DE602006007819D1 - Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese - Google Patents

Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese

Info

Publication number
DE602006007819D1
DE602006007819D1 DE602006007819T DE602006007819T DE602006007819D1 DE 602006007819 D1 DE602006007819 D1 DE 602006007819D1 DE 602006007819 T DE602006007819 T DE 602006007819T DE 602006007819 T DE602006007819 T DE 602006007819T DE 602006007819 D1 DE602006007819 D1 DE 602006007819D1
Authority
DE
Germany
Prior art keywords
synthesis
nucleic acid
free reactants
acid textile
textile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602006007819T
Other languages
German (de)
English (en)
Inventor
David Liu
Kaori Sakurai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of DE602006007819D1 publication Critical patent/DE602006007819D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602006007819T 2005-01-21 2006-01-20 Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese Expired - Lifetime DE602006007819D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64658405P 2005-01-21 2005-01-21
PCT/US2006/002420 WO2006079061A2 (en) 2005-01-21 2006-01-20 Free reactant use in nucleic acid-templated synthesis

Publications (1)

Publication Number Publication Date
DE602006007819D1 true DE602006007819D1 (de) 2009-08-27

Family

ID=36604194

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006007819T Expired - Lifetime DE602006007819D1 (de) 2005-01-21 2006-01-20 Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese

Country Status (7)

Country Link
EP (1) EP1856256B1 (https=)
JP (1) JP4969459B2 (https=)
CN (1) CN101107357B (https=)
AU (1) AU2006206219B2 (https=)
CA (1) CA2595590C (https=)
DE (1) DE602006007819D1 (https=)
WO (1) WO2006079061A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
EP1487978B1 (en) 2002-03-15 2008-11-19 Nuevolution A/S An improved method for synthesising templated molecules
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
PT2348125T (pt) 2002-10-30 2017-08-29 Nuevolution As Método para a síntese de um complexo bifuncional
AU2003291964A1 (en) 2002-12-19 2004-07-14 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
EP1670939B1 (en) 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
HUE056836T2 (hu) 2005-12-01 2022-03-28 Nuevolution As Enzimatikus kódolási eljárások nagy könyvtárak hatékony szintéziséhez
DK2396459T3 (en) 2009-02-13 2017-08-28 X-Chem Inc Method for preparing and screening DNA-encoded libraries
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
DK2748357T3 (en) * 2011-09-07 2018-07-16 X Chem Inc Methods for labeling DNA-encoded libraries
EA201992285A1 (ru) 2012-07-13 2020-05-31 Икс-Чем, Инк. Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами
US11186836B2 (en) 2016-06-16 2021-11-30 Haystack Sciences Corporation Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
EP3619340A4 (en) * 2017-05-02 2021-01-20 Haystack Sciences Corporation OLIGONUCLEOTID-DRIVEN COMBINATORY SYNTHESIS VERIFICATION MOLECULES AND ASSOCIATED MANUFACTURING AND USE PROCESSES
WO2024073349A2 (en) * 2022-09-26 2024-04-04 Ansa Biotechnologies, Inc. Cleavable linkers for the tethering of polymerases to nucleotides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
EP1123305A1 (en) * 1998-10-19 2001-08-16 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
ATE371026T1 (de) * 2001-06-20 2007-09-15 Nuevolution As Eine methode zur synthese von matrizenabhängigen molekülen
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
AU2003263937B2 (en) * 2002-08-19 2010-04-01 The President And Fellows Of Harvard College Evolving new molecular function

Also Published As

Publication number Publication date
CN101107357B (zh) 2013-01-02
JP4969459B2 (ja) 2012-07-04
AU2006206219A1 (en) 2006-07-27
WO2006079061A3 (en) 2006-09-28
JP2008528000A (ja) 2008-07-31
AU2006206219B2 (en) 2012-07-26
EP1856256A2 (en) 2007-11-21
EP1856256B1 (en) 2009-07-15
CN101107357A (zh) 2008-01-16
CA2595590A1 (en) 2006-07-27
CA2595590C (en) 2015-04-21
WO2006079061A2 (en) 2006-07-27

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