CA2597673C - Methods and compositions for detecting a drug resistant egfr mutant - Google Patents

Methods and compositions for detecting a drug resistant egfr mutant Download PDF

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Publication number
CA2597673C
CA2597673C CA2597673A CA2597673A CA2597673C CA 2597673 C CA2597673 C CA 2597673C CA 2597673 A CA2597673 A CA 2597673A CA 2597673 A CA2597673 A CA 2597673A CA 2597673 C CA2597673 C CA 2597673C
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Canada
Prior art keywords
egfr
mutation
mutant
sequence
gefitinib
Prior art date
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Expired - Lifetime
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CA2597673A
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English (en)
French (fr)
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CA2597673A1 (en
Inventor
Harold Varmus
Katerina Politi
William Pao
Vincent Miller
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Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Cancer Center
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36793833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2597673(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CA2597673A1 publication Critical patent/CA2597673A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2597673A 2005-02-11 2006-02-13 Methods and compositions for detecting a drug resistant egfr mutant Expired - Lifetime CA2597673C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65248805P 2005-02-11 2005-02-11
US60/652,488 2005-02-11
PCT/US2006/005050 WO2006086777A2 (en) 2005-02-11 2006-02-13 Methods and compositions for detecting a drug resistant egfr mutant

Publications (2)

Publication Number Publication Date
CA2597673A1 CA2597673A1 (en) 2006-08-17
CA2597673C true CA2597673C (en) 2014-07-08

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ID=36793833

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2597673A Expired - Lifetime CA2597673C (en) 2005-02-11 2006-02-13 Methods and compositions for detecting a drug resistant egfr mutant

Country Status (7)

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US (2) US8067175B2 (enExample)
EP (2) EP1851339B1 (enExample)
JP (2) JP4898710B2 (enExample)
CN (1) CN101193905B (enExample)
CA (1) CA2597673C (enExample)
ES (1) ES2586410T3 (enExample)
WO (1) WO2006086777A2 (enExample)

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* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
EP1851339B1 (en) 2016-05-18
WO2006086777A2 (en) 2006-08-17
US8501413B2 (en) 2013-08-06
ES2586410T3 (es) 2016-10-14
EP1851339A4 (en) 2009-05-27
JP2012070746A (ja) 2012-04-12
HK1118832A1 (en) 2009-02-20
JP4898710B2 (ja) 2012-03-21
WO2006086777A3 (en) 2007-11-22
CN101193905A (zh) 2008-06-04
CN101193905B (zh) 2014-06-25
EP1851339A2 (en) 2007-11-07
CA2597673A1 (en) 2006-08-17
US8067175B2 (en) 2011-11-29
US20120077201A1 (en) 2012-03-29
JP2008529532A (ja) 2008-08-07
US20100173285A1 (en) 2010-07-08
EP2505591A1 (en) 2012-10-03

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