CN101107357B - 用于以核酸为模板的合成中的游离反应物 - Google Patents

用于以核酸为模板的合成中的游离反应物 Download PDF

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Publication number
CN101107357B
CN101107357B CN200680002864.0A CN200680002864A CN101107357B CN 101107357 B CN101107357 B CN 101107357B CN 200680002864 A CN200680002864 A CN 200680002864A CN 101107357 B CN101107357 B CN 101107357B
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reaction
oligonucleotide
sequence
template
free reactant
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Expired - Fee Related
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Chinese (zh)
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CN101107357A (zh
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戴维德·刘
樱井馨
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200680002864.0A 2005-01-21 2006-01-20 用于以核酸为模板的合成中的游离反应物 Expired - Fee Related CN101107357B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64658405P 2005-01-21 2005-01-21
US60/646,584 2005-01-21
PCT/US2006/002420 WO2006079061A2 (en) 2005-01-21 2006-01-20 Free reactant use in nucleic acid-templated synthesis

Publications (2)

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CN101107357A CN101107357A (zh) 2008-01-16
CN101107357B true CN101107357B (zh) 2013-01-02

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CN200680002864.0A Expired - Fee Related CN101107357B (zh) 2005-01-21 2006-01-20 用于以核酸为模板的合成中的游离反应物

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Country Link
EP (1) EP1856256B1 (https=)
JP (1) JP4969459B2 (https=)
CN (1) CN101107357B (https=)
AU (1) AU2006206219B2 (https=)
CA (1) CA2595590C (https=)
DE (1) DE602006007819D1 (https=)
WO (1) WO2006079061A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
EP1487978B1 (en) 2002-03-15 2008-11-19 Nuevolution A/S An improved method for synthesising templated molecules
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
PT2348125T (pt) 2002-10-30 2017-08-29 Nuevolution As Método para a síntese de um complexo bifuncional
AU2003291964A1 (en) 2002-12-19 2004-07-14 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
EP1670939B1 (en) 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
HUE056836T2 (hu) 2005-12-01 2022-03-28 Nuevolution As Enzimatikus kódolási eljárások nagy könyvtárak hatékony szintéziséhez
DK2396459T3 (en) 2009-02-13 2017-08-28 X-Chem Inc Method for preparing and screening DNA-encoded libraries
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
DK2748357T3 (en) * 2011-09-07 2018-07-16 X Chem Inc Methods for labeling DNA-encoded libraries
EA201992285A1 (ru) 2012-07-13 2020-05-31 Икс-Чем, Инк. Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами
US11186836B2 (en) 2016-06-16 2021-11-30 Haystack Sciences Corporation Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
EP3619340A4 (en) * 2017-05-02 2021-01-20 Haystack Sciences Corporation OLIGONUCLEOTID-DRIVEN COMBINATORY SYNTHESIS VERIFICATION MOLECULES AND ASSOCIATED MANUFACTURING AND USE PROCESSES
WO2024073349A2 (en) * 2022-09-26 2024-04-04 Ansa Biotechnologies, Inc. Cleavable linkers for the tethering of polymerases to nucleotides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002103008A2 (en) * 2001-06-20 2002-12-27 Nuevolution A/S Templated molecules and methods for using such molecules
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
EP1123305A1 (en) * 1998-10-19 2001-08-16 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002103008A2 (en) * 2001-06-20 2002-12-27 Nuevolution A/S Templated molecules and methods for using such molecules
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Xiaoyu Li ,David R. Liu.DNA-Templated Organic Synthesis: Nature ├s Strategyfor Controlling Chemical Reactivity Applied to SyntheticMolecules.Angew. Chem. Int. Ed.43.2004,434849-4867.
Xiaoyu Li,David R. Liu.DNA-Templated Organic Synthesis: Nature ├s Strategyfor Controlling Chemical Reactivity Applied to SyntheticMolecules.Angew. Chem. Int. Ed.43.2004,434849-4867. *

Also Published As

Publication number Publication date
JP4969459B2 (ja) 2012-07-04
AU2006206219A1 (en) 2006-07-27
WO2006079061A3 (en) 2006-09-28
JP2008528000A (ja) 2008-07-31
DE602006007819D1 (de) 2009-08-27
AU2006206219B2 (en) 2012-07-26
EP1856256A2 (en) 2007-11-21
EP1856256B1 (en) 2009-07-15
CN101107357A (zh) 2008-01-16
CA2595590A1 (en) 2006-07-27
CA2595590C (en) 2015-04-21
WO2006079061A2 (en) 2006-07-27

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