JP2008537110A5 - - Google Patents
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- Publication number
- JP2008537110A5 JP2008537110A5 JP2008504212A JP2008504212A JP2008537110A5 JP 2008537110 A5 JP2008537110 A5 JP 2008537110A5 JP 2008504212 A JP2008504212 A JP 2008504212A JP 2008504212 A JP2008504212 A JP 2008504212A JP 2008537110 A5 JP2008537110 A5 JP 2008537110A5
- Authority
- JP
- Japan
- Prior art keywords
- general formula
- compound
- immunoassay
- antibody
- immunoassay method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003018 immunoassay Methods 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 27
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 16
- 229960004679 doxorubicin Drugs 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 7
- 230000002163 immunogen Effects 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 4
- IBZGBXXTIGCACK-CWKPULSASA-N Adriamycinone Chemical compound C1[C@@](O)(C(=O)CO)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O IBZGBXXTIGCACK-CWKPULSASA-N 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- -1 imide ester Chemical class 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000287463 Phalacrocorax Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 238000000691 measurement method Methods 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000013610 patient sample Substances 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66628805P | 2005-03-30 | 2005-03-30 | |
| US60/666,288 | 2005-03-30 | ||
| PCT/US2006/011022 WO2006104970A1 (en) | 2005-03-30 | 2006-03-27 | Doxorubicin immunoassay |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008537110A JP2008537110A (ja) | 2008-09-11 |
| JP2008537110A5 true JP2008537110A5 (enExample) | 2009-05-21 |
| JP4896959B2 JP4896959B2 (ja) | 2012-03-14 |
Family
ID=37053697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504212A Expired - Fee Related JP4896959B2 (ja) | 2005-03-30 | 2006-03-27 | ドキソルビシン免疫測定法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7569358B2 (enExample) |
| EP (2) | EP2239573A3 (enExample) |
| JP (1) | JP4896959B2 (enExample) |
| AT (1) | ATE476655T1 (enExample) |
| CA (1) | CA2602849C (enExample) |
| DE (1) | DE602006015929D1 (enExample) |
| DK (1) | DK1864129T3 (enExample) |
| ES (1) | ES2353212T3 (enExample) |
| WO (1) | WO2006104970A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2602849C (en) * | 2005-03-30 | 2013-06-04 | Saladax Biomedical Inc. | Doxorubicin immunoassay |
| US8076097B2 (en) * | 2009-08-19 | 2011-12-13 | Saladax Biomedical Inc. | Imatinib immunoassay |
| US20110165699A1 (en) * | 2009-12-08 | 2011-07-07 | Salamone Salvatore J | Irinotecan immunoassay |
| US20110136253A1 (en) * | 2009-12-08 | 2011-06-09 | Salamone Salvatore J | Irinotecan Immunoassay |
| US8114621B2 (en) * | 2010-03-12 | 2012-02-14 | Saladax Biomedical Inc. | Lenalidomide and thalidomide immunoassays |
| US8088594B2 (en) * | 2010-03-16 | 2012-01-03 | Saladax Biomedical Inc. | Risperidone immunoassay |
| WO2012067670A1 (en) * | 2010-11-18 | 2012-05-24 | Saladax Biomedical Inc. | Irinotecan immunoassay |
| US8426143B2 (en) | 2011-05-24 | 2013-04-23 | Saladax Biomedical Inc. | Gemcitabine immunoassay |
| US8771972B2 (en) * | 2011-05-24 | 2014-07-08 | Saladax Biomedical Inc. | Clozapine immunoassay |
| US20120301973A1 (en) * | 2011-05-24 | 2012-11-29 | Salamone Salvatore J | Clozapine immunoassay |
| WO2012167255A1 (en) * | 2011-06-03 | 2012-12-06 | The Regents Of The University Of Colorado, A Body Corporate | Anticancer prodrug therapies |
| US10782308B2 (en) | 2012-07-16 | 2020-09-22 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Direct reading detection kits for surface contamination by antineoplastic drugs |
| EP2922818B1 (en) | 2012-11-24 | 2018-09-05 | Hangzhou Dac Biotech Co., Ltd | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| AU2014384434B2 (en) | 2014-02-28 | 2016-11-03 | Hangzhou Dac Biotech Co., Ltd | Charged linkers and their uses for conjugation |
| WO2016026916A2 (en) * | 2014-08-19 | 2016-02-25 | Ecole Polytechnique Federale De Lausanne (Epfl) | Phase transfer based chemical sensing |
| NZ739830A (en) | 2015-07-12 | 2021-12-24 | Hangzhou Dac Biotech Co Ltd | Bridge linkers for conjugation of cell-binding molecules |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| KR102345175B1 (ko) | 2016-11-14 | 2021-12-31 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
| CN114149474B (zh) * | 2020-09-08 | 2024-03-19 | 鲁南制药集团股份有限公司 | 一种4’-表柔红霉素的中间体化合物及其制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996344A (en) | 1972-05-15 | 1976-12-07 | Biological Developments, Inc. | Phenethylamine antigenic conjugates, their preparation, antibodies and use |
| US4016146A (en) | 1974-12-10 | 1977-04-05 | Biological Developments, Inc. | Phenethylamine antigenic conjugates, their preparation, antibodies, and use |
| US4269511A (en) | 1979-02-15 | 1981-05-26 | Abbott Laboratories | Apparatus and method for measuring the magnitude of polarization of light |
| US4420568A (en) | 1980-07-30 | 1983-12-13 | Abbott Laboratories | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins |
| IT1223136B (it) * | 1987-11-17 | 1990-09-12 | Ist Naz Stud Cura Dei Tumori | Anticorpi monoclonali capaci di legarsi selettivamente alla doxorubicina ed analoghi e derivati |
| US4990443A (en) * | 1988-01-25 | 1991-02-05 | Boehringer Mannheim Gmbh | Hapten-protein conjugates and methods of use in immunoassays |
| IL106992A (en) | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Acylhydrazone derivatives of anthracycline and methods for their preparation |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5101015A (en) | 1989-04-10 | 1992-03-31 | Abbott Laboratories | Reagents for an amphetamine-class fluorescence polarization immunoassay |
| IT1238675B (it) | 1990-01-26 | 1993-09-01 | Ist Naz Stud Cura Dei Tumori | Anticorpo monoclonale in grado di riconoscere uno specifico epitopo di glicosidi antraciclinici e ibridoma secernente tale anticorpo |
| US5622929A (en) * | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| CA2096495C (en) | 1992-06-16 | 2002-07-09 | Kathy Palmer Ordonez | Dual analyte immunoassay |
| US20020119095A1 (en) * | 1992-07-10 | 2002-08-29 | Reinhard Gabathuler | Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours |
| AU670108B2 (en) * | 1992-09-11 | 1996-07-04 | Becton Dickinson & Company | Improved antibodies to plasmodium falciparum |
| DE4236237A1 (de) | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
| AU1140495A (en) * | 1994-01-27 | 1995-08-03 | Bristol-Myers Squibb Company | Method for preparing thioether conjugates |
| DK0871490T3 (da) * | 1995-12-22 | 2003-07-07 | Bristol Myers Squibb Co | Forgrenede hydrazonlinkere |
| WO2002013843A2 (en) * | 2000-08-17 | 2002-02-21 | University Of British Columbia | Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours |
| US7678551B2 (en) * | 2004-10-25 | 2010-03-16 | Seradyn, Inc. | Immunoassays for lamotrigine |
| CA2602849C (en) * | 2005-03-30 | 2013-06-04 | Saladax Biomedical Inc. | Doxorubicin immunoassay |
-
2006
- 2006-03-27 CA CA2602849A patent/CA2602849C/en not_active Expired - Fee Related
- 2006-03-27 EP EP20100007967 patent/EP2239573A3/en not_active Withdrawn
- 2006-03-27 ES ES06739675T patent/ES2353212T3/es active Active
- 2006-03-27 DK DK06739675.4T patent/DK1864129T3/da active
- 2006-03-27 US US11/389,934 patent/US7569358B2/en active Active
- 2006-03-27 JP JP2008504212A patent/JP4896959B2/ja not_active Expired - Fee Related
- 2006-03-27 AT AT06739675T patent/ATE476655T1/de not_active IP Right Cessation
- 2006-03-27 DE DE602006015929T patent/DE602006015929D1/de active Active
- 2006-03-27 EP EP06739675A patent/EP1864129B1/en not_active Not-in-force
- 2006-03-27 WO PCT/US2006/011022 patent/WO2006104970A1/en not_active Ceased
-
2009
- 2009-04-30 US US12/433,149 patent/US8084586B2/en not_active Expired - Fee Related
- 2009-04-30 US US12/433,111 patent/US8053205B2/en not_active Expired - Fee Related
-
2011
- 2011-09-23 US US13/242,124 patent/US20120015385A1/en not_active Abandoned
-
2012
- 2012-04-30 US US13/459,867 patent/US20120214184A1/en not_active Abandoned
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