JP2008528665A5 - - Google Patents
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- Publication number
- JP2008528665A5 JP2008528665A5 JP2007553689A JP2007553689A JP2008528665A5 JP 2008528665 A5 JP2008528665 A5 JP 2008528665A5 JP 2007553689 A JP2007553689 A JP 2007553689A JP 2007553689 A JP2007553689 A JP 2007553689A JP 2008528665 A5 JP2008528665 A5 JP 2008528665A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- agent
- drug
- independently selected
- adenine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 229930024421 Adenine Natural products 0.000 claims 3
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 3
- 229960000643 adenine Drugs 0.000 claims 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 2
- 101150007969 ADORA1 gene Proteins 0.000 claims 2
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- CQOQCZLTCMUVMX-UHFFFAOYSA-N 2-[4-(2,3-dihydroxypropoxy)phenyl]acetamide Chemical compound NC(=O)CC1=CC=C(OCC(O)CO)C=C1 CQOQCZLTCMUVMX-UHFFFAOYSA-N 0.000 claims 1
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 1
- 108091006027 G proteins Proteins 0.000 claims 1
- 102000030782 GTP binding Human genes 0.000 claims 1
- 108091000058 GTP-Binding Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 229930010555 Inosine Natural products 0.000 claims 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229960003786 inosine Drugs 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 230000003805 potassium influx Effects 0.000 claims 1
- 230000004224 protection Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
- 229940075420 xanthine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0502250.4A GB0502250D0 (en) | 2005-02-03 | 2005-02-03 | Use |
| PCT/GB2006/000343 WO2006082397A1 (en) | 2005-02-03 | 2006-02-01 | New uses of dinucleotide polyphosphate derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008528665A JP2008528665A (ja) | 2008-07-31 |
| JP2008528665A5 true JP2008528665A5 (enExample) | 2009-03-19 |
Family
ID=34307930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007553689A Pending JP2008528665A (ja) | 2005-02-03 | 2006-02-01 | ジヌクレオチドポリリン酸誘導体の使用法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080319184A1 (enExample) |
| EP (1) | EP1846004A1 (enExample) |
| JP (1) | JP2008528665A (enExample) |
| CN (1) | CN101180066A (enExample) |
| AU (1) | AU2006210715A1 (enExample) |
| CA (1) | CA2596959A1 (enExample) |
| GB (1) | GB0502250D0 (enExample) |
| WO (1) | WO2006082397A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201209244D0 (en) * | 2012-05-25 | 2012-07-04 | Globalacorn Ltd | Compositions |
| GB201320962D0 (en) * | 2013-11-27 | 2014-01-08 | Globalacorn Ltd | Compositions |
| GB201320959D0 (en) * | 2013-11-27 | 2014-01-08 | Globalacorn Ltd | Compositions |
| KR102504764B1 (ko) * | 2017-06-21 | 2023-03-02 | 주식회사 종근당 | 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법 |
| WO2021123388A1 (en) * | 2019-12-20 | 2021-06-24 | Nuvamid Sa | Novel nicotinamide di-nucleotide derivatives and use thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| US5681823A (en) * | 1996-05-02 | 1997-10-28 | Prp Inc. | P1, P4 -dithio-P2 -P3 -monochloromethylene 5', 5'"-diadenosine P1, P4 -tetraphosphate as antithrombotic agent |
| US6696425B2 (en) * | 1997-02-06 | 2004-02-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| ES2264197T3 (es) * | 1997-02-06 | 2006-12-16 | Inspire Pharmaceuticals, Inc. | Dinucleotidos y sus usos. |
| US6596725B2 (en) * | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
| GB9711848D0 (en) * | 1997-06-06 | 1997-08-06 | William Harvey Research Limite | Treatment and prophylaxis of infraction |
| WO1999003480A1 (en) * | 1997-07-17 | 1999-01-28 | William Harvey Research Limited | Use of adenosine tri- or tetra-phosphates and their analogues for the treatment of cerebral infarction |
| US7084126B1 (en) * | 2000-05-01 | 2006-08-01 | Healthpartners Research Foundation | Methods and compositions for enhancing cellular function through protection of tissue components |
| US6555675B2 (en) * | 2000-08-21 | 2003-04-29 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists |
| GB2394419B (en) * | 2001-06-25 | 2005-09-07 | Inspire Pharmaceuticals Inc | Joint lubrication with p2y purinergic receptor agonists |
| CN1612739A (zh) * | 2001-11-06 | 2005-05-04 | 印斯拜尔药品股份有限公司 | 治疗或预防炎性疾病的方法 |
| US7203743B2 (en) * | 2001-12-28 | 2007-04-10 | Nortel Networks Limited | Hierarchical tree-based protection scheme for mesh networks |
-
2005
- 2005-02-03 GB GBGB0502250.4A patent/GB0502250D0/en not_active Ceased
-
2006
- 2006-02-01 WO PCT/GB2006/000343 patent/WO2006082397A1/en not_active Ceased
- 2006-02-01 JP JP2007553689A patent/JP2008528665A/ja active Pending
- 2006-02-01 AU AU2006210715A patent/AU2006210715A1/en not_active Abandoned
- 2006-02-01 US US11/883,661 patent/US20080319184A1/en not_active Abandoned
- 2006-02-01 CN CNA2006800090694A patent/CN101180066A/zh active Pending
- 2006-02-01 EP EP06704231A patent/EP1846004A1/en not_active Withdrawn
- 2006-02-01 CA CA002596959A patent/CA2596959A1/en not_active Abandoned
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