CY1108266T1 - Παραγωγα διβενζο(c) χρωμεν-6-ονης ως αντικαρκινικοι παραγοντες - Google Patents

Παραγωγα διβενζο(c) χρωμεν-6-ονης ως αντικαρκινικοι παραγοντες

Info

Publication number
CY1108266T1
CY1108266T1 CY20081100872T CY081100872T CY1108266T1 CY 1108266 T1 CY1108266 T1 CY 1108266T1 CY 20081100872 T CY20081100872 T CY 20081100872T CY 081100872 T CY081100872 T CY 081100872T CY 1108266 T1 CY1108266 T1 CY 1108266T1
Authority
CY
Cyprus
Prior art keywords
cancer
divenzo
chrome
products
endothelial cells
Prior art date
Application number
CY20081100872T
Other languages
English (en)
Inventor
Jonathan Martin Schmidt
Peter Redden
Julie Mercure
Shuguang Zhu
John Whelan
Natalie Lazarowych
Original Assignee
Paloma Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paloma Pharmaceuticals, Inc. filed Critical Paloma Pharmaceuticals, Inc.
Publication of CY1108266T1 publication Critical patent/CY1108266T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/908—Mechanical repair performed/surgical
    • Y10S977/911—Cancer cell destruction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/908—Mechanical repair performed/surgical
    • Y10S977/912—Cancer cell repair

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Περιγράφονται μέθοδοι σύνθεσεις και μόρια που εμφανίζουν αντιπολλαπλασιαστική δράση σε καρκινικές κυτταρικές γραμμές του επιθηλίου και κύτταρα ενδοθηλίου. Τα μόρια προορίζονται για χρήση σε θεραπευτικά παρασκευάσματα για τη θεραπεία του καρκίκου μέσω είτε αντιαγγειογένεσης ή άλλων αντικαρκινικών μηχανισμών. Οι αναφερόμενες ενώσεις είναι παράγωγα 6H-διβενζο[b,d]πυραν-6-όνης και έχουν αντιπολλαπλασιαστική δράση στα ανθρώπινα κύτταρα του επιθηλίου.
CY20081100872T 2001-02-22 2008-08-18 Παραγωγα διβενζο(c) χρωμεν-6-ονης ως αντικαρκινικοι παραγοντες CY1108266T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27019801P 2001-02-22 2001-02-22
US09/934,086 US6632835B2 (en) 2001-02-22 2001-08-21 Dibenzo[c]chromen-6-one derivatives as anti-cancer agents
EP02701135A EP1373260B1 (en) 2001-02-22 2002-02-21 Dibenzo c chromen-6-one derivatives as anti-cancer agents

Publications (1)

Publication Number Publication Date
CY1108266T1 true CY1108266T1 (el) 2014-02-12

Family

ID=26954131

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100872T CY1108266T1 (el) 2001-02-22 2008-08-18 Παραγωγα διβενζο(c) χρωμεν-6-ονης ως αντικαρκινικοι παραγοντες

Country Status (11)

Country Link
US (1) US6632835B2 (el)
EP (1) EP1373260B1 (el)
AT (1) ATE396989T1 (el)
AU (1) AU2002234466B2 (el)
CA (1) CA2438713C (el)
CY (1) CY1108266T1 (el)
DE (1) DE60226851D1 (el)
DK (1) DK1373260T3 (el)
ES (1) ES2307721T3 (el)
PT (1) PT1373260E (el)
WO (1) WO2002066467A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101002822B1 (ko) * 2002-10-30 2010-12-21 스미또모 가가꾸 가부시키가이샤 고분자 화합물 및 이를 이용한 고분자 발광 소자
US20060257337A1 (en) * 2005-04-28 2006-11-16 David Sherris Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
USRE46558E1 (en) 2005-04-28 2017-09-26 Paloma Pharmaceuticals, Inc. Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis
CA2643579C (en) * 2006-02-28 2018-05-15 Paloma Pharmaceuticals, Inc. Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis
CN101431893B (zh) * 2006-02-28 2013-09-04 帕洛马医药公司 治疗具有细胞增殖和血管生成特征的疾病的组合物和方法
MX2010010431A (es) * 2008-03-25 2010-11-25 Paloma Pharmaceuticals Inc Metodos para tratar desordenes fibroticos.
US9381187B2 (en) 2011-02-16 2016-07-05 Paloma Pharmaceuticals, Inc. Radiation countermeasure agents
KR101498671B1 (ko) * 2012-02-03 2015-03-06 한국생명공학연구원 신규한 항균성 화합물

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3573327A (en) * 1970-03-23 1971-03-30 Searle & Co 3-(lower alkoxy)-7,8,9,10-tetrahydro-6h-dibenzo-(b,d) pyran-6,9-diones and derivatives thereof
US5268384A (en) 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
US5359134A (en) * 1992-08-14 1994-10-25 Eastman Chemical Company Process for preparing phenylterephthalic acid
US5763441A (en) 1992-11-13 1998-06-09 Sugen, Inc. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5643900A (en) 1993-07-02 1997-07-01 Fotsis; Theodore Method for treatment of pathological conditions associated with angiogenesis and preparation therefor
US5504074A (en) 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
UA32427C2 (uk) 1993-10-15 2000-12-15 Елі Ліллі Енд Компані Застосування бензотіофенів або їх фармацевтично прийнятних солей або сольватів для інгібування ангіогенезу і/або ангіогенних захворювань
US5646136A (en) 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
US5753230A (en) 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US5639725A (en) 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
US5843925A (en) 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
MXPA02005103A (es) * 1999-10-18 2003-09-25 Alexipharma Inc Ligandos selectivos del receptor de canabinoide (cb2) perifericos.

Also Published As

Publication number Publication date
EP1373260A1 (en) 2004-01-02
DK1373260T3 (da) 2008-09-29
DE60226851D1 (de) 2008-07-10
US6632835B2 (en) 2003-10-14
US20020115711A1 (en) 2002-08-22
ATE396989T1 (de) 2008-06-15
CA2438713C (en) 2011-04-26
CA2438713A1 (en) 2002-08-29
EP1373260B1 (en) 2008-05-28
WO2002066467A1 (en) 2002-08-29
AU2002234466B2 (en) 2006-02-16
ES2307721T3 (es) 2008-12-01
PT1373260E (pt) 2008-09-05

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