JP2008538215A5 - - Google Patents
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- Publication number
- JP2008538215A5 JP2008538215A5 JP2008504422A JP2008504422A JP2008538215A5 JP 2008538215 A5 JP2008538215 A5 JP 2008538215A5 JP 2008504422 A JP2008504422 A JP 2008504422A JP 2008504422 A JP2008504422 A JP 2008504422A JP 2008538215 A5 JP2008538215 A5 JP 2008538215A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- administered
- caused
- modulator
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 31
- LAMQVIQMVKWXOC-UHFFFAOYSA-N 4-methyl-n-[2-[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide Chemical compound CC=1N=C(C=2C=NC=CC=2)SC=1C(=O)NC1=CC=CC=C1C(N=C1SC=2)=CN1C=2CN1CCOCC1 LAMQVIQMVKWXOC-UHFFFAOYSA-N 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 230000004064 dysfunction Effects 0.000 claims 6
- 230000002503 metabolic effect Effects 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 238000011287 therapeutic dose Methods 0.000 claims 5
- 230000000007 visual effect Effects 0.000 claims 5
- 210000001328 optic nerve Anatomy 0.000 claims 4
- 206010057430 Retinal injury Diseases 0.000 claims 3
- 102000011990 Sirtuin Human genes 0.000 claims 3
- 108050002485 Sirtuin Proteins 0.000 claims 3
- 239000012190 activator Substances 0.000 claims 3
- 230000004410 intraocular pressure Effects 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims 2
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical group NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 2
- 208000028389 Nerve injury Diseases 0.000 claims 2
- 208000003435 Optic Neuritis Diseases 0.000 claims 2
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical group C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 2
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 230000008764 nerve damage Effects 0.000 claims 2
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 2
- 239000011618 nicotinamide riboside Substances 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 208000002177 Cataract Diseases 0.000 claims 1
- 208000018380 Chemical injury Diseases 0.000 claims 1
- 206010065319 Macular rupture Diseases 0.000 claims 1
- 206010029240 Neuritis Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66717905P | 2005-03-30 | 2005-03-30 | |
| US68425205P | 2005-05-25 | 2005-05-25 | |
| US11/374,278 US20070014833A1 (en) | 2005-03-30 | 2005-10-28 | Treatment of eye disorders with sirtuin modulators |
| PCT/US2006/011930 WO2006105403A2 (en) | 2005-03-30 | 2006-03-30 | Treatment of eye disorders with sirtuin modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538215A JP2008538215A (ja) | 2008-10-16 |
| JP2008538215A5 true JP2008538215A5 (enExample) | 2009-04-09 |
Family
ID=37054169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504422A Pending JP2008538215A (ja) | 2005-03-30 | 2006-03-30 | サーチュイン活性化剤による眼障害の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070014833A1 (enExample) |
| EP (1) | EP1863462A2 (enExample) |
| JP (1) | JP2008538215A (enExample) |
| AU (1) | AU2006230478B2 (enExample) |
| CA (1) | CA2603009A1 (enExample) |
| WO (1) | WO2006105403A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050158376A1 (en) * | 2003-10-23 | 2005-07-21 | Sardi William F. | Dietary supplement and method of processing same |
| US20090169585A1 (en) * | 2003-10-23 | 2009-07-02 | Resveratrol Partners, Llc | Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity |
| US8017634B2 (en) * | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| WO2005069998A2 (en) * | 2004-01-20 | 2005-08-04 | Brigham Young University Technology Transfer Office | Novel sirtuin activating compounds and methods for making the same |
| US7522995B2 (en) | 2004-02-05 | 2009-04-21 | Nortrup Edward H | Method and system for providing travel time information |
| US20050227327A1 (en) * | 2004-02-10 | 2005-10-13 | Brenner Charles M | Nicotinamide riboside kinase compositions and methods for using the same |
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| CA2609549A1 (en) * | 2005-05-25 | 2006-11-30 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| US20070077310A1 (en) * | 2005-10-03 | 2007-04-05 | University Of Tennessee Research Foundation | Methods of reducing the production of reactive oxygen species and methods of screening or identifying compounds and compositions that reduce the production of reactive oxygen species |
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| US8828966B2 (en) * | 2006-10-03 | 2014-09-09 | Claire Mitchell | Method for treatment of macular degeneration by modulating P2Y12 or P2X7 receptors |
| WO2008060400A2 (en) * | 2006-11-15 | 2008-05-22 | Sirtris Pharmaceuticals, Inc. | Sirtuin polymorphisms and methods of use thereof |
| EP2124985A4 (en) * | 2007-01-26 | 2011-06-08 | Univ Washington | METHOD AND COMPOSITIONS FOR TREATING NERVOUS ELEMENTS |
| USRE47045E1 (en) * | 2007-09-12 | 2018-09-18 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating macular degeneration |
| BRPI0912356A2 (pt) | 2008-05-01 | 2015-10-06 | Sirtris Pharmaceuticals Inc | compostos moduladores de sirtuína, composição farmacêutica compreendendo os mesmos e seu uso |
| CA2729128C (en) | 2008-07-03 | 2016-05-31 | Sirtris Pharmaceuticals, Inc. | Benzimidazoles and related analogs as sirtuin modulators |
| WO2010037129A1 (en) | 2008-09-29 | 2010-04-01 | Sirtris Pharmaceuticals Inc. | Quinazolinone, quinolone and related analogs as sirtuin modulators |
| CA2779303A1 (en) | 2009-10-29 | 2011-05-19 | Sirtris Pharmaceuticals, Inc. | Bicyclic pyridines and analogs as sirtuin modulators |
| US20110105990A1 (en) * | 2009-11-04 | 2011-05-05 | Silvestrini Thomas A | Zonal drug delivery device and method |
| US9125858B2 (en) | 2009-11-30 | 2015-09-08 | Wilmore Labs L.L.C. | Compositions and methods relating to resveratrol |
| US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| WO2012008549A1 (ja) | 2010-07-15 | 2012-01-19 | 武田薬品工業株式会社 | 複素環化合物 |
| US8349005B2 (en) | 2011-01-03 | 2013-01-08 | Masatoshi Murata | Method for burying implant to choroid |
| WO2012149278A1 (en) | 2011-04-29 | 2012-11-01 | Allergan, Inc. | Sustained release latanoprost implant |
| JP5848042B2 (ja) | 2011-06-29 | 2016-01-27 | 株式会社ロッテ | 眼疲労抑制組成物及びそれを含む飲食品 |
| EP3466418A1 (en) | 2011-07-15 | 2019-04-10 | NuSirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
| US9901616B2 (en) | 2011-08-31 | 2018-02-27 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
| US8916528B2 (en) | 2011-11-16 | 2014-12-23 | Resveratrol Partners, Llc | Compositions containing resveratrol and nucleotides |
| US10416167B2 (en) | 2012-02-17 | 2019-09-17 | University Of Georgia Research Foundation, Inc. | Nanoparticles for mitochondrial trafficking of agents |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| JP5948139B2 (ja) * | 2012-05-11 | 2016-07-06 | ヒノキ新薬株式会社 | サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤 |
| WO2014059034A2 (en) | 2012-10-09 | 2014-04-17 | President And Fellows Of Harvard College | Nad biosynthesis and precursors for the treatment and prevention of cancer and proliferation |
| CN108452311A (zh) | 2012-11-13 | 2018-08-28 | 纽斯尔特科学公司 | 用于增强能量代谢的组合物和方法 |
| PL2968306T3 (pl) | 2013-03-15 | 2024-01-29 | Washington University | Podawanie mononukleotydu nikotynamidu do leczenia zespołu suchego oka |
| WO2014152016A1 (en) | 2013-03-15 | 2014-09-25 | Nusirt Sciences, Inc. | Leucine and nicotinic acid reduces lipid levels |
| MX2016011063A (es) | 2014-02-27 | 2016-11-30 | Nusirt Sciences Inc | Composiciones y metodos para la reduccion o prevencion de esteatosis hepatica. |
| US10398663B2 (en) | 2014-03-14 | 2019-09-03 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
| JP6520019B2 (ja) * | 2014-08-28 | 2019-05-29 | 学校法人昭和大学 | 新規スチルベン誘導体 |
| US9968566B2 (en) * | 2014-08-28 | 2018-05-15 | Keio University | Pharmaceutical composition for prophylaxis and/or treatment of corneal and conjunctival diseases or presbyopia containing stilbene compound as active ingredient |
| JP2018100222A (ja) * | 2015-04-20 | 2018-06-28 | 学校法人慶應義塾 | 角膜損傷の治療剤、改善剤または予防剤 |
| ES2955713T3 (es) * | 2016-09-13 | 2023-12-05 | Megumi Tanaka | Agente de mejora de la función visual, y método para mejorar la función visual |
| CN109982692A (zh) * | 2016-11-14 | 2019-07-05 | 王明武 | 用于治疗眼表疾病的制剂和相关方法 |
| JP6986345B2 (ja) * | 2016-11-18 | 2021-12-22 | ロート製薬株式会社 | 経口組成物及びその製造方法 |
| ES2673942B1 (es) * | 2016-11-23 | 2019-04-09 | Consejo Superior Investigacion | Compuestos acilados para el tratamiento de patologias oculares |
| CA3046668A1 (en) * | 2017-01-03 | 2018-07-12 | Vitrean, Inc. | Methods and devices for treating a retinal detachment |
| WO2019108875A1 (en) * | 2017-12-01 | 2019-06-06 | Elysium Health, Inc. | Methods and compositions for treating glaucoma |
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| US4383992A (en) * | 1982-02-08 | 1983-05-17 | Lipari John M | Water-soluble steroid compounds |
| FR2543550B1 (fr) * | 1983-04-01 | 1985-08-09 | Cortial | Nouveaux derives de la tetrahydroxy-3', 4',5,7 flavone, leur methode de preparation et leur emploi therapeutique |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| MY106598A (en) * | 1988-08-31 | 1995-06-30 | Australian Commercial Res & Development Ltd | Compositions and methods for drug delivery and chromatography. |
| US5589483A (en) * | 1994-12-21 | 1996-12-31 | Geron Corporation | Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence |
| IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
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| US7718694B2 (en) * | 1997-10-16 | 2010-05-18 | Children's Hospital & Research Center At Oakland | Compositions and methods for therapy for diseases characterized by defective chloride transport |
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| US20050080024A1 (en) * | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives for the treatment of cardiovascular disorders |
| US20060111318A1 (en) * | 2003-04-18 | 2006-05-25 | Advanced Medicine Research Institute | Agent for treating eye diseases |
| US20060025337A1 (en) * | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| AU2004253579B2 (en) * | 2003-07-01 | 2010-12-23 | Biomol International L.P. | Sirt1 modulators for manipulating cells/organism lifespan/stress response |
| US20050158376A1 (en) * | 2003-10-23 | 2005-07-21 | Sardi William F. | Dietary supplement and method of processing same |
| US8017634B2 (en) * | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| US20050227327A1 (en) * | 2004-02-10 | 2005-10-13 | Brenner Charles M | Nicotinamide riboside kinase compositions and methods for using the same |
| CA2555675A1 (en) * | 2004-02-10 | 2005-08-25 | Trustees Of Dartmouth College | Nicotinamide riboside kinase compositions and methods for using the same |
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| ES2663226T3 (es) * | 2004-06-04 | 2018-04-11 | Washington University | Procedimientos y composiciones para tratar neuropatías |
| WO2006007411A2 (en) * | 2004-06-16 | 2006-01-19 | President And Fellows Of Harvard College | Methods and compositions for modulating bax-mediated apoptosis |
| US20060024385A1 (en) * | 2004-07-27 | 2006-02-02 | Pedersen Mark A | Metabolic capacity enhancing compositions and methods for use in a mammal |
| AU2006204699B2 (en) * | 2005-01-13 | 2012-04-26 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
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| US7838503B2 (en) * | 2005-06-15 | 2010-11-23 | Children's Medical Center Corporation | Methods for extending the replicative lifespan of cells |
| US8093401B2 (en) * | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US8088928B2 (en) * | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| AU2006278504B2 (en) * | 2005-08-04 | 2013-01-17 | Sirtris Pharmaceuticals, Inc. | Imidazopyridine derivatives as sirtuin modulating agents |
| US7855289B2 (en) * | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| ES2670927T3 (es) * | 2005-11-18 | 2018-06-04 | Cornell Research Foundation, Inc. | Composiciones de nicotinoil ribósido y métodos de uso |
| US20100168084A1 (en) * | 2008-05-08 | 2010-07-01 | Huber L Julie | Therapeutic compounds and related methods of use |
| CN102388054B (zh) * | 2008-12-19 | 2015-03-04 | 西特里斯药业公司 | 噻唑并吡啶沉默调节蛋白调节剂的化合物 |
-
2005
- 2005-10-28 US US11/374,278 patent/US20070014833A1/en not_active Abandoned
-
2006
- 2006-03-30 JP JP2008504422A patent/JP2008538215A/ja active Pending
- 2006-03-30 WO PCT/US2006/011930 patent/WO2006105403A2/en not_active Ceased
- 2006-03-30 CA CA002603009A patent/CA2603009A1/en not_active Abandoned
- 2006-03-30 AU AU2006230478A patent/AU2006230478B2/en not_active Ceased
- 2006-03-30 EP EP06749032A patent/EP1863462A2/en not_active Ceased
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