JP2008528000A5 - - Google Patents
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- Publication number
- JP2008528000A5 JP2008528000A5 JP2007552363A JP2007552363A JP2008528000A5 JP 2008528000 A5 JP2008528000 A5 JP 2008528000A5 JP 2007552363 A JP2007552363 A JP 2007552363A JP 2007552363 A JP2007552363 A JP 2007552363A JP 2008528000 A5 JP2008528000 A5 JP 2008528000A5
- Authority
- JP
- Japan
- Prior art keywords
- reactive
- sequence
- oligonucleotide
- reaction
- reaction intermediate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007806 chemical reaction intermediate Substances 0.000 claims 36
- 238000000034 method Methods 0.000 claims 30
- 108091034117 Oligonucleotide Proteins 0.000 claims 27
- 239000007795 chemical reaction product Substances 0.000 claims 17
- 239000000376 reactant Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 108020004705 Codon Proteins 0.000 claims 11
- 108020005098 Anticodon Proteins 0.000 claims 8
- 108020004566 Transfer RNA Proteins 0.000 claims 8
- 230000000295 complement effect Effects 0.000 claims 8
- 238000006243 chemical reaction Methods 0.000 claims 6
- 230000002194 synthesizing effect Effects 0.000 claims 6
- 125000000524 functional group Chemical group 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 238000000137 annealing Methods 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 238000005287 template synthesis Methods 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 238000001308 synthesis method Methods 0.000 claims 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 239000012048 reactive intermediate Substances 0.000 claims 1
- 210000003705 ribosome Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 238000004448 titration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64658405P | 2005-01-21 | 2005-01-21 | |
| US60/646,584 | 2005-01-21 | ||
| PCT/US2006/002420 WO2006079061A2 (en) | 2005-01-21 | 2006-01-20 | Free reactant use in nucleic acid-templated synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008528000A JP2008528000A (ja) | 2008-07-31 |
| JP2008528000A5 true JP2008528000A5 (https=) | 2009-03-26 |
| JP4969459B2 JP4969459B2 (ja) | 2012-07-04 |
Family
ID=36604194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007552363A Expired - Lifetime JP4969459B2 (ja) | 2005-01-21 | 2006-01-20 | 核酸鋳型合成において使用される遊離反応体 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1856256B1 (https=) |
| JP (1) | JP4969459B2 (https=) |
| CN (1) | CN101107357B (https=) |
| AU (1) | AU2006206219B2 (https=) |
| CA (1) | CA2595590C (https=) |
| DE (1) | DE602006007819D1 (https=) |
| WO (1) | WO2006079061A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| US10731151B2 (en) | 2002-03-15 | 2020-08-04 | Nuevolution A/S | Method for synthesising templated molecules |
| EP1539980B1 (en) | 2002-08-01 | 2016-02-17 | Nuevolution A/S | Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules |
| EP2348124B1 (en) | 2002-10-30 | 2013-12-11 | Nuevolution A/S | Synthesis of a bifunctional complex |
| WO2004056994A2 (en) | 2002-12-19 | 2004-07-08 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
| US20070026397A1 (en) | 2003-02-21 | 2007-02-01 | Nuevolution A/S | Method for producing second-generation library |
| US8017323B2 (en) | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
| US11118215B2 (en) | 2003-09-18 | 2021-09-14 | Nuevolution A/S | Method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
| PT3305900T (pt) | 2005-12-01 | 2021-10-27 | Nuevolution As | Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes |
| ES2638324T3 (es) | 2009-02-13 | 2017-10-19 | X-Chem, Inc. | Métodos de creación y examen de bibliotecas codificadas por ADN |
| EP3540059A1 (en) | 2010-04-16 | 2019-09-18 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| IN2014CN02574A (https=) * | 2011-09-07 | 2015-06-26 | Chem Inc X | |
| SG10201907347YA (en) | 2012-07-13 | 2019-09-27 | X Chem Inc | Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases |
| WO2017218293A1 (en) | 2016-06-16 | 2017-12-21 | Richard Edward Watts | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
| US11795580B2 (en) | 2017-05-02 | 2023-10-24 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
| WO2024073349A2 (en) * | 2022-09-26 | 2024-04-04 | Ansa Biotechnologies, Inc. | Cleavable linkers for the tethering of polymerases to nucleotides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| CA2346989A1 (en) * | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
| IL159268A0 (en) * | 2001-06-20 | 2004-06-01 | Nuevolution As | Templated molecules and methods for using such molecules |
| EP1539980B1 (en) * | 2002-08-01 | 2016-02-17 | Nuevolution A/S | Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules |
| WO2004016767A2 (en) * | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
-
2006
- 2006-01-20 CN CN200680002864.0A patent/CN101107357B/zh not_active Expired - Fee Related
- 2006-01-20 CA CA2595590A patent/CA2595590C/en not_active Expired - Fee Related
- 2006-01-20 AU AU2006206219A patent/AU2006206219B2/en not_active Ceased
- 2006-01-20 JP JP2007552363A patent/JP4969459B2/ja not_active Expired - Lifetime
- 2006-01-20 DE DE602006007819T patent/DE602006007819D1/de not_active Expired - Lifetime
- 2006-01-20 WO PCT/US2006/002420 patent/WO2006079061A2/en not_active Ceased
- 2006-01-20 EP EP06733839A patent/EP1856256B1/en not_active Expired - Lifetime
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