JP4898710B2 - 薬剤耐性ｅｇｆｒ突然変異体を検出するための方法および組成物 - Google Patents

薬剤耐性ｅｇｆｒ突然変異体を検出するための方法および組成物 Download PDF

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JP4898710B2
JP4898710B2 JP2007555320A JP2007555320A JP4898710B2 JP 4898710 B2 JP4898710 B2 JP 4898710B2 JP 2007555320 A JP2007555320 A JP 2007555320A JP 2007555320 A JP2007555320 A JP 2007555320A JP 4898710 B2 JP4898710 B2 JP 4898710B2
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egfr
mutation
gefitinib
erlotinib
sequence
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JP2008529532A (ja
JP2008529532A5 (enExample
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ハロルド バーマス，
カテリナ ポリティ，
ウィリアム パオ，
ビンセント ミラー，
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Memorial Sloan Kettering Cancer Center
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2007555320A 2005-02-11 2006-02-13 薬剤耐性ｅｇｆｒ突然変異体を検出するための方法および組成物 Expired - Lifetime JP4898710B2 (ja)

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US65248805P 2005-02-11 2005-02-11
US60/652,488 2005-02-11
PCT/US2006/005050 WO2006086777A2 (en) 2005-02-11 2006-02-13 Methods and compositions for detecting a drug resistant egfr mutant

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JP2008529532A5 JP2008529532A5 (enExample) 2011-01-13
JP4898710B2 true JP4898710B2 (ja) 2012-03-21

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JP2011250657A Pending JP2012070746A (ja) 2005-02-11 2011-11-16 薬剤耐性ｅｇｆｒ突然変異体を検出するための方法および組成物

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CA (1) CA2597673C (enExample)
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EP1881079A1 (en) 2006-07-20 2008-01-23 Pangaea Biotech, S.A. Method for the detection of EGFR mutations in blood samples

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WO2006086777A2 (en) 2006-08-17
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EP1851339A4 (en) 2009-05-27
JP2012070746A (ja) 2012-04-12
HK1118832A1 (en) 2009-02-20
WO2006086777A3 (en) 2007-11-22
CA2597673C (en) 2014-07-08
CN101193905A (zh) 2008-06-04
CN101193905B (zh) 2014-06-25
EP1851339A2 (en) 2007-11-07
CA2597673A1 (en) 2006-08-17
US8067175B2 (en) 2011-11-29
US20120077201A1 (en) 2012-03-29
JP2008529532A (ja) 2008-08-07
US20100173285A1 (en) 2010-07-08
EP2505591A1 (en) 2012-10-03

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