JP2008527042A5 - - Google Patents

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Publication number
JP2008527042A5
JP2008527042A5 JP2007552201A JP2007552201A JP2008527042A5 JP 2008527042 A5 JP2008527042 A5 JP 2008527042A5 JP 2007552201 A JP2007552201 A JP 2007552201A JP 2007552201 A JP2007552201 A JP 2007552201A JP 2008527042 A5 JP2008527042 A5 JP 2008527042A5
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JP
Japan
Prior art keywords
phenyl
methyl
pyrazol
urea
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007552201A
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English (en)
Japanese (ja)
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JP2008527042A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/001516 external-priority patent/WO2006078610A1/en
Publication of JP2008527042A publication Critical patent/JP2008527042A/ja
Publication of JP2008527042A5 publication Critical patent/JP2008527042A5/ja
Withdrawn legal-status Critical Current

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JP2007552201A 2005-01-19 2006-01-17 進行性多病巣性白質脳障害の予防または治療に有用な、５−ｈｔ２ａセロトニン受容体の調節因子としてのジアリールおよびアリールヘテロアリール尿素誘導体 Withdrawn JP2008527042A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64553205P 2005-01-19 2005-01-19
PCT/US2006/001516 WO2006078610A1 (en) 2005-01-19 2006-01-17 Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis or treatment of progressive multifocal leukoencephalopathy

Publications (2)

Publication Number Publication Date
JP2008527042A JP2008527042A (ja) 2008-07-24
JP2008527042A5 true JP2008527042A5 (cg-RX-API-DMAC10.html) 2009-02-26

Family

ID=36423583

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007552201A Withdrawn JP2008527042A (ja) 2005-01-19 2006-01-17 進行性多病巣性白質脳障害の予防または治療に有用な、５−ｈｔ２ａセロトニン受容体の調節因子としてのジアリールおよびアリールヘテロアリール尿素誘導体

Country Status (7)

Country Link
US (1) US20080200530A1 (cg-RX-API-DMAC10.html)
EP (1) EP1843762A1 (cg-RX-API-DMAC10.html)
JP (1) JP2008527042A (cg-RX-API-DMAC10.html)
CN (1) CN101160127A (cg-RX-API-DMAC10.html)
AU (1) AU2006206687A1 (cg-RX-API-DMAC10.html)
CA (1) CA2594563A1 (cg-RX-API-DMAC10.html)
WO (1) WO2006078610A1 (cg-RX-API-DMAC10.html)

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NZ544331A (en) 2003-07-22 2010-03-26 Arena Pharm Inc Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
CN1926114B (zh) * 2004-03-23 2011-08-24 艾尼纳制药公司 用于制备经取代n-芳基-n′-′3-(1h-吡唑-5-基)苯基脲及其中间体的方法
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WO2006062982A2 (en) 2004-12-07 2006-06-15 Locus Pharmaceuticals, Inc. Urea inhibitors of map kinases
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US8148417B2 (en) * 2006-05-18 2012-04-03 Arena Pharmaceuticals, Inc. Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
NZ571829A (en) 2006-05-18 2011-10-28 Arena Pharm Inc Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor
EP2027119A2 (en) 2006-05-18 2009-02-25 Arena Pharmaceuticals, Inc. Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
ES2421237T7 (es) 2007-08-15 2013-09-30 Arena Pharmaceuticals, Inc. Derivados de imidazo[1,2-a]piridin como moduladores del receptor serotoninérgico 5ht2a en el tratamiento de trastornos relacionados con el mismo
WO2009123714A2 (en) * 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US20100041642A1 (en) * 2008-08-15 2010-02-18 Locus Pharmaceuticals, Inc. Urea inhibitors of map kinases
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
TR201805216T4 (en) 2008-10-28 2018-06-21 Arena Pharm Inc COMPOSITIONS OF A USEFUL 5-HT2A SEROTONINE RECEPTOR MODULATOR FOR THE TREATMENT OF RELATED DISORDERS
US8980891B2 (en) 2009-12-18 2015-03-17 Arena Pharmaceuticals, Inc. Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
JP2018516992A (ja) 2015-06-12 2018-06-28 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体
CN108472285A (zh) 2015-07-15 2018-08-31 阿速万科学有限责任公司 用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物
CN118903436A (zh) 2018-01-31 2024-11-08 德西费拉制药有限责任公司 治疗肥大细胞增多症的组合疗法
KR102708177B1 (ko) 2018-01-31 2024-09-23 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양의 치료를 위한 병용 요법
IL330104A (en) 2019-03-11 2026-08-01 Deciphera Pharmaceuticals Llc Crystalline forms of rifatinib
HRP20260411T1 (hr) 2019-08-12 2026-05-08 Deciphera Pharmaceuticals, Llc Ripretinib za liječenje gastrointestinalnih stromalnih tumora
FI4084779T3 (fi) 2019-12-30 2024-12-16 Deciphera Pharmaceuticals Llc 1-(4-bromi-5-(1-etyyli-7-(metyyliamino)-2-okso-1,2-dihydro-1,6-naftyridin-3-yyli)-2-fluorifenyyli)-3-fenyyliurean koostumuksia
CN113855784B (zh) * 2021-09-26 2025-04-15 深圳辰扬生物科技有限公司 多肽的抗抑郁、抗焦虑用途及复合体
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors
JPWO2024122617A1 (cg-RX-API-DMAC10.html) 2022-12-08 2024-06-13

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