palatabilrty, stability and the like and retain or increase patients’ acceptability towards he therapy. Such other excipients, classes of excipients and compositions resulted therefrom are also part of the present invention and covered within the scope of the present invention. .
Vehicles may be used in the liquid compositions of the present invention. Vehicles are the liquid bases that cany drugs and other excipients in dissolved or dispersed state. Vehicles may be aqueous or non-aqueous or mixture thereof. Non-aqueous solvents/co- solvents may also be added in the liquid compositions of the present invention to increase the solubility of poorly soluble substances and enhance the chemical stability of a drug. Suitable solvents/co-solvents, solubilizers or vehicles, that may be employed, in the liquid compositions of the invention include, but are not ' limited to, dichloromethane, acetonitrile, ethyl acetate, acetone, propylene carbonate, water, glycerine, coconut fatty acid diethanolamide, medium and/or long chain fatty acids or glycerides, monoglycerides, diglycerides, triglycerides, structured triglycerides, soyabean oil, peanut oil, com oil, com oil monoglycerides, com oil diglycerides, com oil triglycerides, polyethylene glycol, caprytocaproylmacrogiycerides, caproyl 90, propylene glycol, polyoxyethylenesorbitan fatty acid esters, polyoxyethylene castor oil derivatives, castor oil, cottonseed oil, olive oil, safflower oil, peppermint oil, coconut oil, palm seed oil, beeswax, oleic acid, methanol, ethanol, isopropyl alcohol, butanol, acetone, methyl isobutyl ketone, methyl ethyl ketone and the like or any combinations thereof.
Wetting agents as used herein are routinely used in pharmaceutical formulations, especially in liquid dosage forms to create a homogeneous dispersion of solid particles in a liquid vehicle. This process can be challenging due to a layer of adsorbed air on the particle’s surface. Hence, even particles with a high density may float on the surface of the liquid until the air phase is displaced completely. The use of a wetting agent allows removal of adsorbed air and easy penetration of the liquid vehicle into pores of the particle in a short period of time. For an aqueous vehicle, alcohol, glycerin, and PG are frequently used to facilitate the removal of adsorbed air from the surface of particles. Whereas for a non-aqueous liquid vehicle, mineral oil is commonly used as a wetting
agent Non-limiting examples of wetting agents are Benzalkonium chloride, Benzethonium chloride, Cetylpyridinium chloride, Docusate sodium, Nonoxynol 9, Octoxynol, Poloxamer, Poloxamer 124, Poloxamer 188, 237, 338, 407, Polyoxyl 35 castor oil, Polyoxyl 40 hydrogenated castor oil, Polyoxyl 10 oleyl ether, Polyoxyl 20 cetyistearyl ether, Polyoxyl 40 stearate, Polysorbalc 20, Polysorbate 40, Polysoibatc 60, Polysoibatc 80, Sodium lauryl sulfate, Sorbitan monolaurate, Sorbitan monooleate, Sorbitan monopalmitate, Sorbitan monostearate, Tyloxapol and the like or any combinations thereof.
Solubility enhancing agents may include, but are not limited to, DL-mcthionine, caffeine, nicotinamide, vanillin, benzyl alcohol, ethanol and diethylene glycol monoethyl ether and the like or combinations thereof.
Stabilizing agents may include, but are not limited to, sodium metabisulphite, sodium bisulphite, ethylene diamine tetraacctic acid (EDTA) or salts thereof, ascorbic acid and the like or combinations thereof.
Penetration/permeation enhancers may include, but are not limited to, nicotinamide, caffeine, peppermint oil, sodium glycocholate, phospholipids, alkyl saccharides, aprotinin, benzalkonium chloride, ceramides, cetylpyridinium chloride, chitosan, chitosan-4-thiobutyIamidme, cyclodextrins, dextran sulfate, dodccyl azacycloheptyI-2- ketone, ether lipids (plasmologens), glycerol, glycosylated sphingosines, lauric acid, 23 -lauryl etiicr, lysophosphatidyl choline, menthol, methoxysalicylate, phosphatidyl choline, l-palmitoyl-2-glutaroyl-sn-glycerc>-3-phosphocholme, polycarbophil cysteine, poly-L-argininc, polyoxyethylene, polyoxyethylene-9-lauryl ether, polysoibatc 80, propylene glycol, EDTA, sodium deoxycholate, sodium glycocholate, sodium glycodeoxycholate, sodium lauryl sulfate, sodium salicylate, sodium taurocholate, sodium taurodeoxycholate, sodium taurodihydroflisidate, sphingolipids, sterols and the like or combinations thereof.
Mucoadhesives may also be added in the compositions of the present invention. Examples of suitable mucoadhesives include, but are not limited to, hydroxypropyl cellulose, gelatin, crosslmked polyacrylic acid, polymethacrylic acid, polyhydroxyethyl methacrylic acid, hydroxypropyl methyl cellulose, polyethylene glycol, sodium
carboxymethyl cellulose, hyaluronic acid, chitosan, polycarbophil, pectin, xanthan gum, alginate, copolymers of dextran, polyacrylamide, acacia, copolymer of caprolactone and ethylene oxide, caibopol 934, tragacanth, eudragit and the like or combinations thereof.
The pH of an oral liquid formulation is a key point in many regards. Control of the formulation pH, could prevent large changes during storage. Therefore, most formulations utilize a buffer to control potential changes in the solution pH. The amount of buffer capacity needed is generally between 0.01 and 0.1 M, and a concentration between 0.05 and 0.5 M is usually sufficient The selection of a suitable buffer should be based on (i) Whether the acid-base forms are listed for use in oral liquids, (ii) The stability of the drug and excipients in the buffer, and (iii) The compatibility between the buffer and container. A combination of buffers can also be used to gain a wider range of pH compared to the individual buffer alone. However, not all buffers are suitable for use in oral liquids. For example, aboric add buffer may be used for optical ami IV delivery but not in oral liquids because of its toxicity. The stabilizing effect of buffers dial have multiple charged species in solution could also determine the potential reaction between excipients and API. For example, buffers that use carbonates, citrate, tartrate, and various phosphate salts may precipitate with calcium ions by forming sparingly soluble salts. However, this precipitation is dependent upon the solution pH. The activity of phosphate ions may be lowered due to interactions with other solution components.
There are a number of factors that may also affect the solution pH such as temperature, ionic strength, dilution, and the amount and type of co-solvents present For example, the pH of acetate buffers is known to increase with temperature, whereas the pH of boric acid buffers decreases with temperature. Finally, the drug in solution may itself act as a buffer. If the drug is a weak electrolyte, such as salicylic acid or ephedrine, the addition of base or acid, respectively, will create a system in which the drug can act as a buffer.
One of the most crucial factors involved in formulating a pharmaceutical suspension is tire selection of an appropriate suspending agent. Suspending agents impart viscosity, and thus retard particle sedimentation. Other factors considered in the selection of the
appropriate agent include desired rheological property, suspending ability in the system, chemical compatibility whh other excipients, pH stability, length of time to hydrate, batch-to-batch reproducibility, and cost Non-limiting examples of pH adjusting agents/modifiers and buffers arc Acetic acid, Adipic acid, Ammonium carbonate, Ammonium hydroxide, Ammonium phosphate, Boric acid, Citric acid, Diethanolamine, Fumaric acid, Hydrochloric arid, Malic arid, Nitric acid, Propionic arid, Potassium acetate, Potassium bicarbonate, Potassium chloride, Potassium citrate, Potassium metaphosphate, Potassium phosphate, Sodium acetate, Sodium bicarbonate, Sodium borate, Sodium carbonate. Sodium chloride, Sodium citrate, Sodium gtycolate, Sodium hydroxide, Sodium lactate, Sodium phosphate. Sodium proprionate, Succinic acid, Sulfuric acid, Tartaric acid, Triethylamine, Triethanolamine, Tromethamine, Trolaminc and the like or any combinations thereof.
Suspending agents can be classified into cellulose derivatives, clays, natural gums, and synthetic gums. In many cases, these excipients are used in combination. There are many water soluble hydrocolloids that can act as suspending agents in the formulation of pharmaceutical suspensions. They can be of natural, semi-synthetic or synthetic origin. Non-limiting examples of suspending agents are Acacia, Agar, Algmic add, Carbomer, Carmellose sodium, Dextrin, Gelatin, Veegum or Gel white, Gellan gum, Sodium alginate, Methylcellulose, Hydroxyethyl cellulose, Hydroxypropyl cellulose, Hydroxypropylmcthyl cellulose, Hydroxypropyl starch, Hypromellose, Maltodextrin, Methylcellulose, Modified starch, Pectin, Poloxamer, Polycarbophil, Polyethylene glycol, Polyvinyl acetate, Poly (vinyl alcohol), Potassium alginate, Polyvinyl pyrrolidone, Pregelatinized starch, Propylene glycol alginate, Sodium alginate., Carboxymethyl cellulose or an alkali metal salt thereof Microcrystalline cellulose, gum Arabic, Karaya gum, Sterculia gum, Tragacanth, Xanthangum, Bentonite, Carageenan, Guar gum, Colloidal silicon dioxide and the like or any combinations thereof
Microbiological contamination presents a significant health hazard in oral liquids. Therefore, the use of preservatives become inevitable to prevent tire growth of microorganisms during the product’s manufacture and shelf life, although it may be most desirable to develop a“preservative-free" formulation to address the increasing concerns about the biological activity of these compounds. Most formulations require some kind of preservative to ensure no microbial growth.
The majority of preservatives are bacteriostatic rather than bacteriocidal, and consists of both acid and nonacid types. Among the acidic types are phenol, chloro-cresol, 9- phenyl phenol, alkyl esters of para-hydroxybcnzoic acid, benzoic acid, boric acid, and sorbic acid, and their respective salts. Therefore, the pH of solution, and the pKa of the preservative need to be carefully evaluated prior to selecting a preservative for a formulation. Neutral preservatives include chlorobutanol, benzyl alcohol, and beta- phenylethyl alcohol. Under alkaline conditions, it is generally regarded that microbial growth is insignificant and at these pH values, the need for a preservative is not generally recommended.
Many preservatives listed in the FDA inactive ingredient guide for liquid dosage forms. Unfortunately, many of them are not recommended for use in oral liquids and hence the choice of an acceptable preservative for an oral liquid formulation is limited, hi addition, the solubility of many· preservatives in aqueous system may not be high enough for effective antimicrobial activity. Additionally, it is essential to understand that bacteriostatic agents like para hydroxyl benzoic acids can partition between organic and aqueous phases in a heterogenous liquid formulations in such a way that their activity is significantly reduced. Non-limiting examples of preservatives are Alcohol, Ethanol, Chlorobutanol, Phenoxyethanol, Potassium benzoate, Benzyl alcohol, Benzoic acid, Potassium sorbatc, Sorbic add, Benzalkonium chloride, Benzcthonium chloride, Cetrimonium bromide, Cetylpyridinium chloride, BronopoL, Chlorbutol, Chlorocresol, Cresol, Butylparaben, Methylparabcn, Propylparaben, Ethylparaben, Phenol, Thymol, Phenylethanol, Sodium benzoate, Antimicrobial solvents like Propylene glycol, Glycerin, Chloroform and the like or any combinations thereof. In addition, some formulation ingredients like nonionic surfactants, quaternary ammonium compounds, gelatin, ferric salts, calcium salts and salts of heavy metals, including silver, lead, and mercury prevent microbial growth.
Antioxidants can be compounds that can reduce a drug that has been oxidized, or compounds that are more readily oxidized than the agents they are to protect (oxygen scavengers). Many of the lipid-soluble antioxidants act as scavengers. Antioxidants can also act as chain terminators, reacting with free radicals in solution to stop the free- radical propagation cycle. Mixtures of chelating agents and antioxidants are often used
because there appears to be a synergistic effect This occurs because many of the agents act at differing steps in the oxidative process.
Some substances prone to oxidation include unsaturated oils/fiats, compounds with aldehyde or phenolic groups, colors, flavors, sweeteners, plastics and rubbers, the latter being used in containers for products. Oxidation may manifest as products with an unpleasant odour, taste, appearance, precipitation, discoloration or even a slight loss of activity. The term rancidity refers to many typical off-flavors that result flora autoxidation of un saturated fatty acids that are present in oils ami fits, and it affects many oils and fits. The distinct rancid odour may result from short-chain, volatile monomers resulting flora the cleavage of the longer chain, less volatile oils and fits. Non-limiting examples of anti-oxidants are a-Tocopherol acetate, Ascorbic add, Erythorbic acid, Butylated hydroxytoluene (BHT), d-o-Tocopherol natural, Monothioglycerol, Sodium bisulfite, Sodium sulfite, Sodium metabisulfite, Potassium metabisulfite, Acetone sodium bisulfite, Ascorbyl palmitate, Cysteine, d-a-tocophcrol synthetic, Nordihydroguaiaretic acid, Sodium formaldehyde sulfoxylate, Sodium thiosulfate, Acetylcysteine, Ascorbyl palmitate, Butylated hydroxyanisole (BHA), Cysteine hydrochloride, Dithiothrertol, Propyl gallatc, Thiourea and the like or any combinations thereof.
In some instances, there are insufficient drug particles in a unit dose of suspension to make a pharmaceutically elegant suspension. This is particularly true for the more highly active drugs, where the unit dose is small. Under such circumstances, the formulator will need to add more particles to improve the appearance of the final product, and also to help stabilize the suspension. To serve this purpose, bulking agents, also known as auxiliary suspending agents are used. Non-limiting examples of bulking agents are Calcium carbonate, Calcium hydroxide, Cellulose, Crospovidone, Dibasic calcium phosphate, Magnesium carbonate, Magnesium hydroxide, Microcrystalline cellulose, Silica (silicon dioxide), Titanium dioxide and the like or any . combinations thereof
Many different materials are capable of adsorbing onto the suspended particles, e.g. natural gums, cellulosics and non-ionic surfactants. However, not all of them are able to act as protective colloids and provide steric hindrance to caking at a sufficiently low
concentration. High levels of surfactants, for example, can increase gastro-intestinal motility. Higher molecular weight gums and cellulosics may also cause an unacceptablencrease in the viscosity of the system. There are, however, certain polymers, or grades of polymers, that are capable of acting as protective colloids at concentrations that do not markedly increase the viscosity of the system, or increase gut motility, etc. Such materials include poloxamcrs, lower molecular weight grades of povidone, and low molecular weight grades of some other hydrophilic colloids.
Surfactant is a general name for materials that possess surface activity; in solution they toid to orient at the surface of the liquid. There are several general classes of surfactants: anionic, cationic, amphoteric and non-ionic. Surfactants are amphiphilic molecules, i.e. part of the molecule is hydrophilic, and part is lipophilic. This combination of the two opposite affinities in the same molecule causes them to orient to the interface and thereby reduce the interfacial tension between the continuous and disperse phases, such as in emulsions and suspensions. Ionic surfactants work primarily through electrostatic forces, whereas non-ionic surfactants work primarily through static forces. Non-limiting examples of surfactants are Sodium lauryl sulfate, Docusate sodium, Cocamidopropyl amino betaine, Polyoxyethylene soibitan fatty acid esters (Polysoibale, Tween®), Polyoxyethylene 15 hydroxystearate (Macrogol 15 hydroxystearate, Solutol HS15®), Polyoxyethylene castor oil derivatives (Cremophor® EL, ELP, RH 40), Polyoxyethylene stearates (Myrj®), Soibitan fatty acid esters (Span®), Polyoxyethylene alkyl ethers (Brij®), Polyoxyethylene nonylphenol ether (Nonoxynol®) and the like or any combinations thereof. Anti-foaming agents may be used in the preparation of the liquid pharmaceutical compositions of the present invention to lower the surface tension and cohesive binding of liquid phase. Non-limiting examples of anti-foaming agents are simethicone, organic phosphates, alcohols, paraffin oils, stearates, glycols and the like or any combinations thereof.
Chelating agents, also known as sequestrants, are molecules that have the ability to form stable complexes with metal ions, particularly di-valent and tri-valent metal ions including trace metals and heavy metals. These metal ions are often implicated in API degradation by acting as catalysts, e.g. Mg2* will catalyze both ester hydrolysis and the
Maillaid interaction between primary or secondary amines and reducing sugars. Oxidative degradation is also often catalyzed by heavy metals. In addition, certain trace metals arc required for microbial growth, and chelation (sequestration) to form complexes can help prevent microbial growth and spoilage, and thus allow lower levels of microbiocidal agents to be used. Non-limiting examples of chelating agents arc Calcium disodium edetate, Disodium edetatc, Edetic acid (also known as ethylenediaminetetraacetic acid/EDTA), Citric acid and the like or any combinations thereof Palatabilhy of oral medicines is an important factor in compliance. There are several components to palatability including flavor, mouth-feel and sweetness. Most patients prefer medicines that are not too bitter but may be slightly“tart” (acidic). Most APIs are bitter. However, for bitterness to develop, the drug must be sufficiently soluble to interact with taste receptors on the tongue. For insoluble APIs in the form of suspensions, components of the suspension are also bitter, e.g. preservatives, or very salty, e.g. buffer systems. However, a slight saltiness and a slight bitterness are desirable for palatability.
Traditionally, oral medicines were sweetened using Syrup (concentrated sucrose solution) or honey (contains fructose). However, these materials are inadequate for the formulation of many products because they simply are not able to adequately mask the very bitter taste of many pharmaceutical materials, including APIs and excipients. Several alternative sweetening agents have been developed ova· the years to better mask unpleasant tastes in both processed foods and pharmaceuticals.
Several of the materials classified as sweetening agents are sugar alcohols (also known as polyhydric alcohols, polyols and hydrogenated sugars). Several of the commonly used sweetening agents are ionic and have the potential to interact with other components of the suspension. Some sweetening agents are more stable than others in aqueous solution. These will be important factors in the final selection of the sweetening agent Non-limiting examples of sweetening agents are Glucose, Sucralose, Trehalose, Fructose, Xylose, Dextrose, Galactose, Tagatose, Maltose, Sucrose, Glycerol, Dulcitol, Mannitol, Lactitol, Sorbitol, Xylitol, Saccharine or the corresponding sodium, potassium or calcium salt Cyclamatc or the corresponding
sodium or calcium salt, Aspartame, or Acesulfeme or the potassium salt thereof, Dulcin or Ammonium glycyrrhizinate, Alitame, Inulin, Isomalt, Neohesperidin dihydrochalcone, Thaumatin and the like or any combinations thereof. Flavors are used to improve the palatability of oral medicines. One problem that can arise with oral suspensions is that the suspension may produce a“cloying” sensation in the mouth. While this is not the same as a bitter taste, it can nevertheless cause problems for the patient and affect compliance. This can be a particular problem with high levels of inorganic components. Flavors can help reduce this“cloying” taste and thereby improve palatability, and ultimately patient compliance.
There are many different flavors, and most flavors arc complex mixtures of many components. Today most flavors are developed by specialist flavor houses, and typically the flavor is formulated for each individual application. Since flavor will be part of the suspension continuous phase, it has the maximum potential for interaction, and some flavor components may cause stability issues (physical or chemical) for the suspension. Flavor development and compounding is a specialist discipline. When deciding on which particular flavor is appropriate, the flavor specialist would benefit from knowledge of the other likely components in the suspension, just as the formulation scientist would benefit from knowledge of the components of the flavor.
Flavors can adsorb onto finely divided solids, thus reducing their effectiveness. They can also be absorbed by packaging. Flavor preferences vary with age, but the citrus flavors appear generally acceptable to most age groups. Non-limiting examples of flavoring agents are synthetic flavor oils and flavoring aromatics and/or natural oils, extracts from plants leaves, flowers, fruits, and so forth and the like or any combinations thereof. These may include cinnamon oil, oil ofwintergreen, peppermint oils, clove oil, bay oil, anise oil, eucalyptus, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, oil of bitter almonds, and cassia oil and the like or any combinations thereof. Also useful as flavors are vanilla, citrus oil, including lemon, orange, grape, lime and grapefruit, and fruit essences, including apple, banana, pear, peach, strawberry, raspberry, cherry, plum, pineapple, apricot, and so forth and the like or any combinations thereof. Solid forms, such as spray dried forms of flavoring agents, may also be useful in the liquid compositions disclosed herein.
Coloring agents may also be used in the preparation of the liquid compositions of the present invention. Pharmaceutical colors come in two types; soluble dyes and insoluble pigments. For pharmaceutical suspensions intended for oral use, soluble dyes are often used; however, pigments may also be used and would be part of the disperse phase. Soluble dyes have the potential to interact with other components of the formulation.
In some of the aspects, the liquid pharmaceutical compositions of the present invention are non-caking liquid compositions. The tom“non-caking” as used herein means that the liquid composition has a smooth consistency and doesn’t contain any caking or clumping particles, by visual inspection. Also, the liquid composition in accordance with the present invention does not cake or clump during manufacture, i.e., when mixed with excipients. Nor does it cake or clump upon storage, even under relatively humid conditions, e.g., a relative humidity of about 75% or greater and when stored for relatively long periods such as about 6 months or longer and even at elevated temperatures of about 40°C or greater, or at any combination of such humidity, time and temperature parameters. Thus, the liquid compositions in accordance with the present invention will remain non-caking during typical storage and use conditions.
The term“antiepileptic” as used herein may interchangeably be used with the terms “anticonvulsant” and“antiseizure".
In one of the further aspects, antiepileptic drugs according to the present invention include, but are not limited to Paraldehyde, Stiripentol, Phenobarbital, Methylphcnobaibital, Barbexaclone, Clobazam, Clonazepam, Clorazepatc, Diazepam, Midazolam, Lorazepam, Nitrazepam, Temazepam, Nimetazepam, Felbamate, Carbamazepine, Oxcaibazepine, Rufinamide, Ezogabine, Retigabine, Eslicarbazepine, Vigabatrin, Progabide, Tiagabine, Topiramate, Gabapentin, Pregabalin, Ethotoin, Phenytoin, Mcphcnytoin, Fosphcnytoin, Paramethadionc, Trimethadione, Ethadione, Beclamide, Primidone, Brivaracetam, Etiracetam, Levetiracetam, Seletracetam, Ethosuximidc, Phensuximide, Mcsuximide, Acetazolamide, Sultiame, Methazolamide, Zonisamide, Lamotrigine, Lacosamide, Pheneturide, Phcnaccmidc, Valpromide, Valnoctamide, Perampanel, Pyridoxine or pharmaceutically acceptable salts, chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, amorphous forms, prodrugs, racemic and substantially pure forms, chelates, and complexes thereof
and Valproic acid or its salts such as Sodium valproate, Divalproex sodium or chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, amorphous forms, prodrugs, racemic and substantially pure forms, chelates, and complexes thereof. hi one of the further aspects of the present invention, the dgo of the particles of an antiepileptic drug (active pharmaceutical ingredient) used for the preparation of the liquid compositions of the present invention or the dgo of the particles of an antiepileptic drag present in the liquid compositions of the present invention is less than about 1000 pm, or less than about 950 pm, or less than about 900 pm, or less than about 850 pm, or less than about 800 pm, or less than about 750 pm, or less than about 700 pm, or less than about 650 pm, or less than about 600 pm, or less than about 550 pm, or less than about 500 pm, or less than about 450 pm, or less than about 400 pm, or less than about 350 mm, or less than about 300 pm, or less than about 250 pm, or less than about 200 pm, or less than about 150 pm, or less than about 100 pm, or less than about 90 pm, or less than about 80 pm, or less than about 70 pm, or less than about 60 pm, or less than about 50 pm, or less than about 40 pm, or less than about 30 pm, or less than about 20 pm, or less than about 10 pm, or less than about 5 pm, or less than about 2 pm, or less than about 1 pm, or less than about 0 J pm. In one of the further aspects, the liquid pharmaceutical compositions of the present invention comprise particles of an antiepileptic drug (active pharmaceutical ingredient), wherein the dgo of the particles of an antiepileptic drug (active pharmaceutical ingredient) is less than about 1000 pm, or less than about 950 pm, or less than about 900 pm, or less than about 850 pm, or less than about 800 pm, or less than about 750 pm, or less than about 700 pm, or less than about 650 pm, or less than about 600 pm, or less than about 550 pm, or less than about 500 pm, or less than about 450 pm, or less than about 400 pm, or less than about 350 pm, or less than about 300 pm, or less than about 250 pm, or less than about 200 pm, or less than about 150 pm, or less than about 100 pm, or less than about 90 pm, or less than about 80 pm, or less than about 70 pm, or less than about 60 pm, or less than about 50 pm, or less than about 40 pm, or less than about 30 pm, or less than about 20 pm, or less than about 10 pm, or less than about 5 pm, or less than about 2 pm, or less than about 1 pm, or less than about 0.5 pm.
In one of the aspects, general formula of the liquid pharmaceutical compositions according to the present invention may be provided as follows.
Table-1 : General formula of limn'd nWmnrantir-al < /.U l i lOKt
Those who are skilled in the art will appreciate that different types of liquid pharmaceutical compositions as described herein can be prepared by using suitable excipients or additives known in the art Thus, the name of excipients or additives and proportionate range thereof provided in the Table-1 is provided herein for the illustration purpose only and should not be construed as the exact or the only scope of the present invention. The liquid pharmaceutical compositions of the present invention may be prepared using suitable excipients or additives in any suitable amount
In one of the further aspects, the present invention provides processes for the preparation of the liquid pharmaceutical compositions of antiepileptic drugs.
Process- 1; Preparation of solution dosage forms
1. Add one or more sweeteners) followed by one or more preservative^) in the suitable vehicle;
2. Add an antiepileptic drug or salt thereof;
3. Add one or more buffering agcnt(s) to adjust the desired pH followed by flavoring agent; and
4. Adjust the volume to the required quantity with vehicle. Process-2: Preparation of solution dosage forms
1. Add one or more solvent(s) followed by one or more sweetener(s) and one or more preservative(s) in the suitable vehicle;
2. Add an antiepileptic drug or salt thereof;
3. Add one or more buffering agent(s) to adjust the desired pH followed by flavoring agent; and
4. Adjust the volume to the required quantity with vehicle.
Process-3: Preparation of suspension dosage forms
1. Add one or more preservative^) followed by one or more buffering agent(s) to adjust the desired pH in the suitable vehicle;
2. Add one or more sweeteners) and flavoring agent followed by one or more suitable solvent(s)/co-solvent(s) and/or one or more solubilizers);
3. Add one or more suspending agent(s) followed by one or more anti-foaming agent(s) and one or more surfactants);
4. Add an antiepileptic drug or salt thereof; and
5. Adjust the volume to the required quantity with vehicle.
Process-4: Preparation of suspension dosage forms
1. Add and mix one or more solubilizer(s) in the suitable vehicle;
2. Add one or more suspending agcnt(s);
3. Add one or more antioxidant(s) and one or more sweetener(s) dissolved in the suitable solvents) to step (2);
4. Add an antiepileptic drug or salt thereof; and
5. Add flavoring agent and adjust the volume to the required quantity with vehicle.
Process- 5: Preparation of suspension/ solution dosage forms
1. One or more preservatives are added in the sufficient quantity of the vehicle;
2. One or more sweetener, optionally one or more antifoaming agents, optionally one or more surfactants, one or more solvents/co-solvents or solubilizers are sequentially added;
3. An antiepileptic drug or salt thereof is added;
4. Optionally one or more suspending agents/thickening agents/viscosity modifying agents, one or more pH adjusting agents and/or pH modifying agents and/or buffering agents (to adjust the pH) and one or more flavoring agents are added sequentially; and
5. Required quantity of vehicle is added to make up the volume to the final quantity.
Process-6: Preparation of suspension dnnage forms
1. Mix suitable solubilizing agent and solvent;
2. Add an antiepileptic drug or salt or derivative thereof;
3. Add sufficient quantity of vehicle followed by addition of flavoring agent; and
4. Adjust the volume to the required quantity with vehicle.
Process-7: Preparation of solution/snsnension dosage forms
1. One or more preservative(s) are added in suitable vehicle;
2. Optionally one or more buffering agent(s) arc added;
3. Optionally one or more surfactants) are added;
4. An antiepileptic drug or salt or derivative thereof is added;
5. Optionally one or more solvents) are added;
6. Optionally one or more suspending agcnt(s) are added;
7. One or more sweeteners are added followed by addition of flavoring agent;
8. Adjust tiie volume to the required quantity with vehicle.
Those who are skilled in the art can understand that some variations in the process described herein can be adopted. A skilled person may omit use of some pharmaceutical excipients as described herein above. A skilled person may also alternatively use some or all pharmaceutical excipients as described herein from the same excipient classes. Such variations are well whhin the scope of the present invention. A skilled person can also change and/or omit steps of their sequences of the herein described process for the purposes of suitability and convenience where one or more pharmaceutically acceptable
excipients may or may not be used without affecting and diminishing the quality and characteristics of the resulting product Such variationsZchanges/omissions/additions are well within the scope of the present invention. The liquid pharmaceutical compositions of the present invention may also be prepared using processes generally known to those skilled in die art. The processes for the preparation of liquid pharmaceutical compositions of dm present invention may vary depending upon the final dosage form, e.g. solution, suspension, etc. The processes for the preparation of the liquid compositions of the presort invention may comprise multiple steps. Such steps may include sequential addition of suitable excipients/additives. Such steps may also include physical processes for example mixing, stirring, agitation etc.
In one of the aspects, the present invention provides a liquid composition comprising Primidone or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, anti-foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of tire aspects, the present invention provides a liquid composition comprising Topiramate or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, anti-foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of the aspects, the present invention provides a liquid composition comprising Vigabatrin or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, anti-foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of the further aspects, die present invention provides a liquid composition comprising Perampanel or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, anti- foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of the further aspects, the present invention provides a liquid composition comprising Zonisamidc or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizes, suspending agents or thickening agents or viscosity modifying agents, anti- foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of the further aspects, the preamt invmtion provides a liquid composition comprising Levetiracetam or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, anti- foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, writing agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of the further aspects, the present invmtion provides a liquid composition comprising Gabapentin or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodmgs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, antifoaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of the further aspects, the present invention provides a liquid composition comprising Pregabalin or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, anti-foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of the further aspects, the present invention provides a liquid composition comprising Clobazam or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, anti-foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of the further aspects, the present invention provides a liquid composition comprising Phenobarbital or its pharmaceutically acceptable salts and chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, antifoaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof
In one of the further aspects, the present invention provides a liquid composition comprising Valproic acid or its pharmaceutically acceptable salts and chemical derivatives such as Sodium valproate or Divalproex sodium or polymorphs, solvates, hydrates, anhydrous forms, prodrugs, chelates, and complexes thereof and one or more pharmaceutically acceptable excipients selected from the group comprising of vehicles, solvents or co-solvents or solubilizers, suspending agents or thickening agents or viscosity modifying agents, anti-foaming agents, stabilizing agents, anti-oxidants, pH adjusting agents or pH modifying agents or buffering agents, wetting agents, bulking agents or auxiliary suspending agents, chelating agents, surfactants, preservatives, sweetening agents, coloring agents, flavoring agents or combinations thereof.
In one of the aspects, the liquid pharmaceutical compositions of the present invention are suitable for administration to a subject to treat or prevent a disease or a condition. Preferably, the subject is a mammal- More preferably, tihe mammal is a human. Preferably, the disease or condition is a disease or condition that is treatable by the administration of an antiepileptic drug as described herein.
In one of the aspects, the present invention is directed to the method for the treatment of epilepsy and/or convulsion and/or seizure and/or a disease or a condition that can be treated by antiepileptic drugs comprising administering to a patient, such as human, an effective dosage amount of. a liquid pharmaceutical composition comprising an antiepileptic drug and one or more pharmaceutically acceptable excipients or additives as disclosed and described herein.
“Effective dosage amount” as used herein with respect to, for example liquid pharmaceutical compositions of the present invention shall mean that dosage that provides tire specific pharmacological response for which an antiepileptic drug administered in a significant number of subjects in need of such treatment It is emphasized that "effective dosage amount”, administered to a particular subject in a particular instance will not always be effective in treating the diseases described herein, even though such dosage is deemed a“effective dosage amount” by those skilled in the ait.
In one of the further aspects, the present invention is directed to use liquid pharmaceutical compositions of the present invention for the treatment of epilepsy and/or convulsion and/or seizure and/or a disease or a condition that can be treated by administration of antiepileptic drugs.
The liquid pharmaceutical compositions of the present invention are proposed to have unexpectedly dramatic dissolution profiles. Rapid dissolution of an administered active agent is preferable, as faster dissolution generally leads to greater bioavailability and faster onset of action. To improve the dissolution profile and bioavailability of an antiepileptic drug it would be useful to increase dissolution of the antiepileptic drug used so that it could attain a level close to 100% dissolution of the drug substance.
The liquid pharmaceutical compositions of the present invention comprising an antiepileptic drag or salt thereof or derivative thereof, exhibit improved or comparable pharmacokinetic profiles as compared to marketed or known compositions. For example, the Cmax and/or AUC of the liquid pharmaceutical compositions of an antiepileptic drug of the present invention can be greater than or substantially equal to the Cmax and/or AUC for known or marketed compositions administered at the same dose, hi addition, the Tmax of the liquid compositions of the present invention can be lower than or substantially equal to that obtained for a known or marketed compositions, administered at the same dose. In addition, combinations of an improved or· comparable Cmax, AUC and Tmax profile can be exhibited by the liquid compositions of the invention, as compared to known or marketed compositions, hi further aspects, the liquid compositions of the present invention may result in minimal different absorption levels when administered under fed as compered to fasting conditions.
In one of the aspects, the liquid compositions of the present invention exhibit in comparative pharmacokinetic testing with marketed or known formulation, administered at the same dose, a Tmax not greater than about 90%, not greater than about 80%, not greater than about 70%, not greater than about 60%, not greater than about 50%, not greater than about 30%, not greater than about 25%, not greater than about 20%, not great» than about 15%, not greater than about 10%, or not greater than about 5% of die Tmax exhibited by the marketed or known formulation.
In one of the further aspects, the liquid compositions of the present invention exhibit in comparative pharmacokinetic testing with marketed or known formulation, administered at the same dose, a Cmax which is at least about 50%, at least about 100%, at least about 200%, at least about 300%, at least about 400%, at least about 500%, at least about 600%!, at least about 700%, at least about 800%, at least about 900%, at least about 1000%, at least about 1100%, at least about 1200%, at least about 1300%, at least about 1400%, at least about 1500%, at least about 1600%, at least about 1700%, at least about 1800%, or at least about 1900% greater than the Cmax exhibited by the marketed or known formulation.
In one of the further aspects, the liquid compositions of the present invention exhibit in comparative pharmacokinetic testing with marketed or known formulation, administered at the same dose, an AUC which is at least about 25%, at least about 50%, at least about 75%, at least about 100%, at least about 125%, at least about 150%, at least about 175%, at least about 200%, at least about 225%, at least about 250%, at least about 275%, at least about 300%, at least about 350%, at least about 400%, at least about 450%, at least about 500%, at least about 550%, at least about 600%, at least about 750%, at least about 700%, at least about 750%, at least about 800%, at least about 850%, at least about 900%, at least about 950%, at least about 1000%, at least about 1050%, at least about 1100%, at least about 1150%, or at least about 1200% greater than the AUC exhibited by the marketed or known formulation.
In one of the further aspects, the Tmax of an antiepileptic drug or salt thereof used for the preparation of the liquid composition according to the present invention, when assayed in the plasma of the mammalian subject, is less than about 6 to about 8 hours.
In other aspects of the invention, the Tmax of an antiepileptic drug or salt thereof is less than about 6 hours, less than about 5 hours, less than about 4 hours, less than about 3 hours, less than about 2 hours, less titan about 1 hour, or less than about 30 minutes after administration.
In some aspects, the liquid compositions of the present invention exhibit improved or comparable bioavailability as compared to known or marketed compositions.
The liquid pharmaceutical compositions of the present invention are suitable for use in the industry.
It should be understood that various changes and modifications to the embodiments described herein will be apparent to those skilled in the art Such changes and modifications can be made without departing from the spirit and scope of the subject matter of the present invention and without diminishing its intended advantages. It is therefore intended that such changes and modifications be covered within the scope of tile present invention.
Claims
1. A liquid pharmaceutical composition of an antiepileptic drug comprising an antiepileptic drug or pharmaceutically acceptable salt or derivative thereof and one or more pharmaceutically acceptable excipients or additives.
2. A liquid pharmaceutical composition according to claim 1, wherein one or more pharmaceutically acceptable excipients or additives are selected from the group comprising of vehicles, solvents/co-solvents, solubilizers, solubility enhancing agents, suspending ageots/fhickening agents/viscosity modifying agents, permeation/penetration enhancers, tonicity agents, mucoadhesives, bulking agents/auxiliary suspending agents, chelating agents, wetting agents, antifoaming agents, anti-caking agents, stabilizing agents, anti-oxidants, buffering agents and/or pH modifying agents and/or pH adjusting agents, surfactants, preservatives, sweetening agents, flavoring agents and coloring agents or combination thereof.
3. A liquid pharmaceutical composition according to claim 1 or claim 2, wherein the liquid composition is selected from the group comprising of liquids, liquid dispersions, suspensions, solutions, emulsions, spays, ointments, creams, spot- on, syrups, elixirs, drops, gels, solution-gels, and concentrates.
4. A liquid pharmaceutical composition according to any one of claims 1 to 3 is suitable fix· administration selected from the group comprising of oral, pulmonary, intravenous, rectal, colonic, parenteral, intracistemal, mtraperitoneal, local, buccal, nasal and topical administration.
5. A liquid pharmaceutical composition according to any one of claim* 1 to 4, wherein the liquid composition is solution suitable for oral administration.
6. A liquid pharmaceutical composition according to any one of claims 1 to 4, wherein the liquid composition is suspension suitable for oral administration.
7. A liquid pharmaceutical composition in the form of solution, suitable for oral administration, comprising an antiepileptic drug or pharmaceutically acceptable salt or derivative thereof; and one or more pharmaceutically acceptable excipients or additives selected from the group comprising of vehicles, solvcnts/co-solvcnts, solubilizers, preservatives, surfactants, pH adjusting agents and/or pH modifiers and/or buffering agents, sweetening agents, flavoring agents and coloring agents or combination thereof,
8. A liquid pharmaceutical composition in the form of suspension, suitable for oral administration, comprising an antiepileptic drug or pharmaceutically acceptable salt or derivative thereof, and one or more pharmaceutically acceptable excipients or additives selected from the group comprising of vehicles, solvents/co-solvents, solubilizers, suspending agcnts/thickening agents/viscosity modifying agents, anti-foaming agents, anti-caking agents, preservatives, surfactants, wetting agehts, antioxidants, pH adjusting agents and/or pH modifying agents and/or buffering agents, sweetening agents, flavoring agents and coloring agents or combination thereof.
9. A liquid pharmaceutical composition according to claim 6 or claim 8 comprises particles of an antiepileptic drug or pharmaceutically acceptable salt or derivative thereof, wherein the d»o of the particles are between about 10 pm and about 200 pm.
10. A liquid pharmaceutical .composition according to any one of claims 5 to 9, wherein the liquid composition is ready to use composition of prepared by reconstituting dry powder in suitable diluent or media.
11. A liquid pharmaceutical composition according to any one of claims 5 to 10, wherein the liquid composition is an immediate release composition or a modified release composition.
12. A liquid pharmaceutical composition according to any one of claims 5 to 11, wherein the pH of the composition is between about 3.0 and 8.5.
13. A liquid pharmaceutical composition according to any one of claims 5 to 12, wherein the composition is stable for prolonged time when stored under typical storage conditions and/or accelerated conditions characterized in that any individual impurity present in the composition is less than 2.0% and the total impurities present in the composition are less than 5.0%.
14. A liquid pharmaceutical composition according to any one of claims 5 to 12, wherein the composition has:
(a) a Cmax for an antiepileptic drug, or a salt or a derivative thereof, when assayed in the plasma of a mammalian subject following administration that is at least about 50% to about 1900% greater than the Cmax for the marketed or known formulation, administered at the same dose;
(b) an AUC for an antiepileptic drug, or a salt or a derivative thereof when assayed in the plasma of a mammalian subject following administration that
is at least about 25% to about 1200% greater than the AUC for the marketed or known formulation, administered at the same dose;
(c) a Tmax for an antiepileptic drug, or a salt or a derivative thereof, when assayed in the plasma of a mammalian subject following administration that' is less than about 6 hours to about 8 hours; or
(d) any combination of (a), (b), and (c).
15. Use of a liquid pharmaceutical composition according to any one of the preceding claims in die treatment of epilepsy and/or convulsion and/or seizure and/or a disease or a condition that can be treated by administration of an antiepileptic drug.
16. A liquid pharmaceutical composition according to any one of the preceding claims, wherein an antiepileptic drug is selected from the group comprising of Paraldehyde, Stiripentol, Phenobaibital, Methylphenobarbital, Baibexaclone, Clobazam, Clonazepam, Clorazepate, Diazepam, Midazolam, Lorazepam, Nitrazepam, Temazepam, Nimetazepam, Felbamate, Caibamazepine, Oxcarbazepine, Rufinamide, Ezogabinc, Rctigabine, Eslicarbazcpine, Vigabatrin, Progabide, Tiagabine, Topiramate, Gabapentin, Pregabalin, Ethotoin, Pbenytoin, Mephenytoin, Fosphenytoin, Paramethadione, Trimcthadione, Ethadione, Bcclamide, Primidone, Brivaracetam, Ethacetam, Levetiracetam, Seletracetam, Ethosuximide, Phensuximide, Mesuximide, Acetazolamide, Sultiame, Methazolamidc, Zonisamide, Lamotrigine, Lacosamide, Phencturide, Phenacemide, Valpromide, Valnoctamide, Perampanel, Pyridoxine or pharmaceutically acceptable salts, chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, amorphous forms, prodrugs, racemic mixtures or pure forms, chelates, and complexes thereof and Valproic acid or its salts such as Sodium valproate, Divalproex sodium or chemical derivatives such as polymorphs, solvates, hydrates, anhydrous forms, amorphous forms, prodmgs, racemic mixtures or pure forms, chelates, and complexes thereof.
17. A liquid pharmaceutical composition according to any one of the preceding claims is packaged in the pharmaceutically acceptable packaging material selected from die group comprising of containers, pumps, bottles with spray pump, bottles with dropper assembly, bottles, collapsible tubes, glass ampoules, stoppered vials, pre-filled syringes, wherein the bottles and containers are
clem/tranaparent/opaque or amber colored glass bottles and containers or clear/transparent/qpaquc or amber colored plastic bottles and containers made from polyethylene, low-density polyethylene, high-density polyethylene, polyamide, polyolefin, polycarbonate, acrylic multipolymers, polypropylene, polyethylene tcrephthalatc, polyvinyl chloride, polystyrene.
18. A process fra the preparation of the liquid phannaceutical composition according to any one of claim 5 or claim 7 comprising following steps:
1. Mix suitable solubilizing agent and solvent;
2. Add an antiepileptic drug or salt or derivative thereof;
3. Add suflBcient quantity of vehicle followed by addition of flavoring agent; and
4. Adjust the volume to tiie required quantity with vehicle.
19. A process for the preparation of the liquid phannaceutical composition according to any one of claim 5, claim 6, claim 7 or claim 8' comprising following steps:
1. One or more preservative^) arc added in suitable vehicle;
2. Optionally one or more buffering agent(s) are added;
3. Optionally one or more surfactants) are added;
4. An antiepileptic drug or salt or derivative thereof is added;
5. Optionally one or more solvents) are added;
6. Optionally one or more suspending agent(s) are added;
7. One or more sweeteners ate added followed by addition of flavoring agent;·
8. Adjust the volume to the required quantity with vehicle.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114642633A (en) * | 2022-04-15 | 2022-06-21 | 上海奥科达生物医药科技有限公司 | Vigabatrin preparation liquid composition |
US11433046B2 (en) | 2019-12-10 | 2022-09-06 | Tulex Pharmaceuticals Inc. | Compositions and methods for treating epilepsy, seizures and other conditions |
CN115227658A (en) * | 2022-04-25 | 2022-10-25 | 上海奥科达生物医药科技有限公司 | Vigabatrin solid preparation composition |
CN115737554A (en) * | 2022-11-28 | 2023-03-07 | 宜昌人福药业有限责任公司 | Preparation method of clobazam oral suspension |
WO2024058812A1 (en) * | 2022-09-16 | 2024-03-21 | Pyros Pharmaceuticals, Inc. | Vigabatrin liquid pharmaceutical composition |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5154926A (en) * | 1990-02-06 | 1992-10-13 | Showa Yakuhin Kako Co., Ltd. | Acetaminophen or phenobarbital syrup composition |
US20030095927A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders |
US20030130267A1 (en) * | 2001-12-24 | 2003-07-10 | Special Products Limited | Pharmaceutical composition |
US20040072904A1 (en) * | 2001-04-17 | 2004-04-15 | Kulkarni Neema M | Liquid pharmaceutical compositions |
US20050238724A1 (en) * | 2002-04-23 | 2005-10-27 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing lamotrigine particles of defined morphology |
US20050244503A1 (en) * | 2003-05-19 | 2005-11-03 | Rabinow Barrett E | Small-particle pharmaceutical formulations of antiseizure and antidementia agents and immunosuppressive agents |
US20060270611A1 (en) * | 2005-05-25 | 2006-11-30 | Dries Willy M A | Pediatric formulation of topiramate |
US20080045583A1 (en) * | 2006-08-18 | 2008-02-21 | David Delmarre | Stable levetiracetam compositions and methods |
-
2019
- 2019-03-30 WO PCT/IB2019/052642 patent/WO2019186515A1/en active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5154926A (en) * | 1990-02-06 | 1992-10-13 | Showa Yakuhin Kako Co., Ltd. | Acetaminophen or phenobarbital syrup composition |
US20030095927A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders |
US20040072904A1 (en) * | 2001-04-17 | 2004-04-15 | Kulkarni Neema M | Liquid pharmaceutical compositions |
US20030130267A1 (en) * | 2001-12-24 | 2003-07-10 | Special Products Limited | Pharmaceutical composition |
US20050238724A1 (en) * | 2002-04-23 | 2005-10-27 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing lamotrigine particles of defined morphology |
US20050244503A1 (en) * | 2003-05-19 | 2005-11-03 | Rabinow Barrett E | Small-particle pharmaceutical formulations of antiseizure and antidementia agents and immunosuppressive agents |
US20060270611A1 (en) * | 2005-05-25 | 2006-11-30 | Dries Willy M A | Pediatric formulation of topiramate |
US20080045583A1 (en) * | 2006-08-18 | 2008-02-21 | David Delmarre | Stable levetiracetam compositions and methods |
Non-Patent Citations (4)
Title |
---|
ANONYMOUS: "DIAZEPAM Oral Solution 5 mg per 5 mL DIAZEPAM Intensol TM Oral Solution (Concentrate) 5 mg per mL", July 2012 (2012-07-01), pages 1 - 4, XP055598682, Retrieved from the Internet <URL:https://docs.boehringer-ingelheim.com/Prescribing%20Information/PIs/Roxane/Diazepam/Diazepam%20Oral%20Solution.pdf> [retrieved on 20190624] * |
ANONYMOUS: "Epilim Sodium Valproate, Consumer Medicine Information", November 2016 (2016-11-01), pages 1 - 5, XP055598688, Retrieved from the Internet <URL:http://products.sanofi.com.au/nzl_cmi_epilimOral.pdf> [retrieved on 20190624] * |
ANONYMOUS: "MIDAZOLAM INJECTION: Midazolam 1 mg/mL and 5 mg/mL Injection", 2 February 2018 (2018-02-02), pages 1 - 14, XP055598691, Retrieved from the Internet <URL:https://medsafe.govt.nz/profs/Datasheet/m/MidazolaminjPfizer.pdf> [retrieved on 20190624] * |
ANONYMOUS: "RIVOTRIL Clonazepam: oral drops (2.5 mg/ml); injection (1 mg).", 3 May 2017 (2017-05-03), pages 1 - 7, XP055598685, Retrieved from the Internet <URL:https://medsafe.govt.nz/Consumers/cmi/r/rivotril.pdf> [retrieved on 20190624] * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11433046B2 (en) | 2019-12-10 | 2022-09-06 | Tulex Pharmaceuticals Inc. | Compositions and methods for treating epilepsy, seizures and other conditions |
US11633374B2 (en) | 2019-12-10 | 2023-04-25 | Tulex Pharmaceuticals Inc. | Compositions and methods for treating epilepsy, seizures and other conditions |
US11826343B2 (en) | 2019-12-10 | 2023-11-28 | Tulex Pharmaceuticals Inc. | Compositions and methods for treating epilepsy, seizures and other conditions |
US11911362B2 (en) | 2019-12-10 | 2024-02-27 | Tulex Pharmaceuticals Inc. | Compositions and methods for treating epilepsy, seizures and other conditions |
CN114642633A (en) * | 2022-04-15 | 2022-06-21 | 上海奥科达生物医药科技有限公司 | Vigabatrin preparation liquid composition |
CN115227658A (en) * | 2022-04-25 | 2022-10-25 | 上海奥科达生物医药科技有限公司 | Vigabatrin solid preparation composition |
CN115227658B (en) * | 2022-04-25 | 2023-09-22 | 上海奥科达医药科技股份有限公司 | Solid preparation composition of vigabatrin acid |
WO2024058812A1 (en) * | 2022-09-16 | 2024-03-21 | Pyros Pharmaceuticals, Inc. | Vigabatrin liquid pharmaceutical composition |
CN115737554A (en) * | 2022-11-28 | 2023-03-07 | 宜昌人福药业有限责任公司 | Preparation method of clobazam oral suspension |
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