JP2008533066A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008533066A5 JP2008533066A5 JP2008501196A JP2008501196A JP2008533066A5 JP 2008533066 A5 JP2008533066 A5 JP 2008533066A5 JP 2008501196 A JP2008501196 A JP 2008501196A JP 2008501196 A JP2008501196 A JP 2008501196A JP 2008533066 A5 JP2008533066 A5 JP 2008533066A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- aryl
- heterocyclyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- -1 -CF 3 Chemical group 0.000 claims description 13
- 125000000623 heterocyclic group Chemical group 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 27
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 claims 1
- 101100134929 Gallus gallus COR9 gene Proteins 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 description 2
- 125000004502 1,2,3-oxadiazolyl group Chemical group 0.000 description 1
- 125000004511 1,2,3-thiadiazolyl group Chemical group 0.000 description 1
- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 description 1
- 125000004514 1,2,4-thiadiazolyl group Chemical group 0.000 description 1
- 125000004506 1,2,5-oxadiazolyl group Chemical group 0.000 description 1
- 125000004517 1,2,5-thiadiazolyl group Chemical group 0.000 description 1
- 125000001781 1,3,4-oxadiazolyl group Chemical group 0.000 description 1
- 125000004520 1,3,4-thiadiazolyl group Chemical group 0.000 description 1
- 125000005955 1H-indazolyl group Chemical group 0.000 description 1
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical compound C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 description 1
- AUEUBSJNKBZSKK-UHFFFAOYSA-N 5-benzylsulfonyl-2-[2-(dimethylamino)ethyl-ethylamino]-n,n-diethyl-4-(4-phenylpiperidin-1-yl)benzamide Chemical compound C1=C(N(CC)CCN(C)C)C(C(=O)N(CC)CC)=CC(S(=O)(=O)CC=2C=CC=CC=2)=C1N(CC1)CCC1C1=CC=CC=C1 AUEUBSJNKBZSKK-UHFFFAOYSA-N 0.000 description 1
- 102000000853 LDL receptors Human genes 0.000 description 1
- 108010001831 LDL receptors Proteins 0.000 description 1
- BBAWTPDTGRXPDG-UHFFFAOYSA-N [1,3]thiazolo[4,5-b]pyridine Chemical compound C1=CC=C2SC=NC2=N1 BBAWTPDTGRXPDG-UHFFFAOYSA-N 0.000 description 1
- 125000000641 acridinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3C=C12)* 0.000 description 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 description 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 description 1
- 125000004623 carbolinyl group Chemical group 0.000 description 1
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 description 1
- 125000004230 chromenyl group Chemical group O1C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 description 1
- 125000004856 decahydroquinolinyl group Chemical group N1(CCCC2CCCCC12)* 0.000 description 1
- 125000003838 furazanyl group Chemical group 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 125000002632 imidazolidinyl group Chemical group 0.000 description 1
- 125000002636 imidazolinyl group Chemical group 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 description 1
- 125000003384 isochromanyl group Chemical group C1(OCCC2=CC=CC=C12)* 0.000 description 1
- 125000005438 isoindazolyl group Chemical group 0.000 description 1
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 description 1
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 description 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
- 125000004930 octahydroisoquinolinyl group Chemical group C1(NCCC2CCCC=C12)* 0.000 description 1
- 125000001715 oxadiazolyl group Chemical group 0.000 description 1
- 125000000160 oxazolidinyl group Chemical group 0.000 description 1
- 125000005968 oxazolinyl group Chemical group 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 125000004934 phenanthridinyl group Chemical group C1(=CC=CC2=NC=C3C=CC=CC3=C12)* 0.000 description 1
- 125000004625 phenanthrolinyl group Chemical group N1=C(C=CC2=CC=C3C=CC=NC3=C12)* 0.000 description 1
- 125000001791 phenazinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3N=C12)* 0.000 description 1
- 125000001484 phenothiazinyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 description 1
- 125000005954 phenoxathiinyl group Chemical group 0.000 description 1
- 125000001644 phenoxazinyl group Chemical group C1(=CC=CC=2OC3=CC=CC=C3NC12)* 0.000 description 1
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
- 125000002755 pyrazolinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000001422 pyrrolinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005012875A DE102005012875B4 (de) | 2005-03-19 | 2005-03-19 | Verwendung von Amino substituierten 8-N-Benzimidazolen |
| PCT/EP2006/002057 WO2006099942A2 (de) | 2005-03-19 | 2006-03-07 | Verwendung von amino substituierten benzimidazolen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008533066A JP2008533066A (ja) | 2008-08-21 |
| JP2008533066A5 true JP2008533066A5 (enExample) | 2009-04-23 |
Family
ID=36933932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008501196A Abandoned JP2008533066A (ja) | 2005-03-19 | 2006-03-07 | アミノ置換８−ｎ−ベンゾイミダゾールの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8003668B2 (enExample) |
| EP (1) | EP1863488B1 (enExample) |
| JP (1) | JP2008533066A (enExample) |
| AT (1) | ATE458482T1 (enExample) |
| AU (1) | AU2006226639A1 (enExample) |
| BR (1) | BRPI0608451A2 (enExample) |
| CA (1) | CA2602236A1 (enExample) |
| DE (2) | DE102005012875B4 (enExample) |
| IL (1) | IL185807A0 (enExample) |
| MX (1) | MX2007010836A (enExample) |
| WO (1) | WO2006099942A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100029615A1 (en) * | 2006-12-15 | 2010-02-04 | Michael John Munchhof | Benzimidazole derivatives |
| HRP20161562T2 (hr) | 2007-06-29 | 2017-04-21 | Pfizer Inc. | Derivati benzimidazola |
| CN104507473A (zh) * | 2012-02-17 | 2015-04-08 | 奇尼塔四有限责任公司 | 用于治疗沙粒病毒感染的抗病毒药物 |
| HUE070649T2 (hu) * | 2017-10-19 | 2025-06-28 | Teijin Pharma Ltd | Benzimidazol-származékok és felhasználásuk |
| PT3860998T (pt) | 2018-10-05 | 2024-04-02 | Annapurna Bio Inc | Compostos e composições para o tratamento de condições associadas à atividade do recetor apj |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997012613A1 (en) * | 1995-10-05 | 1997-04-10 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
| US6340681B1 (en) * | 1999-07-16 | 2002-01-22 | Pfizer Inc | 2-benzimidazolylamine compounds as ORL-1-receptor agonists |
| AU2003240742A1 (en) * | 2002-06-07 | 2003-12-22 | Altana Pharma Ag | 4,5-dihydro-imidazo (4,5,1-ij) quinolin-6-ones derivatives and their use as poly (adp-ribosyl) transferase (parp) inhibitors |
-
2005
- 2005-03-19 DE DE102005012875A patent/DE102005012875B4/de not_active Expired - Lifetime
-
2006
- 2006-03-07 AT AT06723256T patent/ATE458482T1/de active
- 2006-03-07 BR BRPI0608451-6A patent/BRPI0608451A2/pt not_active Application Discontinuation
- 2006-03-07 WO PCT/EP2006/002057 patent/WO2006099942A2/de not_active Ceased
- 2006-03-07 CA CA002602236A patent/CA2602236A1/en not_active Abandoned
- 2006-03-07 AU AU2006226639A patent/AU2006226639A1/en not_active Abandoned
- 2006-03-07 DE DE502006006241T patent/DE502006006241D1/de not_active Expired - Lifetime
- 2006-03-07 EP EP06723256A patent/EP1863488B1/de not_active Expired - Lifetime
- 2006-03-07 JP JP2008501196A patent/JP2008533066A/ja not_active Abandoned
- 2006-03-07 MX MX2007010836A patent/MX2007010836A/es not_active Application Discontinuation
-
2007
- 2007-09-06 IL IL185807A patent/IL185807A0/en unknown
- 2007-09-14 US US11/855,231 patent/US8003668B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008533067A5 (enExample) | ||
| JP2006528602A5 (enExample) | ||
| JP2010514719A5 (enExample) | ||
| JP2008543956A5 (enExample) | ||
| JP2006528601A5 (enExample) | ||
| JP2010514721A5 (enExample) | ||
| JP7327900B2 (ja) | アジリジン含有ｄｎａアルキル化剤 | |
| CN102775340B (zh) | 以贝壳为钙源的焦谷氨酸钙合成方法 | |
| JP2019524690A5 (enExample) | ||
| JP2012097115A5 (enExample) | ||
| DE60002554D1 (de) | Pyrazino(aza)indolderivate | |
| CN106831570A (zh) | 喹啉类化合物及其制备方法和作为尿酸盐转运体抑制剂类药物的用途 | |
| SG194675A1 (en) | Derivatives of n- [(1h-pyrazol-1-yl) aryl] - 1h - indole or 1h - indazole - 3 - carboxamide, their preparation and their use as p2y12 antagonists | |
| NO20050088L (no) | Kationisk substituerte difenylazefidinoner, fremgangsmate for deres fremstilling, medikamenter inneholdende nevnte forbindelser og anvendelse derav | |
| ATE496026T1 (de) | 1,3-disubstituierte 4-methyl-1 h-pyrrol-2- carbonsäureamide und ihre verwendung zur herstellung von arzneimitteln | |
| ES2616470T3 (es) | Compuestos de azetidiniloxifenilpirrolidina | |
| CN103772238A (zh) | 一类新的含酯基芳香丙酰胺化合物及其制备方法和用途 | |
| MX2010003983A (es) | 5,6-diarilpiridinas sustituidas en la posicion 2 y 3, su preparacion y su uso terapeutico. | |
| RU2014141934A (ru) | Комбинация производного 6-оксо-1,6-дигидро-пиридазина, которая обладает противораковым действием с другими противоопухолевыми соединениями | |
| CN101531653B (zh) | 3-(4-氨基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮及其衍生物的盐或盐的多晶型物及其制备和应用 | |
| CN102531989A (zh) | 一种（s）-奥拉西坦的纯化方法 | |
| ES2918948T3 (es) | Sustancia polimórfica de hidrocloruro de yonkenafil, método de preparación de la misma y composición y uso de la misma | |
| IL201491A0 (en) | Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands | |
| CN106277163A (zh) | 一种Fe‑MCM‑41/CA共混膜及其制备方法和应用 | |
| CN102993199A (zh) | 杂环取代的吡啶并吡咯激酶抑制剂 |