JP2008535493A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008535493A5 JP2008535493A5 JP2008505602A JP2008505602A JP2008535493A5 JP 2008535493 A5 JP2008535493 A5 JP 2008535493A5 JP 2008505602 A JP2008505602 A JP 2008505602A JP 2008505602 A JP2008505602 A JP 2008505602A JP 2008535493 A5 JP2008535493 A5 JP 2008535493A5
- Authority
- JP
- Japan
- Prior art keywords
- dendritic cells
- rna
- monocytes
- ratio
- mature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004443 Dendritic Cells Anatomy 0.000 claims 27
- 210000001616 Monocytes Anatomy 0.000 claims 15
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 9
- 210000003819 Peripheral blood mononuclear cell Anatomy 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000038129 antigens Human genes 0.000 claims 4
- 108091007172 antigens Proteins 0.000 claims 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 4
- 102100011550 ACTB Human genes 0.000 claims 3
- 101700033661 ACTB Proteins 0.000 claims 3
- 101710032514 ACTI Proteins 0.000 claims 3
- 102100006400 CSF2 Human genes 0.000 claims 3
- 101710037135 GAPC2 Proteins 0.000 claims 3
- 101710037116 GAPC3 Proteins 0.000 claims 3
- 101710025049 GAPDG Proteins 0.000 claims 3
- 101710008404 GAPDH Proteins 0.000 claims 3
- 102100006425 GAPDH Human genes 0.000 claims 3
- 101710010461 Gapdh1 Proteins 0.000 claims 3
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 3
- 101710025050 MK0970 Proteins 0.000 claims 3
- 101710025091 cbbGC Proteins 0.000 claims 3
- 210000004027 cells Anatomy 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 101710025070 gapdh-2 Proteins 0.000 claims 3
- 108010029697 CD40 Ligand Proteins 0.000 claims 2
- 102100003729 CD40LG Human genes 0.000 claims 2
- 102100019451 CD80 Human genes 0.000 claims 2
- 101700080477 CD80 Proteins 0.000 claims 2
- 102100008186 CD83 Human genes 0.000 claims 2
- 101700013105 CD83 Proteins 0.000 claims 2
- -1 CD86 Proteins 0.000 claims 2
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 2
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims 2
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 claims 2
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 2
- 108020004999 Messenger RNA Proteins 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920002106 messenger RNA Polymers 0.000 claims 2
- 102100010730 ALOX15 Human genes 0.000 claims 1
- 101710022933 ALOX15 Proteins 0.000 claims 1
- 102000013135 CD52 Antigen Human genes 0.000 claims 1
- 108010065524 CD52 Antigen Proteins 0.000 claims 1
- 101700080416 CD69 Proteins 0.000 claims 1
- 102100005832 CD69 Human genes 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
- 102000003816 Interleukin-13 Human genes 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 102000003812 Interleukin-15 Human genes 0.000 claims 1
- 108090000172 Interleukin-15 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 102000004388 Interleukin-4 Human genes 0.000 claims 1
- 101700068316 TLR1 Proteins 0.000 claims 1
- 102100002617 TLR1 Human genes 0.000 claims 1
- 101700064022 TLR2 Proteins 0.000 claims 1
- 102100012096 TLR2 Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000001717 pathogenic Effects 0.000 claims 1
- 244000052769 pathogens Species 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
- 229960005486 vaccines Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66946805P | 2005-04-08 | 2005-04-08 | |
| US60/669,468 | 2005-04-08 | ||
| PCT/US2006/013159 WO2006127150A2 (en) | 2005-04-08 | 2006-04-07 | Dendritic cell compositions and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008535493A JP2008535493A (ja) | 2008-09-04 |
| JP2008535493A5 true JP2008535493A5 (ko) | 2009-05-28 |
| JP5020935B2 JP5020935B2 (ja) | 2012-09-05 |
Family
ID=36992670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008505602A Active JP5020935B2 (ja) | 2005-04-08 | 2006-04-07 | 樹状細胞組成物および方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | USRE46152E1 (ko) |
| EP (1) | EP1882031B1 (ko) |
| JP (1) | JP5020935B2 (ko) |
| KR (6) | KR101368035B1 (ko) |
| CN (1) | CN101155914B (ko) |
| AU (1) | AU2006249640C1 (ko) |
| CA (1) | CA2602434C (ko) |
| ES (1) | ES2650569T3 (ko) |
| IL (2) | IL185977A0 (ko) |
| MX (1) | MX2007012221A (ko) |
| NO (1) | NO345353B1 (ko) |
| WO (1) | WO2006127150A2 (ko) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| US9771558B2 (en) * | 2005-12-08 | 2017-09-26 | Dandrit Diotech A/S | Method for generating dendritic cells employing decreased temperature |
| KR20090045886A (ko) | 2006-04-14 | 2009-05-08 | 어드밴스드 셀 테크놀로지, 인코포레이티드 | 혈관 콜로니 형성 세포 |
| US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| US8524495B2 (en) | 2007-05-16 | 2013-09-03 | Yale University | Methods for inducing the differentiation of blood monocytes into functional dendritic cells |
| KR100935826B1 (ko) | 2007-11-27 | 2010-01-08 | 주식회사 바이넥스 | 부유밀도구배 원심분리를 이용하여 말초혈액단핵구로부터 단세포를 분리하는 방법 |
| EP2254998B1 (en) | 2008-02-28 | 2015-12-23 | Argos Therapeutics, Inc. | Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection |
| WO2009120891A2 (en) * | 2008-03-27 | 2009-10-01 | Geron Corporation | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells |
| US9789129B2 (en) | 2008-04-17 | 2017-10-17 | Pds Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
| KR20110081336A (ko) * | 2008-11-04 | 2011-07-13 | 이데라 파마슈티칼즈, 인코포레이티드 | 안티센스 올리고누클레오티드에 의한 ｔｏｌｌ―유사 수용체 2 발현의 조절 |
| BR112012005713A2 (pt) | 2009-09-14 | 2019-09-24 | Baylor Res Institute | vacinas direcionadas a célula langerhans. |
| CA3080368A1 (en) * | 2009-12-04 | 2011-06-09 | Stem Cell & Regenerative Medicine International, Inc. | Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts |
| AU2011227447B2 (en) * | 2010-03-15 | 2016-04-14 | The Trustees Of The University Of Pennsylvania | System and method of preparing and storing activated mature dendritic cells |
| KR101819250B1 (ko) | 2010-03-31 | 2018-01-16 | 스타빌리테크 리미티드 | 알룸 아쥬반트 및 알룸 아쥬반트를 포함하는 백신의 보존방법 |
| ES2543795T3 (es) | 2010-03-31 | 2015-08-21 | Stabilitech Ltd. | Estabilización de partículas virales |
| GB2490644A (en) | 2010-03-31 | 2012-11-07 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
| US20130011438A1 (en) * | 2011-07-05 | 2013-01-10 | SOTIO a.s. | Means And Methods For Active Cellular Immunotherapy Of Cancer By Using Tumor Cells Killed By High Hydrostatic Pressure and Dendritic Cells |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| EP2749639B1 (en) * | 2012-02-10 | 2016-10-12 | Hakushinkouseikai Foundation | Proliferating agent for monocyte, culture medium for proliferating monocyte, method for producing monocyte, method for producing dendritic cell, and method for producing dendritic cell vaccine |
| EP2857498B1 (en) * | 2012-05-31 | 2018-04-25 | JW Creagene Inc. | Composition for maturing dendritic cells, and method for preparing antigen-specific dendritic cells using same |
| TWI672149B (zh) | 2012-09-21 | 2019-09-21 | 美商Ｐｄｓ生技公司 | 改良之疫苗組成物及使用方法 |
| CN105531289B (zh) * | 2013-02-01 | 2019-02-22 | 树突细胞生物科技有限公司 | 抗cd83抗体及其用途 |
| JP6742902B2 (ja) * | 2013-03-15 | 2020-08-19 | ジェンザイム・コーポレーション | 高密度細胞バンキングの方法 |
| CA2940163C (en) * | 2014-02-21 | 2022-05-17 | Argos Therapeutics, Inc. | Tscm cells and methods for use |
| CN103948917A (zh) * | 2014-04-02 | 2014-07-30 | 江苏和泽生物科技有限公司 | 树突状细胞疫苗的制备方法 |
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| GB201413665D0 (en) | 2014-07-03 | 2014-09-17 | Transimmune Ag And Yale University | Method for obtaining globally activated monocytes |
| KR101518972B1 (ko) * | 2014-08-01 | 2015-05-18 | 제이더블유크레아젠 주식회사 | 수지상세포의 제조방법, 이에 의해 제조된 수지상세포 및 그 용도 |
| JP6531256B2 (ja) * | 2014-11-14 | 2019-06-19 | 日本赤十字社 | 臍帯血および末梢血の凍結保存方法および凍結保存用溶液 |
| EP3316897A4 (en) * | 2015-07-02 | 2019-03-13 | Primevax Immuno-Oncology, Inc. | COMPOSITIONS AND METHODS FOR COMBINATION THERAPY WITH DENGUE VIRUS AND DENDRITIC CELLS |
| AU2016354590B2 (en) * | 2015-11-13 | 2023-11-23 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
| JP6779616B2 (ja) * | 2015-12-25 | 2020-11-04 | 富士ソフト株式会社 | Ｎｋｔ細胞活性化医薬組成物、その製造方法、及び抗原提示細胞の保存方法 |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| AU2018328209A1 (en) | 2017-09-05 | 2020-04-23 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| EP3706765A4 (en) | 2017-11-07 | 2021-07-14 | Coimmune, Inc. | METHODS AND USES FOR DENDRITIC CELL THERAPY |
| WO2019136155A1 (en) * | 2018-01-08 | 2019-07-11 | The Regents Of The University Of Michigan | Aldh1 antigen-pulsed dendritic cells |
| WO2019196088A1 (en) * | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
| EP3820486A4 (en) | 2018-07-15 | 2022-05-04 | Enochian Biopharma, Inc. | METHODS AND COMPOSITIONS USING RECOMBINANT DENDRITIC CELLS FOR CANCER THERAPY |
| KR102159766B1 (ko) * | 2018-11-12 | 2020-09-24 | 조선대학교산학협력단 | 홍조류추출물을 이용한 미성숙수지상세포 분화유도용 배지조성물 및 미성숙수지상세포 분화유도방법 |
| US20220249555A1 (en) * | 2019-03-21 | 2022-08-11 | Gamida Cell Ltd. | Expanded nk cell fractions for transplantation in combination therapy |
| CN114621921A (zh) * | 2020-12-11 | 2022-06-14 | 深圳先进技术研究院 | 一种提取神经突触体的方法 |
| CN113980901B (zh) * | 2021-12-28 | 2022-06-17 | 上海惠盾因泰生物科技有限公司 | 一种制备高纯度的成熟人树突状细胞的方法及应用 |
| WO2023245609A1 (en) * | 2022-06-24 | 2023-12-28 | Lihpao Life Science Corp. | Method for producing mature dendritic cells |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7659119B2 (en) | 1996-02-12 | 2010-02-09 | Argos Therapeutics, Inc. | Method and compositions for obtaining mature dendritic cells |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| AU705647B2 (en) | 1996-07-10 | 1999-05-27 | Immunex Corporation | Method of activating dendritic cells |
| US20050158856A1 (en) | 1999-04-20 | 2005-07-21 | Edelson Richard L. | Methods for producing functional antigen presenting dendritic cells using biodegradable microparticles for delivery of antigenic materials |
| US20050084966A1 (en) | 1999-04-20 | 2005-04-21 | Edelson Richard L. | Methods for inducing the differentiation of blood monocytes into functional dendritic cells |
| CA2368855C (en) | 1999-04-20 | 2012-05-29 | Richard Leslie Edelson | Differentiation of monocytes into functional dendritic cells |
| IT1312570B1 (it) * | 1999-05-28 | 2002-04-22 | Genera Spa | Metodo per il traferimento di antigeni a cellule dendritiche. |
| DE10041515A1 (de) | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
| EP1270732A1 (en) * | 2001-06-21 | 2003-01-02 | Schuler, Gerold | Improved transfection of eukaryontic cells with linear polynucleotides by electroporation |
| FR2833271B1 (fr) | 2001-12-10 | 2004-09-17 | Coletica | Production de cellules dendritiques in vitro a partir de monocytes cd14+, pour notamment la realisation de modeles cellulaires et/ou tissulaires en suspension, en monocouches et tridimentionnels; utilisation de ces modeles |
| US7695627B2 (en) | 2002-06-19 | 2010-04-13 | Northwest Biotherapeutics, Inc. | Tangential flow filtration devices and methods for leukocyte enrichment |
| EP1389480A1 (en) * | 2002-08-14 | 2004-02-18 | Mondobiotech Interferon SA | Therapeutical use of guanylhydrazones for the inhibition of CD83 dependent processes and dendritic cell maturation |
| EP2301356A3 (en) | 2002-12-04 | 2012-05-30 | Baylor Research Institute | Rapid one-step method for generation of antigen loaded dendritic cell vaccine from precursors |
| CN1264974C (zh) * | 2003-01-17 | 2006-07-19 | 江西医学院 | 白血病细胞诱导生成树突状细胞的培养基及其培养方法与应用 |
| EP1604016B1 (en) | 2003-02-27 | 2009-01-14 | NorthWest Biotherapeutics, Inc. | Generation of dendritic cells from monocytic dendritic precursor cells with gm-csf in the absence of additional cytokines |
| KR101390072B1 (ko) | 2004-09-14 | 2014-04-30 | 아고스 쎄라퓨틱스, 인코포레이티드 | 병원체의 균주 독립성 증폭 및 그에 대한 백신 |
| US8513008B2 (en) * | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| DE602005025005D1 (de) * | 2004-10-07 | 2011-01-05 | Argos Therapeutics Inc | Zusammensetzungen reifer dendritischer zellen und verfahren zu deren kultivierung |
-
2006
- 2006-04-07 KR KR1020077025609A patent/KR101368035B1/ko active IP Right Grant
- 2006-04-07 CA CA2602434A patent/CA2602434C/en active Active
- 2006-04-07 KR KR1020177020072A patent/KR20170086700A/ko active Search and Examination
- 2006-04-07 MX MX2007012221A patent/MX2007012221A/es active IP Right Grant
- 2006-04-07 JP JP2008505602A patent/JP5020935B2/ja active Active
- 2006-04-07 AU AU2006249640A patent/AU2006249640C1/en active Active
- 2006-04-07 KR KR1020207016974A patent/KR20200072566A/ko not_active Application Discontinuation
- 2006-04-07 US US14/450,092 patent/USRE46152E1/en not_active Expired - Fee Related
- 2006-04-07 KR KR1020167009557A patent/KR20160045151A/ko active Search and Examination
- 2006-04-07 CN CN2006800113802A patent/CN101155914B/zh active Active
- 2006-04-07 KR KR20157005703A patent/KR20150032915A/ko not_active Application Discontinuation
- 2006-04-07 US US11/918,076 patent/US8153425B2/en not_active Ceased
- 2006-04-07 KR KR1020137010879A patent/KR20130061753A/ko not_active Application Discontinuation
- 2006-04-07 EP EP06749566.3A patent/EP1882031B1/en active Active
- 2006-04-07 ES ES06749566.3T patent/ES2650569T3/es active Active
- 2006-04-07 WO PCT/US2006/013159 patent/WO2006127150A2/en active Application Filing
-
2007
- 2007-09-17 IL IL185977A patent/IL185977A0/en unknown
- 2007-10-10 NO NO20075166A patent/NO345353B1/no unknown
-
2012
- 2012-01-17 US US13/351,510 patent/US8501470B2/en active Active
-
2013
- 2013-06-28 US US13/929,889 patent/US20130280805A1/en not_active Abandoned
-
2014
- 2014-04-03 IL IL231889A patent/IL231889A/en active IP Right Grant
- 2014-06-18 US US14/307,991 patent/US20150132844A1/en not_active Abandoned
-
2015
- 2015-10-09 US US14/879,336 patent/US20160102291A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008535493A5 (ko) | ||
| Maynard et al. | Diversity in the contribution of interleukin‐10 to T‐cell‐mediated immune regulation | |
| Goddard et al. | Interleukin-10 secretion differentiates dendritic cells from human liver and skin | |
| Zhang et al. | Mesenchymal stem cells alleviate bacteria‐induced liver injury in mice by inducing regulatory dendritic cells | |
| Park et al. | MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins | |
| Lu et al. | Th9 cells promote antitumor immune responses in vivo | |
| Kalantari et al. | Generation of immunogenic and tolerogenic clinical-grade dendritic cells | |
| Liu et al. | miR‐223 suppresses differentiation of tumor‐induced CD11b+ Gr1+ myeloid‐derived suppressor cells from bone marrow cells | |
| Wang et al. | Murine bone marrow mesenchymal stem cells cause mature dendritic cells to promote T‐cell tolerance | |
| Min et al. | TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7 | |
| Shin et al. | Human periodontal ligament stem cells suppress T‐cell proliferation via down‐regulation of non‐classical major histocompatibility complex‐like glycoprotein CD 1b on dendritic cells | |
| Hodge et al. | Overexpression of microRNA-155 enhances the efficacy of dendritic cell vaccine against breast cancer | |
| Amado et al. | Cross‐regulation between cytokine and microRNA pathways in T cells | |
| Lin et al. | Chitosan as an adjuvant-like substrate for dendritic cell culture to enhance antitumor effects | |
| JP2004536615A5 (ko) | ||
| Chiang et al. | Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate | |
| Díaz‐Zúñiga et al. | T‐lymphocyte phenotype and function triggered by Aggregatibacter actinomycetemcomitans is serotype‐dependent | |
| Liu et al. | Induction on differentiation and modulation of bone marrow progenitor of dendritic cell by methionine enkephalin (MENK) | |
| Landi et al. | Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS | |
| Croci et al. | Human dental pulp stem cells modulate cytokine production in vitro by peripheral blood mononuclear cells from coronavirus disease 2019 patients | |
| Nail et al. | Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments | |
| Thorne et al. | Tumor necrosis factor–α promotes survival and phenotypic maturation of poly (I: C)-treated dendritic cells but impairs their Th1 and Th17 polarizing capability | |
| Monasterio et al. | Immunostimulatory activity of low-molecular-weight hyaluronan on dendritic cells stimulated with Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis | |
| Son et al. | Prostaglandin E2 is a negative regulator on human plasmacytoid dendritic cells | |
| Van den Heuvel et al. | Glucocorticoids modulate the development of dendritic cells from blood precursors |