JP2008534523A - メトホルミンの経口経粘膜送達のための組成物 - Google Patents
メトホルミンの経口経粘膜送達のための組成物 Download PDFInfo
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- JP2008534523A JP2008534523A JP2008503334A JP2008503334A JP2008534523A JP 2008534523 A JP2008534523 A JP 2008534523A JP 2008503334 A JP2008503334 A JP 2008503334A JP 2008503334 A JP2008503334 A JP 2008503334A JP 2008534523 A JP2008534523 A JP 2008534523A
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- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
- AWDRATDZQPNJFN-VAYUFCLWSA-N taurodeoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 AWDRATDZQPNJFN-VAYUFCLWSA-N 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000012784 weak cation exchange Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
Images
Classifications
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Organic Chemistry (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US66647505P | 2005-03-30 | 2005-03-30 | |
| PCT/CA2006/000472 WO2006102752A1 (en) | 2005-03-30 | 2006-03-30 | Compositions for oral transmucosal delivery of metformin |
Publications (2)
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| JP2008534523A true JP2008534523A (ja) | 2008-08-28 |
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| JP2008503334A Withdrawn JP2008534523A (ja) | 2005-03-30 | 2006-03-30 | メトホルミンの経口経粘膜送達のための組成物 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012509891A (ja) * | 2008-11-26 | 2012-04-26 | サティオゲン ファーマシューティカルズ，インク． | 肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤 |
| US10188646B2 (en) | 2010-05-26 | 2019-01-29 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| US10512657B2 (en) | 2011-10-28 | 2019-12-24 | Lumena Pharmaceutials Llc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US12145959B2 (en) | 2011-10-28 | 2024-11-19 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009080025A1 (en) * | 2007-12-20 | 2009-07-02 | Fertin Pharma A/S | Compressed chewing gum comprising metformin |
| WO2009090210A2 (en) * | 2008-01-16 | 2009-07-23 | Janssen Pharmaceutica Nv | Combination of metformin and an mtp inhibitor |
| CA2638240C (en) * | 2008-08-29 | 2010-02-02 | Alexander Macgregor | Method of treating dysglycemia and glucose excursions |
| EP2445494A4 (en) * | 2009-06-24 | 2012-12-12 | Univ Koebenhavn | TREATMENT OF INSULIN RESISTANCE AND OBESITY BY STIMULATING GLP-1 RELEASE |
| WO2011051974A1 (en) * | 2009-10-29 | 2011-05-05 | Nutracryst Therapeutics Private Limited | Metformin and a-amino acids |
| EP3696281A1 (en) * | 2019-02-13 | 2020-08-19 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Arginase as biomarker and drug target for pcos |
| WO2020227344A1 (en) * | 2019-05-06 | 2020-11-12 | The Regents Of The University Of California | Chloride intracellular channel 1 for regulation of food intake |
Family Cites Families (17)
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| DK161428C (da) * | 1985-05-10 | 1991-12-16 | Fertin Lab As | Fast, oralt cariesmodvirkende middel |
| DK365389D0 (da) * | 1989-07-24 | 1989-07-24 | Fertin Lab As | Antifungalt tyggegummipraeparat |
| US20030095925A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders |
| FR2775188B1 (fr) * | 1998-02-23 | 2001-03-09 | Lipha | Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption |
| US6099859A (en) * | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| WO1999055320A1 (en) * | 1998-04-29 | 1999-11-04 | Sumitomo Pharmaceuticals Co., Ltd. | Oral formulation comprising biguanide and an organic acid |
| DK0974356T3 (da) * | 1998-07-15 | 2003-10-27 | Merck Sante Sas | Tabletter omfattende en kombination af metformin og glibenclamid |
| US6099862A (en) * | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
| US6344222B1 (en) * | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
| US6312665B1 (en) * | 1998-12-21 | 2001-11-06 | Generex Pharmaceuticals Incorporated | Aerosol formulations for buccal and pulmonary application |
| US6432383B1 (en) * | 2000-03-30 | 2002-08-13 | Generex Pharmaceuticals Incorporated | Method for administering insulin |
| BR0115390A (pt) * | 2000-11-03 | 2004-02-25 | Andrx Corp | Formulações para liberação controlada de metformina, liberação controlada da forma farmacêutica oral, método de diminuição dos nìveis de glicose sanguìnea, uso da forma farmacêutica |
| ITMI20011337A1 (it) * | 2001-06-26 | 2002-12-26 | Farmatron Ltd | Composizioni farmaceutiche orali a rilascio modificato del principio attivo |
| ITFI20010230A1 (it) * | 2001-11-29 | 2003-05-29 | Menarini Int Operations Lu Sa | Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii |
| KR20100137023A (ko) * | 2002-09-20 | 2010-12-29 | 안드렉스 랩스 엘엘씨 | 약제학적 정제 |
| US20040253307A1 (en) * | 2003-02-04 | 2004-12-16 | Brian Hague | Sugar-free oral transmucosal solid dosage forms and uses thereof |
| WO2005041926A1 (en) * | 2003-10-31 | 2005-05-12 | Alza Corporation | Compositions and dosage forms for enhanced absorption of 3-amino-n-butyl-phosphinic acid |
-
2006
- 2006-03-29 UY UY29445A patent/UY29445A1/es not_active Application Discontinuation
- 2006-03-29 PE PE2006000346A patent/PE20061245A1/es not_active Application Discontinuation
- 2006-03-30 BR BRPI0611555-1A patent/BRPI0611555A2/pt not_active IP Right Cessation
- 2006-03-30 AU AU2006228949A patent/AU2006228949A1/en not_active Abandoned
- 2006-03-30 EP EP06721733A patent/EP1863465A4/en not_active Withdrawn
- 2006-03-30 MX MX2007012047A patent/MX2007012047A/es not_active Application Discontinuation
- 2006-03-30 AR ARP060101262A patent/AR052960A1/es not_active Application Discontinuation
- 2006-03-30 US US11/887,284 patent/US20090069437A1/en not_active Abandoned
- 2006-03-30 RU RU2007139886/15A patent/RU2409357C2/ru not_active IP Right Cessation
- 2006-03-30 JP JP2008503334A patent/JP2008534523A/ja not_active Withdrawn
- 2006-03-30 WO PCT/CA2006/000472 patent/WO2006102752A1/en not_active Ceased
- 2006-03-30 CA CA002603450A patent/CA2603450A1/en not_active Abandoned
- 2006-03-30 NZ NZ560990A patent/NZ560990A/en not_active IP Right Cessation
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2007
- 2007-09-04 CR CR9363A patent/CR9363A/es not_active Application Discontinuation
- 2007-09-11 IL IL185931A patent/IL185931A0/en unknown
- 2007-10-16 ZA ZA200708834A patent/ZA200708834B/xx unknown
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2010
- 2010-09-20 RU RU2010139163/15A patent/RU2010139163A/ru unknown
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012509891A (ja) * | 2008-11-26 | 2012-04-26 | サティオゲン ファーマシューティカルズ，インク． | 肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤 |
| JP2014144961A (ja) * | 2008-11-26 | 2014-08-14 | Satiogen Pharmaceuticals Inc | 肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤 |
| US9339480B2 (en) | 2008-11-26 | 2016-05-17 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| US10555950B2 (en) | 2008-11-26 | 2020-02-11 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| US10188646B2 (en) | 2010-05-26 | 2019-01-29 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| US10251880B2 (en) | 2010-05-26 | 2019-04-09 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| US11260053B2 (en) | 2010-05-26 | 2022-03-01 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| US10512657B2 (en) | 2011-10-28 | 2019-12-24 | Lumena Pharmaceutials Llc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US11229661B2 (en) | 2011-10-28 | 2022-01-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US11376251B2 (en) | 2011-10-28 | 2022-07-05 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US12145959B2 (en) | 2011-10-28 | 2024-11-19 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| US12350267B2 (en) | 2011-10-28 | 2025-07-08 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007139886A (ru) | 2009-05-10 |
| RU2010139163A (ru) | 2012-03-27 |
| US20090069437A1 (en) | 2009-03-12 |
| AU2006228949A1 (en) | 2006-10-05 |
| BRPI0611555A2 (pt) | 2010-09-21 |
| EP1863465A1 (en) | 2007-12-12 |
| ZA200708834B (en) | 2008-11-26 |
| WO2006102752A1 (en) | 2006-10-05 |
| NZ560990A (en) | 2009-02-28 |
| RU2409357C2 (ru) | 2011-01-20 |
| UY29445A1 (es) | 2006-10-02 |
| MX2007012047A (es) | 2007-12-12 |
| CR9363A (es) | 2008-02-12 |
| IL185931A0 (en) | 2008-02-09 |
| EP1863465A4 (en) | 2010-12-15 |
| AR052960A1 (es) | 2007-04-11 |
| PE20061245A1 (es) | 2007-01-06 |
| CA2603450A1 (en) | 2006-10-05 |
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