JP2008529532A5 - - Google Patents
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- Publication number
- JP2008529532A5 JP2008529532A5 JP2007555320A JP2007555320A JP2008529532A5 JP 2008529532 A5 JP2008529532 A5 JP 2008529532A5 JP 2007555320 A JP2007555320 A JP 2007555320A JP 2007555320 A JP2007555320 A JP 2007555320A JP 2008529532 A5 JP2008529532 A5 JP 2008529532A5
- Authority
- JP
- Japan
- Prior art keywords
- egfr
- gefitinib
- erlotinib
- cancer
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 21
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 12
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 11
- 101800003838 Epidermal growth factor Proteins 0.000 claims 11
- 229940116977 epidermal growth factor Drugs 0.000 claims 11
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 10
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 10
- 229960001433 erlotinib Drugs 0.000 claims 10
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 10
- 229960002584 gefitinib Drugs 0.000 claims 10
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 206010069754 Acquired gene mutation Diseases 0.000 claims 6
- 230000037439 somatic mutation Effects 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 5
- 108091093088 Amplicon Proteins 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108091008794 FGF receptors Proteins 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 238000012408 PCR amplification Methods 0.000 claims 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65248805P | 2005-02-11 | 2005-02-11 | |
| US60/652,488 | 2005-02-11 | ||
| PCT/US2006/005050 WO2006086777A2 (en) | 2005-02-11 | 2006-02-13 | Methods and compositions for detecting a drug resistant egfr mutant |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011250657A Division JP2012070746A (ja) | 2005-02-11 | 2011-11-16 | 薬剤耐性ｅｇｆｒ突然変異体を検出するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008529532A JP2008529532A (ja) | 2008-08-07 |
| JP2008529532A5 true JP2008529532A5 (enExample) | 2011-01-13 |
| JP4898710B2 JP4898710B2 (ja) | 2012-03-21 |
Family
ID=36793833
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007555320A Expired - Lifetime JP4898710B2 (ja) | 2005-02-11 | 2006-02-13 | 薬剤耐性ｅｇｆｒ突然変異体を検出するための方法および組成物 |
| JP2011250657A Pending JP2012070746A (ja) | 2005-02-11 | 2011-11-16 | 薬剤耐性ｅｇｆｒ突然変異体を検出するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011250657A Pending JP2012070746A (ja) | 2005-02-11 | 2011-11-16 | 薬剤耐性ｅｇｆｒ突然変異体を検出するための方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8067175B2 (enExample) |
| EP (2) | EP1851339B1 (enExample) |
| JP (2) | JP4898710B2 (enExample) |
| CN (1) | CN101193905B (enExample) |
| CA (1) | CA2597673C (enExample) |
| ES (1) | ES2586410T3 (enExample) |
| WO (1) | WO2006086777A2 (enExample) |
Families Citing this family (77)
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- 2006-02-13 EP EP06720702.7A patent/EP1851339B1/en not_active Revoked
- 2006-02-13 US US11/815,985 patent/US8067175B2/en active Active
- 2006-02-13 JP JP2007555320A patent/JP4898710B2/ja not_active Expired - Lifetime
- 2006-02-13 CN CN200680011674.5A patent/CN101193905B/zh not_active Expired - Lifetime
- 2006-02-13 EP EP12168082A patent/EP2505591A1/en not_active Ceased
- 2006-02-13 ES ES06720702.7T patent/ES2586410T3/es not_active Expired - Lifetime
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2011
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