CY1111240T1 - Παραγωγα ετεροαρυλουριας χρησιμα για την αναστολη της chk1 - Google Patents

Παραγωγα ετεροαρυλουριας χρησιμα για την αναστολη της chk1

Info

Publication number
CY1111240T1
CY1111240T1 CY20111100117T CY111100117T CY1111240T1 CY 1111240 T1 CY1111240 T1 CY 1111240T1 CY 20111100117 T CY20111100117 T CY 20111100117T CY 111100117 T CY111100117 T CY 111100117T CY 1111240 T1 CY1111240 T1 CY 1111240T1
Authority
CY
Cyprus
Prior art keywords
chk1
hetero
inhibition
derivatives useful
aryl derivatives
Prior art date
Application number
CY20111100117T
Other languages
Greek (el)
English (en)
Inventor
Frank Diaz
Francine S Farouz
Ryan Holcomb
Edward A Kesicki
Hua Chee Ooi
Alexander Rudolph
Frank Stappenbeck
Eugene Thorsett
John Joseph Gaudino
Kimba L Fisher
Adam Wade Cook
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of CY1111240T1 publication Critical patent/CY1111240T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
CY20111100117T 2005-03-29 2011-02-03 Παραγωγα ετεροαρυλουριας χρησιμα για την αναστολη της chk1 CY1111240T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66602605P 2005-03-29 2005-03-29
EP06748900A EP1869020B1 (en) 2005-03-29 2006-03-29 Heteroaryl urea derivatives useful for inhibiting chk1

Publications (1)

Publication Number Publication Date
CY1111240T1 true CY1111240T1 (el) 2015-06-11

Family

ID=36677174

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100117T CY1111240T1 (el) 2005-03-29 2011-02-03 Παραγωγα ετεροαρυλουριας χρησιμα για την αναστολη της chk1

Country Status (31)

Country Link
US (1) US8093244B2 (enExample)
EP (2) EP1869020B1 (enExample)
JP (2) JP5117374B2 (enExample)
KR (2) KR100912998B1 (enExample)
CN (2) CN102219784A (enExample)
AR (1) AR056645A1 (enExample)
AT (1) ATE490248T1 (enExample)
AU (1) AU2006230337B2 (enExample)
BR (1) BRPI0609667A2 (enExample)
CA (1) CA2602199C (enExample)
CR (1) CR9395A (enExample)
CY (1) CY1111240T1 (enExample)
DE (1) DE602006018590D1 (enExample)
DK (1) DK1869020T3 (enExample)
EA (1) EA011287B1 (enExample)
ES (1) ES2356068T3 (enExample)
HR (1) HRP20100678T1 (enExample)
IL (1) IL185481A0 (enExample)
MA (1) MA29439B1 (enExample)
MX (1) MX2007012116A (enExample)
NO (1) NO20074944L (enExample)
NZ (1) NZ561458A (enExample)
PL (1) PL1869020T3 (enExample)
PT (1) PT1869020E (enExample)
RS (1) RS51616B (enExample)
SI (1) SI1869020T1 (enExample)
TN (1) TNSN07369A1 (enExample)
TW (1) TWI375559B (enExample)
UA (1) UA92164C2 (enExample)
WO (1) WO2006105262A1 (enExample)
ZA (1) ZA200707715B (enExample)

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CN101200429B (zh) * 2006-12-13 2012-08-22 上海睿智化学研究有限公司 2-硝基-4,5-二卤代苯酚类和2-氨基-4,5-二卤代苯酚类及其盐及其合成方法
GB201008005D0 (en) 2010-05-13 2010-06-30 Sentinel Oncology Ltd Pharmaceutical compounds
CA2938626A1 (en) 2013-07-26 2015-01-29 John Rothman Compositions to improve the therapeutic benefit of bisantrene
SG11201610500WA (en) 2014-06-17 2017-01-27 Vertex Pharma Method for treating cancer using a combination of chk1 and atr inhibitors
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
KR102678021B1 (ko) 2015-09-30 2024-06-26 버텍스 파마슈티칼스 인코포레이티드 Dna 손상제와 병용되는, atr 저해제를 포함하는 암 치료용 약제학적 조성물
PT3411036T (pt) 2016-02-04 2022-02-21 Pharmaengine Inc Pirazóis 3,5-dissubstituídos úteis como inibidores da checkpoint quinase 1 (chk1) e as suas preparações e aplicações
JP7158023B2 (ja) 2016-03-15 2022-10-21 オリソン ヘノミクス エセ. アー. 固形腫瘍の治療における使用のための、lsd1阻害剤の組合せ
EP3600247A1 (en) * 2017-03-31 2020-02-05 Seattle Genetics, Inc. Combinations of chk1- and wee1 - inhibitors
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
CN112457306A (zh) 2019-09-06 2021-03-09 上海瑛派药业有限公司 3,5-二取代吡唑化合物作为激酶抑制剂及其应用
US12404332B2 (en) * 2020-03-13 2025-09-02 Research Development Foundation Methods for diagnosing and treating cancers

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US6174993B1 (en) 1997-05-21 2001-01-16 The Children's Medical Center Corp. Short peptides which selectively modulate the activity of serine/threonine kinases
GB9718952D0 (en) 1997-09-05 1997-11-12 Medical Res Council Mammalian chk1 effector cell cycle checkpoint protein kinase materials and methods
US6218109B1 (en) 1997-09-05 2001-04-17 Baylor College Of Medicine Mammalian checkpoint genes and proteins
DE69818083T2 (de) 1997-10-06 2004-07-08 Abbott Gmbh & Co. Kg INDENO[1,2-c]-,NAPHTHO[1,2-C]-UND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLDERIVATE
EP1135135A4 (en) 1998-09-18 2006-08-09 Smithkline Beecham Corp CHK1 KINASE INHIBITORS
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
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Also Published As

Publication number Publication date
ES2356068T3 (es) 2011-04-04
CN102219784A (zh) 2011-10-19
NZ561458A (en) 2011-03-31
EA200702094A1 (ru) 2008-02-28
NO20074944L (no) 2007-10-24
HRP20100678T1 (hr) 2011-02-28
PL1869020T3 (pl) 2011-05-31
EA011287B1 (ru) 2009-02-27
JP2008535830A (ja) 2008-09-04
AR056645A1 (es) 2007-10-17
CA2602199A1 (en) 2006-10-05
DK1869020T3 (da) 2011-01-24
IL185481A0 (en) 2008-01-06
SI1869020T1 (sl) 2011-02-28
KR20070107178A (ko) 2007-11-06
RS51616B (sr) 2011-08-31
TNSN07369A1 (en) 2008-12-31
US20090143357A1 (en) 2009-06-04
US8093244B2 (en) 2012-01-10
JP5117374B2 (ja) 2013-01-16
ATE490248T1 (de) 2010-12-15
ZA200707715B (en) 2009-09-30
CN101151259A (zh) 2008-03-26
UA92164C2 (ru) 2010-10-11
TWI375559B (en) 2012-11-01
CA2602199C (en) 2013-09-10
BRPI0609667A2 (pt) 2010-04-20
PT1869020E (pt) 2010-12-23
AU2006230337B2 (en) 2011-10-27
AU2006230337A1 (en) 2006-10-05
KR20090031459A (ko) 2009-03-25
MX2007012116A (es) 2008-04-08
MA29439B1 (fr) 2008-05-02
JP2009227682A (ja) 2009-10-08
EP1869020A1 (en) 2007-12-26
EP1869020B1 (en) 2010-12-01
TW200722090A (en) 2007-06-16
CR9395A (es) 2008-03-31
EP2330105A1 (en) 2011-06-08
WO2006105262A1 (en) 2006-10-05
HK1119670A1 (en) 2009-03-13
DE602006018590D1 (de) 2011-01-13
KR100912998B1 (ko) 2009-08-20
CN101151259B (zh) 2011-06-15

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