JP2008526695A5 - - Google Patents
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- Publication number
- JP2008526695A5 JP2008526695A5 JP2007548720A JP2007548720A JP2008526695A5 JP 2008526695 A5 JP2008526695 A5 JP 2008526695A5 JP 2007548720 A JP2007548720 A JP 2007548720A JP 2007548720 A JP2007548720 A JP 2007548720A JP 2008526695 A5 JP2008526695 A5 JP 2008526695A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonyl
- amino
- naphthalene
- acid
- ylmethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04031009A EP1676834A1 (en) | 2004-12-30 | 2004-12-30 | Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation |
| EP04031009.6 | 2004-12-30 | ||
| PCT/EP2005/013624 WO2006069656A1 (en) | 2004-12-30 | 2005-12-17 | Fused bicyclic carboxamide derivatives for use as cxcr2 inhibitors in the treatment of inflammation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008526695A JP2008526695A (ja) | 2008-07-24 |
| JP2008526695A5 true JP2008526695A5 (https=) | 2009-02-12 |
| JP5123667B2 JP5123667B2 (ja) | 2013-01-23 |
Family
ID=34928051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548720A Expired - Fee Related JP5123667B2 (ja) | 2004-12-30 | 2005-12-17 | 炎症の治療においてｃｘｃｒ２阻害剤として使用される縮合二環式カルボキサミド誘導体 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7919628B2 (https=) |
| EP (2) | EP1676834A1 (https=) |
| JP (1) | JP5123667B2 (https=) |
| KR (1) | KR20070091634A (https=) |
| CN (1) | CN101094830A (https=) |
| AR (1) | AR055830A1 (https=) |
| AT (1) | ATE543795T1 (https=) |
| AU (1) | AU2005321609B2 (https=) |
| BR (1) | BRPI0519452A2 (https=) |
| CA (1) | CA2592430A1 (https=) |
| IL (1) | IL184173A (https=) |
| MA (1) | MA29113B1 (https=) |
| MX (1) | MX2007007068A (https=) |
| NO (1) | NO20073932L (https=) |
| NZ (1) | NZ556192A (https=) |
| PE (1) | PE20060855A1 (https=) |
| RU (1) | RU2404962C2 (https=) |
| TW (1) | TW200639141A (https=) |
| UY (1) | UY29322A1 (https=) |
| WO (1) | WO2006069656A1 (https=) |
| ZA (1) | ZA200704089B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060014785A1 (en) * | 2004-05-25 | 2006-01-19 | Metabolex, Inc. | Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation |
| EP1676834A1 (en) | 2004-12-30 | 2006-07-05 | Sanofi-Aventis Deutschland GmbH | Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation |
| EP2476669A1 (en) | 2006-01-27 | 2012-07-18 | Fibrogen, Inc. | Cyanoisoquinoline compounds and methods of use thereof |
| CN103497184A (zh) | 2006-04-04 | 2014-01-08 | 菲布罗根有限公司 | 作为hif调节剂的吡咯并吡啶和噻唑并吡啶化合物 |
| WO2008000408A1 (en) | 2006-06-28 | 2008-01-03 | Sanofi-Aventis | Cxcr2 antagonists |
| KR20090023645A (ko) | 2006-06-28 | 2009-03-05 | 사노피-아벤티스 | 신규한 ｃｘｃｒ2 억제제 |
| JP5232144B2 (ja) * | 2006-06-28 | 2013-07-10 | サノフイ | Ｃｘｃｒ２阻害剤 |
| JP5352455B2 (ja) | 2006-06-30 | 2013-11-27 | サノフイ | Ｃｘｃｒ２阻害剤 |
| DE602007009865D1 (de) * | 2006-11-23 | 2010-11-25 | Novartis Ag | 5-sulfanylmethylä1,2,4ütriazolä1,5-aüpyrimidin-7-olderivate als cxcr2-antagonisten |
| CA2669579A1 (en) * | 2006-11-23 | 2008-05-29 | Novartis Ag | 5-sulfanylmethyl-pyrazolo [1,5-a] pyrimidin-7-ol derivatives as cxcr2 antagonists |
| KR101364353B1 (ko) * | 2006-11-30 | 2014-02-18 | 다우 아그로사이언시즈 엘엘씨 | 2-치환된-5-(1-알킬티오)알킬피리딘의 제조 방법 |
| CL2008001632A1 (es) * | 2007-06-05 | 2009-10-16 | Sanofi Aventis | Compuestos derivados de acidos benzoilamino-indan-2-carboxilicos sustituidos, inhibidores del receptor cxcr5; composicion farmaceutica; y su uso en el tratamiento de efecciones fisiologicas inflamatorias, tales como artritis reumatoidea y asma. |
| WO2010056767A1 (en) | 2008-11-14 | 2010-05-20 | Fibrogen, Inc. | Thiochromene derivatives as hip hydroxylase inhibitors |
| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| AU2013203591B2 (en) * | 2009-05-01 | 2017-01-19 | University Court Of The University Of Dundee | Treatment or prophylaxis of proliferative conditions |
| WO2012079154A1 (en) * | 2010-12-14 | 2012-06-21 | Dalhousie University | Selective estrogen receptor modulators |
| BR112014030474A2 (pt) * | 2012-06-19 | 2017-06-27 | Hoffmann La Roche | novos compostos bicíclicos de tiofenilamida |
| CN104619705B (zh) * | 2012-09-12 | 2018-01-02 | 霍夫曼-拉罗奇有限公司 | 作为脂肪酸结合蛋白(fabp)4和/或5的抑制剂的非成环噻吩基酰胺 |
| WO2014114603A1 (en) * | 2013-01-24 | 2014-07-31 | F. Hoffmann-La Roche Ag | Substituted thiazole compounds |
| CA2899024C (en) | 2013-01-24 | 2022-01-04 | Fibrogen, Inc. | Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid |
| WO2015127548A1 (en) * | 2014-02-28 | 2015-09-03 | The Royal Institution For The Advancement Of Learning / Mcgill University | Tc-ptp inhibitors as apc activators for immunotherapy |
| RU2744460C2 (ru) * | 2014-04-15 | 2021-03-09 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости |
| RU2017106172A (ru) * | 2014-07-31 | 2018-08-28 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Применение антагонистов cxcr2 для предотвращения и/или лечения периферической невропатии, вызванной химиотерапией (cipn) |
| CN105906608B (zh) * | 2016-05-03 | 2018-10-19 | 中山大学 | 8-氨基喹啉-松果体素杂联体及其药物组合物 |
| CN106187974B (zh) * | 2016-07-01 | 2018-01-12 | 广州军区广州总医院 | 具有抗肿瘤作用的鱼藤素断环结构与氨基酸衍生物的合成方法 |
| PT3717646T (pt) | 2017-12-01 | 2025-07-28 | Texas A & M Univ Sys | Tratamento antisense da síndrome de angelman |
| PE20210367A1 (es) | 2018-02-02 | 2021-02-26 | Maverix Oncology Inc | Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina |
| GB201807924D0 (en) * | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| AU2019301510B2 (en) | 2018-07-09 | 2024-06-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelminthic heterocyclic compounds |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| EP4058434A1 (en) | 2019-11-12 | 2022-09-21 | Genzyme Corporation | 6-membered heteroarylaminosulfonamides for treating diseases and conditions mediated by deficient cftr activity |
| WO2021113808A1 (en) * | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Cftr-modulating arylamides |
| WO2021113806A1 (en) * | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
| CN114981265B (zh) | 2019-12-18 | 2025-01-03 | Ctxt私人有限公司 | 化合物 |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| CN111559991B (zh) * | 2020-06-01 | 2022-01-25 | 河南省锐达医药科技有限公司 | 一种萘胺类化合物及其盐的制备方法和应用 |
| UY39995A (es) | 2021-11-01 | 2023-05-15 | Boehringer Ingelheim Vetmedica GmbH | Compuestos de pirrolopiridazina como antihelmínticos |
| CN115385865B (zh) * | 2022-06-29 | 2023-06-16 | 深圳大学 | 一种具有cxcr2抑制活性的小分子抑制剂及其制备方法与应用 |
| CN116041300B (zh) * | 2023-02-20 | 2024-04-26 | 沈阳药科大学 | 一种2,2-二甲基苯并吡喃类衍生物及其制备方法和应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962224A (en) * | 1987-12-23 | 1990-10-09 | American Home Products Corporation | N-naphthoylglycines as aldose reductase inhibitors |
| US4994477A (en) * | 1988-03-24 | 1991-02-19 | Abbott Laboratories | Heterocyclic renin inhibitors |
| US6531467B2 (en) * | 1996-09-12 | 2003-03-11 | Idun Pharmaceuticals, Inc. | Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
| GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| DE10006139A1 (de) * | 2000-02-11 | 2001-08-16 | Merck Patent Gmbh | Indol-3-yl-Derivate |
| IT1317826B1 (it) | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
| FR2825706B1 (fr) * | 2001-06-06 | 2003-12-12 | Pf Medicament | Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase |
| US6673791B2 (en) * | 2001-07-30 | 2004-01-06 | Boehringer Ingelheim (Canada) Ltd. | Non-nucleoside reverse transcriptase inhibitors |
| GB2389580A (en) * | 2002-06-12 | 2003-12-17 | Bayer Ag | 2-Naphthamide PGI2 antagonists |
| CA2528232C (en) * | 2003-06-06 | 2010-05-25 | Fibrogen, Inc. | Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin |
| WO2005014533A2 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| EP1670804A2 (en) | 2003-09-10 | 2006-06-21 | GPC Biotech AG | Heterobicyclic compounds as pharmaceutically active agents |
| US20050085531A1 (en) | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| EP1687292B1 (en) | 2003-11-20 | 2007-08-22 | Eli Lilly And Company | Vitamin d receptor modulators |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| WO2006040646A1 (en) | 2004-10-14 | 2006-04-20 | Pfizer, Inc. | Benzimidazole or indole amides as inhibitors of pin1 |
| AU2005304962B2 (en) | 2004-11-09 | 2009-11-19 | Smithkline Beecham Corporation | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof |
| EP1676834A1 (en) | 2004-12-30 | 2006-07-05 | Sanofi-Aventis Deutschland GmbH | Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation |
| AR055319A1 (es) | 2005-03-17 | 2007-08-15 | Wyeth Corp | Derivados de isoquinoleina, composiciones farmaceuticas y usos |
-
2004
- 2004-12-30 EP EP04031009A patent/EP1676834A1/en not_active Withdrawn
-
2005
- 2005-12-17 CN CNA2005800454624A patent/CN101094830A/zh active Pending
- 2005-12-17 RU RU2007128949/04A patent/RU2404962C2/ru not_active IP Right Cessation
- 2005-12-17 WO PCT/EP2005/013624 patent/WO2006069656A1/en not_active Ceased
- 2005-12-17 NZ NZ556192A patent/NZ556192A/en not_active IP Right Cessation
- 2005-12-17 BR BRPI0519452-0A patent/BRPI0519452A2/pt not_active Application Discontinuation
- 2005-12-17 AU AU2005321609A patent/AU2005321609B2/en not_active Ceased
- 2005-12-17 AT AT05818685T patent/ATE543795T1/de active
- 2005-12-17 JP JP2007548720A patent/JP5123667B2/ja not_active Expired - Fee Related
- 2005-12-17 CA CA002592430A patent/CA2592430A1/en not_active Withdrawn
- 2005-12-17 KR KR1020077015119A patent/KR20070091634A/ko not_active Withdrawn
- 2005-12-17 MX MX2007007068A patent/MX2007007068A/es active IP Right Grant
- 2005-12-17 EP EP05818685A patent/EP1836158B1/en not_active Expired - Lifetime
- 2005-12-28 AR ARP050105577A patent/AR055830A1/es unknown
- 2005-12-28 TW TW094146875A patent/TW200639141A/zh unknown
- 2005-12-30 UY UY29322A patent/UY29322A1/es unknown
-
2006
- 2006-01-03 PE PE2006000027A patent/PE20060855A1/es not_active Application Discontinuation
-
2007
- 2007-05-21 ZA ZA200704089A patent/ZA200704089B/xx unknown
- 2007-06-24 IL IL184173A patent/IL184173A/en unknown
- 2007-06-26 MA MA30032A patent/MA29113B1/fr unknown
- 2007-06-29 US US11/771,958 patent/US7919628B2/en not_active Expired - Fee Related
- 2007-07-26 NO NO20073932A patent/NO20073932L/no unknown
-
2011
- 2011-04-04 US US13/079,522 patent/US8283479B2/en not_active Expired - Fee Related
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