JP2008538215A5 - - Google Patents
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- Publication number
- JP2008538215A5 JP2008538215A5 JP2008504422A JP2008504422A JP2008538215A5 JP 2008538215 A5 JP2008538215 A5 JP 2008538215A5 JP 2008504422 A JP2008504422 A JP 2008504422A JP 2008504422 A JP2008504422 A JP 2008504422A JP 2008538215 A5 JP2008538215 A5 JP 2008538215A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- administered
- caused
- modulator
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 31
- LAMQVIQMVKWXOC-UHFFFAOYSA-N 4-methyl-n-[2-[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide Chemical compound CC=1N=C(C=2C=NC=CC=2)SC=1C(=O)NC1=CC=CC=C1C(N=C1SC=2)=CN1C=2CN1CCOCC1 LAMQVIQMVKWXOC-UHFFFAOYSA-N 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 230000004064 dysfunction Effects 0.000 claims 6
- 230000002503 metabolic effect Effects 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 238000011287 therapeutic dose Methods 0.000 claims 5
- 230000000007 visual effect Effects 0.000 claims 5
- 210000001328 optic nerve Anatomy 0.000 claims 4
- 206010057430 Retinal injury Diseases 0.000 claims 3
- 102000011990 Sirtuin Human genes 0.000 claims 3
- 108050002485 Sirtuin Proteins 0.000 claims 3
- 239000012190 activator Substances 0.000 claims 3
- 230000004410 intraocular pressure Effects 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims 2
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical group NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 2
- 208000028389 Nerve injury Diseases 0.000 claims 2
- 208000003435 Optic Neuritis Diseases 0.000 claims 2
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical group C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 2
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 230000008764 nerve damage Effects 0.000 claims 2
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 2
- 239000011618 nicotinamide riboside Substances 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 208000002177 Cataract Diseases 0.000 claims 1
- 208000018380 Chemical injury Diseases 0.000 claims 1
- 206010065319 Macular rupture Diseases 0.000 claims 1
- 206010029240 Neuritis Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66717905P | 2005-03-30 | 2005-03-30 | |
| US68425205P | 2005-05-25 | 2005-05-25 | |
| US11/374,278 US20070014833A1 (en) | 2005-03-30 | 2005-10-28 | Treatment of eye disorders with sirtuin modulators |
| PCT/US2006/011930 WO2006105403A2 (en) | 2005-03-30 | 2006-03-30 | Treatment of eye disorders with sirtuin modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538215A JP2008538215A (ja) | 2008-10-16 |
| JP2008538215A5 true JP2008538215A5 (enExample) | 2009-04-09 |
Family
ID=37054169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504422A Pending JP2008538215A (ja) | 2005-03-30 | 2006-03-30 | サーチュイン活性化剤による眼障害の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070014833A1 (enExample) |
| EP (1) | EP1863462A2 (enExample) |
| JP (1) | JP2008538215A (enExample) |
| AU (1) | AU2006230478B2 (enExample) |
| CA (1) | CA2603009A1 (enExample) |
| WO (1) | WO2006105403A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090169585A1 (en) * | 2003-10-23 | 2009-07-02 | Resveratrol Partners, Llc | Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity |
| US20050158376A1 (en) * | 2003-10-23 | 2005-07-21 | Sardi William F. | Dietary supplement and method of processing same |
| US8017634B2 (en) * | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| AU2005207029B2 (en) * | 2004-01-20 | 2011-09-01 | Brigham Young University | Novel sirtuin activating compounds and methods for making the same |
| US7522995B2 (en) | 2004-02-05 | 2009-04-21 | Nortrup Edward H | Method and system for providing travel time information |
| US20050227327A1 (en) * | 2004-02-10 | 2005-10-13 | Brenner Charles M | Nicotinamide riboside kinase compositions and methods for using the same |
| US20070212395A1 (en) * | 2006-03-08 | 2007-09-13 | Allergan, Inc. | Ocular therapy using sirtuin-activating agents |
| AU2006204699B2 (en) * | 2005-01-13 | 2012-04-26 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
| US7998974B2 (en) | 2005-03-03 | 2011-08-16 | Sirtris Pharmaceuticals, Inc. | Fused heterocyclic compounds and their use as sirtuin modulators |
| CA2609549A1 (en) * | 2005-05-25 | 2006-11-30 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| US20070077310A1 (en) * | 2005-10-03 | 2007-04-05 | University Of Tennessee Research Foundation | Methods of reducing the production of reactive oxygen species and methods of screening or identifying compounds and compositions that reduce the production of reactive oxygen species |
| WO2007112366A2 (en) * | 2006-03-24 | 2007-10-04 | Cella Charles H | Animal product enrichment using resveratrol |
| US8828966B2 (en) * | 2006-10-03 | 2014-09-09 | Claire Mitchell | Method for treatment of macular degeneration by modulating P2Y12 or P2X7 receptors |
| WO2008060400A2 (en) * | 2006-11-15 | 2008-05-22 | Sirtris Pharmaceuticals, Inc. | Sirtuin polymorphisms and methods of use thereof |
| CA2676609A1 (en) * | 2007-01-26 | 2008-07-31 | Washington University | Methods and compositions for treating neuropathies |
| JP5149388B2 (ja) * | 2007-09-12 | 2013-02-20 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 黄斑変性症を処置するための組成物及び方法 |
| AU2009243006B2 (en) | 2008-05-01 | 2013-03-21 | Sirtris Pharmaceuticals, Inc. | Quinolines and related analogs as sirtuin modulators |
| BRPI0914006A2 (pt) | 2008-07-03 | 2015-10-27 | Sirtris Pharmaceuticals Inc | benzimidazóis e análogos relacionados como moduladores de sirtuína |
| CA2738794C (en) | 2008-09-29 | 2016-01-05 | Sirtris Pharmaceuticals, Inc. | Chromenone analogs as sirtuin modulators |
| WO2011059839A1 (en) | 2009-10-29 | 2011-05-19 | Sirtris Pharmaceuticals, Inc. | Bicyclic pyridines and analogs as sirtuin modulators |
| US20110105990A1 (en) * | 2009-11-04 | 2011-05-05 | Silvestrini Thomas A | Zonal drug delivery device and method |
| US9125858B2 (en) * | 2009-11-30 | 2015-09-08 | Wilmore Labs L.L.C. | Compositions and methods relating to resveratrol |
| US8529492B2 (en) * | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| JP5722892B2 (ja) | 2010-07-15 | 2015-05-27 | 武田薬品工業株式会社 | 複素環化合物 |
| US8349005B2 (en) | 2011-01-03 | 2013-01-08 | Masatoshi Murata | Method for burying implant to choroid |
| EP3494959A3 (en) | 2011-04-29 | 2019-09-11 | Allergan, Inc. | Sustained release latanoprost implant |
| JP5848042B2 (ja) | 2011-06-29 | 2016-01-27 | 株式会社ロッテ | 眼疲労抑制組成物及びそれを含む飲食品 |
| MX2014000419A (es) | 2011-07-15 | 2014-09-22 | Nusirt Sciences Inc | Composicones y metodos para modular trayectorias metabolicas. |
| US9901616B2 (en) | 2011-08-31 | 2018-02-27 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
| WO2013074948A1 (en) | 2011-11-16 | 2013-05-23 | Resveratrol Partners, Llc | Compositions containing resveratrol and nucleotides |
| US10416167B2 (en) | 2012-02-17 | 2019-09-17 | University Of Georgia Research Foundation, Inc. | Nanoparticles for mitochondrial trafficking of agents |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| JP5948139B2 (ja) * | 2012-05-11 | 2016-07-06 | ヒノキ新薬株式会社 | サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤 |
| WO2014059034A2 (en) | 2012-10-09 | 2014-04-17 | President And Fellows Of Harvard College | Nad biosynthesis and precursors for the treatment and prevention of cancer and proliferation |
| BR112015010947A2 (en) | 2012-11-13 | 2018-06-05 | Nusirt Sciences, Inc. | compositions and methods for increasing energy metabolism. |
| SG11201507046UA (en) | 2013-03-15 | 2015-10-29 | Nusirt Sciences Inc | Leucine and nicotinic acid reduces lipid levels |
| WO2014146044A1 (en) | 2013-03-15 | 2014-09-18 | Washington University | Administration of nicotinamide mononucleotide in the treatment of disease |
| CA2939833A1 (en) | 2014-02-27 | 2015-09-03 | Nusirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| WO2015138992A1 (en) | 2014-03-14 | 2015-09-17 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
| JP6590223B2 (ja) * | 2014-08-28 | 2019-10-16 | 学校法人慶應義塾 | スチルベン化合物を有効成分とする角結膜疾患又は老視の予防及び／又は治療のための医薬組成物 |
| JP6520019B2 (ja) * | 2014-08-28 | 2019-05-29 | 学校法人昭和大学 | 新規スチルベン誘導体 |
| JP2018100222A (ja) * | 2015-04-20 | 2018-06-28 | 学校法人慶應義塾 | 角膜損傷の治療剤、改善剤または予防剤 |
| US10898738B2 (en) | 2016-09-13 | 2021-01-26 | Megumi Tanaka | Visual function printing agent, and method for improving visual functions |
| CA3043327C (en) * | 2016-11-14 | 2020-08-11 | Mingwu Wang | Ambroxol formulations for the treatment of ocular surface diseases and related methods |
| JP6986345B2 (ja) * | 2016-11-18 | 2021-12-22 | ロート製薬株式会社 | 経口組成物及びその製造方法 |
| ES2673942B1 (es) * | 2016-11-23 | 2019-04-09 | Consejo Superior Investigacion | Compuestos acilados para el tratamiento de patologias oculares |
| US10849855B2 (en) * | 2017-01-03 | 2020-12-01 | Vitrean, Inc. | Methods and devices for treating a retinal detachment |
| WO2019108875A1 (en) * | 2017-12-01 | 2019-06-06 | Elysium Health, Inc. | Methods and compositions for treating glaucoma |
| WO2020144753A1 (ja) | 2019-01-09 | 2020-07-16 | 公立大学法人大阪 | 神経変性疾患の予防又は治療薬 |
| WO2023230430A1 (en) * | 2022-05-21 | 2023-11-30 | Neuvision Development Llc | Topical ocular administration of ambroxol for ocular pain |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4383992A (en) * | 1982-02-08 | 1983-05-17 | Lipari John M | Water-soluble steroid compounds |
| FR2543550B1 (fr) * | 1983-04-01 | 1985-08-09 | Cortial | Nouveaux derives de la tetrahydroxy-3', 4',5,7 flavone, leur methode de preparation et leur emploi therapeutique |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| MY106598A (en) * | 1988-08-31 | 1995-06-30 | Australian Commercial Res & Development Ltd | Compositions and methods for drug delivery and chromatography. |
| US5589483A (en) * | 1994-12-21 | 1996-12-31 | Geron Corporation | Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence |
| IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
| US6028111A (en) * | 1996-03-08 | 2000-02-22 | Oxigene, Inc. | Compositions and use of benzamides and nicotinamides as anti-inflammatory agents |
| SK284054B6 (sk) * | 1996-10-16 | 2004-08-03 | Icn Pharmaceuticals, Inc. | Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie |
| GB9712370D0 (en) * | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
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| US7718694B2 (en) * | 1997-10-16 | 2010-05-18 | Children's Hospital & Research Center At Oakland | Compositions and methods for therapy for diseases characterized by defective chloride transport |
| US6008260A (en) * | 1998-01-09 | 1999-12-28 | Pharmascience | Cancer chemopreventative composition and method |
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| US6028099A (en) * | 1998-03-13 | 2000-02-22 | John Hopkins University, School Of Medicine | Use of an inhibitor of the protein tyrosine kinase pathway in the treatment of choroidal neovascularization |
| US7030155B2 (en) * | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| US20030086986A1 (en) * | 1998-08-06 | 2003-05-08 | Bruijn Chris De | Ophthalmic, pharmaceutical and other healthcare preparations with naturally occurring plant compounds, extracts and derivatives |
| US6096733A (en) * | 1998-12-10 | 2000-08-01 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
| US6399655B1 (en) * | 1998-12-22 | 2002-06-04 | Johns Hopkins University, School Of Medicine | Method for the prophylactic treatment of cataracts |
| US6573299B1 (en) * | 1999-09-20 | 2003-06-03 | Advanced Medical Instruments | Method and compositions for treatment of the aging eye |
| US6569903B2 (en) * | 1999-12-07 | 2003-05-27 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic compositions |
| US7452664B2 (en) * | 1999-12-15 | 2008-11-18 | Massachusetts Institute Of Technology | Methods for identifying agents which alter histone protein acetylation |
| US6489335B2 (en) * | 2000-02-18 | 2002-12-03 | Gholam A. Peyman | Treatment of ocular disease |
| US6864243B1 (en) * | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
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| US6716596B2 (en) * | 2001-03-12 | 2004-04-06 | The Regents Of The University Of California | Agents for replacement of NAD+/NADH system in enzymatic reactions |
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| EP1549301A2 (en) * | 2002-06-10 | 2005-07-06 | Oklahoma Medical Research Foundation | A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US20050080024A1 (en) * | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives for the treatment of cardiovascular disorders |
| US20060111318A1 (en) * | 2003-04-18 | 2006-05-25 | Advanced Medicine Research Institute | Agent for treating eye diseases |
| US20060025337A1 (en) * | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| US20050096256A1 (en) * | 2003-07-01 | 2005-05-05 | President And Fellows Of Harvard College | Compositions for manipulating the lifespan and stress response of cells and organisms |
| US20050158376A1 (en) * | 2003-10-23 | 2005-07-21 | Sardi William F. | Dietary supplement and method of processing same |
| US8017634B2 (en) * | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| US20050227327A1 (en) * | 2004-02-10 | 2005-10-13 | Brenner Charles M | Nicotinamide riboside kinase compositions and methods for using the same |
| EP1723227A4 (en) * | 2004-02-10 | 2007-09-19 | Dartmouth College | NICOTINAMIDRIBOSIDE KINASE COMPOSITIONS AND METHOD FOR THEIR USE |
| US20050244472A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Intraocular drug delivery systems containing excipients with reduced toxicity and related methods |
| CN1964627B (zh) * | 2004-06-04 | 2011-10-19 | 华盛顿大学 | 治疗神经病变的方法和组合物 |
| US20060084085A1 (en) * | 2004-06-16 | 2006-04-20 | Sinclair David A | Methods and compositions for modulating Bax-mediated apoptosis |
| US20060024385A1 (en) * | 2004-07-27 | 2006-02-02 | Pedersen Mark A | Metabolic capacity enhancing compositions and methods for use in a mammal |
| AU2006204699B2 (en) * | 2005-01-13 | 2012-04-26 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
| AU2006206274A1 (en) * | 2005-01-20 | 2006-07-27 | Sirtris Pharmaceuticals, Inc. | Use of sirtuin-activating compounds for treating flushing and drug induced weight gain |
| US7838503B2 (en) * | 2005-06-15 | 2010-11-23 | Children's Medical Center Corporation | Methods for extending the replicative lifespan of cells |
| US8093401B2 (en) * | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US7855289B2 (en) * | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US8088928B2 (en) * | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US7345178B2 (en) * | 2005-08-04 | 2008-03-18 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| WO2007061798A2 (en) * | 2005-11-18 | 2007-05-31 | Cornell Research Foundation, Inc. | Nicotinoyl riboside compositions and methods of use |
| US20100168084A1 (en) * | 2008-05-08 | 2010-07-01 | Huber L Julie | Therapeutic compounds and related methods of use |
| CN102388054B (zh) * | 2008-12-19 | 2015-03-04 | 西特里斯药业公司 | 噻唑并吡啶沉默调节蛋白调节剂的化合物 |
-
2005
- 2005-10-28 US US11/374,278 patent/US20070014833A1/en not_active Abandoned
-
2006
- 2006-03-30 AU AU2006230478A patent/AU2006230478B2/en not_active Ceased
- 2006-03-30 JP JP2008504422A patent/JP2008538215A/ja active Pending
- 2006-03-30 CA CA002603009A patent/CA2603009A1/en not_active Abandoned
- 2006-03-30 WO PCT/US2006/011930 patent/WO2006105403A2/en not_active Ceased
- 2006-03-30 EP EP06749032A patent/EP1863462A2/en not_active Ceased
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