CN101155602A - 包含胱天蛋白酶-3底物的成像剂 - Google Patents

包含胱天蛋白酶-3底物的成像剂 Download PDF

Info

Publication number
CN101155602A
CN101155602A CNA2006800110749A CN200680011074A CN101155602A CN 101155602 A CN101155602 A CN 101155602A CN A2006800110749 A CNA2006800110749 A CN A2006800110749A CN 200680011074 A CN200680011074 A CN 200680011074A CN 101155602 A CN101155602 A CN 101155602A
Authority
CN
China
Prior art keywords
preparation
precursor
group
caspase
chemical compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800110749A
Other languages
English (en)
Chinese (zh)
Inventor
B·吉尔贝
S·钱皮安
A·M·吉布森
S·-A·里克茨
M·阿沃里
B·E·阿博
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN101155602A publication Critical patent/CN101155602A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CNA2006800110749A 2005-02-04 2006-02-03 包含胱天蛋白酶-3底物的成像剂 Pending CN101155602A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0502277.7 2005-02-04
GBGB0502277.7A GB0502277D0 (en) 2005-02-04 2005-02-04 Novel imaging agents

Publications (1)

Publication Number Publication Date
CN101155602A true CN101155602A (zh) 2008-04-02

Family

ID=34307944

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800110749A Pending CN101155602A (zh) 2005-02-04 2006-02-03 包含胱天蛋白酶-3底物的成像剂

Country Status (6)

Country Link
US (1) US20080286201A1 (https=)
EP (1) EP1853324A1 (https=)
JP (1) JP2008528672A (https=)
CN (1) CN101155602A (https=)
GB (1) GB0502277D0 (https=)
WO (1) WO2006082434A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102056903A (zh) * 2008-06-09 2011-05-11 路德维希马克西米利安慕尼黑大学 抑制与蛋白聚集有关的疾病和/或神经变性疾病中涉及的蛋白聚集的新药

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101578225B1 (ko) 2007-05-16 2015-12-17 지이 헬스케어 에이에스 영상화를 위한 표지된 ｈｇｆ 결합성 펩티드
CA2722858C (en) 2008-04-30 2017-08-29 Siemens Medical Solutions Usa, Inc. Substrate based pet imaging agents
DK2288615T3 (en) 2008-05-21 2017-09-04 Genesis Tech Ltd SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF
GB0819280D0 (en) * 2008-10-21 2008-11-26 Gen Electric Imgaing and radiotherapy methods
EP2697246B1 (en) 2011-04-15 2018-03-07 Genesis Technologies Limited Selective cysteine protease inhibitors and uses thereof
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
WO2016065174A1 (en) * 2014-10-22 2016-04-28 Seed Research And Development Llc Caspase probes for detection of apoptosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2328457A1 (en) * 1998-06-20 1999-12-29 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
EP1379284A4 (en) * 2001-01-05 2007-07-25 Gen Hospital ACTIVE IMAGING PROBES
US6979530B2 (en) * 2001-05-21 2005-12-27 Applera Corporation Peptide conjugates and fluorescence detection methods for intracellular caspase assay
GB0327494D0 (en) * 2003-11-26 2003-12-31 Amersham Plc Novel imaging agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102056903A (zh) * 2008-06-09 2011-05-11 路德维希马克西米利安慕尼黑大学 抑制与蛋白聚集有关的疾病和/或神经变性疾病中涉及的蛋白聚集的新药
CN102056903B (zh) * 2008-06-09 2015-04-15 路德维希马克西米利安慕尼黑大学 抑制与蛋白聚集有关的疾病和/或神经变性疾病中涉及的蛋白聚集的新药

Also Published As

Publication number Publication date
EP1853324A1 (en) 2007-11-14
US20080286201A1 (en) 2008-11-20
JP2008528672A (ja) 2008-07-31
GB0502277D0 (en) 2005-03-09
WO2006082434A1 (en) 2006-08-10

Similar Documents

Publication Publication Date Title
Bullok et al. Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with 99mTc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy
EP0772628B1 (en) Peptide derived radionuclide chelators
US12156920B2 (en) Double-labeled probe for molecular imaging and use thereof
Bandari et al. Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN (7-14) NH2], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer
US11638765B2 (en) Double-labeled probe for molecular imaging and use thereof
CN118852331A (zh) 伊文思蓝衍生物的化学缀合物及其作为靶向前列腺癌的放射疗法和显像剂的用途
US7803351B2 (en) Blood brain barrier permeation peptides
CN112574280B (zh) 一种双酶体系探针及其应用
CN101454026A (zh) 新型成像剂
JP2002518521A (ja) 医用画像解析、診断および治療のための膜透過性ペプチド錯体
Guo et al. Design and evaluation of new Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptides for melanoma imaging
CN103483422B (zh) 一种ngr多肽放射性药物及其制备方法与应用
Achilefu et al. Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors
AU2004212997A1 (en) Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
KR20110002493A (ko) 기질 기재 ｐｅｔ 조영제
CN101155602A (zh) 包含胱天蛋白酶-3底物的成像剂
CN107753962A (zh) 放射性示踪剂组合物
PL239934B1 (pl) Pochodne inhibitorów PSMA do znakowania ⁹⁹ᵐTc poprzez HYNIC, zestaw radiofarmaceutyczny, preparat radiofarmaceutyczny oraz ich zastosowanie w diagnostyce raka prostaty
Richter et al. Fluorine‐18 labeling of phosphopeptides: A potential approach for the evaluation of phosphopeptide metabolism in vivo
JP5709522B2 (ja) 新規イメージング法
WO2025191096A1 (en) Bicyclic peptide
Sun Specific PET Imaging Probes for Early Detection of Prostate Cancer Metastases
HK1212219A1 (en) 177-lu labeled peptide for site-specific upar-targeting

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20080402