MX2007009497A - Receptores t2r humanos para acetaminofen, ranitidina, estricnina y denatonio, y ensayos relacionados para identificar moduladores de sabor amargo humanos. - Google Patents

Receptores t2r humanos para acetaminofen, ranitidina, estricnina y denatonio, y ensayos relacionados para identificar moduladores de sabor amargo humanos.

Info

Publication number
MX2007009497A
MX2007009497A MX2007009497A MX2007009497A MX2007009497A MX 2007009497 A MX2007009497 A MX 2007009497A MX 2007009497 A MX2007009497 A MX 2007009497A MX 2007009497 A MX2007009497 A MX 2007009497A MX 2007009497 A MX2007009497 A MX 2007009497A
Authority
MX
Mexico
Prior art keywords
receptors
denatonium
strychnine
ranitidine
acetaminophen
Prior art date
Application number
MX2007009497A
Other languages
English (en)
Inventor
Li Xiaodong
Hong Xu
Huixiang Tang
Qing Li
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of MX2007009497A publication Critical patent/MX2007009497A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

La presente invencion se relaciona al descubrimiento de que receptores de sabor humanos especificos en la familia de receptores de sabor T2R responden a ligandos amargos particulares, es decir, acetaminofen ranitidina, estricnina y denatonio. La presente invencion ademas se relaciona al uso de estos receptores en ensayos para identificar ligandos que modulan la activacion de estos receptores de sabor y que pueden ser usados como aditivos en alimentos, bebidas y medicinas para modificar (bloquear) el sabor amargo asociado con T2R.
MX2007009497A 2005-02-08 2006-01-06 Receptores t2r humanos para acetaminofen, ranitidina, estricnina y denatonio, y ensayos relacionados para identificar moduladores de sabor amargo humanos. MX2007009497A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65055505P 2005-02-08 2005-02-08
PCT/US2006/002509 WO2006086150A2 (en) 2005-02-08 2006-01-06 Phuman t2r receptors for acetaminophen, ranitidine, strychnine and denatonium and related assays for identifying human bitter taste modulators

Publications (1)

Publication Number Publication Date
MX2007009497A true MX2007009497A (es) 2008-01-18

Family

ID=36793558

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007009497A MX2007009497A (es) 2005-02-08 2006-01-06 Receptores t2r humanos para acetaminofen, ranitidina, estricnina y denatonio, y ensayos relacionados para identificar moduladores de sabor amargo humanos.

Country Status (10)

Country Link
US (3) US7407765B2 (es)
EP (1) EP1851548A4 (es)
JP (1) JP2008537473A (es)
CN (1) CN101467040A (es)
AU (1) AU2006213039A1 (es)
CA (1) CA2597085A1 (es)
IL (1) IL185109A0 (es)
MX (1) MX2007009497A (es)
NO (1) NO20074143L (es)
WO (1) WO2006086150A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101416055A (zh) 2005-06-22 2009-04-22 塞诺米克斯公司 被咖啡中的苦味分子(绿原酸内酯)激活的人t2r受体的鉴定和用于鉴定人苦味调节剂的相关测定法
EP1975612A1 (en) * 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
EP3009513A1 (en) * 2008-02-01 2016-04-20 Chromocell Corporation Novel cell lines and methods
EP2329263A1 (en) 2008-08-07 2011-06-08 Givaudan SA Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46
EP2329271B1 (en) * 2008-08-29 2012-06-20 Givaudan SA Methods to identify modulators
EA018270B1 (ru) * 2008-09-05 2013-06-28 Унилевер Н.В. Соединения и композиции для снижения или устранения горечи, вызываемой флаван-3-олами
US9579315B2 (en) 2010-08-09 2017-02-28 University Of Maryland, Baltimore Methods of treating obstructive lung diseases using bitter tastants
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
US9169311B2 (en) 2013-03-15 2015-10-27 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
MX2015013013A (es) 2013-03-15 2015-12-01 Applied Food Biotech Inc Receptores felinos del gusto amargo y metodos.
WO2015123282A1 (en) 2014-02-12 2015-08-20 Fotsing Joseph R Improved process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones
DE102016009766A1 (de) * 2016-08-11 2018-02-15 Julius-Maximilians-Universität Würzburg Herstellung von Bitterstoffderivaten
CN113230256A (zh) * 2021-06-08 2021-08-10 广州医科大学附属中医医院 士的宁在制备肝细胞代谢药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1289525C (zh) * 1999-09-10 2006-12-13 加利福尼亚大学董事会 T2r,一类味觉受体
WO2001077676A1 (en) * 2000-04-07 2001-10-18 Senomyx, Inc. T2r taste receptors and genes encoding same
US7338771B2 (en) * 2001-07-10 2008-03-04 Alexey Pronin Use of specific T2R taste receptors to identify compounds that block bitter taste
WO2004069191A2 (en) * 2003-02-03 2004-08-19 Senomyx Inc. Identification of t1r and t2r modulators

Also Published As

Publication number Publication date
US20110281749A1 (en) 2011-11-17
US7915003B2 (en) 2011-03-29
US7407765B2 (en) 2008-08-05
US20090087866A1 (en) 2009-04-02
WO2006086150A2 (en) 2006-08-17
WO2006086150A3 (en) 2009-02-26
JP2008537473A (ja) 2008-09-18
CA2597085A1 (en) 2006-08-17
NO20074143L (no) 2007-11-05
US8273542B2 (en) 2012-09-25
CN101467040A (zh) 2009-06-24
US20060199227A1 (en) 2006-09-07
AU2006213039A1 (en) 2006-08-17
EP1851548A2 (en) 2007-11-07
EP1851548A4 (en) 2010-04-28
IL185109A0 (en) 2007-12-03

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Legal Events

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FA Abandonment or withdrawal