CN101467040A - 对乙酰氨基酚、雷尼替丁、士的宁和地那铵的人t2r受体和鉴定人苦味调节剂的相关测定方法 - Google Patents

对乙酰氨基酚、雷尼替丁、士的宁和地那铵的人t2r受体和鉴定人苦味调节剂的相关测定方法 Download PDF

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Publication number
CN101467040A
CN101467040A CNA2006800099858A CN200680009985A CN101467040A CN 101467040 A CN101467040 A CN 101467040A CN A2006800099858 A CNA2006800099858 A CN A2006800099858A CN 200680009985 A CN200680009985 A CN 200680009985A CN 101467040 A CN101467040 A CN 101467040A
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CN
China
Prior art keywords
assay
taste receptor
compound
seq
acid sequence
Prior art date
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Pending
Application number
CNA2006800099858A
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English (en)
Chinese (zh)
Inventor
李晓东
H·许
H·唐
Q·李
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Firmenich Inc
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Senomyx Inc
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Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of CN101467040A publication Critical patent/CN101467040A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2006800099858A 2005-02-08 2006-01-06 对乙酰氨基酚、雷尼替丁、士的宁和地那铵的人t2r受体和鉴定人苦味调节剂的相关测定方法 Pending CN101467040A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65055505P 2005-02-08 2005-02-08
US60/650,555 2005-02-08

Publications (1)

Publication Number Publication Date
CN101467040A true CN101467040A (zh) 2009-06-24

Family

ID=36793558

Family Applications (1)

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CNA2006800099858A Pending CN101467040A (zh) 2005-02-08 2006-01-06 对乙酰氨基酚、雷尼替丁、士的宁和地那铵的人t2r受体和鉴定人苦味调节剂的相关测定方法

Country Status (10)

Country Link
US (3) US7407765B2 (enExample)
EP (1) EP1851548A4 (enExample)
JP (1) JP2008537473A (enExample)
CN (1) CN101467040A (enExample)
AU (1) AU2006213039A1 (enExample)
CA (1) CA2597085A1 (enExample)
IL (1) IL185109A0 (enExample)
MX (1) MX2007009497A (enExample)
NO (1) NO20074143L (enExample)
WO (1) WO2006086150A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007002026A2 (en) * 2005-06-22 2007-01-04 Senomyx, Inc. Identification of human t2r recepors that are activated by bitter molecules in coffee (chlorogenic lactones) and related assays for identifying human bitter taste modulators
EP1975612A1 (en) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
CA2713885A1 (en) * 2008-02-01 2009-08-20 Chromocell Corporation Novel cell lines and methods
EP2329263A1 (en) * 2008-08-07 2011-06-08 Givaudan SA Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46
US8557530B2 (en) 2008-08-29 2013-10-15 Givaudan Sa Use of a TAS2R7 nucleic acid sequence to identify modulators
WO2010026003A1 (en) * 2008-09-05 2010-03-11 Unilever Plc Flavan-3-ol containing foodstuffs
WO2012021291A2 (en) * 2010-08-09 2012-02-16 University Of Maryland, Baltimore Methods of treating obstructive lung diseases using bitter tastants
WO2013022948A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
ES2797547T3 (es) 2013-03-15 2020-12-02 Applied Food Biotech Inc Receptores del sabor amargo felino y métodos.
US9169311B2 (en) 2013-03-15 2015-10-27 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
ES2802376T3 (es) 2014-02-12 2021-01-19 Firmenich Incorporated Procedimiento mejorado para la síntesis de 1-bencil-3-(1-(isoxazol-4-ilmetil)-1h-pirazol-4-il)imidazolidin-2,4-dionas sustituidas
DE102016009766A1 (de) * 2016-08-11 2018-02-15 Julius-Maximilians-Universität Würzburg Herstellung von Bitterstoffderivaten
BR112023021573A2 (pt) * 2021-05-07 2023-12-19 Firmenich Incorporated Células expressando receptores de sabor amargo e usos das mesmas
CN113230256A (zh) * 2021-06-08 2021-08-10 广州医科大学附属中医医院 士的宁在制备肝细胞代谢药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001018050A2 (en) * 1999-09-10 2001-03-15 The Regents Of The University Of California T2r taste receptor family
AU2001251258B2 (en) * 2000-04-07 2008-06-05 Senomyx, Inc. T2r taste receptors and genes encoding same
EP1502112A4 (en) * 2001-07-10 2008-07-23 Senomyx Inc USE OF SPECIFIC T2R TASTE RECIPES TO IDENTIFY CONNECTIONS WHICH BLOCK A BITTER TASTE
WO2004069191A2 (en) * 2003-02-03 2004-08-19 Senomyx Inc. Identification of t1r and t2r modulators

Also Published As

Publication number Publication date
WO2006086150A2 (en) 2006-08-17
US20090087866A1 (en) 2009-04-02
MX2007009497A (es) 2008-01-18
US7915003B2 (en) 2011-03-29
EP1851548A2 (en) 2007-11-07
WO2006086150A3 (en) 2009-02-26
IL185109A0 (en) 2007-12-03
US20060199227A1 (en) 2006-09-07
CA2597085A1 (en) 2006-08-17
JP2008537473A (ja) 2008-09-18
US7407765B2 (en) 2008-08-05
EP1851548A4 (en) 2010-04-28
US20110281749A1 (en) 2011-11-17
US8273542B2 (en) 2012-09-25
AU2006213039A1 (en) 2006-08-17
NO20074143L (no) 2007-11-05

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Application publication date: 20090624