JP2008531702A5 - - Google Patents

Info

Publication number

JP2008531702A5

JP2008531702A5 JP2007558127A JP2007558127A JP2008531702A5 JP 2008531702 A5 JP2008531702 A5 JP 2008531702A5 JP 2007558127 A JP2007558127 A JP 2007558127A JP 2007558127 A JP2007558127 A JP 2007558127A JP 2008531702 A5 JP2008531702 A5 JP 2008531702A5

Authority

JP

Japan

Prior art keywords

alkyl

substituted

group

alkoxy

compound

Prior art date

2006-02-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• 150000001875 compounds Chemical class 0.000 claims 15
• 125000001072 heteroaryl group Chemical group 0.000 claims 12
• 125000000217 alkyl group Chemical group 0.000 claims 10
• 125000003118 aryl group Chemical group 0.000 claims 8
• 229910052739 hydrogen Inorganic materials 0.000 claims 8
• 239000001257 hydrogen Substances 0.000 claims 8
• 125000000753 cycloalkyl group Chemical group 0.000 claims 6
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
• 125000004429 atom Chemical group 0.000 claims 5
• 229910052736 halogen Inorganic materials 0.000 claims 5
• 150000002367 halogens Chemical class 0.000 claims 5
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
• 125000001424 substituent group Chemical group 0.000 claims 5
• 125000003107 substituted aryl group Chemical group 0.000 claims 5
• -1 carboxyl ester Chemical class 0.000 claims 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
• 125000002877 alkyl aryl group Chemical group 0.000 claims 3
• 125000003277 amino group Chemical group 0.000 claims 3
• 125000003710 aryl alkyl group Chemical group 0.000 claims 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
• 125000005842 heteroatom Chemical group 0.000 claims 3
• 150000002431 hydrogen Chemical class 0.000 claims 3
• 125000002252 acyl group Chemical group 0.000 claims 2
• 230000010933 acylation Effects 0.000 claims 2
• 238000005917 acylation reaction Methods 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000003545 alkoxy group Chemical group 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 125000004104 aryloxy group Chemical group 0.000 claims 2
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• UECIPBUIMXSXEI-BNSVOVDNSA-N eremomycin Chemical compound O([C@@H]1C2=CC=C(C=C2)OC=2C=C3C=C(C=2O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2O[C@@H](C)[C@H](O)[C@@](C)(N)C2)OC2=CC=C(C=C2Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]2C(=O)N[C@@H]1C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@@H](O)[C@H](C)O1 UECIPBUIMXSXEI-BNSVOVDNSA-N 0.000 claims 2
• 108010013356 eremomycin Proteins 0.000 claims 2
• UECIPBUIMXSXEI-UHFFFAOYSA-N eremomycin Natural products C=1C2=CC=C(O)C=1C1=C(O)C=C(O)C=C1C(C(O)=O)NC(=O)C1NC(=O)C2NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC(C=3OC4C(C(O)C(O)C(CO)O4)OC4OC(C)C(O)C(C)(N)C4)=CC2=CC=3OC(C=C2)=CC=C2C1OC1CC(C)(N)C(O)C(C)O1 UECIPBUIMXSXEI-UHFFFAOYSA-N 0.000 claims 2
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 125000005309 thioalkoxy group Chemical group 0.000 claims 2
• DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical group NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 1
• 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims 1
• 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 claims 1
• KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
• 230000029936 alkylation Effects 0.000 claims 1
• 238000005804 alkylation reaction Methods 0.000 claims 1
• 150000001408 amides Chemical class 0.000 claims 1
• 230000000844 anti-bacterial effect Effects 0.000 claims 1
• 230000000845 anti-microbial effect Effects 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1
• 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
• 125000000547 substituted alkyl group Chemical group 0.000 claims 1