JP4969459B2 - 核酸鋳型合成において使用される遊離反応体 - Google Patents

核酸鋳型合成において使用される遊離反応体 Download PDF

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JP4969459B2
JP4969459B2 JP2007552363A JP2007552363A JP4969459B2 JP 4969459 B2 JP4969459 B2 JP 4969459B2 JP 2007552363 A JP2007552363 A JP 2007552363A JP 2007552363 A JP2007552363 A JP 2007552363A JP 4969459 B2 JP4969459 B2 JP 4969459B2
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reactive
reaction
sequence
oligonucleotide
template
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JP2008528000A5 (https=
JP2008528000A (ja
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デイビッド リュー，
香里 櫻井
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2007552363A 2005-01-21 2006-01-20 核酸鋳型合成において使用される遊離反応体 Expired - Lifetime JP4969459B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64658405P 2005-01-21 2005-01-21
US60/646,584 2005-01-21
PCT/US2006/002420 WO2006079061A2 (en) 2005-01-21 2006-01-20 Free reactant use in nucleic acid-templated synthesis

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JP2008528000A JP2008528000A (ja) 2008-07-31
JP2008528000A5 JP2008528000A5 (https=) 2009-03-26
JP4969459B2 true JP4969459B2 (ja) 2012-07-04

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JP2007552363A Expired - Lifetime JP4969459B2 (ja) 2005-01-21 2006-01-20 核酸鋳型合成において使用される遊離反応体

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EP (1) EP1856256B1 (https=)
JP (1) JP4969459B2 (https=)
CN (1) CN101107357B (https=)
AU (1) AU2006206219B2 (https=)
CA (1) CA2595590C (https=)
DE (1) DE602006007819D1 (https=)
WO (1) WO2006079061A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
EP2348124B1 (en) 2002-10-30 2013-12-11 Nuevolution A/S Synthesis of a bifunctional complex
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
PT3305900T (pt) 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
ES2638324T3 (es) 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
EP3540059A1 (en) 2010-04-16 2019-09-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
IN2014CN02574A (https=) * 2011-09-07 2015-06-26 Chem Inc X
SG10201907347YA (en) 2012-07-13 2019-09-27 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
WO2024073349A2 (en) * 2022-09-26 2024-04-04 Ansa Biotechnologies, Inc. Cleavable linkers for the tethering of polymerases to nucleotides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
CA2346989A1 (en) * 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
IL159268A0 (en) * 2001-06-20 2004-06-01 Nuevolution As Templated molecules and methods for using such molecules
EP1539980B1 (en) * 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function

Also Published As

Publication number Publication date
CA2595590A1 (en) 2006-07-27
AU2006206219B2 (en) 2012-07-26
EP1856256A2 (en) 2007-11-21
CN101107357A (zh) 2008-01-16
AU2006206219A1 (en) 2006-07-27
EP1856256B1 (en) 2009-07-15
JP2008528000A (ja) 2008-07-31
CN101107357B (zh) 2013-01-02
DE602006007819D1 (de) 2009-08-27
WO2006079061A2 (en) 2006-07-27
CA2595590C (en) 2015-04-21
WO2006079061A3 (en) 2006-09-28

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