CA2651943C - Antiviral drugs for treatment of arenavirus infection - Google Patents
Antiviral drugs for treatment of arenavirus infection Download PDFInfo
- Publication number
- CA2651943C CA2651943C CA2651943A CA2651943A CA2651943C CA 2651943 C CA2651943 C CA 2651943C CA 2651943 A CA2651943 A CA 2651943A CA 2651943 A CA2651943 A CA 2651943A CA 2651943 C CA2651943 C CA 2651943C
- Authority
- CA
- Canada
- Prior art keywords
- methoxy
- phenyl
- benzimidazol
- composition
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US77810706P | 2006-03-02 | 2006-03-02 | |
| US60/778,107 | 2006-03-02 | ||
| PCT/US2007/005263 WO2007103111A2 (en) | 2006-03-02 | 2007-03-02 | Antiviral drugs for treatment of arenavirus infection |
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| Publication Number | Publication Date |
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| CA2651943A1 CA2651943A1 (en) | 2007-09-13 |
| CA2651943C true CA2651943C (en) | 2015-06-30 |
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| US (2) | US7872037B2 (enExample) |
| EP (1) | EP1988776B1 (enExample) |
| JP (1) | JP5380078B2 (enExample) |
| AP (1) | AP2267A (enExample) |
| CA (1) | CA2651943C (enExample) |
| ES (1) | ES2395101T3 (enExample) |
| WO (1) | WO2007103111A2 (enExample) |
| ZA (1) | ZA200807507B (enExample) |
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| US8530509B2 (en) | 2003-06-20 | 2013-09-10 | Siga Technologies, Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7687641B2 (en) * | 2003-06-20 | 2010-03-30 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7994221B2 (en) | 2004-12-06 | 2011-08-09 | Siga Technologies, Inc. | Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| US8410149B2 (en) * | 2004-12-06 | 2013-04-02 | Siga Technologies Inc. | Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| JP5285276B2 (ja) | 2004-12-06 | 2013-09-11 | シガ テクノロジーズ，インコーポレーテッド | アレナウイルスに関連した感染をはじめとする出血熱ウイルスを処置するための、スルホニルセミカルバジド、セミカルバジドおよび尿素、その医薬組成物および方法 |
| US8791110B2 (en) | 2006-02-01 | 2014-07-29 | Siga Technologies, Inc. | Anti-arenaviral compounds |
| US8106058B2 (en) | 2006-02-01 | 2012-01-31 | Siga Technologies, Inc. | Anti-arenaviral compounds |
| JP2009528367A (ja) * | 2006-03-02 | 2009-08-06 | サイガ・テクノロジーズ・インコーポレーテッド | アレナウイルス感染の治療のための抗ウイルス薬剤 |
| US7977365B2 (en) * | 2006-03-02 | 2011-07-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| EP1988776B1 (en) | 2006-03-02 | 2012-08-08 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| US8871746B2 (en) | 2006-03-02 | 2014-10-28 | Kineta Four, LLC | Antiviral drugs for treatment of arenavirus infection |
| US20080033755A1 (en) * | 2006-06-07 | 2008-02-07 | Krusz John C | Medical treatment modality for headache, pain, and other medical disorders |
| CN101034257B (zh) * | 2007-04-06 | 2010-09-08 | 上海复旦天臣新技术有限公司 | 用于全息记录的感光薄膜及其制备方法 |
| CA2866037C (en) * | 2007-04-23 | 2017-05-16 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| PH12012502343A1 (en) * | 2007-05-23 | 2013-06-17 | Siga Tech Inc | Antiviral drugs for treatment or prevention of dengue infection |
| WO2009025743A2 (en) * | 2007-08-17 | 2009-02-26 | University Of Massachusetts Medical School | Use of trail compositions as antiviral agents |
| WO2009029622A2 (en) | 2007-08-27 | 2009-03-05 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| US8940730B2 (en) | 2007-09-18 | 2015-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| JP5715820B2 (ja) * | 2007-09-18 | 2015-05-13 | スタンフォード ユニバーシティー | フラビウイルス科ファミリーのウイルスへの感染を治療する方法ならびに、フラビウイルス科ファミリーのウイルスへの感染を治療するための組成物 |
| US9149463B2 (en) | 2007-09-18 | 2015-10-06 | The Board Of Trustees Of The Leland Standford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| US9101628B2 (en) | 2007-09-18 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and composition of treating a flaviviridae family viral infection |
| AU2009232276B2 (en) * | 2008-01-15 | 2013-10-24 | Kineta Four Llc | Antiviral drugs for treatment of arenavirus infection |
| EP2408449A4 (en) | 2009-03-18 | 2012-08-08 | Univ Leland Stanford Junior | METHOD AND COMPOSITIONS FOR TREATING FLAVIVIRIDAE VIRUS INFECTIONS |
| US8609663B2 (en) | 2009-11-18 | 2013-12-17 | University Of Massachusetts | Compounds for modulating TLR2 |
| CA2793533C (en) | 2010-03-23 | 2019-02-26 | Siga Technologies, Inc. | Polymorphic forms of st-246 and methods of preparation |
| WO2013123215A2 (en) | 2012-02-17 | 2013-08-22 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
| CN108272838A (zh) * | 2018-03-23 | 2018-07-13 | 三峡大学 | 小花清风藤提取物及其提取方法和应用 |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| EP3980015A4 (en) * | 2019-06-06 | 2024-02-21 | University of Maryland, Baltimore | BROAD-SPECTRUM ANTIVIRAL COMPOUNDS TARGETING THE SKI COMPLEX |
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| US4492708A (en) * | 1982-09-27 | 1985-01-08 | Eli Lilly And Company | Antiviral benzimidazoles |
| EP1206265B1 (en) | 1999-06-30 | 2003-11-12 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| WO2003026587A2 (en) * | 2001-09-26 | 2003-04-03 | Bristol-Myers Squibb Company | Compounds useful for treating hepatitus c virus |
| CA2486187C (en) | 2002-05-23 | 2013-02-19 | Cytopia Pty Ltd. | Kinase inhibitors |
| US7737168B2 (en) | 2003-06-20 | 2010-06-15 | Siga Technologies, Inc. | Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7687641B2 (en) | 2003-06-20 | 2010-03-30 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| CN1829709A (zh) * | 2003-08-01 | 2006-09-06 | 健亚生物科技公司 | 对抗黄病毒的双环咪唑衍生物 |
| DE10348023A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| JP2007519704A (ja) * | 2004-01-30 | 2007-07-19 | ファイザー・インク | 治療剤の組み合わせ |
| JP5285276B2 (ja) | 2004-12-06 | 2013-09-11 | シガ テクノロジーズ，インコーポレーテッド | アレナウイルスに関連した感染をはじめとする出血熱ウイルスを処置するための、スルホニルセミカルバジド、セミカルバジドおよび尿素、その医薬組成物および方法 |
| US7994221B2 (en) | 2004-12-06 | 2011-08-09 | Siga Technologies, Inc. | Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| RU2008115539A (ru) | 2005-11-03 | 2009-12-10 | Рэдпойнт Био Корпорэйшн (Us) | Производные гидразона и их применение |
| US8106058B2 (en) | 2006-02-01 | 2012-01-31 | Siga Technologies, Inc. | Anti-arenaviral compounds |
| JP2009528367A (ja) | 2006-03-02 | 2009-08-06 | サイガ・テクノロジーズ・インコーポレーテッド | アレナウイルス感染の治療のための抗ウイルス薬剤 |
| US7977365B2 (en) | 2006-03-02 | 2011-07-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| EP1988776B1 (en) | 2006-03-02 | 2012-08-08 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| CA2866037C (en) | 2007-04-23 | 2017-05-16 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| PH12012502343A1 (en) | 2007-05-23 | 2013-06-17 | Siga Tech Inc | Antiviral drugs for treatment or prevention of dengue infection |
| WO2009029622A2 (en) | 2007-08-27 | 2009-03-05 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| AU2009232276B2 (en) | 2008-01-15 | 2013-10-24 | Kineta Four Llc | Antiviral drugs for treatment of arenavirus infection |
| AP2010005480A0 (en) | 2008-06-03 | 2010-12-31 | Siga Technologies Inc | Small molecule inhibitors for the treatment or prevention of denque virus infection. |
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2007
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- 2007-03-02 JP JP2008557379A patent/JP5380078B2/ja not_active Expired - Fee Related
- 2007-03-02 US US11/712,918 patent/US7872037B2/en not_active Expired - Fee Related
- 2007-03-02 CA CA2651943A patent/CA2651943C/en not_active Expired - Fee Related
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1988776B1 (en) | 2012-08-08 |
| EP1988776A4 (en) | 2010-09-01 |
| US7872037B2 (en) | 2011-01-18 |
| CA2651943A1 (en) | 2007-09-13 |
| AP2267A (en) | 2011-08-02 |
| JP2009528368A (ja) | 2009-08-06 |
| US20070254934A1 (en) | 2007-11-01 |
| EP1988776A2 (en) | 2008-11-12 |
| WO2007103111A8 (en) | 2012-04-12 |
| US20110172281A1 (en) | 2011-07-14 |
| ZA200807507B (en) | 2009-08-26 |
| AP2008004594A0 (en) | 2008-08-31 |
| ES2395101T3 (es) | 2013-02-08 |
| WO2007103111A2 (en) | 2007-09-13 |
| JP5380078B2 (ja) | 2014-01-08 |
| US8629170B2 (en) | 2014-01-14 |
| WO2007103111A3 (en) | 2007-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190304 |