JP2009528368A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009528368A5 JP2009528368A5 JP2008557379A JP2008557379A JP2009528368A5 JP 2009528368 A5 JP2009528368 A5 JP 2009528368A5 JP 2008557379 A JP2008557379 A JP 2008557379A JP 2008557379 A JP2008557379 A JP 2008557379A JP 2009528368 A5 JP2009528368 A5 JP 2009528368A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methoxy
- composition
- benzyl
- benzimidazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JPSZEXYTKSIPDW-UHFFFAOYSA-N 1-(4-methoxyphenyl)-n-[(4-propan-2-ylphenyl)methyl]benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NCC=3C=CC(=CC=3)C(C)C)C=C2N=C1 JPSZEXYTKSIPDW-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims 58
- -1 2-substituted phenyl Chemical group 0.000 claims 34
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 4
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims 4
- 125000005251 aryl acyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- UQOPUGXBYMSITD-UHFFFAOYSA-N n-[[4-(dimethylamino)phenyl]methyl]-1-phenylbenzimidazol-5-amine Chemical compound C1=CC(N(C)C)=CC=C1CNC1=CC=C(N(C=N2)C=3C=CC=CC=3)C2=C1 UQOPUGXBYMSITD-UHFFFAOYSA-N 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- CITVAIAZDOSXLX-UHFFFAOYSA-N 1-(2-methoxyphenyl)-n-[(2-methoxyphenyl)methyl]benzimidazol-5-amine Chemical compound COC1=CC=CC=C1CNC1=CC=C(N(C=N2)C=3C(=CC=CC=3)OC)C2=C1 CITVAIAZDOSXLX-UHFFFAOYSA-N 0.000 claims 2
- OKEQVACWLNFZTP-UHFFFAOYSA-N 1-(2-methoxyphenyl)-n-[(4-methoxyphenyl)methyl]benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1CNC1=CC=C(N(C=N2)C=3C(=CC=CC=3)OC)C2=C1 OKEQVACWLNFZTP-UHFFFAOYSA-N 0.000 claims 2
- UGDIFWIKOWHDAS-UHFFFAOYSA-N 1-(4-methoxyphenyl)-n-(naphthalen-1-ylmethyl)benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NCC=3C4=CC=CC=C4C=CC=3)C=C2N=C1 UGDIFWIKOWHDAS-UHFFFAOYSA-N 0.000 claims 2
- CWVNGHGRVCDVIO-UHFFFAOYSA-N 1-(4-methoxyphenyl)-n-[(2-methoxyphenyl)methyl]benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NCC=3C(=CC=CC=3)OC)C=C2N=C1 CWVNGHGRVCDVIO-UHFFFAOYSA-N 0.000 claims 2
- FFFWZKABVHAJQQ-UHFFFAOYSA-N 1-(4-methoxyphenyl)-n-[(3-methoxyphenyl)methyl]benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NCC=3C=C(OC)C=CC=3)C=C2N=C1 FFFWZKABVHAJQQ-UHFFFAOYSA-N 0.000 claims 2
- NPIICRVNFVQQQJ-UHFFFAOYSA-N 1-(4-methoxyphenyl)-n-[(4-methoxyphenyl)methyl]benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1CNC1=CC=C(N(C=N2)C=3C=CC(OC)=CC=3)C2=C1 NPIICRVNFVQQQJ-UHFFFAOYSA-N 0.000 claims 2
- OPMYSQUCKVLCAM-UHFFFAOYSA-N 1-(4-methoxyphenyl)-n-[(4-methylphenyl)methyl]benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NCC=3C=CC(C)=CC=3)C=C2N=C1 OPMYSQUCKVLCAM-UHFFFAOYSA-N 0.000 claims 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 2
- 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- 208000005989 Arenaviridae Infections Diseases 0.000 claims 2
- 241000712891 Arenavirus Species 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 235000010290 biphenyl Nutrition 0.000 claims 2
- 239000004305 biphenyl Substances 0.000 claims 2
- 125000006267 biphenyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 2
- 125000000336 imidazol-5-yl group Chemical group [H]N1C([H])=NC([H])=C1[*] 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- DGGFGNOCHBWENN-UHFFFAOYSA-N n-[(2,3-dimethoxyphenyl)methyl]-1-(4-methoxyphenyl)benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NCC=3C(=C(OC)C=CC=3)OC)C=C2N=C1 DGGFGNOCHBWENN-UHFFFAOYSA-N 0.000 claims 2
- FLPMDKMKNCSOHN-UHFFFAOYSA-N n-[(3,4-dimethoxyphenyl)methyl]-1-(4-methoxyphenyl)benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NCC=3C=C(OC)C(OC)=CC=3)C=C2N=C1 FLPMDKMKNCSOHN-UHFFFAOYSA-N 0.000 claims 2
- JFIVTZMAXDALFV-UHFFFAOYSA-N n-[(4-bromophenyl)methyl]-1-(4-methoxyphenyl)benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NCC=3C=CC(Br)=CC=3)C=C2N=C1 JFIVTZMAXDALFV-UHFFFAOYSA-N 0.000 claims 2
- WZZXYDZGTLLJGD-UHFFFAOYSA-N n-[(4-chlorophenyl)methyl]-1-(4-methoxyphenyl)benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NCC=3C=CC(Cl)=CC=3)C=C2N=C1 WZZXYDZGTLLJGD-UHFFFAOYSA-N 0.000 claims 2
- HITDOSQAZSVIQP-UHFFFAOYSA-N n-[(4-ethoxyphenyl)methyl]-n-[1-(2-methoxyphenyl)benzimidazol-5-yl]-4-methylbenzenesulfonamide Chemical compound C1=CC(OCC)=CC=C1CN(S(=O)(=O)C=1C=CC(C)=CC=1)C1=CC=C(N(C=N2)C=3C(=CC=CC=3)OC)C2=C1 HITDOSQAZSVIQP-UHFFFAOYSA-N 0.000 claims 2
- PTYAJMSVGMUCFR-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-1-(4-methylphenyl)benzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1CNC1=CC=C(N(C=N2)C=3C=CC(C)=CC=3)C2=C1 PTYAJMSVGMUCFR-UHFFFAOYSA-N 0.000 claims 2
- FZBMDVNZKSEYOE-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-1-phenylbenzimidazol-5-amine Chemical compound C1=CC(OC)=CC=C1CNC1=CC=C(N(C=N2)C=3C=CC=CC=3)C2=C1 FZBMDVNZKSEYOE-UHFFFAOYSA-N 0.000 claims 2
- DUNDKBOYYKJVAY-UHFFFAOYSA-N n-[1-(4-methoxyphenyl)benzimidazol-5-yl]-4-methyl-n-[(4-propan-2-ylphenyl)methyl]benzenesulfonamide Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(N(CC=3C=CC(=CC=3)C(C)C)S(=O)(=O)C=3C=CC(C)=CC=3)C=C2N=C1 DUNDKBOYYKJVAY-UHFFFAOYSA-N 0.000 claims 2
- XVVZOSKRTBLLBJ-UHFFFAOYSA-N n-[1-(4-methoxyphenyl)benzimidazol-5-yl]-n-[(4-propan-2-ylphenyl)methyl]acetamide Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(N(CC=3C=CC(=CC=3)C(C)C)C(C)=O)C=C2N=C1 XVVZOSKRTBLLBJ-UHFFFAOYSA-N 0.000 claims 2
- ZPPFTBLVAQQGMW-UHFFFAOYSA-N n-[[4-(dimethylamino)phenyl]methyl]-1-(2-methoxyphenyl)benzimidazol-5-amine Chemical compound COC1=CC=CC=C1N1C2=CC=C(NCC=3C=CC(=CC=3)N(C)C)C=C2N=C1 ZPPFTBLVAQQGMW-UHFFFAOYSA-N 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000003944 tolyl group Chemical group 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77810706P | 2006-03-02 | 2006-03-02 | |
| US60/778,107 | 2006-03-02 | ||
| PCT/US2007/005263 WO2007103111A2 (en) | 2006-03-02 | 2007-03-02 | Antiviral drugs for treatment of arenavirus infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528368A JP2009528368A (ja) | 2009-08-06 |
| JP2009528368A5 true JP2009528368A5 (enExample) | 2010-07-29 |
| JP5380078B2 JP5380078B2 (ja) | 2014-01-08 |
Family
ID=38475385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557379A Expired - Fee Related JP5380078B2 (ja) | 2006-03-02 | 2007-03-02 | アレナウイルス感染の治療のための抗ウイルス薬剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7872037B2 (enExample) |
| EP (1) | EP1988776B1 (enExample) |
| JP (1) | JP5380078B2 (enExample) |
| AP (1) | AP2267A (enExample) |
| CA (1) | CA2651943C (enExample) |
| ES (1) | ES2395101T3 (enExample) |
| WO (1) | WO2007103111A2 (enExample) |
| ZA (1) | ZA200807507B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8530509B2 (en) | 2003-06-20 | 2013-09-10 | Siga Technologies, Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7687641B2 (en) * | 2003-06-20 | 2010-03-30 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7994221B2 (en) | 2004-12-06 | 2011-08-09 | Siga Technologies, Inc. | Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| US8410149B2 (en) * | 2004-12-06 | 2013-04-02 | Siga Technologies Inc. | Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| JP5285276B2 (ja) | 2004-12-06 | 2013-09-11 | シガ テクノロジーズ，インコーポレーテッド | アレナウイルスに関連した感染をはじめとする出血熱ウイルスを処置するための、スルホニルセミカルバジド、セミカルバジドおよび尿素、その医薬組成物および方法 |
| US8791110B2 (en) | 2006-02-01 | 2014-07-29 | Siga Technologies, Inc. | Anti-arenaviral compounds |
| US8106058B2 (en) | 2006-02-01 | 2012-01-31 | Siga Technologies, Inc. | Anti-arenaviral compounds |
| JP2009528367A (ja) * | 2006-03-02 | 2009-08-06 | サイガ・テクノロジーズ・インコーポレーテッド | アレナウイルス感染の治療のための抗ウイルス薬剤 |
| US7977365B2 (en) * | 2006-03-02 | 2011-07-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| EP1988776B1 (en) | 2006-03-02 | 2012-08-08 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| US8871746B2 (en) | 2006-03-02 | 2014-10-28 | Kineta Four, LLC | Antiviral drugs for treatment of arenavirus infection |
| US20080033755A1 (en) * | 2006-06-07 | 2008-02-07 | Krusz John C | Medical treatment modality for headache, pain, and other medical disorders |
| CN101034257B (zh) * | 2007-04-06 | 2010-09-08 | 上海复旦天臣新技术有限公司 | 用于全息记录的感光薄膜及其制备方法 |
| CA2866037C (en) * | 2007-04-23 | 2017-05-16 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| PH12012502343A1 (en) * | 2007-05-23 | 2013-06-17 | Siga Tech Inc | Antiviral drugs for treatment or prevention of dengue infection |
| WO2009025743A2 (en) * | 2007-08-17 | 2009-02-26 | University Of Massachusetts Medical School | Use of trail compositions as antiviral agents |
| WO2009029622A2 (en) | 2007-08-27 | 2009-03-05 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| US8940730B2 (en) | 2007-09-18 | 2015-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| JP5715820B2 (ja) * | 2007-09-18 | 2015-05-13 | スタンフォード ユニバーシティー | フラビウイルス科ファミリーのウイルスへの感染を治療する方法ならびに、フラビウイルス科ファミリーのウイルスへの感染を治療するための組成物 |
| US9149463B2 (en) | 2007-09-18 | 2015-10-06 | The Board Of Trustees Of The Leland Standford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| US9101628B2 (en) | 2007-09-18 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and composition of treating a flaviviridae family viral infection |
| AU2009232276B2 (en) * | 2008-01-15 | 2013-10-24 | Kineta Four Llc | Antiviral drugs for treatment of arenavirus infection |
| EP2408449A4 (en) | 2009-03-18 | 2012-08-08 | Univ Leland Stanford Junior | METHOD AND COMPOSITIONS FOR TREATING FLAVIVIRIDAE VIRUS INFECTIONS |
| US8609663B2 (en) | 2009-11-18 | 2013-12-17 | University Of Massachusetts | Compounds for modulating TLR2 |
| CA2793533C (en) | 2010-03-23 | 2019-02-26 | Siga Technologies, Inc. | Polymorphic forms of st-246 and methods of preparation |
| WO2013123215A2 (en) | 2012-02-17 | 2013-08-22 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
| CN108272838A (zh) * | 2018-03-23 | 2018-07-13 | 三峡大学 | 小花清风藤提取物及其提取方法和应用 |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| EP3980015A4 (en) * | 2019-06-06 | 2024-02-21 | University of Maryland, Baltimore | BROAD-SPECTRUM ANTIVIRAL COMPOUNDS TARGETING THE SKI COMPLEX |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4492708A (en) * | 1982-09-27 | 1985-01-08 | Eli Lilly And Company | Antiviral benzimidazoles |
| EP1206265B1 (en) | 1999-06-30 | 2003-11-12 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| WO2003026587A2 (en) * | 2001-09-26 | 2003-04-03 | Bristol-Myers Squibb Company | Compounds useful for treating hepatitus c virus |
| CA2486187C (en) | 2002-05-23 | 2013-02-19 | Cytopia Pty Ltd. | Kinase inhibitors |
| US7737168B2 (en) | 2003-06-20 | 2010-06-15 | Siga Technologies, Inc. | Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7687641B2 (en) | 2003-06-20 | 2010-03-30 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| CN1829709A (zh) * | 2003-08-01 | 2006-09-06 | 健亚生物科技公司 | 对抗黄病毒的双环咪唑衍生物 |
| DE10348023A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| JP2007519704A (ja) * | 2004-01-30 | 2007-07-19 | ファイザー・インク | 治療剤の組み合わせ |
| JP5285276B2 (ja) | 2004-12-06 | 2013-09-11 | シガ テクノロジーズ，インコーポレーテッド | アレナウイルスに関連した感染をはじめとする出血熱ウイルスを処置するための、スルホニルセミカルバジド、セミカルバジドおよび尿素、その医薬組成物および方法 |
| US7994221B2 (en) | 2004-12-06 | 2011-08-09 | Siga Technologies, Inc. | Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| RU2008115539A (ru) | 2005-11-03 | 2009-12-10 | Рэдпойнт Био Корпорэйшн (Us) | Производные гидразона и их применение |
| US8106058B2 (en) | 2006-02-01 | 2012-01-31 | Siga Technologies, Inc. | Anti-arenaviral compounds |
| JP2009528367A (ja) | 2006-03-02 | 2009-08-06 | サイガ・テクノロジーズ・インコーポレーテッド | アレナウイルス感染の治療のための抗ウイルス薬剤 |
| US7977365B2 (en) | 2006-03-02 | 2011-07-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| EP1988776B1 (en) | 2006-03-02 | 2012-08-08 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| CA2866037C (en) | 2007-04-23 | 2017-05-16 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| PH12012502343A1 (en) | 2007-05-23 | 2013-06-17 | Siga Tech Inc | Antiviral drugs for treatment or prevention of dengue infection |
| WO2009029622A2 (en) | 2007-08-27 | 2009-03-05 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| AU2009232276B2 (en) | 2008-01-15 | 2013-10-24 | Kineta Four Llc | Antiviral drugs for treatment of arenavirus infection |
| AP2010005480A0 (en) | 2008-06-03 | 2010-12-31 | Siga Technologies Inc | Small molecule inhibitors for the treatment or prevention of denque virus infection. |
-
2007
- 2007-03-02 EP EP07751991A patent/EP1988776B1/en not_active Not-in-force
- 2007-03-02 JP JP2008557379A patent/JP5380078B2/ja not_active Expired - Fee Related
- 2007-03-02 US US11/712,918 patent/US7872037B2/en not_active Expired - Fee Related
- 2007-03-02 CA CA2651943A patent/CA2651943C/en not_active Expired - Fee Related
- 2007-03-02 AP AP2008004594A patent/AP2267A/xx active
- 2007-03-02 ES ES07751991T patent/ES2395101T3/es active Active
- 2007-03-02 WO PCT/US2007/005263 patent/WO2007103111A2/en not_active Ceased
-
2008
- 2008-09-01 ZA ZA200807507A patent/ZA200807507B/xx unknown
-
2010
- 2010-10-26 US US12/912,325 patent/US8629170B2/en not_active Expired - Fee Related