JP2008537473A5 - - Google Patents

Info

Publication number

JP2008537473A5

JP2008537473A5 JP2007555113A JP2007555113A JP2008537473A5 JP 2008537473 A5 JP2008537473 A5 JP 2008537473A5 JP 2007555113 A JP2007555113 A JP 2007555113A JP 2007555113 A JP2007555113 A JP 2007555113A JP 2008537473 A5 JP2008537473 A5 JP 2008537473A5

Authority

JP

Japan

Prior art keywords

seq

acid sequence

assay

contained

amino acid

Prior art date

2006-01-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 238000003556 assay Methods 0.000 claims 33
• 125000003275 alpha amino acid group Chemical group 0.000 claims 28
• 150000001875 compounds Chemical class 0.000 claims 24
• 229920001184 polypeptide Polymers 0.000 claims 18
• 102000004196 processed proteins & peptides Human genes 0.000 claims 18
• 108090000765 processed proteins & peptides Proteins 0.000 claims 18
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
• 150000007523 nucleic acids Chemical group 0.000 claims 16
• 238000009396 hybridization Methods 0.000 claims 14
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 8
• 230000004913 activation Effects 0.000 claims 8
• 230000000694 effects Effects 0.000 claims 8
• QMGVPVSNSZLJIA-FVWCLLPLSA-N strychnine Chemical compound O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 QMGVPVSNSZLJIA-FVWCLLPLSA-N 0.000 claims 6
• VWTINHYPRWEBQY-UHFFFAOYSA-N denatonium Chemical compound [O-]C(=O)C1=CC=CC=C1.C=1C=CC=CC=1C[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C VWTINHYPRWEBQY-UHFFFAOYSA-N 0.000 claims 5
• 229960001610 denatonium benzoate Drugs 0.000 claims 5
• 108091005708 gustatory receptors Proteins 0.000 claims 5
• 108020003175 receptors Proteins 0.000 claims 5
• 102000005962 receptors Human genes 0.000 claims 5
• 235000019658 bitter taste Nutrition 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 229960005489 paracetamol Drugs 0.000 claims 4
• VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 claims 4
• 229960000620 ranitidine Drugs 0.000 claims 4
• 238000012216 screening Methods 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 claims 3
• 241001279009 Strychnos toxifera Species 0.000 claims 3
• 229960005453 strychnine Drugs 0.000 claims 3
• 230000001939 inductive effect Effects 0.000 claims 1