DE602006007819D1 - Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese - Google Patents

Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese

Info

Publication number
DE602006007819D1
DE602006007819D1 DE602006007819T DE602006007819T DE602006007819D1 DE 602006007819 D1 DE602006007819 D1 DE 602006007819D1 DE 602006007819 T DE602006007819 T DE 602006007819T DE 602006007819 T DE602006007819 T DE 602006007819T DE 602006007819 D1 DE602006007819 D1 DE 602006007819D1
Authority
DE
Germany
Prior art keywords
synthesis
nucleic acid
free reactants
acid textile
textile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602006007819T
Other languages
German (de)
English (en)
Inventor
David Liu
Kaori Sakurai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of DE602006007819D1 publication Critical patent/DE602006007819D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602006007819T 2005-01-21 2006-01-20 Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese Expired - Lifetime DE602006007819D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64658405P 2005-01-21 2005-01-21
PCT/US2006/002420 WO2006079061A2 (en) 2005-01-21 2006-01-20 Free reactant use in nucleic acid-templated synthesis

Publications (1)

Publication Number Publication Date
DE602006007819D1 true DE602006007819D1 (de) 2009-08-27

Family

ID=36604194

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006007819T Expired - Lifetime DE602006007819D1 (de) 2005-01-21 2006-01-20 Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese

Country Status (7)

Country Link
EP (1) EP1856256B1 (https=)
JP (1) JP4969459B2 (https=)
CN (1) CN101107357B (https=)
AU (1) AU2006206219B2 (https=)
CA (1) CA2595590C (https=)
DE (1) DE602006007819D1 (https=)
WO (1) WO2006079061A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
EP2348124B1 (en) 2002-10-30 2013-12-11 Nuevolution A/S Synthesis of a bifunctional complex
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
PT3305900T (pt) 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
ES2638324T3 (es) 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
EP3540059A1 (en) 2010-04-16 2019-09-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
IN2014CN02574A (https=) * 2011-09-07 2015-06-26 Chem Inc X
SG10201907347YA (en) 2012-07-13 2019-09-27 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
WO2024073349A2 (en) * 2022-09-26 2024-04-04 Ansa Biotechnologies, Inc. Cleavable linkers for the tethering of polymerases to nucleotides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
CA2346989A1 (en) * 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
IL159268A0 (en) * 2001-06-20 2004-06-01 Nuevolution As Templated molecules and methods for using such molecules
EP1539980B1 (en) * 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function

Also Published As

Publication number Publication date
CA2595590A1 (en) 2006-07-27
AU2006206219B2 (en) 2012-07-26
JP4969459B2 (ja) 2012-07-04
EP1856256A2 (en) 2007-11-21
CN101107357A (zh) 2008-01-16
AU2006206219A1 (en) 2006-07-27
EP1856256B1 (en) 2009-07-15
JP2008528000A (ja) 2008-07-31
CN101107357B (zh) 2013-01-02
WO2006079061A2 (en) 2006-07-27
CA2595590C (en) 2015-04-21
WO2006079061A3 (en) 2006-09-28

Similar Documents

Publication Publication Date Title
DE602006007819D1 (de) Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese
EP2268813A4 (en) RNA MOLECULES AND USES THEREOF
FR2872715B1 (fr) Microreacteur goutte
EP2370598A4 (en) CLASSIFICATION OF NUCLEIC ACID TEMPLATES
ZA200707522B (en) Nucleic acid constructs
DK4008721T3 (da) Syntese af boronester og syre forbindelser
BRPI0923225A2 (pt) metodo para sintese de acidos nucleicos modificados no atomo de fosforo
EP2417270A4 (en) Digital quantification of DNA methylation
EP2321654A4 (en) ACTIVITY STATUS CLASSIFICATION
EP1883519A4 (en) HYDROGEL CONSTRUCTS MANUFACTURED BY STEREOLITHOGRAPHY
BRPI0910689A2 (pt) processo de síntese de rna por via química
DE602006011867D1 (de) Verwendung dekrementeller zuweisungen
ITMI20060620A1 (it) Fibbia con barra di fissaggio per correggia
ATE486076T1 (de) 6-carboxy-normorphinan-derivate, ihre synthese und verwendung
ATE510923T1 (de) Nukleinsäure
DK1868967T3 (da) Kulbrintesyntese
EP2216884A4 (en) FIELD ELEMENT CORE
EP1756129A4 (en) NEW INTERCALATORS INTO THE DNA
DE602005027253D1 (de) Herbizidresistenz verleihende gene
ATE417818T1 (de) Katalytisches eintopfverfahren zur synthese von isocyanaten
EP1957474A4 (en) SYNTHESIS OF FTSZ HEMMERN
ATE500249T1 (de) Synthese von himbacinanaloga
DE602005024305D1 (de) Verfahren zu synthese von glycolonitril
DE602006009513D1 (de) Verwendung von phenylsemicarbazonen für die saatgutbeizung
DE602006013098D1 (de) Phosphoramidit-aktivator für oligonukleotidsynthese

Legal Events

Date Code Title Description
8364 No opposition during term of opposition