JP2008540558A5 - - Google Patents
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- JP2008540558A5 JP2008540558A5 JP2008511345A JP2008511345A JP2008540558A5 JP 2008540558 A5 JP2008540558 A5 JP 2008540558A5 JP 2008511345 A JP2008511345 A JP 2008511345A JP 2008511345 A JP2008511345 A JP 2008511345A JP 2008540558 A5 JP2008540558 A5 JP 2008540558A5
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- JP
- Japan
- Prior art keywords
- group
- polymer
- protein
- ketal
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003112 inhibitor Substances 0.000 claims 16
- 239000002245 particle Substances 0.000 claims 16
- 229920000642 polymer Polymers 0.000 claims 15
- 239000000693 micelle Substances 0.000 claims 14
- 239000013543 active substance Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 239000002955 immunomodulating agent Substances 0.000 claims 8
- 229940121354 immunomodulator Drugs 0.000 claims 8
- 230000002584 immunomodulator Effects 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- -1 1,4-dimethylcyclohexyl group Chemical group 0.000 claims 4
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 claims 4
- 101710127675 Antiviral innate immune response receptor RIG-I Proteins 0.000 claims 4
- 108090000342 C-Type Lectins Proteins 0.000 claims 4
- 102000003930 C-Type Lectins Human genes 0.000 claims 4
- 102100040840 C-type lectin domain family 7 member A Human genes 0.000 claims 4
- 102100032218 Cytokine-inducible SH2-containing protein Human genes 0.000 claims 4
- 101710132484 Cytokine-inducible SH2-containing protein Proteins 0.000 claims 4
- 108010037897 DC-specific ICAM-3 grabbing nonintegrin Proteins 0.000 claims 4
- 101001011382 Homo sapiens Interferon regulatory factor 3 Proteins 0.000 claims 4
- 101001032342 Homo sapiens Interferon regulatory factor 7 Proteins 0.000 claims 4
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims 4
- 102100029843 Interferon regulatory factor 3 Human genes 0.000 claims 4
- 102100038070 Interferon regulatory factor 7 Human genes 0.000 claims 4
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 claims 4
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 claims 4
- 102000007568 Proto-Oncogene Proteins c-fos Human genes 0.000 claims 4
- 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 claims 4
- 102000004265 STAT2 Transcription Factor Human genes 0.000 claims 4
- 108010081691 STAT2 Transcription Factor Proteins 0.000 claims 4
- 102000008036 Suppressor of Cytokine Signaling Proteins Human genes 0.000 claims 4
- 108010075383 Suppressor of Cytokine Signaling Proteins Proteins 0.000 claims 4
- 102100024333 Toll-like receptor 2 Human genes 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 229920001400 block copolymer Polymers 0.000 claims 4
- 108010025838 dectin 1 Proteins 0.000 claims 4
- 210000004443 dendritic cell Anatomy 0.000 claims 4
- 239000000032 diagnostic agent Substances 0.000 claims 4
- 229940039227 diagnostic agent Drugs 0.000 claims 4
- 210000002540 macrophage Anatomy 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 230000037361 pathway Effects 0.000 claims 4
- 230000000069 prophylactic effect Effects 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 102000006992 Interferon-alpha Human genes 0.000 claims 3
- 108010047761 Interferon-alpha Proteins 0.000 claims 3
- 108020004459 Small interfering RNA Proteins 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000003431 cross linking reagent Substances 0.000 claims 3
- 150000002009 diols Chemical class 0.000 claims 3
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Substances CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229920001600 hydrophobic polymer Polymers 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920001855 polyketal Polymers 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- HEWZVZIVELJPQZ-UHFFFAOYSA-N 2,2-dimethoxypropane Chemical compound COC(C)(C)OC HEWZVZIVELJPQZ-UHFFFAOYSA-N 0.000 claims 1
- 101000959820 Homo sapiens Interferon alpha-1/13 Proteins 0.000 claims 1
- 102100040019 Interferon alpha-1/13 Human genes 0.000 claims 1
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 claims 1
- ACIAHEMYLLBZOI-ZZXKWVIFSA-N Unsaturated alcohol Chemical compound CC\C(CO)=C/C ACIAHEMYLLBZOI-ZZXKWVIFSA-N 0.000 claims 1
- YIMQCDZDWXUDCA-UHFFFAOYSA-N [4-(hydroxymethyl)cyclohexyl]methanol Chemical compound OCC1CCC(CO)CC1 YIMQCDZDWXUDCA-UHFFFAOYSA-N 0.000 claims 1
- BWVAOONFBYYRHY-UHFFFAOYSA-N [4-(hydroxymethyl)phenyl]methanol Chemical compound OCC1=CC=C(CO)C=C1 BWVAOONFBYYRHY-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229920000578 graft copolymer Polymers 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67948005P | 2005-05-10 | 2005-05-10 | |
| US72009905P | 2005-09-23 | 2005-09-23 | |
| PCT/US2006/018182 WO2006122223A2 (en) | 2005-05-10 | 2006-05-10 | Strategies for delivery of active agents using micelles and particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008540558A JP2008540558A (ja) | 2008-11-20 |
| JP2008540558A5 true JP2008540558A5 (https=) | 2009-07-02 |
Family
ID=37056867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008511345A Pending JP2008540558A (ja) | 2005-05-10 | 2006-05-10 | ミセルおよび粒子を用いた、活性物質の送達のための新規の戦略 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100062968A1 (https=) |
| EP (1) | EP1893661B1 (https=) |
| JP (1) | JP2008540558A (https=) |
| AT (1) | ATE541875T1 (https=) |
| AU (1) | AU2006243960A1 (https=) |
| CA (1) | CA2608086A1 (https=) |
| WO (1) | WO2006122223A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008062909A1 (en) * | 2006-11-22 | 2008-05-29 | The University Of Tokyo | ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-BRIDGED POLYMERIC MICELLE |
| WO2008127532A1 (en) * | 2007-04-12 | 2008-10-23 | Emory University | Novel strategies for delivery of active agents using micelles and particles |
| JP2010534335A (ja) * | 2007-07-24 | 2010-11-04 | アイエスエス イミューン システム スティミュレーション アーベー | 全身性エリテマトーデス感受性を予測するための方法及び手段 |
| WO2010072797A1 (en) * | 2008-12-22 | 2010-07-01 | The Provost, Fellows and Scholars of The Holy and Undivided Trinity of Queen Elizabeth, Near Dublin | Compounds and methods for the treatment of autoimmune and inflammatory disease |
| CA2756072A1 (en) * | 2009-03-30 | 2010-10-14 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
| WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
| WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
| JP2012524780A (ja) * | 2009-04-21 | 2012-10-18 | セレクタ バイオサイエンシーズ インコーポレーテッド | Ｔｈ１バイアス応答をもたらす免疫ナノ治療薬（Ｉｍｍｕｎｏｎａｎｏｔｈｅｒａｐｅｕｔｉｃｓ） |
| BRPI1012036A2 (pt) | 2009-05-27 | 2017-10-10 | Selecta Biosciences Inc | nanocarreadores que possuem componentes com diferentes taxas de liberação |
| EP2553019A1 (en) | 2010-03-26 | 2013-02-06 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| CA2798739A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| MX374963B (es) | 2011-04-29 | 2025-03-06 | Selecta Biosciences Inc | Nanoportadores sintéticos tolerogénicos para reducir las respuestas de anticuerpos. |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| WO2013036301A1 (en) * | 2011-09-06 | 2013-03-14 | Selecta Biosciences, Inc. | Induced tolerogenic dendritic cells for inducing regulatory b cells |
| KR102266567B1 (ko) * | 2013-03-11 | 2021-06-21 | 크리스탈 딜리버리 비.브이. | 백신접종 조성물 |
| JP6508506B2 (ja) | 2013-03-25 | 2019-05-08 | 日油株式会社 | ベンジリデンアセタールリンカーを有する親水性ポリマー誘導体 |
| BR122020023215B1 (pt) | 2013-05-03 | 2022-11-22 | Selecta Biosciences, Inc | Composição e kit de nanocarreadores sintéticos tolerogênicos para reduzir ou prevenir anafilaxia em resposta a um antígeno não alergênico |
| US9919058B2 (en) | 2014-07-15 | 2018-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer |
| JP7242180B2 (ja) | 2014-09-07 | 2023-03-20 | セレクタ バイオサイエンシーズ インコーポレーテッド | 抗ウイルス導入ベクター免疫応答を減弱化するための方法および組成物 |
| CA3016457A1 (en) * | 2016-03-02 | 2017-09-08 | The Board Of Regents Of The University Of Texas System | Sting activating nanovaccine for immunotherapy |
| CN106750333B (zh) * | 2016-12-06 | 2019-09-24 | 长春斯菲尔生物科技有限公司 | 一种改性的聚缩酮pcadk及制备方法和医用用途 |
| ES3036482T3 (en) | 2017-03-11 | 2025-09-19 | Cartesian Therapeutics Inc | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| WO2020112913A1 (en) * | 2018-11-26 | 2020-06-04 | Duke University | Compositions and methods for inducing scarring by peri-tumoral cells |
| AU2020287627A1 (en) | 2019-06-04 | 2021-11-18 | Selecta Biosciences, Inc. | Formulations and doses of PEGylated uricase |
| CN115192524B (zh) * | 2021-04-13 | 2023-08-29 | 杭州汉菁生物科技有限公司 | 一种包载链状难溶药物的聚合型胶束及制备方法和应用 |
| US20250011193A1 (en) * | 2021-11-09 | 2025-01-09 | Massachusetts Institute Of Technology | Particles containing pollutant-capturing micelles and related methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093709A (en) * | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| CA1211752A (en) * | 1982-09-30 | 1986-09-23 | Donald R. Kelsey | Monomers and polyketal polymers from such monomers |
| US4639366A (en) * | 1984-06-06 | 1987-01-27 | Merck & Co., Inc. | Polymers containing pendant acid functionalities and labile backbone bonds |
| US4765973A (en) * | 1984-06-06 | 1988-08-23 | Merck & Co., Inc. | Polymers containing pendant acid functionalities and labile backbone bonds |
| US4950795A (en) * | 1987-08-27 | 1990-08-21 | Ciba-Geigy Corporation | Oligomeric benzil ketals and their use as photoinitiators |
| DE60323936D1 (de) * | 2002-01-14 | 2008-11-20 | Gen Hospital Corp | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
| US7160551B2 (en) * | 2002-07-09 | 2007-01-09 | The Board Of Trustees Of The University Of Illinois | Injectable system for controlled drug delivery |
| ATE507845T1 (de) * | 2003-09-05 | 2011-05-15 | Gen Hospital Corp | Polyacetal-arzneimittelkonjugate als freisetzungssystem |
| US20060046961A1 (en) * | 2004-09-02 | 2006-03-02 | Mckay William F | Controlled and directed local delivery of anti-inflammatory compositions |
| US7741375B2 (en) * | 2006-02-17 | 2010-06-22 | Medtronic, Inc | Polyketal polymers, and methods of making and using same |
-
2006
- 2006-05-10 WO PCT/US2006/018182 patent/WO2006122223A2/en not_active Ceased
- 2006-05-10 CA CA002608086A patent/CA2608086A1/en not_active Abandoned
- 2006-05-10 EP EP06770201A patent/EP1893661B1/en active Active
- 2006-05-10 US US11/920,330 patent/US20100062968A1/en not_active Abandoned
- 2006-05-10 AT AT06770201T patent/ATE541875T1/de active
- 2006-05-10 AU AU2006243960A patent/AU2006243960A1/en not_active Abandoned
- 2006-05-10 JP JP2008511345A patent/JP2008540558A/ja active Pending
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