JP2008528617A5 - - Google Patents
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- Publication number
- JP2008528617A5 JP2008528617A5 JP2007553278A JP2007553278A JP2008528617A5 JP 2008528617 A5 JP2008528617 A5 JP 2008528617A5 JP 2007553278 A JP2007553278 A JP 2007553278A JP 2007553278 A JP2007553278 A JP 2007553278A JP 2008528617 A5 JP2008528617 A5 JP 2008528617A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- subject
- composition
- patient
- multiple myeloma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims 29
- 239000000203 mixture Substances 0.000 claims 28
- 208000034578 Multiple myelomas Diseases 0.000 claims 20
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 20
- 206010060862 Prostate cancer Diseases 0.000 claims 18
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 7
- 210000000988 bone and bone Anatomy 0.000 claims 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940122361 Bisphosphonate Drugs 0.000 claims 2
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 2
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 2
- 208000034951 Genetic Translocation Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 150000004663 bisphosphonates Chemical class 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims 2
- 150000003893 lactate salts Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- -1 tautomers Chemical class 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64756805P | 2005-01-27 | 2005-01-27 | |
| US60/647,568 | 2005-01-27 | ||
| US66924505P | 2005-04-06 | 2005-04-06 | |
| US60/669,245 | 2005-04-06 | ||
| US72205305P | 2005-09-29 | 2005-09-29 | |
| US60/722,053 | 2005-09-29 | ||
| PCT/US2006/002979 WO2006081445A2 (en) | 2005-01-27 | 2006-01-27 | Treatment of metastasized tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013129277A Division JP2013177464A (ja) | 2005-01-27 | 2013-06-20 | 転移した腫瘍の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008528617A JP2008528617A (ja) | 2008-07-31 |
| JP2008528617A5 true JP2008528617A5 (https=) | 2009-01-29 |
| JP5371246B2 JP5371246B2 (ja) | 2013-12-18 |
Family
ID=36741085
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007553278A Expired - Fee Related JP5371246B2 (ja) | 2005-01-27 | 2006-01-27 | 転移した腫瘍の治療 |
| JP2013129277A Withdrawn JP2013177464A (ja) | 2005-01-27 | 2013-06-20 | 転移した腫瘍の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013129277A Withdrawn JP2013177464A (ja) | 2005-01-27 | 2013-06-20 | 転移した腫瘍の治療 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20060183750A1 (https=) |
| EP (2) | EP1845990B1 (https=) |
| JP (2) | JP5371246B2 (https=) |
| KR (1) | KR101387985B1 (https=) |
| CN (1) | CN103893181A (https=) |
| AT (1) | ATE526025T1 (https=) |
| AU (1) | AU2006208012B2 (https=) |
| BR (1) | BRPI0607285A2 (https=) |
| CA (1) | CA2596084A1 (https=) |
| CY (1) | CY1112570T1 (https=) |
| DK (1) | DK1845990T3 (https=) |
| ES (2) | ES2374570T3 (https=) |
| IL (1) | IL184866A0 (https=) |
| MA (1) | MA29266B1 (https=) |
| MX (1) | MX2007009099A (https=) |
| NO (1) | NO20074360L (https=) |
| PL (2) | PL1845990T3 (https=) |
| PT (2) | PT2301546E (https=) |
| SG (1) | SG173317A1 (https=) |
| SI (1) | SI2301546T1 (https=) |
| TN (1) | TNSN07294A1 (https=) |
| WO (1) | WO2006081445A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1313734B1 (en) | 2000-09-01 | 2009-11-11 | Novartis Vaccines and Diagnostics, Inc. | Aza heterocyclic derivatives and their therapeutic use |
| CZ304344B6 (cs) | 2000-09-11 | 2014-03-19 | Novartis Vaccines & Diagnostics, Inc. | Chinolinonový derivát a jeho použití a farmaceutický prostředek s obsahem tohoto derivátu |
| CA2496164C (en) | 2002-08-23 | 2010-11-09 | Chiron Corporation | Benzimidazole quinolinones and uses thereof |
| CA2608171C (en) * | 2005-05-13 | 2014-02-04 | Novartis Ag | Use of quinolinone compounds for treating drug resistant cancers |
| MX2007014782A (es) * | 2005-05-23 | 2008-02-19 | Novartis Ag | Formas cristalinas y otras formas de las sales de acido lactico de 4-amino-5-fluoro-3-[6-(4-metilpiperazin-1-il)-1h-bencimidazol-2 -il]-1h quinolin-2-ona. |
| PE20091628A1 (es) * | 2008-03-19 | 2009-11-19 | Novartis Ag | Formas cristalinas y dos formas solvatadas de sales de acido lactico de 4-amino-5-fluoro-3-[5-(4-metilpiperazin-1-il)-1h-benzimidazol-2-il]quinolin-2(1h)-ona |
| EP2432451A2 (en) * | 2009-05-20 | 2012-03-28 | Children's Medical Center Corporation | Compositions for the treatment of metastatic cancer and methods of use thereof |
| ES2707625T3 (es) * | 2010-04-16 | 2019-04-04 | Novartis Ag | Compuesto orgánico para su utilización en el tratamiento del cáncer de hígado |
| BR112013029246A2 (pt) * | 2011-05-19 | 2017-02-14 | Novartis Ag | 4-amino-5-flúor-3-[6- (4-metilpiperazin- 1 - il) - 1h - benzimidazol - 2 - il] - 1h - quinolin-2-ona para uso no tratamento de carcinoma adenoide cístico |
| JP2015505562A (ja) * | 2012-01-31 | 2015-02-23 | ノバルティス アーゲー | Ｒｔｋ阻害剤と抗エストロゲン剤との組合せ、およびがん治療のためのその使用 |
| KR102494647B1 (ko) * | 2016-07-14 | 2023-01-31 | 브리스톨-마이어스 스큅 컴퍼니 | 비시클릭 헤테로아릴 치환된 화합물 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3663606A (en) * | 1966-06-21 | 1972-05-16 | Mitsui Toatsu Chemicals | Organic imino-compounds |
| DE2363459A1 (de) | 1973-12-20 | 1975-06-26 | Basf Ag | Neue fluoreszierende chinolinverbindungen |
| US4659657A (en) * | 1982-12-24 | 1987-04-21 | Bayer Aktiengesellschaft | Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases |
| US5073492A (en) * | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
| JPH0699497B2 (ja) | 1987-04-16 | 1994-12-07 | 富士写真フイルム株式会社 | 光重合性組成物 |
| DE3932953A1 (de) * | 1989-10-03 | 1991-04-11 | Boehringer Mannheim Gmbh | Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB9108547D0 (en) | 1991-04-22 | 1991-06-05 | Fujisawa Pharmaceutical Co | Quinoline derivatives |
| US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| USRE37650E1 (en) * | 1991-05-10 | 2002-04-09 | Aventis Pharmacetical Products, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
| US5856115A (en) * | 1991-05-24 | 1999-01-05 | Fred Hutchinson Cancer Research Center | Assay for identification therapeutic agents |
| EP1306095A3 (en) * | 1992-03-05 | 2003-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| JP3142378B2 (ja) | 1992-06-22 | 2001-03-07 | ティーディーケイ株式会社 | 有機ｅｌ素子 |
| US5981569A (en) * | 1992-11-13 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease |
| US5763441A (en) * | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
| US5792771A (en) * | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
| JPH0743896A (ja) | 1993-07-28 | 1995-02-14 | Toyobo Co Ltd | 光重合性組成物 |
| JPH0829973A (ja) | 1994-07-11 | 1996-02-02 | Toyobo Co Ltd | 光重合性組成物 |
| JP3441246B2 (ja) | 1995-06-07 | 2003-08-25 | 富士写真フイルム株式会社 | 光重合性組成物 |
| GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE19610723A1 (de) | 1996-03-19 | 1997-09-25 | Bayer Ag | Elektrolumineszierende Anordnungen unter Verwendung von Blendsystemen |
| US5942385A (en) * | 1996-03-21 | 1999-08-24 | Sugen, Inc. | Method for molecular diagnosis of tumor angiogenesis and metastasis |
| CA2258728C (en) * | 1996-06-19 | 2011-09-27 | Rhone Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
| HUP9904567A3 (en) | 1996-06-20 | 2001-10-29 | Univ Texas | Use of azo, thioalkyl, thiocarbonyl derivatives substituted by fused heterocycles and/or phenyl group for the preparation of pharmaceutical compositions stimulating bone growth |
| US6111110A (en) * | 1996-10-30 | 2000-08-29 | Eli Lilly And Company | Synthesis of benzo[f]quinolinones |
| AU778042B2 (en) | 1999-10-19 | 2004-11-11 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| HRP20020349A2 (en) * | 1999-10-19 | 2004-02-29 | Merck & Co Inc | Tyrosine kinase inhibitors |
| US6313138B1 (en) * | 2000-02-25 | 2001-11-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| AU778417B2 (en) | 2000-02-25 | 2004-12-02 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US6420382B2 (en) | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| EP1313734B1 (en) * | 2000-09-01 | 2009-11-11 | Novartis Vaccines and Diagnostics, Inc. | Aza heterocyclic derivatives and their therapeutic use |
| WO2002020500A2 (en) * | 2000-09-01 | 2002-03-14 | Icos Corporation | Materials and methods to potentiate cancer treatment |
| CZ304344B6 (cs) | 2000-09-11 | 2014-03-19 | Novartis Vaccines & Diagnostics, Inc. | Chinolinonový derivát a jeho použití a farmaceutický prostředek s obsahem tohoto derivátu |
| US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
| US7064215B2 (en) * | 2001-07-03 | 2006-06-20 | Chiron Corporation | Indazole benzimidazole compounds |
| US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
| CA2496164C (en) * | 2002-08-23 | 2010-11-09 | Chiron Corporation | Benzimidazole quinolinones and uses thereof |
| AU2003290699B2 (en) * | 2002-11-13 | 2009-08-27 | Novartis Vaccines And Diagnostics, Inc. | Methods of treating cancer and related methods |
| US6774327B1 (en) * | 2003-09-24 | 2004-08-10 | Agilent Technologies, Inc. | Hermetic seals for electronic components |
| CN102225926A (zh) * | 2003-11-07 | 2011-10-26 | 诺华疫苗和诊断公司 | 具有改进药物特性的喹啉酮类化合物的药学上可接受的盐 |
| US7875624B2 (en) * | 2004-02-20 | 2011-01-25 | Novartis Vaccines And Diagnostics, Inc. | Modulating and measuring cellular adhesion |
| BRPI0613200A2 (pt) * | 2005-05-18 | 2012-01-03 | M & G Polimeri Italia Spa | composiÇço de poliÉster |
| KR102639757B1 (ko) | 2017-01-09 | 2024-02-23 | 엘지이노텍 주식회사 | 카메라 모듈 및 이를 포함하는 광학기기 |
-
2006
- 2006-01-27 KR KR1020077019428A patent/KR101387985B1/ko not_active Expired - Fee Related
- 2006-01-27 WO PCT/US2006/002979 patent/WO2006081445A2/en not_active Ceased
- 2006-01-27 EP EP06733986A patent/EP1845990B1/en not_active Expired - Lifetime
- 2006-01-27 BR BRPI0607285-2A patent/BRPI0607285A2/pt not_active IP Right Cessation
- 2006-01-27 PL PL06733986T patent/PL1845990T3/pl unknown
- 2006-01-27 SI SI200631858T patent/SI2301546T1/sl unknown
- 2006-01-27 AT AT06733986T patent/ATE526025T1/de active
- 2006-01-27 ES ES06733986T patent/ES2374570T3/es not_active Expired - Lifetime
- 2006-01-27 DK DK06733986.1T patent/DK1845990T3/da active
- 2006-01-27 CN CN201410121175.8A patent/CN103893181A/zh active Pending
- 2006-01-27 PL PL10186757T patent/PL2301546T3/pl unknown
- 2006-01-27 PT PT101867570T patent/PT2301546E/pt unknown
- 2006-01-27 ES ES10186757.0T patent/ES2525670T3/es not_active Expired - Lifetime
- 2006-01-27 CA CA002596084A patent/CA2596084A1/en not_active Abandoned
- 2006-01-27 JP JP2007553278A patent/JP5371246B2/ja not_active Expired - Fee Related
- 2006-01-27 US US11/342,257 patent/US20060183750A1/en not_active Abandoned
- 2006-01-27 AU AU2006208012A patent/AU2006208012B2/en not_active Ceased
- 2006-01-27 PT PT06733986T patent/PT1845990E/pt unknown
- 2006-01-27 EP EP10186757.0A patent/EP2301546B1/en not_active Revoked
- 2006-01-27 SG SG2011046166A patent/SG173317A1/en unknown
- 2006-01-27 MX MX2007009099A patent/MX2007009099A/es not_active Application Discontinuation
-
2007
- 2007-07-26 IL IL184866A patent/IL184866A0/en unknown
- 2007-07-27 TN TNP2007000294A patent/TNSN07294A1/en unknown
- 2007-08-23 MA MA30162A patent/MA29266B1/fr unknown
- 2007-08-27 NO NO20074360A patent/NO20074360L/no not_active Application Discontinuation
-
2009
- 2009-12-31 US US12/650,725 patent/US20100173873A1/en not_active Abandoned
-
2011
- 2011-12-06 CY CY20111101216T patent/CY1112570T1/el unknown
-
2013
- 2013-06-20 JP JP2013129277A patent/JP2013177464A/ja not_active Withdrawn
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