JP2008526805A5 - - Google Patents
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- Publication number
- JP2008526805A5 JP2008526805A5 JP2007549866A JP2007549866A JP2008526805A5 JP 2008526805 A5 JP2008526805 A5 JP 2008526805A5 JP 2007549866 A JP2007549866 A JP 2007549866A JP 2007549866 A JP2007549866 A JP 2007549866A JP 2008526805 A5 JP2008526805 A5 JP 2008526805A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- phenyl
- quinolin
- phenylamino
- ethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 9
- 229940114081 cinnamate Drugs 0.000 claims 5
- AFDXODALSZRGIH-QPJJXVBHSA-N 4-Methoxycinnamic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 claims 4
- RURHILYUWQEGOS-UHFFFAOYSA-M 3-(4-methylphenyl)prop-2-enoate Chemical compound CC1=CC=C(C=CC([O-])=O)C=C1 RURHILYUWQEGOS-UHFFFAOYSA-M 0.000 claims 3
- DMJDEZUEYXVYNO-UHFFFAOYSA-M 3-(4-phenylphenyl)prop-2-enoate Chemical class C1=CC(C=CC(=O)[O-])=CC=C1C1=CC=CC=C1 DMJDEZUEYXVYNO-UHFFFAOYSA-M 0.000 claims 3
- JRRKWFRTDFOWAB-SANMLTNESA-N 5-[(1R)-2-[2-[4-[4-(2-amino-2-methylpropoxy)anilino]phenyl]ethylamino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one Chemical compound C1=CC(OCC(C)(N)C)=CC=C1NC(C=C1)=CC=C1CCNC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 JRRKWFRTDFOWAB-SANMLTNESA-N 0.000 claims 3
- YUGFVTIFFGNEOT-SNYZSRNZSA-N 5-[(1R)-2-[2-[4-[4-(2-amino-2-methylpropoxy)anilino]phenyl]ethylamino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one;3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(C=CC(O)=O)C=C1.C1=CC(OCC(C)(N)C)=CC=C1NC(C=C1)=CC=C1CCNC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 YUGFVTIFFGNEOT-SNYZSRNZSA-N 0.000 claims 2
- UCJOIXDFPVSTTG-SNYZSRNZSA-N 5-[(1R)-2-[2-[4-[4-(2-amino-2-methylpropoxy)anilino]phenyl]ethylamino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one;3-(4-methylphenyl)prop-2-enoic acid Chemical compound CC1=CC=C(C=CC(O)=O)C=C1.C1=CC(OCC(C)(N)C)=CC=C1NC(C=C1)=CC=C1CCNC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 UCJOIXDFPVSTTG-SNYZSRNZSA-N 0.000 claims 2
- CIKAGNFCKFROKQ-ROPHLPQBSA-N 5-[(1R)-2-[2-[4-[4-(2-amino-2-methylpropoxy)anilino]phenyl]ethylamino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one;3-(4-phenylphenyl)prop-2-enoic acid Chemical compound C1=CC(C=CC(=O)O)=CC=C1C1=CC=CC=C1.C1=CC(C=CC(=O)O)=CC=C1C1=CC=CC=C1.C1=CC(OCC(C)(N)C)=CC=C1NC(C=C1)=CC=C1CCNC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 CIKAGNFCKFROKQ-ROPHLPQBSA-N 0.000 claims 2
- 229930016911 cinnamic acid Natural products 0.000 claims 2
- 235000013985 cinnamic acid Nutrition 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 230000001225 therapeutic Effects 0.000 claims 2
- RURHILYUWQEGOS-VOTSOKGWSA-N (E)-3-(4-methylphenyl)prop-2-enoic acid Chemical compound CC1=CC=C(\C=C\C(O)=O)C=C1 RURHILYUWQEGOS-VOTSOKGWSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Claims (22)
- 式(I)：
で表される化合物の塩であって、ケイヒ酸塩、4-メトキシケイヒ酸塩、ジ-(4-フェニルケイヒ酸)塩及び4-メチルケイヒ酸塩から選択される、前記塩。 - 5-[(R)-2-(2-{4-[4-(2-アミノ-2-メチル-プロポキシ)-フェニルアミノ]-フェニル}-エチルアミノ)-1-ヒドロキシ-エチル]-8-ヒドロキシ-1H-キノリン-2-オン 4-メチルケイヒ酸塩。
- 5-[(R)-2-(2-{4-[4-(2-アミノ-2-メチル-プロポキシ)-フェニルアミノ]-フェニル}-エチルアミノ)-1-ヒドロキシ-エチル]-8-ヒドロキシ-1H-キノリン-2-オン ケイヒ酸塩。
- 5-[(R)-2-(2-{4-[4-(2-アミノ-2-メチル-プロポキシ)-フェニルアミノ]-フェニル}-エチルアミノ)-1-ヒドロキシ-エチル]-8-ヒドロキシ-1H-キノリン-2-オン 4-メトキシケイヒ酸塩。
- 5-[(R)-2-(2-{4-[4-(2-アミノ-2-メチル-プロポキシ)-フェニルアミノ]-フェニル}-エチルアミノ)-1-ヒドロキシ-エチル]-8-ヒドロキシ-1H-キノリン-2-オン ジ-(4-フェニルケイヒ酸)塩。
- 式：
で表される化合物の4-メチルケイヒ酸塩。 - 式：
で表される化合物のケイヒ酸塩。 - 式：
で表される化合物の4-メトキシケイヒ酸塩。 - 式：
で表される化合物の4-フェニルケイヒ酸塩。 - 結晶質5-[(R)-2-(2-{4-[4-(2-アミノ-2-メチル-プロポキシ)-フェニルアミノ]-フェニル}-エチルアミノ)-1-ヒドロキシ-エチル]-8-ヒドロキシ-1H-キノリン-2-オン 4-メチルケイヒ酸塩。
- 結晶質5-[(R)-2-(2-{4-[4-(2-アミノ-2-メチル-プロポキシ)-フェニルアミノ]-フェニル}-エチルアミノ)-1-ヒドロキシ-エチル]-8-ヒドロキシ-1H-キノリン-2-オン ケイヒ酸塩。
- 結晶質5-[(R)-2-(2-{4-[4-(2-アミノ-2-メチル-プロポキシ)-フェニルアミノ]-フェニル}-エチルアミノ)-1-ヒドロキシ-エチル]-8-ヒドロキシ-1H-キノリン-2-オン 4-メトキシケイヒ酸塩。
- 結晶質5-[(R)-2-(2-{4-[4-(2-アミノ-2-メチル-プロポキシ)-フェニルアミノ]-フェニル}-エチルアミノ)-1-ヒドロキシ-エチル]-8-ヒドロキシ-1H-キノリン-2-オン ジ-(4-フェニルケイヒ酸)塩。
- 式：
で表される化合物の結晶質4-メチルケイヒ酸塩。 - 式：
で表される化合物の結晶質ケイヒ酸塩。 - 式：
で表される化合物の結晶質4-メトキシケイヒ酸塩。 - 式：
で表される化合物の結晶質4-フェニルケイヒ酸塩。 - 請求項１〜１７のいずれかに記載の化合物及び製薬上許容される担体又は賦形剤を含み、かつ1種類以上の別の治療成分を含んでいてよい、医薬製剤。
- 請求項１〜１７のいずれかに記載の化合物と1種類以上の別の治療成分を含んでいる組合せ。
- 選択的β2-アドレナリン受容体作動薬の適応がある臨床状態を予防又は治療するための医薬の製造における、請求項１〜１７のいずれかに記載の化合物の使用。
- 医薬療法で使用するための、請求項１〜１７のいずれかに記載の化合物。
- 請求項１〜１７のいずれかに記載の結晶質化合物を調製する方法であって、溶液状態で5-[(R)-2-(2-{4-[4-(2-アミノ-2-メチル-プロポキシ)-フェニルアミノ]-フェニル}-エチルアミノ)-1-ヒドロキシ-エチル]-8-ヒドロキシ-1H-キノリン-2-オンをケイヒ酸、4-メトキシケイヒ酸、ジ-(4-フェニルケイヒ酸)及び4-メチルケイヒ酸から選択される酸と接触させることを含む、前記方法。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64284405P | 2005-01-11 | 2005-01-11 | |
| GB0500513A GB0500513D0 (en) | 2005-01-11 | 2005-01-11 | Novel compounds |
| GB0514199A GB0514199D0 (en) | 2005-07-11 | 2005-07-11 | Novel compounds |
| GB0514200A GB0514200D0 (en) | 2005-07-11 | 2005-07-11 | Novel compounds |
| PCT/EP2006/000141 WO2006074897A1 (en) | 2005-01-11 | 2006-01-09 | Cinnamate salts of a beta-2 adrenergic agonist |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526805A JP2008526805A (ja) | 2008-07-24 |
| JP2008526805A5 true JP2008526805A5 (ja) | 2009-02-05 |
Family
ID=36046933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007549866A Pending JP2008526805A (ja) | 2005-01-11 | 2006-01-09 | ベータ−２アドレナリン作動薬のケイヒ酸塩 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20080125462A1 (ja) |
| EP (1) | EP1846374A1 (ja) |
| JP (1) | JP2008526805A (ja) |
| KR (1) | KR20070097106A (ja) |
| CN (1) | CN101137625A (ja) |
| AU (1) | AU2006205933A1 (ja) |
| BR (1) | BRPI0606712A2 (ja) |
| CA (1) | CA2594484A1 (ja) |
| EA (1) | EA200701260A1 (ja) |
| IL (1) | IL184246A0 (ja) |
| MA (1) | MA29167B1 (ja) |
| MX (1) | MX2007008459A (ja) |
| NO (1) | NO20073282L (ja) |
| NZ (1) | NZ556335A (ja) |
| WO (1) | WO2006074897A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007008459A (es) * | 2005-01-11 | 2007-07-25 | Glaxo Group Ltd | Sales de cinamato de un agonista beta-2 adrenergico. |
| TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| CA2660707C (en) | 2006-08-10 | 2014-07-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Preparation of (r,r)-fenoterol and (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure |
| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| PL2231642T3 (pl) | 2008-01-11 | 2014-04-30 | Novartis Ag | Pirymidyny jako inhibitory kinazy |
| UY31905A (es) | 2008-06-18 | 2010-01-29 | Astrazeneca Ab | Derivados de benzoxazinona, procesos de preparación, composiciones farmacéuticas conteniéndolos y aplicaciones. |
| EP2544676B1 (en) | 2010-03-10 | 2018-09-19 | The United States of America, as represented by The Secretary, Department of Health and Human Services | The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| CA2828219A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Pyrazolo [1,5-a] pyridines as trk inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US694568A (en) * | 1901-01-03 | 1902-03-04 | James W Mccarthy | Yarn or thread guide for spinning-machines. |
| US4353656A (en) * | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
| US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| FI88112C (fi) * | 1985-07-30 | 1993-04-13 | Glaxo Group Ltd | Anordning foer administrering av laekemedel till patienter |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US5552438A (en) * | 1992-04-02 | 1996-09-03 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
| US5998428A (en) * | 1995-05-31 | 1999-12-07 | Smithkline Beecham Corporation | Compounds and methods for treating PDE IV-related diseases |
| GB9700226D0 (en) * | 1997-01-08 | 1997-02-26 | Glaxo Group Ltd | Inhalation device |
| US6632666B2 (en) * | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| US20030229058A1 (en) | 2001-11-13 | 2003-12-11 | Moran Edmund J. | Aryl aniline beta2 adrenergic receptor agonists |
| US6653323B2 (en) | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| ATE450511T1 (de) | 2003-05-08 | 2009-12-15 | Theravance Inc | Kristalline formen eines arylanilin-beta-2- adrenergenrezeptor-agonists |
| TW200526547A (en) | 2003-09-22 | 2005-08-16 | Theravance Inc | Amino-substituted ethylamino β2 adrenergic receptor agonists |
| TW200531692A (en) * | 2004-01-12 | 2005-10-01 | Theravance Inc | Aryl aniline derivatives as β2 adrenergic receptor agonists |
| US7317023B2 (en) * | 2004-07-21 | 2008-01-08 | Theravance, Inc. | Diaryl ether β2 adrenergic receptor agonists |
| MX2007008459A (es) * | 2005-01-11 | 2007-07-25 | Glaxo Group Ltd | Sales de cinamato de un agonista beta-2 adrenergico. |
-
2006
- 2006-01-09 MX MX2007008459A patent/MX2007008459A/es not_active Application Discontinuation
- 2006-01-09 EA EA200701260A patent/EA200701260A1/ru unknown
- 2006-01-09 CN CNA2006800073097A patent/CN101137625A/zh active Pending
- 2006-01-09 KR KR1020077018424A patent/KR20070097106A/ko not_active Application Discontinuation
- 2006-01-09 BR BRPI0606712-3A patent/BRPI0606712A2/pt not_active IP Right Cessation
- 2006-01-09 US US11/722,801 patent/US20080125462A1/en not_active Abandoned
- 2006-01-09 JP JP2007549866A patent/JP2008526805A/ja active Pending
- 2006-01-09 CA CA002594484A patent/CA2594484A1/en not_active Abandoned
- 2006-01-09 EP EP06700503A patent/EP1846374A1/en not_active Withdrawn
- 2006-01-09 NZ NZ556335A patent/NZ556335A/en not_active IP Right Cessation
- 2006-01-09 WO PCT/EP2006/000141 patent/WO2006074897A1/en active Application Filing
- 2006-01-09 US US11/327,886 patent/US7772250B2/en not_active Expired - Fee Related
- 2006-01-09 AU AU2006205933A patent/AU2006205933A1/en not_active Abandoned
-
2007
- 2007-06-26 IL IL184246A patent/IL184246A0/en unknown
- 2007-06-27 NO NO20073282A patent/NO20073282L/no not_active Application Discontinuation
- 2007-07-26 MA MA30100A patent/MA29167B1/fr unknown
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