JP2011506973A5 - - Google Patents
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- Publication number
- JP2011506973A5 JP2011506973A5 JP2010538187A JP2010538187A JP2011506973A5 JP 2011506973 A5 JP2011506973 A5 JP 2011506973A5 JP 2010538187 A JP2010538187 A JP 2010538187A JP 2010538187 A JP2010538187 A JP 2010538187A JP 2011506973 A5 JP2011506973 A5 JP 2011506973A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrophobic drug
- medium
- antibody
- bioavailability
- solubilizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims 19
- 239000003814 drug Substances 0.000 claims 19
- 230000002209 hydrophobic effect Effects 0.000 claims 19
- 239000002904 solvent Substances 0.000 claims 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 239000002207 metabolite Substances 0.000 claims 3
- 229920005862 polyol Polymers 0.000 claims 3
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000003077 polyols Chemical class 0.000 claims 2
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 2
- 150000005690 diesters Chemical class 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 239000003219 hemolytic agent Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 150000005691 triesters Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000012491 analyte Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/956,603 US7910378B2 (en) | 2007-12-14 | 2007-12-14 | Methods for detection of hydrophobic drugs |
| US11/956,603 | 2007-12-14 | ||
| PCT/US2008/086602 WO2009079374A1 (en) | 2007-12-14 | 2008-12-12 | Methods for detection of hydrophobic drugs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012021160A Division JP5571108B2 (ja) | 2007-12-14 | 2012-02-02 | 疎水性薬物検出法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506973A JP2011506973A (ja) | 2011-03-03 |
| JP2011506973A5 true JP2011506973A5 (enExample) | 2012-01-26 |
| JP4940438B2 JP4940438B2 (ja) | 2012-05-30 |
Family
ID=40753794
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538187A Active JP4940438B2 (ja) | 2007-12-14 | 2008-12-12 | 疎水性薬物検出法 |
| JP2012021160A Active JP5571108B2 (ja) | 2007-12-14 | 2012-02-02 | 疎水性薬物検出法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012021160A Active JP5571108B2 (ja) | 2007-12-14 | 2012-02-02 | 疎水性薬物検出法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7910378B2 (enExample) |
| EP (1) | EP2217926B1 (enExample) |
| JP (2) | JP4940438B2 (enExample) |
| ES (1) | ES2605247T3 (enExample) |
| WO (1) | WO2009079374A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013010952B1 (pt) | 2010-10-22 | 2020-08-25 | T2 Biosystems, Inc. | métodos para detectar a presença de um analito de ácido nucleico e uma espécie de candida em uma amostra líquida, para detectar a presença de um patógeno, um vírus e um ácido nucleico alvo em uma amostra de sangue total, e para amplificação de um ácido nucleico de patógeno alvo em uma amostra de sangue total, bem como sistema para a detecção de um ou mais analitos e cartucho removível dimensionado para facilitar inserção e remoção de um sistema |
| US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US8586322B2 (en) | 2012-03-07 | 2013-11-19 | Siemens Healthcare Diagnostics, Inc | Sandwich assay for immunosuppressant drugs |
| US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
| US9658218B2 (en) * | 2012-05-07 | 2017-05-23 | Siemens Healthcare Diagnostics Inc. | Determination of total analyte concentration |
| AR090964A1 (es) * | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
| US9121859B2 (en) * | 2012-12-04 | 2015-09-01 | Siemens Healthcare Diagnostics Inc. | Compounds and methods for determination of FKBP-binding immunosuppressant drugs |
| CN104749009B (zh) * | 2015-03-30 | 2018-05-04 | 上海云泽生物科技有限公司 | 用于免疫分析的免疫抑制剂药物提取试剂 |
| US10383860B2 (en) | 2015-07-28 | 2019-08-20 | Nippon Kayaku Kabushiki Kaisha | Pharmaceutical composition comprising rapamycin or derivative thereof, and method for producing the same |
| CA3011901A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
| WO2019131380A1 (ja) * | 2017-12-25 | 2019-07-04 | 富士レビオ株式会社 | マクロライド系免疫抑制剤についての血液検査方法 |
| JP7143678B2 (ja) * | 2018-08-24 | 2022-09-29 | 東ソー株式会社 | 標的細胞を検出する方法 |
| ES2992864T3 (en) * | 2018-11-02 | 2024-12-18 | Siemens Healthcare Diagnostics Inc | Binding competitors for use in macrophilin-binding pharmaceutical assays and methods of use thereof |
| CN114008457A (zh) * | 2019-06-28 | 2022-02-01 | 美国西门子医学诊断股份有限公司 | 使用颗粒增强凝集检测的夹心免疫测定试剂及其生产和使用方法 |
| US20210048436A1 (en) | 2019-08-15 | 2021-02-18 | Psychemedics Corporation | Homogeneous enzyme immunoassay for keratinized structures |
| CN114964939B (zh) * | 2021-12-20 | 2024-09-13 | 上海云泽生物科技有限公司 | 一种药物-蛋白解离组合物、含其的环孢霉素检测试剂盒及应用 |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4661408A (en) | 1986-03-18 | 1987-04-28 | E.I. Du Pont De Nemours And Company | Coated chromium dioxide particles |
| JPH01503808A (ja) | 1987-07-16 | 1989-12-21 | イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー（インコーポレイテツド） | 固定化された凝集剤を用いるアフイニテイ分離 |
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| US5158871A (en) | 1988-02-12 | 1992-10-27 | University Of Connecticut | Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates |
| US5147529A (en) | 1988-08-10 | 1992-09-15 | E. I. Du Pont De Nemours And Company | Method for automatically processing magnetic solid phase reagents |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| US5135863A (en) | 1988-12-23 | 1992-08-04 | Syntex (U.S.A.) Inc. | Compositions and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine |
| US5151348A (en) | 1988-12-23 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Enzyme-linked immunoassay for measurement of cyclosporin a levels in whole blood samples |
| US5101015A (en) | 1989-04-10 | 1992-03-31 | Abbott Laboratories | Reagents for an amphetamine-class fluorescence polarization immunoassay |
| US5135875A (en) * | 1990-08-15 | 1992-08-04 | Abbott Laboratories | Protein precipitation reagent |
| ES2181734T3 (es) * | 1990-11-20 | 2003-03-01 | Dade Behring Marburg Gmbh | Ensayo inmunologico de ciclosporina. |
| US5128103A (en) | 1990-12-14 | 1992-07-07 | E. I. Du Pont De Nemours And Company | Apparatus for automatically processing magnetic solid phase reagents |
| US6777190B1 (en) * | 1991-04-10 | 2004-08-17 | Biosite, Inc. | Crosstalk inhibitors and their uses |
| US5340716A (en) * | 1991-06-20 | 1994-08-23 | Snytex (U.S.A.) Inc. | Assay method utilizing photoactivated chemiluminescent label |
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| US6455288B1 (en) | 1993-04-08 | 2002-09-24 | Dade Behring Marburg Gmbh | Homogeneous immunoassays using mutant glucose-6-phosphate dehydrogenases |
| JP3498960B2 (ja) | 1993-09-03 | 2004-02-23 | デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 蛍光酸素チャンネリングイムノアッセイ |
| US6187547B1 (en) * | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
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| US6225073B1 (en) * | 1994-07-07 | 2001-05-01 | Dade Behring Marburg Gmbh | Immunoassay for mycophenolic acid |
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| CA2331587A1 (en) * | 1998-05-15 | 1999-11-25 | Katsumi Yoshikawa | Immunoassay reagents and immunoassay method |
| BR9804648A (pt) * | 1998-11-23 | 2000-05-30 | Fundacao Oswaldo Cruz | Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos. |
| US7592187B2 (en) * | 2003-10-15 | 2009-09-22 | Reverse Proteomics Research Institute Co., Ltd. | Method of calibrating ligand specificity |
| US7186518B2 (en) * | 2003-11-21 | 2007-03-06 | Dade Behring Inc. | Method and composition useful for determining FK 506 |
| US7189582B2 (en) * | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
| US7575875B2 (en) * | 2005-10-13 | 2009-08-18 | Abbott Laboratories, Inc. | Method of tacrolimus extraction and quantification using aqueous detergents |
| GB0606998D0 (en) * | 2006-04-06 | 2006-05-17 | Oxford Biosensors Ltd | Lipoprotein sensor |
| US7914999B2 (en) * | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
| ES2377167T3 (es) * | 2007-05-24 | 2012-03-23 | Abbott Laboratories | Inmunoensayos que muestran reactividad cruzada reducida con metabolitos de analito de fármacos hidrófobos |
-
2007
- 2007-12-14 US US11/956,603 patent/US7910378B2/en active Active
-
2008
- 2008-12-12 EP EP08862673.4A patent/EP2217926B1/en active Active
- 2008-12-12 WO PCT/US2008/086602 patent/WO2009079374A1/en not_active Ceased
- 2008-12-12 JP JP2010538187A patent/JP4940438B2/ja active Active
- 2008-12-12 ES ES08862673.4T patent/ES2605247T3/es active Active
-
2011
- 2011-02-14 US US13/026,756 patent/US8071317B2/en active Active
- 2011-10-27 US US13/282,957 patent/US8334104B2/en active Active
-
2012
- 2012-02-02 JP JP2012021160A patent/JP5571108B2/ja active Active
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