JP2008528672A - カスパーゼ−３基質含有造影剤 - Google Patents

カスパーゼ−３基質含有造影剤 Download PDF

Info

Publication number
JP2008528672A
JP2008528672A JP2007553702A JP2007553702A JP2008528672A JP 2008528672 A JP2008528672 A JP 2008528672A JP 2007553702 A JP2007553702 A JP 2007553702A JP 2007553702 A JP2007553702 A JP 2007553702A JP 2008528672 A JP2008528672 A JP 2008528672A
Authority
JP
Japan
Prior art keywords
group
contrast agent
caspase
compound
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007553702A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008528672A5 (https=
Inventor
ギルバート，ベネディクト
チャンピオン，スー
ギブソン，アレキサンダー・マーク
リケッツ，サリー−アン
エイヴォリー，ミシェル
アルボ，ベント・イー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of JP2008528672A publication Critical patent/JP2008528672A/ja
Publication of JP2008528672A5 publication Critical patent/JP2008528672A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2007553702A 2005-02-04 2006-02-03 カスパーゼ−３基質含有造影剤 Pending JP2008528672A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0502277.7A GB0502277D0 (en) 2005-02-04 2005-02-04 Novel imaging agents
PCT/GB2006/000398 WO2006082434A1 (en) 2005-02-04 2006-02-03 Caspase-3 substrate comprising imaging agents

Publications (2)

Publication Number Publication Date
JP2008528672A true JP2008528672A (ja) 2008-07-31
JP2008528672A5 JP2008528672A5 (https=) 2009-03-19

Family

ID=34307944

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007553702A Pending JP2008528672A (ja) 2005-02-04 2006-02-03 カスパーゼ−３基質含有造影剤

Country Status (6)

Country Link
US (1) US20080286201A1 (https=)
EP (1) EP1853324A1 (https=)
JP (1) JP2008528672A (https=)
CN (1) CN101155602A (https=)
GB (1) GB0502277D0 (https=)
WO (1) WO2006082434A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012506439A (ja) * 2008-10-21 2012-03-15 ジーイー・ヘルスケア・リミテッド イメージング及び放射線治療法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101578225B1 (ko) 2007-05-16 2015-12-17 지이 헬스케어 에이에스 영상화를 위한 표지된 ｈｇｆ 결합성 펩티드
CA2722858C (en) 2008-04-30 2017-08-29 Siemens Medical Solutions Usa, Inc. Substrate based pet imaging agents
DK2288615T3 (en) 2008-05-21 2017-09-04 Genesis Tech Ltd SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF
US20110293520A1 (en) * 2008-06-09 2011-12-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases
EP2697246B1 (en) 2011-04-15 2018-03-07 Genesis Technologies Limited Selective cysteine protease inhibitors and uses thereof
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
WO2016065174A1 (en) * 2014-10-22 2016-04-28 Seed Research And Development Llc Caspase probes for detection of apoptosis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002518521A (ja) * 1998-06-20 2002-06-25 ワシントン・ユニバーシティ 医用画像解析、診断および治療のための膜透過性ペプチド錯体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1379284A4 (en) * 2001-01-05 2007-07-25 Gen Hospital ACTIVE IMAGING PROBES
US6979530B2 (en) * 2001-05-21 2005-12-27 Applera Corporation Peptide conjugates and fluorescence detection methods for intracellular caspase assay
GB0327494D0 (en) * 2003-11-26 2003-12-31 Amersham Plc Novel imaging agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002518521A (ja) * 1998-06-20 2002-06-25 ワシントン・ユニバーシティ 医用画像解析、診断および治療のための膜透過性ペプチド錯体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012506439A (ja) * 2008-10-21 2012-03-15 ジーイー・ヘルスケア・リミテッド イメージング及び放射線治療法

Also Published As

Publication number Publication date
EP1853324A1 (en) 2007-11-14
US20080286201A1 (en) 2008-11-20
GB0502277D0 (en) 2005-03-09
CN101155602A (zh) 2008-04-02
WO2006082434A1 (en) 2006-08-10

Similar Documents

Publication Publication Date Title
RU2594167C2 (ru) Композиции пептидных радиоактивных индикаторов
CN101454026B (zh) 成像剂
CN104768573B (zh) 用于位点特异性uPAR靶向的177‑Lu标记肽
US20080267882A1 (en) Imaging compounds, methods of making imaging compounds, methods of imaging, therapeutic compounds, methods of making therapeutic compounds, and methods of therapy
US12156920B2 (en) Double-labeled probe for molecular imaging and use thereof
US11638765B2 (en) Double-labeled probe for molecular imaging and use thereof
KR101367219B1 (ko) 기질 기재 ｐｅｔ 조영제
CN103547291B (zh) 锝标记的肽
US20250288704A1 (en) Cxcr4-ligands for diagnostic and therapeutic use and precursors thereof
JP2007512302A (ja) カスパーゼ−３阻害剤を含む新規な造影剤
JP2008528672A (ja) カスパーゼ−３基質含有造影剤
CN109316609B (zh) 选择患者的方法
KR20130124522A (ko) 방사성 추적자 조성물
US20240182520A1 (en) New peptide-based diagnostic and therapeutic agents
US20080279769A1 (en) Enzyme Inhibitor Imaging Agents
US20150320892A1 (en) Imaging fibrosis
WO2008003954A1 (en) Dye imaging agents
JP5709522B2 (ja) 新規イメージング法
JP2024506070A (ja) 新規ｈｅｒ２結合ポリペプチド
HK40118167A (zh) 伊文思蓝衍生物的化学缀合物及其作为靶向前列腺癌的放射疗法和显像剂的用途
US20070031333A1 (en) Novel F-18 labeled annexin V, synthesis thereof, and use thereof
HK1186119A (en) Peptide radiotracer compositions

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090129

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090129

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20110207

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110207

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110719

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20111017

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20111024

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120117

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120821

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121121

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121129

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130423