JP2008535830A5 - - Google Patents

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Publication number
JP2008535830A5
JP2008535830A5 JP2008504337A JP2008504337A JP2008535830A5 JP 2008535830 A5 JP2008535830 A5 JP 2008535830A5 JP 2008504337 A JP2008504337 A JP 2008504337A JP 2008504337 A JP2008504337 A JP 2008504337A JP 2008535830 A5 JP2008535830 A5 JP 2008535830A5
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JP
Japan
Prior art keywords
compound
methyl
cancer
chk1
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008504337A
Other languages
English (en)
Japanese (ja)
Other versions
JP5117374B2 (ja
JP2008535830A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/011584 external-priority patent/WO2006105262A1/en
Publication of JP2008535830A publication Critical patent/JP2008535830A/ja
Publication of JP2008535830A5 publication Critical patent/JP2008535830A5/ja
Application granted granted Critical
Publication of JP5117374B2 publication Critical patent/JP5117374B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2008504337A 2005-03-29 2006-03-29 Chk1阻害に有用なヘテロアリール尿素誘導体 Expired - Fee Related JP5117374B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66602605P 2005-03-29 2005-03-29
US60/666,026 2005-03-29
PCT/US2006/011584 WO2006105262A1 (en) 2005-03-29 2006-03-29 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009122107A Division JP2009227682A (ja) 2005-03-29 2009-05-20 Chk1阻害に有用なヘテロアリール尿素誘導体

Publications (3)

Publication Number Publication Date
JP2008535830A JP2008535830A (ja) 2008-09-04
JP2008535830A5 true JP2008535830A5 (enExample) 2009-07-09
JP5117374B2 JP5117374B2 (ja) 2013-01-16

Family

ID=36677174

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008504337A Expired - Fee Related JP5117374B2 (ja) 2005-03-29 2006-03-29 Chk1阻害に有用なヘテロアリール尿素誘導体
JP2009122107A Pending JP2009227682A (ja) 2005-03-29 2009-05-20 Chk1阻害に有用なヘテロアリール尿素誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009122107A Pending JP2009227682A (ja) 2005-03-29 2009-05-20 Chk1阻害に有用なヘテロアリール尿素誘導体

Country Status (31)

Country Link
US (1) US8093244B2 (enExample)
EP (2) EP1869020B1 (enExample)
JP (2) JP5117374B2 (enExample)
KR (2) KR20090031459A (enExample)
CN (2) CN102219784A (enExample)
AR (1) AR056645A1 (enExample)
AT (1) ATE490248T1 (enExample)
AU (1) AU2006230337B2 (enExample)
BR (1) BRPI0609667A2 (enExample)
CA (1) CA2602199C (enExample)
CR (1) CR9395A (enExample)
CY (1) CY1111240T1 (enExample)
DE (1) DE602006018590D1 (enExample)
DK (1) DK1869020T3 (enExample)
EA (1) EA011287B1 (enExample)
ES (1) ES2356068T3 (enExample)
HR (1) HRP20100678T1 (enExample)
IL (1) IL185481A0 (enExample)
MA (1) MA29439B1 (enExample)
MX (1) MX2007012116A (enExample)
NO (1) NO20074944L (enExample)
NZ (1) NZ561458A (enExample)
PL (1) PL1869020T3 (enExample)
PT (1) PT1869020E (enExample)
RS (1) RS51616B (enExample)
SI (1) SI1869020T1 (enExample)
TN (1) TNSN07369A1 (enExample)
TW (1) TWI375559B (enExample)
UA (1) UA92164C2 (enExample)
WO (1) WO2006105262A1 (enExample)
ZA (1) ZA200707715B (enExample)

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CN101200429B (zh) * 2006-12-13 2012-08-22 上海睿智化学研究有限公司 2-硝基-4,5-二卤代苯酚类和2-氨基-4,5-二卤代苯酚类及其盐及其合成方法
GB201008005D0 (en) 2010-05-13 2010-06-30 Sentinel Oncology Ltd Pharmaceutical compounds
AU2014293013A1 (en) 2013-07-26 2016-03-17 Race Oncology Ltd. Combinatorial methods to improve the therapeutic benefit of bisantrene
AU2015277212B2 (en) 2014-06-17 2020-07-02 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of Chk1 and ATR inhibitors
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
RU2768621C1 (ru) 2015-09-30 2022-03-24 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr
HRP20220351T1 (hr) 2016-02-04 2022-05-13 Pharmaengine, Inc. 3,5-disupstituirani pirazoli korisni kao inhibitori kinaze 1 kontrolne točke (chk1), i njihove pripreme i primjene
SG10201913331VA (en) 2016-03-15 2020-03-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
MX2019011506A (es) * 2017-03-31 2019-11-01 Seattle Genetics Inc Inhibicion de cinasa 1 de punto de control (chk1) para el tratamiento de cancer.
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
CN112457306A (zh) 2019-09-06 2021-03-09 上海瑛派药业有限公司 3,5-二取代吡唑化合物作为激酶抑制剂及其应用
WO2021183973A1 (en) * 2020-03-13 2021-09-16 Research Development Foundation Methods for diagnosing and treating cancers

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US6174993B1 (en) 1997-05-21 2001-01-16 The Children's Medical Center Corp. Short peptides which selectively modulate the activity of serine/threonine kinases
US6218109B1 (en) 1997-09-05 2001-04-17 Baylor College Of Medicine Mammalian checkpoint genes and proteins
GB9718952D0 (en) 1997-09-05 1997-11-12 Medical Res Council Mammalian chk1 effector cell cycle checkpoint protein kinase materials and methods
PT1023063E (pt) 1997-10-06 2004-02-27 Abbott Gmbh & Co Kg Derivados de indeno¬1,2-c|- nafto¬1,2-c|- e benzo¬6,7|ciclo-hepta¬1,2-c|pirazole
JP2002526450A (ja) 1998-09-18 2002-08-20 スミスクライン・ビーチャム・コーポレイション Chk1キナーゼ阻害物質
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
AU3974001A (en) 2000-02-03 2001-08-14 Ali R. Fattaey Method and reagent for the inhibition of checkpoint kinase-1 (chk 1) enzyme
WO2001062900A1 (en) 2000-02-25 2001-08-30 The Regents Of The University Of California. Scytonemin and methods of using thereof
US6211164B1 (en) 2000-03-10 2001-04-03 Abbott Laboratories Antisense oligonucleotides of the human chk1 gene and uses thereof
US6534691B2 (en) 2000-07-18 2003-03-18 E. I. Du Pont De Nemours And Company Manufacturing process for α-olefins
ATE295354T1 (de) 2000-08-18 2005-05-15 Agouron Pharma Heterozyklische-hydroximino-fluorene und ihre verwendung zur inhibierung von proteinkinasen
CA2434066A1 (en) 2001-01-26 2002-09-12 Pharmacia Italia S.P.A. Chromane derivatives, process for their preparation and their use as antitumor agents
UA76977C2 (en) * 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
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MXPA04010617A (es) 2002-04-26 2004-12-13 Warner Lambert Co Inhibidores de quinasa de puntos de control (wee1 y chk1).
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EP1539754A4 (en) 2002-08-23 2009-02-25 Novartis Vaccines & Diagnostic BENZIMIDAZOCHINOLINONE AND ITS USE
EA200500721A1 (ru) 2002-11-28 2005-12-29 Шеринг Акциенгезельшафт Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств
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CA2679908A1 (en) 2009-09-23 2011-03-23 Shell Internationale Research Maatschappij B.V. Closed loop solvent extraction process for oil sands
CN104407475B (zh) 2014-12-04 2017-04-05 厦门天马微电子有限公司 液晶显示面板

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