JP2008526861A5 - - Google Patents

Info

Publication number

JP2008526861A5

JP2008526861A5 JP2007550445A JP2007550445A JP2008526861A5 JP 2008526861 A5 JP2008526861 A5 JP 2008526861A5 JP 2007550445 A JP2007550445 A JP 2007550445A JP 2007550445 A JP2007550445 A JP 2007550445A JP 2008526861 A5 JP2008526861 A5 JP 2008526861A5

Authority

JP

Japan

Prior art keywords

cyclopentyl

trifluoromethyl

isopropyl

pharmaceutical composition

statin

Prior art date

2006-01-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 239000002604 chemokine receptor CCR2 antagonist Substances 0.000 claims 13
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 12
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 11
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 11
• 150000003839 salts Chemical class 0.000 claims 10
• 150000004677 hydrates Chemical class 0.000 claims 6
• RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 5
• 229960002855 simvastatin Drugs 0.000 claims 5
• RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 5
• PCVWIXCNNYBRCS-DWRADNJXSA-N 2-[(3s,4r)-3-methyl-1-[(1r,3s)-2-oxo-3-propan-2-yl-3-[[6-(trifluoromethyl)-2,4-dihydro-1,3-benzoxazin-3-yl]methyl]cyclopentyl]piperidin-4-yl]benzoic acid Chemical compound C1([C@@H]2CCN(C[C@H]2C)[C@@H]2CC[C@@](C2=O)(CN2CC3=CC(=CC=C3OC2)C(F)(F)F)C(C)C)=CC=CC=C1C(O)=O PCVWIXCNNYBRCS-DWRADNJXSA-N 0.000 claims 4
• 150000001412 amines Chemical class 0.000 claims 4
• 239000002552 dosage form Substances 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• NXZNYBUBXWWKCP-JMOWIOHXSA-N n-[2-[[(3r)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Chemical compound C1=NC(OC)=CC=C1C1(O)CCC(N2C[C@@H](CC2)NC(=O)CNC(=O)C=2C=C(C=CC=2)C(F)(F)F)CC1 NXZNYBUBXWWKCP-JMOWIOHXSA-N 0.000 claims 4
• ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims 3
• XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 3
• XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 3
• PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 3
• TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims 3
• 229960005370 atorvastatin Drugs 0.000 claims 3
• 229960003765 fluvastatin Drugs 0.000 claims 3
• 208000027866 inflammatory disease Diseases 0.000 claims 3
• 229960004844 lovastatin Drugs 0.000 claims 3
• PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 3
• QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 3
• 229960002965 pravastatin Drugs 0.000 claims 3
• TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 3
• 229960000672 rosuvastatin Drugs 0.000 claims 3
• BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 3
• 102000006440 Chemokine CCL26 Human genes 0.000 claims 2
• 108010083698 Chemokine CCL26 Proteins 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 229960002797 pitavastatin Drugs 0.000 claims 2
• VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 claims 2
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• PIFXKNIDTXTEHA-INYSMAPRSA-N [(1s,3r)-3-[[(3s,4s)-3-methyloxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[7-(trifluoromethyl)-3,4-dihydro-1h-isoquinolin-2-yl]methanone Chemical compound N([C@@H]1CC[C@](C1)(C(C)C)C(=O)N1CC2=CC(=CC=C2CC1)C(F)(F)F)[C@H]1CCOC[C@H]1C PIFXKNIDTXTEHA-INYSMAPRSA-N 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1