JP2008535909A5 - - Google Patents
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- Publication number
- JP2008535909A5 JP2008535909A5 JP2008506051A JP2008506051A JP2008535909A5 JP 2008535909 A5 JP2008535909 A5 JP 2008535909A5 JP 2008506051 A JP2008506051 A JP 2008506051A JP 2008506051 A JP2008506051 A JP 2008506051A JP 2008535909 A5 JP2008535909 A5 JP 2008535909A5
- Authority
- JP
- Japan
- Prior art keywords
- ccr2
- molecule
- mcp
- amino acid
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 22
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 22
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 13
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000003937 drug carrier Substances 0.000 claims 9
- 206010003210 Arteriosclerosis Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 206010001889 Alveolitis Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 2
- 206010006448 Bronchiolitis Diseases 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010024305 Leukaemia monocytic Diseases 0.000 claims 2
- 206010028851 Necrosis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 229920000147 Styrene maleic anhydride Polymers 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 206010009887 colitis Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 2
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000004005 microsphere Substances 0.000 claims 2
- 201000006894 monocytic leukemia Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 230000017074 necrotic cell death Effects 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 229960000834 vinyl ether Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67147605P | 2005-04-15 | 2005-04-15 | |
| PCT/IL2006/000454 WO2006109301A2 (en) | 2005-04-15 | 2006-04-10 | Molecules and methods of using same for treating mcp-1/ccr2 associated diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008535909A JP2008535909A (ja) | 2008-09-04 |
| JP2008535909A5 true JP2008535909A5 (cg-RX-API-DMAC7.html) | 2009-04-02 |
Family
ID=36688002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506051A Pending JP2008535909A (ja) | 2005-04-15 | 2006-04-10 | Ｍｃｐ−１／ｃｃｒ２関連疾患を治療するための分子およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8388962B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1871798B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008535909A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101160323A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE445644T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006233927A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2597789A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE602006009786D1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2333358T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007010484A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006109301A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE445644T1 (de) | 2005-04-15 | 2009-10-15 | Rappaport Family Inst For Res | Anwendung von molekülen und verfahren zur behandlung von mit mcp-1/ccr2 assoziierten krankheiten |
| WO2007100920A2 (en) * | 2006-03-01 | 2007-09-07 | The Regents Of The University Of Michigan | Diagnosis and treatment of prostate cancer |
| WO2009028411A1 (ja) * | 2007-08-24 | 2009-03-05 | Keio University | 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 |
| CN102370981B (zh) * | 2010-08-11 | 2014-07-16 | 中国科学院上海生命科学研究院 | 防治神经退行性疾病的试剂和方法 |
| KR20160036564A (ko) * | 2013-08-06 | 2016-04-04 | 고쿠리쓰다이가쿠호진 규슈다이가쿠 | 유기산 중합체를 유효 성분으로 하는 암 세포의 생착 예방 또는 생착 억제를 위한 의약 |
| NO2776305T3 (cg-RX-API-DMAC7.html) | 2014-04-23 | 2018-01-27 | ||
| CN107362353A (zh) * | 2016-05-11 | 2017-11-21 | 上海长海医院 | 一种去势抵抗的前列腺癌相关的药物靶点及其应用 |
| KR102308102B1 (ko) * | 2018-05-18 | 2021-10-07 | 가톨릭대학교 산학협력단 | Ccr2를 유효성분으로 포함하는 골질환의 예방 또는 치료용 조성물 |
| KR102308099B1 (ko) * | 2019-11-15 | 2021-10-01 | 가톨릭대학교 산학협력단 | Soluble CCR2 발현 유도된 줄기세포를 유효성분으로 포함하는 골질환의 예방 또는 치료용 조성물 |
| US20220409698A1 (en) * | 2019-11-15 | 2022-12-29 | The Catholic University Of Korea Industry-Academic Cooperation Foundation | Composition for preventing or treating bone diseases comprising ccr2 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3532570B2 (ja) * | 1994-01-13 | 2004-05-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 哺乳類単球化学誘引物質タンパク質レセプター |
| SE9600820D0 (sv) | 1996-03-01 | 1996-03-01 | Pharmacia Ab | Antibodies and their use |
| US6528625B1 (en) * | 1996-10-28 | 2003-03-04 | Millennium Pharmaceuticals, Inc. | Anti-CCR5 antibodies and kits comprising same |
| AU2001241463A1 (en) | 2000-02-09 | 2001-08-20 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor (CCR5) HDGNR10 |
| FR2828102B1 (fr) * | 2001-03-28 | 2004-07-09 | Ifc Sa | Utilisation des lipoaminoacides dans une composition pharmaceutique comme promoteur et systeme disperse a usage pharmaceutique contenant de tels composes |
| KR100453877B1 (ko) * | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| CA2531526C (en) | 2003-07-24 | 2012-08-21 | Amgen Inc. | Compositions and methods relating to multimeric and oligomeric soluble fragments of the tweak receptor |
| IL157398A0 (en) | 2003-08-14 | 2004-02-19 | Hadasit Med Res Service | Pharmaceutical compositions comprising ccr5 antagonists |
| GB2423472A (en) | 2003-12-11 | 2006-08-30 | Univ Yale | Methods and compositions relating to ccr5 antagonist,ifn-&gammed;and il-13 induced inflammation |
| US20050215543A1 (en) | 2004-03-24 | 2005-09-29 | Pin-Fang Lin | Methods of treating HIV infection |
| ATE445644T1 (de) | 2005-04-15 | 2009-10-15 | Rappaport Family Inst For Res | Anwendung von molekülen und verfahren zur behandlung von mit mcp-1/ccr2 assoziierten krankheiten |
-
2006
- 2006-04-10 AT AT06728255T patent/ATE445644T1/de not_active IP Right Cessation
- 2006-04-10 ES ES06728255T patent/ES2333358T3/es active Active
- 2006-04-10 US US11/883,725 patent/US8388962B2/en not_active Expired - Fee Related
- 2006-04-10 AU AU2006233927A patent/AU2006233927A1/en not_active Abandoned
- 2006-04-10 DE DE602006009786T patent/DE602006009786D1/de active Active
- 2006-04-10 JP JP2008506051A patent/JP2008535909A/ja active Pending
- 2006-04-10 MX MX2007010484A patent/MX2007010484A/es active IP Right Grant
- 2006-04-10 CA CA002597789A patent/CA2597789A1/en not_active Abandoned
- 2006-04-10 CN CNA2006800125405A patent/CN101160323A/zh active Pending
- 2006-04-10 EP EP06728255A patent/EP1871798B1/en not_active Not-in-force
- 2006-04-10 WO PCT/IL2006/000454 patent/WO2006109301A2/en not_active Ceased
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