JP2008539430A5 - - Google Patents
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- Publication number
- JP2008539430A5 JP2008539430A5 JP2008508905A JP2008508905A JP2008539430A5 JP 2008539430 A5 JP2008539430 A5 JP 2008539430A5 JP 2008508905 A JP2008508905 A JP 2008508905A JP 2008508905 A JP2008508905 A JP 2008508905A JP 2008539430 A5 JP2008539430 A5 JP 2008539430A5
- Authority
- JP
- Japan
- Prior art keywords
- particles
- sample
- medium
- platelet
- lyophilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims description 30
- 239000003153 chemical reaction reagent Substances 0.000 claims description 12
- 102000005962 receptors Human genes 0.000 claims description 12
- 108020003175 receptors Proteins 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims description 9
- 101710149643 Integrin alpha-IIb Proteins 0.000 claims description 9
- 239000003446 ligand Substances 0.000 claims description 9
- 230000002776 aggregation Effects 0.000 claims description 5
- 238000004220 aggregation Methods 0.000 claims description 5
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 2
- 108010049003 Fibrinogen Proteins 0.000 claims description 2
- 102000008946 Fibrinogen Human genes 0.000 claims description 2
- 102100037362 Fibronectin Human genes 0.000 claims description 2
- 108010067306 Fibronectins Proteins 0.000 claims description 2
- 102100035140 Vitronectin Human genes 0.000 claims description 2
- 108010031318 Vitronectin Proteins 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 229940012952 fibrinogen Drugs 0.000 claims description 2
- 108010047303 von Willebrand Factor Proteins 0.000 claims description 2
- 102100036537 von Willebrand factor Human genes 0.000 claims description 2
- 229960001134 von willebrand factor Drugs 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 36
- 238000003556 assay Methods 0.000 claims 16
- 239000002609 medium Substances 0.000 claims 10
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 8
- 229940114079 arachidonic acid Drugs 0.000 claims 4
- 235000021342 arachidonic acid Nutrition 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 230000003078 antioxidant effect Effects 0.000 claims 3
- 239000012736 aqueous medium Substances 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 230000005714 functional activity Effects 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 239000006096 absorbing agent Substances 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940127218 antiplatelet drug Drugs 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- CPYVQXAASIFAMD-KNIFDHDWSA-N (2s)-2-aminobutanedioic acid;(2s)-2,6-diaminohexanoic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O.NCCCC[C@H](N)C(O)=O CPYVQXAASIFAMD-KNIFDHDWSA-N 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 229940122388 Thrombin inhibitor Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/119,360 | 2005-04-28 | ||
| US11/119,360 US7205115B2 (en) | 2005-04-28 | 2005-04-28 | Method and system for stabilization of arachidonic acid for use in platelet function assay |
| PCT/US2006/014136 WO2006115844A1 (en) | 2005-04-28 | 2006-04-14 | Method and system for stabilization of arachidonic acid for use in platelet function assay |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012142879A Division JP5810039B2 (ja) | 2005-04-28 | 2012-06-26 | 血小板機能アッセイに使用するアラキドン酸の安定化方法および装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008539430A JP2008539430A (ja) | 2008-11-13 |
| JP2008539430A5 true JP2008539430A5 (https=) | 2012-08-16 |
| JP5349957B2 JP5349957B2 (ja) | 2013-11-20 |
Family
ID=37215050
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508905A Expired - Fee Related JP5349957B2 (ja) | 2005-04-28 | 2006-04-14 | 血小板機能アッセイに使用するアラキドン酸の安定化方法および装置 |
| JP2012142879A Expired - Lifetime JP5810039B2 (ja) | 2005-04-28 | 2012-06-26 | 血小板機能アッセイに使用するアラキドン酸の安定化方法および装置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012142879A Expired - Lifetime JP5810039B2 (ja) | 2005-04-28 | 2012-06-26 | 血小板機能アッセイに使用するアラキドン酸の安定化方法および装置 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7205115B2 (https=) |
| EP (2) | EP1877786B1 (https=) |
| JP (2) | JP5349957B2 (https=) |
| KR (1) | KR101350528B1 (https=) |
| CN (1) | CN101208603A (https=) |
| AT (1) | ATE524734T1 (https=) |
| AU (1) | AU2006240257B2 (https=) |
| CA (1) | CA2604845A1 (https=) |
| WO (1) | WO2006115844A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070243632A1 (en) * | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| US7790362B2 (en) * | 2003-07-08 | 2010-09-07 | Accumetrics, Inc. | Controlled platelet activation to monitor therapy of ADP antagonists |
| US20090305315A1 (en) * | 2008-06-09 | 2009-12-10 | Kent Raphael Gandola | Hubbed dual cannula device for closed container sampling systems |
| EP2352025B1 (en) * | 2008-08-11 | 2020-07-15 | Fujimori Kogyo Co., Ltd. | Blood-platelet test method |
| US8448499B2 (en) | 2008-12-23 | 2013-05-28 | C A Casyso Ag | Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method |
| RU2490690C1 (ru) * | 2012-08-21 | 2013-08-20 | Российская Федерация, от имени которой выступает Государственная корпорация по атомной энергии "Росатом" | Способ регулирования и контроля влажности в герметизированных контейнерах для хранения гигроскопичных материалов |
| JP6322144B2 (ja) * | 2012-12-20 | 2018-05-09 | 藤森工業株式会社 | 血小板凝集能の総合的評価方法 |
| US10816559B2 (en) | 2014-09-29 | 2020-10-27 | Ca Casyso Ag | Blood testing system and method |
| US10539579B2 (en) | 2014-09-29 | 2020-01-21 | C A Casyso Gmbh | Blood testing system and method |
| KR20250047404A (ko) * | 2015-12-08 | 2025-04-03 | 바이오매트리카 인코포레이티드 | 적혈구 침강 속도의 감소 |
| CN113156144A (zh) * | 2021-01-29 | 2021-07-23 | 郑州普湾医疗技术有限公司 | 一种血小板聚集功能花生四烯酸杯检测试剂及其制备方法 |
| CN119291207B (zh) * | 2024-08-30 | 2026-04-17 | 北京睿瑧生物技术有限公司 | 一种用于测定血小板数量的组合物、装置及检测方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763199A (en) | 1994-09-29 | 1998-06-09 | Mount Sinai School Of Medicine Of The City University Of New York | Platelet blockade assay |
| US5922551A (en) * | 1997-03-20 | 1999-07-13 | Accumetrics, Inc. | Agglutrimetric platelet binding assays in blood |
| US6010911A (en) * | 1997-04-30 | 2000-01-04 | Medtronic, Inc. | Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique |
| US6016712A (en) * | 1997-09-18 | 2000-01-25 | Accumetrics | Device for receiving and processing a sample |
| US6531150B1 (en) * | 1997-10-30 | 2003-03-11 | Morishita Jintan Co., Ltd. | Encapsulated unsaturated fatty acid substance and method for producing the same |
| JP4085218B2 (ja) * | 1998-06-03 | 2008-05-14 | 三菱瓦斯化学株式会社 | 脱酸素剤組成物及び保存方法 |
| DE69909902T2 (de) * | 1998-06-03 | 2004-05-06 | Mitsubishi Gas Chemical Co., Inc. | Sauerstoffabsorbierende Zusammensetzung, Sauerstoffabsorbierendes Harz und Konservierungsverfahren |
-
2005
- 2005-04-28 US US11/119,360 patent/US7205115B2/en not_active Expired - Fee Related
-
2006
- 2006-04-14 AT AT06750226T patent/ATE524734T1/de not_active IP Right Cessation
- 2006-04-14 CN CNA2006800228492A patent/CN101208603A/zh active Pending
- 2006-04-14 KR KR1020077027636A patent/KR101350528B1/ko not_active Expired - Fee Related
- 2006-04-14 EP EP06750226A patent/EP1877786B1/en not_active Expired - Lifetime
- 2006-04-14 JP JP2008508905A patent/JP5349957B2/ja not_active Expired - Fee Related
- 2006-04-14 WO PCT/US2006/014136 patent/WO2006115844A1/en not_active Ceased
- 2006-04-14 EP EP10193726A patent/EP2341347A1/en not_active Withdrawn
- 2006-04-14 AU AU2006240257A patent/AU2006240257B2/en not_active Ceased
- 2006-04-14 CA CA002604845A patent/CA2604845A1/en not_active Abandoned
-
2012
- 2012-06-26 JP JP2012142879A patent/JP5810039B2/ja not_active Expired - Lifetime
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