JP4940438B2 - 疎水性薬物検出法 - Google Patents

疎水性薬物検出法 Download PDF

Info

Publication number
JP4940438B2
JP4940438B2 JP2010538187A JP2010538187A JP4940438B2 JP 4940438 B2 JP4940438 B2 JP 4940438B2 JP 2010538187 A JP2010538187 A JP 2010538187A JP 2010538187 A JP2010538187 A JP 2010538187A JP 4940438 B2 JP4940438 B2 JP 4940438B2
Authority
JP
Japan
Prior art keywords
hydrophobic drug
drug
medium
antibody
hydrophobic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2010538187A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011506973A (ja
JP2011506973A5 (enExample
Inventor
ウェイ，ティエ・キュー
クレイグ，アラン
ポージー，エイミー
Original Assignee
シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド filed Critical シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド
Publication of JP2011506973A publication Critical patent/JP2011506973A/ja
Publication of JP2011506973A5 publication Critical patent/JP2011506973A5/ja
Application granted granted Critical
Publication of JP4940438B2 publication Critical patent/JP4940438B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493—Immunosupressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625—Dilution

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2010538187A 2007-12-14 2008-12-12 疎水性薬物検出法 Active JP4940438B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/956,603 2007-12-14
US11/956,603 US7910378B2 (en) 2007-12-14 2007-12-14 Methods for detection of hydrophobic drugs
PCT/US2008/086602 WO2009079374A1 (en) 2007-12-14 2008-12-12 Methods for detection of hydrophobic drugs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012021160A Division JP5571108B2 (ja) 2007-12-14 2012-02-02 疎水性薬物検出法

Publications (3)

Publication Number Publication Date
JP2011506973A JP2011506973A (ja) 2011-03-03
JP2011506973A5 JP2011506973A5 (enExample) 2012-01-26
JP4940438B2 true JP4940438B2 (ja) 2012-05-30

Family

ID=40753794

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010538187A Active JP4940438B2 (ja) 2007-12-14 2008-12-12 疎水性薬物検出法
JP2012021160A Active JP5571108B2 (ja) 2007-12-14 2012-02-02 疎水性薬物検出法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012021160A Active JP5571108B2 (ja) 2007-12-14 2012-02-02 疎水性薬物検出法

Country Status (5)

Country Link
US (3) US7910378B2 (enExample)
EP (1) EP2217926B1 (enExample)
JP (2) JP4940438B2 (enExample)
ES (1) ES2605247T3 (enExample)
WO (1) WO2009079374A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP3974831A1 (en) 2010-10-22 2022-03-30 T2 Biosystems, Inc. Methods for detecting the presence of a bacterium in a whole blood sample
US8586322B2 (en) 2012-03-07 2013-11-19 Siemens Healthcare Diagnostics, Inc Sandwich assay for immunosuppressant drugs
WO2013158281A1 (en) 2012-04-20 2013-10-24 T2 Biosystems, Inc. Compositions and methods for detection of candida species
US9658218B2 (en) * 2012-05-07 2017-05-23 Siemens Healthcare Diagnostics Inc. Determination of total analyte concentration
AR090964A1 (es) 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
US9121859B2 (en) * 2012-12-04 2015-09-01 Siemens Healthcare Diagnostics Inc. Compounds and methods for determination of FKBP-binding immunosuppressant drugs
CN104749009B (zh) * 2015-03-30 2018-05-04 上海云泽生物科技有限公司 用于免疫分析的免疫抑制剂药物提取试剂
WO2017018433A1 (ja) 2015-07-28 2017-02-02 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物及びその製造方法
US11519016B2 (en) 2016-01-21 2022-12-06 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
WO2019131380A1 (ja) * 2017-12-25 2019-07-04 富士レビオ株式会社 マクロライド系免疫抑制剤についての血液検査方法
JP7143678B2 (ja) * 2018-08-24 2022-09-29 東ソー株式会社 標的細胞を検出する方法
EP3873509B1 (en) * 2018-11-02 2024-06-12 Siemens Healthcare Diagnostics, Inc. Binding competitors for use in macrophilin-binding pharmaceutical assays and methods of use thereof
EP3990923A4 (en) * 2019-06-28 2022-08-31 Siemens Healthcare Diagnostics, Inc. REAGENTS FOR SANDWICH IMMUNOASSAYS USING IMPROVED AGGLUTINATION DETECTION MEANS OF PARTICLES, AND METHODS OF MAKING AND USE THEREOF
US20210048436A1 (en) * 2019-08-15 2021-02-18 Psychemedics Corporation Homogeneous enzyme immunoassay for keratinized structures
CN114964939B (zh) * 2021-12-20 2024-09-13 上海云泽生物科技有限公司 一种药物-蛋白解离组合物、含其的环孢霉素检测试剂盒及应用
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same
WO2026052704A1 (en) * 2024-09-05 2026-03-12 Roche Diagnostics Gmbh Extraction of macrocyclic analytes
CN122218056B (zh) * 2026-04-23 2026-07-24 杭州市第一人民医院(西湖大学附属杭州市第一人民医院) 基于胶束三重富集效应的电化学发光信号增强方法、传感器及应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4661408A (en) 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles
EP0367795A4 (en) 1987-07-16 1992-01-15 E.I. Du Pont De Nemours And Company Affinity separating using immobilized flocculating reagents
US5089390A (en) 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
US5158871A (en) 1988-02-12 1992-10-27 University Of Connecticut Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates
US5147529A (en) 1988-08-10 1992-09-15 E. I. Du Pont De Nemours And Company Method for automatically processing magnetic solid phase reagents
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5151348A (en) 1988-12-23 1992-09-29 E. I. Du Pont De Nemours And Company Enzyme-linked immunoassay for measurement of cyclosporin a levels in whole blood samples
US5135863A (en) 1988-12-23 1992-08-04 Syntex (U.S.A.) Inc. Compositions and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine
US5101015A (en) 1989-04-10 1992-03-31 Abbott Laboratories Reagents for an amphetamine-class fluorescence polarization immunoassay
US5135875A (en) * 1990-08-15 1992-08-04 Abbott Laboratories Protein precipitation reagent
CA2055813A1 (en) 1990-11-20 1992-05-21 Dariush Davalian Cyclosporin immunoassay
US5128103A (en) 1990-12-14 1992-07-07 E. I. Du Pont De Nemours And Company Apparatus for automatically processing magnetic solid phase reagents
US6777190B1 (en) 1991-04-10 2004-08-17 Biosite, Inc. Crosstalk inhibitors and their uses
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
JPH06509646A (ja) 1991-07-26 1994-10-27 デイド・ケミストリイ・システムズ・インコーポレーテツド 懸濁された固体支持体の存在下でのシグナル検出アッセイ
US6455288B1 (en) 1993-04-08 2002-09-24 Dade Behring Marburg Gmbh Homogeneous immunoassays using mutant glucose-6-phosphate dehydrogenases
WO1995006877A1 (en) 1993-09-03 1995-03-09 Behringwerke Ag Fluorescent oxygen channeling immunoassays
US6187547B1 (en) 1993-09-08 2001-02-13 Novartis Ag Assay kit
US5565326A (en) 1994-05-31 1996-10-15 Johnson & Johnson Clinical Diagnostics, Inc. Separation-free specific binding assays using anti-inhibitor antibodies
US6225073B1 (en) 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
US5650288A (en) 1995-07-14 1997-07-22 Macfarlane; Gordon D. Immunophilin-bound immunosuppressant assay
JP3706895B2 (ja) 1996-07-18 2005-10-19 ベーリングウエルケ、アクティエンゲゼルシャフト リガンド検定用試薬
US6231982B1 (en) 1997-12-10 2001-05-15 Dade Behring Inc. Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group
AU751938B2 (en) 1998-05-15 2002-08-29 Sekisui Chemical Co., Ltd. Immunoassay reagents and immunoassay method
BR9804648A (pt) 1998-11-23 2000-05-30 Fundacao Oswaldo Cruz Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos.
US7592187B2 (en) 2003-10-15 2009-09-22 Reverse Proteomics Research Institute Co., Ltd. Method of calibrating ligand specificity
US7186518B2 (en) * 2003-11-21 2007-03-06 Dade Behring Inc. Method and composition useful for determining FK 506
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
US7575875B2 (en) 2005-10-13 2009-08-18 Abbott Laboratories, Inc. Method of tacrolimus extraction and quantification using aqueous detergents
GB0606998D0 (en) * 2006-04-06 2006-05-17 Oxford Biosensors Ltd Lipoprotein sensor
US7914999B2 (en) * 2006-12-29 2011-03-29 Abbott Laboratories Non-denaturing lysis reagent
ATE535813T1 (de) * 2007-05-24 2011-12-15 Abbott Lab Reduzierte kreuzreaktivität mit hydrophoben arzneistoffanalyt-stoffwechselprodukten zeigende immuntestverfahren

Also Published As

Publication number Publication date
ES2605247T3 (es) 2017-03-13
US7910378B2 (en) 2011-03-22
US20110136136A1 (en) 2011-06-09
EP2217926A4 (en) 2011-04-06
WO2009079374A1 (en) 2009-06-25
US20090155929A1 (en) 2009-06-18
JP2011506973A (ja) 2011-03-03
US8071317B2 (en) 2011-12-06
US20120064546A1 (en) 2012-03-15
US8334104B2 (en) 2012-12-18
EP2217926B1 (en) 2016-10-05
JP5571108B2 (ja) 2014-08-13
JP2012112971A (ja) 2012-06-14
EP2217926A1 (en) 2010-08-18

Similar Documents

Publication Publication Date Title
JP5571108B2 (ja) 疎水性薬物検出法
JP5690888B2 (ja) 免疫抑制剤の検出方法
US12111310B2 (en) Pretreatment agent in non-agglutination assays
EP2585832B1 (en) Reduction in false results in assay measurements
EP2847588B1 (en) Determination of total analyte concentration
US8084223B2 (en) Detection of false results in assays
US8809003B2 (en) Reduction in false results in assay measurements
US4433058A (en) Membrane receptor assay

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111017

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20111017

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20111017

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20111114

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20111205

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120110

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120202

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

Ref document number: 4940438

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150309

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250