JP2008528446A5 - - Google Patents
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- Publication number
- JP2008528446A5 JP2008528446A5 JP2007549559A JP2007549559A JP2008528446A5 JP 2008528446 A5 JP2008528446 A5 JP 2008528446A5 JP 2007549559 A JP2007549559 A JP 2007549559A JP 2007549559 A JP2007549559 A JP 2007549559A JP 2008528446 A5 JP2008528446 A5 JP 2008528446A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- component
- nanoparticles
- composition according
- chitosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 239000002105 nanoparticle Substances 0.000 claims 24
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 13
- 229920001661 Chitosan Polymers 0.000 claims 10
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 10
- 102000004877 Insulin Human genes 0.000 claims 6
- 108090001061 Insulin Proteins 0.000 claims 6
- 239000012867 bioactive agent Substances 0.000 claims 6
- 239000002775 capsule Substances 0.000 claims 6
- 229940125396 insulin Drugs 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 108700022290 poly(gamma-glutamic acid) Proteins 0.000 claims 2
- 229920002643 polyglutamic acid Polymers 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 239000004026 insulin derivative Substances 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002088 nanocapsule Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/029,082 US7265090B2 (en) | 2004-10-05 | 2005-01-04 | Nanoparticles for paracellular drug delivery |
| US11/029,082 | 2005-01-04 | ||
| US11/284,734 | 2005-11-21 | ||
| US11/284,734 US7282194B2 (en) | 2004-10-05 | 2005-11-21 | Nanoparticles for protein drug delivery |
| PCT/US2005/047125 WO2006073950A2 (en) | 2005-01-04 | 2005-12-27 | Nanoparticles for protein drug delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013112996A Division JP2013177434A (ja) | 2005-01-04 | 2013-05-29 | タンパク質ドラッグデリバリ用ナノ粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008528446A JP2008528446A (ja) | 2008-07-31 |
| JP2008528446A5 true JP2008528446A5 (cg-RX-API-DMAC7.html) | 2009-02-12 |
| JP5384831B2 JP5384831B2 (ja) | 2014-01-08 |
Family
ID=36648027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007549559A Expired - Fee Related JP5384831B2 (ja) | 2005-01-04 | 2005-12-27 | タンパク質ドラッグデリバリ用ナノ粒子 |
| JP2013112996A Pending JP2013177434A (ja) | 2005-01-04 | 2013-05-29 | タンパク質ドラッグデリバリ用ナノ粒子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013112996A Pending JP2013177434A (ja) | 2005-01-04 | 2013-05-29 | タンパク質ドラッグデリバリ用ナノ粒子 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US7282194B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1833470A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5384831B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101360486B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005322940B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0518093A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2592991C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006073950A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (81)
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| ES2226567B1 (es) * | 2003-06-20 | 2006-07-01 | Universidad De Santiago De Compostela | Nanoparticulas de acido hialuronico. |
| US7282194B2 (en) * | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7265090B2 (en) * | 2004-10-05 | 2007-09-04 | Gp Medical, Inc. | Nanoparticles for paracellular drug delivery |
| US7879819B1 (en) * | 2005-01-04 | 2011-02-01 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7611690B2 (en) * | 2005-01-04 | 2009-11-03 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7541046B1 (en) * | 2005-01-04 | 2009-06-02 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7604795B1 (en) * | 2005-01-04 | 2009-10-20 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7541028B2 (en) * | 2005-01-04 | 2009-06-02 | Gp Medical, Inc. | Nanoparticles for monoclonal antibody delivery |
| US7291598B2 (en) * | 2005-01-04 | 2007-11-06 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US20070148251A1 (en) * | 2005-12-22 | 2007-06-28 | Hossainy Syed F A | Nanoparticle releasing medical devices |
-
2005
- 2005-11-21 US US11/284,734 patent/US7282194B2/en not_active Expired - Fee Related
- 2005-12-27 EP EP05857226A patent/EP1833470A4/en not_active Withdrawn
- 2005-12-27 CN CN2005800449397A patent/CN101360486B/zh not_active Expired - Fee Related
- 2005-12-27 AU AU2005322940A patent/AU2005322940B2/en not_active Ceased
- 2005-12-27 JP JP2007549559A patent/JP5384831B2/ja not_active Expired - Fee Related
- 2005-12-27 BR BRPI0518093-7A patent/BRPI0518093A/pt not_active IP Right Cessation
- 2005-12-27 WO PCT/US2005/047125 patent/WO2006073950A2/en not_active Ceased
- 2005-12-27 CA CA2592991A patent/CA2592991C/en not_active Expired - Fee Related
-
2007
- 2007-07-26 US US11/881,217 patent/US7803748B2/en not_active Expired - Fee Related
-
2008
- 2008-04-24 US US12/150,027 patent/US7455830B2/en not_active Expired - Fee Related
-
2010
- 2010-08-27 US US12/807,084 patent/US8454966B2/en not_active Expired - Fee Related
-
2013
- 2013-05-29 JP JP2013112996A patent/JP2013177434A/ja active Pending
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