JP2008528672A5 - - Google Patents
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- Publication number
- JP2008528672A5 JP2008528672A5 JP2007553702A JP2007553702A JP2008528672A5 JP 2008528672 A5 JP2008528672 A5 JP 2008528672A5 JP 2007553702 A JP2007553702 A JP 2007553702A JP 2007553702 A JP2007553702 A JP 2007553702A JP 2008528672 A5 JP2008528672 A5 JP 2008528672A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- asp
- contrast agent
- alkyl
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002872 contrast media Substances 0.000 claims 8
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 102000003952 Caspase 3 Human genes 0.000 claims 2
- 108090000397 Caspase 3 Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- -1 alkyl tosylate Chemical compound 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 210000000170 cell membrane Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000010534 nucleophilic substitution reaction Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- XUNKPNYCNUKOAU-VXJRNSOOSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]a Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O XUNKPNYCNUKOAU-VXJRNSOOSA-N 0.000 claims 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- 108700003968 Human immunodeficiency virus 1 tat peptide (49-57) Proteins 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- 102000003939 Membrane transport proteins Human genes 0.000 claims 1
- 108090000301 Membrane transport proteins Proteins 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001350 alkyl halides Chemical class 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000007336 electrophilic substitution reaction Methods 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 230000005251 gamma ray Effects 0.000 claims 1
- 150000002337 glycosamines Chemical class 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000009061 membrane transport Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 150000002902 organometallic compounds Chemical class 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0502277.7A GB0502277D0 (en) | 2005-02-04 | 2005-02-04 | Novel imaging agents |
| PCT/GB2006/000398 WO2006082434A1 (en) | 2005-02-04 | 2006-02-03 | Caspase-3 substrate comprising imaging agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008528672A JP2008528672A (ja) | 2008-07-31 |
| JP2008528672A5 true JP2008528672A5 (https=) | 2009-03-19 |
Family
ID=34307944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007553702A Pending JP2008528672A (ja) | 2005-02-04 | 2006-02-03 | カスパーゼ−３基質含有造影剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080286201A1 (https=) |
| EP (1) | EP1853324A1 (https=) |
| JP (1) | JP2008528672A (https=) |
| CN (1) | CN101155602A (https=) |
| GB (1) | GB0502277D0 (https=) |
| WO (1) | WO2006082434A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101578225B1 (ko) | 2007-05-16 | 2015-12-17 | 지이 헬스케어 에이에스 | 영상화를 위한 표지된 ｈｇｆ 결합성 펩티드 |
| CA2722858C (en) | 2008-04-30 | 2017-08-29 | Siemens Medical Solutions Usa, Inc. | Substrate based pet imaging agents |
| DK2288615T3 (en) | 2008-05-21 | 2017-09-04 | Genesis Tech Ltd | SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF |
| US20110293520A1 (en) * | 2008-06-09 | 2011-12-01 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases |
| GB0819280D0 (en) * | 2008-10-21 | 2008-11-26 | Gen Electric | Imgaing and radiotherapy methods |
| EP2697246B1 (en) | 2011-04-15 | 2018-03-07 | Genesis Technologies Limited | Selective cysteine protease inhibitors and uses thereof |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| WO2016065174A1 (en) * | 2014-10-22 | 2016-04-28 | Seed Research And Development Llc | Caspase probes for detection of apoptosis |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2328457A1 (en) * | 1998-06-20 | 1999-12-29 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| EP1379284A4 (en) * | 2001-01-05 | 2007-07-25 | Gen Hospital | ACTIVE IMAGING PROBES |
| US6979530B2 (en) * | 2001-05-21 | 2005-12-27 | Applera Corporation | Peptide conjugates and fluorescence detection methods for intracellular caspase assay |
| GB0327494D0 (en) * | 2003-11-26 | 2003-12-31 | Amersham Plc | Novel imaging agents |
-
2005
- 2005-02-04 GB GBGB0502277.7A patent/GB0502277D0/en not_active Ceased
-
2006
- 2006-02-03 EP EP06709644A patent/EP1853324A1/en not_active Withdrawn
- 2006-02-03 CN CNA2006800110749A patent/CN101155602A/zh active Pending
- 2006-02-03 JP JP2007553702A patent/JP2008528672A/ja active Pending
- 2006-02-03 WO PCT/GB2006/000398 patent/WO2006082434A1/en not_active Ceased
- 2006-02-03 US US11/815,360 patent/US20080286201A1/en not_active Abandoned
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