CA2603450A1 - Compositions for oral transmucosal delivery of metformin - Google Patents
Compositions for oral transmucosal delivery of metformin Download PDFInfo
- Publication number
- CA2603450A1 CA2603450A1 CA002603450A CA2603450A CA2603450A1 CA 2603450 A1 CA2603450 A1 CA 2603450A1 CA 002603450 A CA002603450 A CA 002603450A CA 2603450 A CA2603450 A CA 2603450A CA 2603450 A1 CA2603450 A1 CA 2603450A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- subject
- metformin
- concentration
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 130
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title claims abstract description 71
- 229960003105 metformin Drugs 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 35
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- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 20
- 238000002360 preparation method Methods 0.000 claims abstract description 19
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- 238000010521 absorption reaction Methods 0.000 claims description 31
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims description 30
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66647505P | 2005-03-30 | 2005-03-30 | |
| US60/666,475 | 2005-03-30 | ||
| PCT/CA2006/000472 WO2006102752A1 (en) | 2005-03-30 | 2006-03-30 | Compositions for oral transmucosal delivery of metformin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2603450A1 true CA2603450A1 (en) | 2006-10-05 |
Family
ID=37052910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002603450A Abandoned CA2603450A1 (en) | 2005-03-30 | 2006-03-30 | Compositions for oral transmucosal delivery of metformin |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090069437A1 (enExample) |
| EP (1) | EP1863465A4 (enExample) |
| JP (1) | JP2008534523A (enExample) |
| AR (1) | AR052960A1 (enExample) |
| AU (1) | AU2006228949A1 (enExample) |
| BR (1) | BRPI0611555A2 (enExample) |
| CA (1) | CA2603450A1 (enExample) |
| CR (1) | CR9363A (enExample) |
| IL (1) | IL185931A0 (enExample) |
| MX (1) | MX2007012047A (enExample) |
| NZ (1) | NZ560990A (enExample) |
| PE (1) | PE20061245A1 (enExample) |
| RU (2) | RU2409357C2 (enExample) |
| UY (1) | UY29445A1 (enExample) |
| WO (1) | WO2006102752A1 (enExample) |
| ZA (1) | ZA200708834B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009080025A1 (en) * | 2007-12-20 | 2009-07-02 | Fertin Pharma A/S | Compressed chewing gum comprising metformin |
| CA2710815A1 (en) * | 2008-01-16 | 2009-07-23 | Janssen Pharmaceutica Nv | Combination of metformin and an mtp inhibitor |
| CA2638240C (en) * | 2008-08-29 | 2010-02-02 | Alexander Macgregor | Method of treating dysglycemia and glucose excursions |
| EP2367554A4 (en) * | 2008-11-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | Bile acid reflux inhibitor for the treatment of obesity and diabetes |
| WO2010149170A1 (en) * | 2009-06-24 | 2010-12-29 | Københavns Universitet | Treatment of insulin resistance and obesity by stimulating glp-1 release |
| WO2011051974A1 (en) * | 2009-10-29 | 2011-05-05 | Nutracryst Therapeutics Private Limited | Metformin and a-amino acids |
| EP4137137A1 (en) | 2010-05-26 | 2023-02-22 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| EA038594B1 (ru) | 2011-10-28 | 2021-09-21 | Шайр Хьюман Дженетик Терапис, Инк. | Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени |
| JP6217938B2 (ja) | 2011-10-28 | 2017-10-25 | ルメナ ファーマシューティカルズ エルエルシー | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| EP3696281A1 (en) * | 2019-02-13 | 2020-08-19 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Arginase as biomarker and drug target for pcos |
| US12303479B2 (en) * | 2019-05-06 | 2025-05-20 | The Regents Of The University Of California | Chloride intracellular channel 1 for regulation of food intake |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161428C (da) * | 1985-05-10 | 1991-12-16 | Fertin Lab As | Fast, oralt cariesmodvirkende middel |
| DK365389D0 (da) * | 1989-07-24 | 1989-07-24 | Fertin Lab As | Antifungalt tyggegummipraeparat |
| US20030095925A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders |
| FR2775188B1 (fr) * | 1998-02-23 | 2001-03-09 | Lipha | Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption |
| US6099859A (en) * | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| ES2224634T3 (es) * | 1998-04-29 | 2005-03-01 | Sumitomo Pharmaceuticals Company, Limited | Formulacion oral que comprende biguanida y un acido organico. |
| DE69818444T2 (de) * | 1998-07-15 | 2004-05-06 | Merck Santé | Tabletten enthaltend eine Kombination von Glibenclamid und Metformin |
| US6099862A (en) * | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
| US6344222B1 (en) * | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
| US6312665B1 (en) * | 1998-12-21 | 2001-11-06 | Generex Pharmaceuticals Incorporated | Aerosol formulations for buccal and pulmonary application |
| US6432383B1 (en) * | 2000-03-30 | 2002-08-13 | Generex Pharmaceuticals Incorporated | Method for administering insulin |
| JP2004531463A (ja) * | 2000-11-03 | 2004-10-14 | アンドルクス ラブス，エルエルシー | 徐放メトホルミン組成物 |
| ITMI20011337A1 (it) * | 2001-06-26 | 2002-12-26 | Farmatron Ltd | Composizioni farmaceutiche orali a rilascio modificato del principio attivo |
| ITFI20010230A1 (it) * | 2001-11-29 | 2003-05-29 | Menarini Int Operations Lu Sa | Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii |
| ES2529180T3 (es) * | 2002-09-20 | 2015-02-17 | Andrx Labs Llc | Formulación multietapa que contiene una biguanida y un derivado de tiazolidinodiona |
| US20040253307A1 (en) * | 2003-02-04 | 2004-12-16 | Brian Hague | Sugar-free oral transmucosal solid dosage forms and uses thereof |
| RU2006118801A (ru) * | 2003-10-31 | 2007-12-10 | Алза Корпорейшн (Us) | Композиции и лекарственные формы для усиления всасывания габапентина и прегабалина |
-
2006
- 2006-03-29 UY UY29445A patent/UY29445A1/es not_active Application Discontinuation
- 2006-03-29 PE PE2006000346A patent/PE20061245A1/es not_active Application Discontinuation
- 2006-03-30 JP JP2008503334A patent/JP2008534523A/ja not_active Withdrawn
- 2006-03-30 RU RU2007139886/15A patent/RU2409357C2/ru not_active IP Right Cessation
- 2006-03-30 MX MX2007012047A patent/MX2007012047A/es not_active Application Discontinuation
- 2006-03-30 AU AU2006228949A patent/AU2006228949A1/en not_active Abandoned
- 2006-03-30 US US11/887,284 patent/US20090069437A1/en not_active Abandoned
- 2006-03-30 NZ NZ560990A patent/NZ560990A/en not_active IP Right Cessation
- 2006-03-30 EP EP06721733A patent/EP1863465A4/en not_active Withdrawn
- 2006-03-30 BR BRPI0611555-1A patent/BRPI0611555A2/pt not_active IP Right Cessation
- 2006-03-30 AR ARP060101262A patent/AR052960A1/es not_active Application Discontinuation
- 2006-03-30 WO PCT/CA2006/000472 patent/WO2006102752A1/en not_active Ceased
- 2006-03-30 CA CA002603450A patent/CA2603450A1/en not_active Abandoned
-
2007
- 2007-09-04 CR CR9363A patent/CR9363A/es not_active Application Discontinuation
- 2007-09-11 IL IL185931A patent/IL185931A0/en unknown
- 2007-10-16 ZA ZA200708834A patent/ZA200708834B/xx unknown
-
2010
- 2010-09-20 RU RU2010139163/15A patent/RU2010139163A/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2409357C2 (ru) | 2011-01-20 |
| AU2006228949A1 (en) | 2006-10-05 |
| JP2008534523A (ja) | 2008-08-28 |
| EP1863465A4 (en) | 2010-12-15 |
| WO2006102752A1 (en) | 2006-10-05 |
| ZA200708834B (en) | 2008-11-26 |
| MX2007012047A (es) | 2007-12-12 |
| US20090069437A1 (en) | 2009-03-12 |
| PE20061245A1 (es) | 2007-01-06 |
| NZ560990A (en) | 2009-02-28 |
| EP1863465A1 (en) | 2007-12-12 |
| CR9363A (es) | 2008-02-12 |
| RU2010139163A (ru) | 2012-03-27 |
| IL185931A0 (en) | 2008-02-09 |
| RU2007139886A (ru) | 2009-05-10 |
| AR052960A1 (es) | 2007-04-11 |
| UY29445A1 (es) | 2006-10-02 |
| BRPI0611555A2 (pt) | 2010-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130402 |